Üst Keser Dişlerde Meydana Gelen Travma Sonrası Multidisipliner Tedavi Yaklaşımı: Bir Olgu Sunumu

Amaç: Travma sonrası dişlerde hasar meydana gelmesi sıklıkla karşılaşılan problemlerdendir. Daimi dentisyon sırasında medya gelen travmalarda ise kesici dişlerin avülsüyonuna rastlanabilir. Bu durumlarda splintlenme önerilmekte ancak çapraşıklığı olan olgularda travma sonrası splint yapımında güçlükler yaşanabilmektedir. Bu vaka raporunda amaç travma sonrasında fiber ile güçlendirilmiş lingual retainerın splint olarak etkinliğini ve iyileşme sonrası yapılan ortodontik ve protetik tedavileri göstermektir. Olgu sunumu: 22 yaşındaki bayan hasta travma sonrası üst kesici dişlerinde hasar şikayetiyle başvurmuştur. Alınan anamnezde avülse olan kesici dişin ilk başvurduğu hekim tarafından soket içerisine yerleştirilmeye çalışılıp fakültemize gönderildiği anlaşılmıştır. Yapılan reimplantasyon işleminden sonra fiber ile güçlendirilmiş lingual retainer ile dişler splintlenmiştir. Takip döneminden sonra sol üst orta kesici dişin çekimi gerekmiş ve sol üst yan kesici diş ortodontik tedavi ile sol orta kesicinin yerine getirilmiş ve uygun protetik tedaviler yapılmıştır. Sonuç: Çapraşıklığı bulunan travma hastalarında ağız içerisinde kompozit tel kombinasyonu splint yapımı zor olduğundan fiber ile güçlendirilmiş lingual retainer bir alternatif olabilir

Using Hemostatic Agents During Orthodontic Bonding: An In Vitro Study

Objective:The aim of this in vitro study was to compare the effect of a traditional hemostatic agent on the shear bond strength (SBS) of conventional and self-etching bonding systems to find an efficient procedure for orthodontic bonding.Material and Methods:Extracted human premolars (n=108) were divided into 6 equal groups. Conventional light cure primer was used in groups 1, 2, and 3. Acid etching and primer were applied directly in group 1. Enamel surfaces were covered with a Ankaferd Blood Stopper (ABS), which was used as a hemostatic agent in groups 2 and 3. Orthophosphoric acid was applied on ABS-covered enamel in group 2. Before the acid was applied, the enamel surface was cleaned with wet surgical gauze in group 3. A self-etching primer was used in groups 4, 5, and 6. Similar to the first 3 groups, primer was applied on the enamel surface in group 4. Samples were covered with ABS before the primer was applied in groups 4 and 5. The ABS residue was cleaned with gauze before primer application in group 6. The samples were debonded using a universal testing machine. In addition, SBS and residual adhesive were evaluated.Results:Samples contaminated with hemostatic agent and bonded with the self-etching primer without cleaning the hemostatic agent showed significantly lower SBS (p,0.05). Cleaning the ABS on the enamel surfaces increased the bonding strength of self-etching primers. Groups 5 and 6 showed significantly lower ARI scores (p,0.05).Conclusion:Before bonding orthodontic attachments with conventional and light-cure primers, ABS can be safely used. However, using self-etch primers directly on the ABS-applied enamel surface should be avoided. (Turkish J Orthod 2015;28:38– 43

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C

Effectiveness of an antibacterial primer used with adhesive-coated brackets on enamel demineralization around brackets: an in vivo study

Abstract Background The aim of the study is to assess the clinical effect of an antibacterial monomer-containing primer on preventing white spot lesions (WSLs) during fixed orthodontic treatment. Subject and methods The study included 35 patients. A split-mouth design was used during bonding of the brackets. In Clearfil (CF) group, adhesive-coated brackets (APC Plus Victory series, 3M Unitek, Monrovia, CA, USA) were bonded with an antibacterial monomer-containing primer (Clearfil Protect Bond, Kuraray Medical, Okayama, Japan). In Transbond (TB) group, the same adhesive-coated brackets were bonded using a conventional primer (Transbond XT Primer; 3M Unitek, Monrovia, CA, USA). The mean duration of orthodontic treatment was 16 months. Digital images of each tooth were used to assess the WSLs. The areas of the WSLs were measured with a software. The bond failures during orthodontic treatment were also recorded. Results After fixed orthodontic treatment, 23 of the 35 patients showed one or more WSLs. Of the total of 666 teeth, 114 WSLs occurred over the orthodontic treatment time. Rates of WSL in the CF and TB groups were 8.03% and 9.24%, respectively. The difference in WSL rates between the two groups was not statistically significant. No significant difference was observed in the lesion areas between the groups. Moreover, the difference in bracket failure rates between the two groups was also not statistically significant. Conclusion The results of this long-term clinical study indicated no significant difference between the antibacterial monomer-containing primer group and the control group in the efficacy of reducing demineralization throughout the orthodontic treatment

Hemostatic Effects Of Adrenaline And Ankaferd (Blood Stopper) During Orthodontic Attachment Bonding

Background/aim: Moisture prevention during the bonding of orthodontic attachments on impacted teeth is crucial for accomplishment. It was aimed to compare the hemostatic effects of adrenaline and Ankaferd Blood Stopper (ABS) during the surgical exposure of the impacted maxillary canine. Materials and methods: The study consists of 20 patients, whose orthodontic treatments were outlined with the surgical exposure of maxillary impacted canine. Patients were divided into groups of 10; where each group was treated with one of the two medicines to control bleeding. Group A was treated with adrenaline, and group B was treated with Ankaferd Blood Stopper (ABS). The bleeding period was recorded as the time from the exposure of the crown until the inception of bonding. Results: It was observed that both the bleeding period and the cumulative duration were significantly shorter in group B (the ABS group) than in group A (the adrenaline group) (P < 0.05), but no significant deviation in bonding times was recorded. Conclusion: ABS is a good alternative hemostatic agent for the prevention of bleeding at the surgical exposure of impacted teeth without affecting the bonding.WoSScopu

