57 research outputs found
Corrosion resistance of anodic layers grown on 304L stainless steel at different anodizing times and stirring speeds
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2019
- Field of study
Different chemical and physical treatments have been used to improve the properties and functionalities of steels. Anodizing is one of the most promising treatments, due to its versatility and easy industrial implementation. It allows the growth of nanoestructured oxide films with interesting properties able to be employed in different industrial sectors. The present work studies the influence of the anodizing time (15, 30, 45 and 60 min), as well as the stirring speed (0, 200, 400, and 600 rpm), on the morphology and the corrosion resistance of the anodic layers grown in 304L stainless steel. The anodic layers were characterized morphologically, compositionally, and electrochemically, in order to determine the influence of the anodization parameters on their corrosion behavior in a 0.6 mol L-1 NaCl solution. The results show that at 45 and 60 min anodizing times, the formation of two microstructures is favored, associated with the collapse of the nanoporous structures at the metal-oxide interphace. However, both the stirring speed and the anodizing time have a negligeable effect on the corrosion behavior of the anodized 304L SS samples, since their electrochemical values are similar to those of the non-anodized ones
Electrochemical Detection of Iron in a Lixiviant Solution of Polluted Soil Using a Modified Glassy Carbon Electrode
- Publication venue
- Publication date
- 23/04/2020
- Field of study
This paper presents preliminary results on the modification of glassy carbon electrodes with Multiwall Carbon Nanotubes with or without Polyaniline and Pt nanoparticles as electrocatalytic materials for metallic pollutants detection. Electrodes were constructed and incorporated as amperometric detectors of ionic iron electroreduction using the Flow Injection Amperometric technique in aqueous solution. The results not only revealed the modified electrode with nanotubes, polyaniline and platinum nanoparticles were the most selective and sensitive, but also provided an electroanalytic tool to analyze iron in lixiviated samples of polluted soil. The proposed iron sensor exhibited a linear response between 0 and 10 mM with detection and quantification limits of 0.003 and 0.012 μM, respectively. The aqueous samples were taken from a lixiviated solution of polluted soil from Mineral de Pozos, Guanajuato, Mexico, to define the erosion grade of soil
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
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- Zhou H.
- Zhou J.
- Zhou J.
- Zhou J.
- Zhou J.
- Zhou K.
- Zhou R.
- Zhou X. -J.
- Zhou Y.
- Zhou Y.
- Zhou Y.
- Zhou Z.
- Zhou Z. -Y.
- Zhu B.
- Zhu C.
- Zhu G. -Q.
- Zhu H.
- Zhu H.
- Zhu H.
- Zhu W. -G.
- Zhu Y.
- Zhu Y.
- Zhuang H.
- Zhuang X.
- Zientara-Rytter K.
- Zimmermann C. M.
- Ziviani E.
- Zoladek T.
- Zong W. -X.
- Zorov D. B.
- Zorzano A.
- Zou W.
- Zou Z.
- Zou Z.
- Zuryn S.
- Zwerschke W.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies
- Author
- Abad R. D.
- Abe T.
- Abelha P.
- Abroug F.
- Adams J. C.
- Adamsson R. O.
- Adderly J.
- Adhikari A.
- Adolfsson A.
- Aguilar R. Z.
- Aguirre J. S.
- Aguirre S.
- Aguirre-Bermeo H.
- Ahsan A.
- Aisa T. M.
- Aisiku I.
- Ajetunmobi O. O.
- Akaraborworn O.
- Aker M.
- Akgun N.
- Akhtar A.
- Akyol O. O.
- Al Dorzi H. M.
- Al Jabbary A. S.
- Alam A. S.
- Albaiceta G. M.
- Albarrak M. M.
- Alberts E.
- Albiero D.
- Alda R. S.
- Alejandro R. V.
- Alexander P.
- Alfonso A. A. T.
- Algaba A.
- Algera A. G.
- Ali S. M.
- Aliaga F. A.
- Alisasis A. U.
- Allan R. M.
- Allue R. M.
- Almeida R. D. S.
- Almekhlafi G.
- Alonso J. G.
- Altaf W.
