Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats

Capparis decidua belongs to family Capparidaceae in wastelands of India. The study aim was to determine the role of C. decidua fruits on the free fatty acids (FFA) profile in fat-rich diet (FRD) dyslipidemic rats. The methanolic extract of edible fruit of C. decidua (CD) was given orally to obese dyslipidemic rats at the dose of 125 mg/kg and 250 mg/kg for consecutive 28 days. CD treatment in FRD rats significantly restricts the body weight gains. Blood lipid profile was altered dose dependently and significantly after 4-week treatment with CD to FRD. rats. It significantly (p<0.05) enhanced serum FFA especially, -linolinate, -linolinate, arachidonate, ecosapentaenoate, docosapentaenoate and docosahexaenoate. Moreover, 3-PUFA content was also enhanced (50.3% and 78.8%) in the serum of CD treated animals, whereas MUFA was lowered (31.1% and 40%). Therefore, Capparis decidua fruit has a promising role on dyslipidemia and obesity and has the capabilities to regulate beneficial free fatty acids

Phyto-chemical Standardization of Herbal Formulation (PMM3) for Blood Sugar Attenuating Actions in Streptozotocin induced Rats

The present study was intended to prepare herbal formulation, PMM3 using purified and modified parts of five common Indian herbs like, Trigonella foenum-graccum, Tinospora cordifolia, Scoparia dulcis, Adhatoda vasica and Cassia occidental. PMM3 was standardized using physico-chemical, phytochemical, UV-VIS spectral, HPTLC, AAS and GC methods. The phenolics and flavonoids contents were assessed. Anti-hyperglycaemic activities of PMM3 was evaluated on Streptozotocin induced (50mg/kg, i.v) diabetic rats. PMM3 (50-150 mg/kg, p.o) exhibited best potentiality in reducing blood glucose within 14 days treatment in comparison with Diabecon® (Himalaya, India) at the same dose. The preset observation identified formulation PMM3 for anti-hyperglycaemic effect

Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats

Capparis decidua belongs to family Capparidaceae in wastelands of India. The study aim was to determine the role of C. decidua fruits on the free fatty acids (FFA) profile in fat-rich diet (FRD) dyslipidemic rats. The methanolic extract of edible fruit of C. decidua (CD) was given orally to obese dyslipidemic rats at the dose of 125 mg/kg and 250 mg/kg for consecutive 28 days. CD treatment in FRD rats significantly restricts the body weight gains. Blood lipid profile was altered dose dependently and significantly after 4-week treatment with CD to FRD. rats. It significantly (p<0.05) enhanced serum FFA especially, -linolinate, -linolinate, arachidonate, ecosapentaenoate, docosapentaenoate and docosahexaenoate. Moreover, 3-PUFA content was also enhanced (50.3% and 78.8%) in the serum of CD treated animals, whereas MUFA was lowered (31.1% and 40%). Therefore, Capparis decidua fruit has a promising role on dyslipidemia and obesity and has the capabilities to regulate beneficial free fatty acids

The seasonal toxicological profile of four puffer fish species collected along Bengal coast, India

276-280Toxicological profiles of the livers and ovaries of four Indian marine puffer fish species viz. Chelonodon patoca, Takifugu oblongus, Lagocephalus lunaris, Lagocephalus inermis collected along coastal Bengal of Digha-Talsari region were evaluated by mouse bioassay. Toxicity expressed in MU (mouse unit)/g in ovaries of all four species were high in monsoon (13.9 – 80 MU/g) and postmonsoon (8.9 – 136 MU/g) seasons during annual reproductive cycle. However, toxicity of livers was much lower (3.2 – 18.5 MU/g) in all the species with seasonal variation. Chelonodon patoca specimens were found to be most toxic and Lagocephalus inermis were least toxic in comparison to other species under investigation. Therefore, health hazard due to puffer fish consumption could be minimised by the information given in this study regarding lethality

J8683/1-6

ABSTRACT: The puffer fishes Chelonodon patoca, Sphaeroides oblongus, Lagocephalus lunaris, and L. inermis of Indian coastal waters are wasted in huge quantity. The livers of these fishes were investigated for their lipid contents and fatty acid compositions in different seasons. It was found that monsoon season is the suitable time to obtain the maximal lipids (40.1-48.8%) from their livers, an amount similar to cod liver lipid content (39.5-55.0%). The fatty acids were mostly saturates and monoenes (60-70%). Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) concentrations (7-12%) were high during monsoon season. Neutral lipids were the predominant lipid class (&gt;80%) and comprised triglycerides (277-674 mg/g) and cholesterol (0.6-3.1 mg/g). Quality indices of puffer liver lipids, e.g., specific gravity, refractive index, acid value, iodine value, saponification value and unsaponifiable matter, were evaluated. Puffer liver lipids were quantitatively and qualitatively comparable to other commercially important marine fish oils. The overall study suggests the possibility of future commercial utilization of liver lipids from puffer, an unconventional, cheap, and easily available source

Antioxidant activity and total phenolics of some mangroves in Sundarbans

The antioxidant activity of 23 extracts from different plant parts (leaves, stem bark and root) of 6 mangroves and 4 mangrove associates was examined. The content of total phenolics in the extracts was calculated as gallic acid equivalent (GAE) and anti-radical activity was estimated as IC 50 values using 1,1-diphenyl-2-picrylhydrazyl (DPPH). Remarkable high phenolic content (GAE &gt; 25 mg/g), strong reducing ability (ascorbic acid equivalent, AAE &gt; 3.5 mg/g) and anti-radical activity (IC 50 &lt; 2.9 mg/ml) were found in 11 different extracts comprising of 6 mangrove and 4 mangrove associate species. The best results were obtained for Ceriops decandra stem bark extract (phenolic content as GAE = 94.4 mg/g, reducing power as AAE = 13.04 mg/g and DPPH radical scavenging ability as IC 50 = 0.65 mg/ml). A significant correlation was observed between GAE and AAE of respective extracts. The results indicate promising mangrove species for the utilization as significant source of natural antioxidant

<span style="font-size:11.0pt;font-family: "Times New Roman";mso-fareast-font-family:"Times New Roman";mso-bidi-font-family: Mangal;mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language: HI" lang="EN-GB">Variation of total phenolic content, flavonoid and radical scavenging activity of <i>Ipomoea pes-caprae</i> with respect to harvesting time and location</span>

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Crystal Structure and Electronic Properties of a Piroxicam Derivative: A Combined X-Ray Analysis and Quantum Mechanical Studies

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