A comparison of surgical outcome of fasciocutaneous V-Y advancement flap and Limberg transposition flap for recurrent sacrococcygeal pilonidal sinus disease

Objective: The aim of this study was to compare the surgical outcome of fasciocutaneous V-Y advancement flap and limberg transposition flap used to treat recurrent sacrococcygeal PSD

Laparoscopic Appendectomy Using Hem-o-lok Polymer Clips: A Single-Center Experience

Although the surgical technique of laparoscopic appendectomy (LA) stump has been well understood, there are many alternative techniques in relation to torocar positioning and closure of appendicular stump. In recent times, Hem-o-lok polymer clips (HOLP) was implemented in several studies in the closure of appendicular stump because of its lower cost and easy implementation. The purpose of this study to investigate the safety, usefulness, and cost effectiveness of HOLP for the closure appendecular stumps in LA. The study was carried out between December 2011 and December 2013. Patients with acute appendicitis were included in the study. Two groups were defined as patients with the HOLP and patients with endoloop. The prospectively collected data, including age, sex, body mass index, operative time, hospital stay, cost effectiveness, intraoperative, and postoperative complications were retrospectively analyzed. A total of 66 (35 male, 31 female) LA were performed. The endoloop group consisted of 30 patients (16 male, 14 female, and mean age, 30.4 +/- 1.8), while the HOLP group consisted of 36 patients (19 male, 17 female, and mean age, 28.6 +/- 1.6). The mean operative time was 42.5 +/- 1.3 in the HOLP group and 53.8 +/- 1.5 in the endoloop group (P < 0.0001). The mean hospital stay was 2.1 +/- 0.2 days in HOLP group and 2 +/- 0.2 in the endoloop group (P = 0.73). Both patient groups had no intraoperative complication, and no cases were converted to open procedure. Total hospital cost was 1170.8 +/- 6.3 dollars in the HOLP group and 1094 +/- 6.9 dollars in the endoloop group (P < 0.0001). The use of HOLP for the appendicular stumps in LA is a feasible, safe, and cost-effective procedure in patients with uncomplicated acute appendicitis

The relationship of patients, giving or not giving a pathological full response, wıth YAP (Yes Associated Protein) in breast cancer cases to which neo-adjuvant chemotherapy is applied

© 2022, Edizioni Luigi Pozzi. All rights reserved.AIM: We aimed to evaluate (immunohistochemically) the YAP expression in breast cancer patients undergoing neoadjuvant chemotherapy and to clarify the relationship between the molecular characteristics, treatment response and survival data and the YAP expression, and hence, to clarify the prognostic significance. MATERIAL AND METHODS: One hundred and four patients who were diagnosed with Breast Cancer between 2015-2020 and underwent Neo Adjuvant Chemotherapy were included in the study. Estrogen Receptor(ER), Progesterone Receptor(PR), Human Epidermal Growth Receptor-2(HER2) and Ki-67. Expression are routinely stained immunohistochemically. In this study, existing immunohistochemical markers were reviewed and also, the relationship of YAP with these biological markers was evaluated by using immunohistochemistry and its effect on prognosis has been investigated. RESULTS: The average age of the patients was 52.37. While YAP was positive in 78 patients (75%), it was negative in 26 patients (25%). In the evaluation after neoadjuvant therapy, pathological complete response (MillerPayne Grade5 response) in 28 patients (26.9%), relapse in 6 patients (5.8%), and exitus in 6 patients (5.8%) were detected. In the pathological evaluation, invasive Ductal Carcinoma was the most common one observed in 88 patients (84.6%). As a result of the statistical evaluation, no significant result was obtained between the parameters and YAP negative/positive. CONCLUSION: As a result of staining with additional YAP in patients who were diagnosed with breast cancer and routinely stained with ER, PR, Cerb B2 and Ki-67 in pathology samples, we could not reach a result that would contribute positively to survival. Longer studies to be conducted prospectively will be meaningful

Effects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis

Background/aims: The aim of this trial was to study the role of glucagon-like peptide-2 in reducing bacterial translocation by virtue of its anti-inflammatory effects and ability to decrease intestinal permeability in rat models of inflammatory bowel diseases. On the basis of our results and those of other recent studies, we suggest a new treatment modality for colitis. To our knowledge, this is the first study of the effectiveness of glucagon-like peptide-2 on bacterial translocation, in treating an. experimental colitis model. Methods: Rats were randomized into 3 groups of 7 rats each-the control group, colitis group, and treatment group. On the 75 day after induction of colitis, the levels of tissue myeloperoxidase, serum tumor necrosis factor-alpha, and plasma endotoxin were measured. Tissue samples were obtained from the liver, spleen, and mesenteric lymph nodes for evaluating bacterial translocation. Results: Bacterial translocation in samples of the liver, spleen, mesenteric lymph nodes, and portal and systemic blood obtained from the treatment group was lower than that in samples obtained from the colitis group (p<0.05). The levels of tissue myeloperoxidase, serum tumor necrosis factor-alpha, and plasma endotoxin in the treatment group were significantly lower than those in the colitis group (p<0.05). Conclusions: In experimental colitis models, which were induced using trinitrobenzene sulfonic acid in ethanol, glucagon-like peptide-2 treatment reduced inflammation and bacterial translocation from the intestinal mucosa. Our results indicate that glucagon-like peptide-2 is a potential agent for treating colitis; however, extensive trials are needed to confirm our results