- Alvarez A. M.
- Alvarez J.
- Alves R. A.
- Alzugaray P.
- Amendola C. P.
- Amin P.
- Amir F.
- Amor M.
- Ampinelli A. M. R.
- An Y.
- Andersen F. H.
- Andoh K.
- Andruszkiewicz P.
- Aneman A.
- Anquez N.
- Antonelli M. M.
- Antonio A. C. P.
- Aoki N.
- Appelberg H.
- Arabi Y.
- Arabi Y. M.
- Aragao D.
- Araujo A. M.
- Arizmendi A.
- Arnal J. -M.
- Artiga M. J. D.
- Artigas A.
- Arumoli J.
- Asaduzzaman M.
- Ascoli A.
- Assuncao M. S.
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- Avendano R.
- Avila L. E.
- Aydin D.
- Aytulun A.
- Azad R.
- Azauddin S. N. S.
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- Publication date
- 01/01/2022
- Field of study
Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding
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- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
- Üstün S
- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome: Insights From the Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE Study
- Author
- Abad RD
- Abe T
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Á
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlaf G
- Alonso JG
- Altaf W
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- Unnikrishnan R
- Uppalapati A
- van Haren F
- van Haren F.
- Van Wezel HM
- Vargas MP
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- Veljovic M.
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- Vercueil A
- Vermassen J
- Verstraete R
- Villagomez A
- Villagomez AJ
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- Zeggwagh AA
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- Zogheib EH
- Ñamendys-Silva SA
- Ünal N
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2019
- Field of study
OBJECTIVES: To describe the characteristics and outcomes of patients with acute respiratory distress syndrome with or without spontaneous breathing and to investigate whether the effects of spontaneous breathing on outcome depend on acute respiratory distress syndrome severity. DESIGN: Planned secondary analysis of a prospective, observational, multicentre cohort study. SETTING: International sample of 459 ICUs from 50 countries. PATIENTS: Patients with acute respiratory distress syndrome and at least 2 days of invasive mechanical ventilation and available data for the mode of mechanical ventilation and respiratory rate for the 2 first days. INTERVENTIONS: Analysis of patients with and without spontaneous breathing, defined by the mode of mechanical ventilation and by actual respiratory rate compared with set respiratory rate during the first 48 hours of mechanical ventilation. MEASUREMENTS AND MAIN RESULTS: Spontaneous breathing was present in 67% of patients with mild acute respiratory distress syndrome, 58% of patients with moderate acute respiratory distress syndrome, and 46% of patients with severe acute respiratory distress syndrome. Patients with spontaneous breathing were older and had lower acute respiratory distress syndrome severity, Sequential Organ Failure Assessment scores, ICU and hospital mortality, and were less likely to be diagnosed with acute respiratory distress syndrome by clinicians. In adjusted analysis, spontaneous breathing during the first 2 days was not associated with an effect on ICU or hospital mortality (33% vs 37%; odds ratio, 1.18 [0.92-1.51]; p = 0.19 and 37% vs 41%; odds ratio, 1.18 [0.93-1.50]; p = 0.196, respectively ). Spontaneous breathing was associated with increased ventilator-free days (13 [0-22] vs 8 [0-20]; p = 0.014) and shorter duration of ICU stay (11 [6-20] vs 12 [7-22]; p = 0.04). CONCLUSIONS: Spontaneous breathing is common in patients with acute respiratory distress syndrome during the first 48 hours of mechanical ventilation. Spontaneous breathing is not associated with worse outcomes and may hasten liberation from the ventilator and from ICU. Although these results support the use of spontaneous breathing in patients with acute respiratory distress syndrome independent of acute respiratory distress syndrome severity, the use of controlled ventilation indicates a bias toward use in patients with higher disease severity. In addition, because the lack of reliable data on inspiratory effort in our study, prospective studies incorporating the magnitude of inspiratory effort and adjusting for all potential severity confounders are required
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
- Author
- Abad RD
- Abe T
- Abe T.
- Abroug F
- Adams JC
- Adamsson RO
- Adolfsson A
- Aguilar RZ
- Aguirre JS
- Aguirre-Bermeo H
- Aisa TM
- Aisiku I
- Ajetunmobi OO
- Aker M
- Akyol OO
- Al Dorzi HM
- Al Jabbary AS
- Albaiceta GM
- Albarrak MM
- Albiero D
- Alda RS
- Alejandro RV
- Alexander P
- Algaba Á
- Aliaga FA
- Alisasis AU
- Allan RM
- Allue RM
- Almekhlafi G
- Alonso JG
- Altaf W
- Alvarez AM
- Alvarez J
- Amin P
- Amir F
- Amor M
- An Y
- Andersen FH
- Andoh K
- Andruszkiewicz P
- Aneman A
- Antonelli MM
- Antônio ACP
- Aoki N
- Appelberg H
- Arabi Y
- Arabi YM
- Arabim YM
- Araujo AM
- Arizmendi A
- Arnal JM
- Artiga MJD
- Artigas A
- Ascoli A
- Au SM
- Avila LE
- Azad R
- Azevedo LC
- Baboi L
- Badie JC
- Bailey IM
- Bailey MB
- Bajwa E
- Balkhi H
- Baltus T
- Banner-Goodspeed VM
- Barberet G
- Baron RM
- Baronia AK
- Barratt-Due A
- Barros FM
- Barros NC
- Batra H
- Battle CE
- Bauer PR
- Beck E
- Beck O
- Bedreag OH
- Beegle SH
- Beitler JR
- Bellani G
- Bellani G.
- Beloncle F
- Benslama A
- Beraldo DO
- Berghe C
- Berkelmans F
- Besset SL
- Bettini LR
- Beuret P
- Bezzi MG
- Bhardwaj VK
- Bhowmick K
- Biehler J
- Bigot C
- Bihari S
- Biondi RS
- Biscione RR
- Bisso MC
- Black CS
- Blakeman TC
- Blanco J
- Bolon S
- Borello SA
- Borotto EE
- Botteri M
- Bouchoucha S
- Boukhazna M
- Bouw MJ
- Boyd O
- Bramall J
- Braschi A
- Brazzi L
- Breen DM
- Briquet A
- Brito VA
- Brizuela M
- Brochard L
- Broman LM
- Brown SM
- Browne TS
- Bruhn AR
- Brunettini B
- Bruns MM
- Buensuseso JA
- Bugedo G
- Buise MP
- Bulpa PA
- Bumbasierevic V
- Bumbasirevic V
- Burtenshaw AJ
- Burtin P
- Buzancais G
- Béduneau G
- Camsooksai J
- Cani A
- Carbayo-Gorriz C
- Cardonnet LP
- Careless JP
- Carpentier D
- Carreño NG
- Carteaux G
- Casalena P
- Casement J
- Castro AG
- Castro S
- Catorze NT
- Cazorla-Barranquero FG
- Ceniceros-Barros A
- Cereijo E
- Cerny V
- Cerrato VI
- Cervantes MR
- Cesar PS
- Ceunen H
- Ceylan I
- Chabanne R
- Chapman R
- Chau SK
- Chelly J
- Chen K
- Chena A
- Cheng MP
- Chiche JD
- Chile SC
- Chouchene I
- Choudry S
- Cimic N
- Cinnella G
- Cirone R
- Citalán JE
- Claraco-Vega LM
- Clarkson K
- Clarkson KP
- Claverias L
- Cohen JE
- Cole JM
- Collins DV
- Collyer T
- Colombo R
- Combaux DM
- Combes A
- Conti S
- Cooper R
- Coppadoro A
- Corneci DE
- Cortegiani A
- Cortez CA
- Coxo CM
- Cracchiolo AN
- Cranshaw JH
- Crapelli G
- Crouch DR
- Crova PJ
- Csabi P
- Curley G
- Curto EG
- Daldin J
- Dangers L
- Danin PE
- Daubin C
- Daviaud F
- Davies KG
- Dawson H
- de Cima-Iglesias S
- de Gordoa LO
- de Haro C
- de Pablo R
- de Prost N
- Dean MN
- Declercq PM
- Dector D
- Dector DM
- Deicas A
- Del Carmen Lorente M
- Dellamonica J
- Dellera C
- Delsing A
- Demirkiran O
- Demoule A
- Dempsey G
- Dendane T
- Depuydt P
- Depuydt P
- Derman SS
- Di Tomasso NN
- Di YD
- Diaz-Rodriguez E
- Dive AM
- Dixit SB
- do Vale Fernandes A
- Dolva MS
- Donnelly A
- Dowling AT
- Doyen D
- Dres M
- Dreyer KR
- Dunne ES
- Dupont H
- Duranteau J
- Dwyer R
- Démpair G
- Ebeid A
- Elatrous S
- Elisabet GM
- Elkhayari M
- Ellis HE
- Elmasri M
- Erbabacan E
- Eriksson KE
- Esteban A
- Estenssoro E
- Esteve F
- Estilita JM
- Estrella CR
- Ezzouine H
- Fan E
- Fartoukh M
- Farías PA
- Fawkes DA
- Ferguson A
- Ferguson ND
- Fernandez AM
- Fernandez RO
- Fierro JM
- Floris L
- Fontenele DC
- Formenti P
- Forteza C
- Fossali T
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteristics, management and outcomes of patients that received tracheostomy, in the cohort of patients that developed ARDS on day 1-2 of acute hypoxemic respiratory failure, and in a subsequent propensity-matched cohort. Results: Of the 2377 patients with ARDS that fulfilled the inclusion criteria, 309 (13.0%) underwent tracheostomy during their ICU stay. Patients from high-income European countries (n = 198/1263) more frequently underwent tracheostomy compared to patients from non-European high-income countries (n = 63/649) or patients from middle-income countries (n = 48/465). Only 86/309 (27.8%) underwent tracheostomy on or before day 7, while the median timing of tracheostomy was 14 (Q1-Q3, 7-21) days after onset of ARDS. In the subsample matched by propensity score, ICU and hospital stay were longer in patients with tracheostomy. While patients with tracheostomy had the highest survival probability, there was no difference in 60-day or 90-day mortality in either the patient subgroup that survived for at least 5 days in ICU, or in the propensity-matched subsample. Conclusions: Most patients that receive tracheostomy do so after the first week of critical illness. Tracheostomy may prolong patient survival but does not reduce 60-day or 90-day mortality. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
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- Mercat A
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- Mirabella L
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- Perez Mp
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- Pham T
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- Pillai S
- Pintado Mc
- Piquilloud L
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- Pittini G
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- Zogheib Eh
- Ñamendys-Silva Sa
- Ünal N
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS. Trial registration: NCT02010073. Registered on 12 December 2013
New Quantitative Estimates of Long-Term Military Spending in Spain (1850–2009)
- Author
- Ballbé M.
- Banks A. S.
- Blanco Nuñez J. M.
- Brzoska M.
- Cardona G.
- Cardona G.
- CEPAL
- Comín F.
- Comín F.
- Comín F.
- Comín F.
- Dunne P.
- Eloranta J.
- Espuelas S.
- García Alonso J. M.
- García Pérez R.
- González Calleja E.
- Gómez Castañeda J.
- Hobson J. M.
- Huget M.
- Instituto de Estudios Fiscales
- International Institute for Strategic Studies
- Lemus E.
- Lleixá J.
- López Garrido D.
- Morcillo Sánchez E.
- Oliveres A.
- Olmeda Gómez J. A.
- Ortega M.
- Prados de la Escosura L.
- Puell de la Villa F.
- Puell de la Villa F.
- Puell de la Villa F.
- Pérez Munielo F.
- Ritzmann H.
- Rodríguez González A. R.
- Roldán I.
- Roldán I.
- San Román E.
- Sempere Doménech M.
- Singer J. D.
- Tilly C.
- Torre del Río R.
- Valério N.
- Velarde J.
- Vilar J. B.
- Viñas A.
- Viñas A.
- Publication venue
- 'Emerald'
- Publication date
- 01/01/2016
- Field of study
Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi Hasan M.
- Al Jabbary Ahmed S.
- Albaiceta Guillermo M.
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain U.
- Allan Russell M.
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier G.
- Altaf Wahid
- Alvarez António M.
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Abdellatif Benslama Mourad
- An Youzhong
- Andersen Finn H.
- Andoh Kohkichi
- Andruszkiewicz Pawel
- Aneman Anders
- Antonelli Massimo M.
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Yaasen
- Arabi Yaseen M.
- Araujo Ana M.
- Arizmendi Alfons
- Arnal Jean-Michel
- Artiga Maria Jose D.
- Artigas Antonio
- Ascoli Aline
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- Avila Luis E.
- Azad Raman
- Azevedo Luciano Cesar
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- Balkhi Hicham
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- Beitler Jeremy R.
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- Beloncle Francois
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
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- Bhowmick Kaushik
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- Boyd Owen
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- Braschi Antonio
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- Burtenshaw Andrew J.
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- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
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- Cardonnet Luis P.
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- Cerny Vladimir
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- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman Rhiannon
- Chau Simon K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng Meisy Perez
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry Shazia
- Christiansen Aage
- Cimic Nedim
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega Luis M.
- Clarkson Kevin
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- Claverias Laura
- Cohen Jason E.
- Cole Jade M.
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- Collyer Thomas
- Colombo Riccardo
- Combaux Daniele M.
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- Cooper Raphael
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- Corneci Dan E.
- Cortegiani Andrea
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- Cracchiolo Andrea N.
- Cranshaw Julius H.
- Crapelli Giulia
- Crouch Daniel R.
- Crova Philippe J.
- Csabi Peter
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric
- Daubin C. dric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson Heidi
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- de Haro Candelaria
- de Pablo Raul
- de Prost Nicolas
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- Dector Dulce
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- Deicas Alberto
- del Carmen Lorente Maria
- Dellamonica Jean
- Dellera Christian
- Delsing Angela
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane Tarek
- Depuydt P.
- Depuydt Pieter
- Derman Suleyman S.
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- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
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- Dowling Anna T.
- Doyen Denis
- Dres Martin
- Dreyer Kyle R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
- Dwyer Rory
- Démpaire Gabriel
- Ebeid Alejandro
- Elatrous Souheil
- Elisabet Garcia M.
- Elkhayari Mina
- Ellis Helen E.
- Elmasri Mary
- Erbabacan Emre
- Eriksson Karin E.
- Esteban Andres
- Estenssoro Elisa
- Esteve Francisco
- Estilita Joana M.
- Estrella Claudia R.
- Ezzouine Hanane
- Fan Eddy
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- Fartoukh Muriel
- Farías Pamela A.
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- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
- Fernandez Ruben O.
- Fierro Jonathan M.
- Floris Leda
- Follin Arnaud
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- Formenti Paolo
- Forteza Catalina
- Fossali Tommaso
- Foti Giuseppe
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- França Ana G.
- Frati Elena
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- Frigyik Aniko D.
- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
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- Gazenkampf Andrey A.
- Gelée Bruno
- George Fernando G.
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- Giarratano Antonino
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- Glietsch Rita
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- Gomez-Flores Saira S.
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- Gonzalez Daniel R.
- Gonzalez Marcos
- González Rojas Manuel A.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C.
- Gordo Federico
- Gosselin Ryan J.
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- Graziani Romano
- Grelon Fabien
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- Grijalba Carolina Quintana
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- Gritsan Alexey I.
- Grubissich Nicolas
- Gueret Renaud M.
- Gurjar Mohan
- Guttormsen Anne B.
- Guérin Claude
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- Haddad Youssef
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- Hedlund Lars
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- Herbrecht Jean-Etienne
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- Hessell Robert J.
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- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia Teresa
- Hopf Hans-Bernd F.
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- Hurtado Javier
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- Ichikado Kazuya
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- Imai Hiroshi
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- Kamel Ghassan
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- Kamoun Salma
- Kander Thomas
- Kannan Santhana G.
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- Kashiwa Yozo
- Kedelv Hans
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- Kheir Fayez
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- Lebbinck Herve
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- Lemiale Virginie
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- Li Qingdong
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- Ñamendys-Silva Silvio A.
- Ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe
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