Computed tomographic imaging characteristics of the normal canine lacrimal glands.

BackgroundThe canine lacrimal gland (LG) and accessory lacrimal gland of the third eyelid (TEG) are responsible for production of the aqueous portion of the precorneal tear film. Immune-mediated, toxic, neoplastic, or infectious processes can affect the glands directly or can involve adjacent tissues, with secondary gland involvement. Disease affecting these glands can cause keratoconjunctivitis sicca, corneal ulcers, and loss of vision. Due to their location in the orbit, these small structures are difficult to evaluate and measure, making cross-sectional imaging an important diagnostic tool. The detailed cross-sectional imaging appearance of the LG and TEG in dogs using computed tomography (CT) has not been reported to date.ResultsForty-two dogs were imaged, and the length, width, and height were measured and the volume calculated for the LGs & TEGs. The glands were best visualized in contrast-enhanced CT images. The mean volume of the LG was 0.14 cm3 and the TEG was 0.1 cm3. The mean height, width, and length of the LG were, 9.36 mm, 4.29 mm, and 9.35 mm, respectively; the corresponding values for the TEG was 2.02 mm, 9.34 mm, and 7.90 mm. LG and TEG volume were positively correlated with body weight (p < 0.05).ConclusionsContrast-enhanced CT is a valuable tool for noninvasive assessment of canine lacrimal glands

Comparing the Cognitive Demand of Traditional and Reform Algebra 1 Textbooks

Research has shown that students achieved higher standardized test scores in mathematics and gained more positive attitudes towards mathematics after learning from reform curricula. Because these studies involve actual students and teachers, there are classroom variables that are involved in these findings (Silver and Stein, 1996; Stein et al., 1996). To understand how much these curricula by themselves contribute to higher test scores, I have studied the cognitive demand of tasks in two traditional and two reform curricula. This work required the creation of a scale to categorize tasks based on their level of cognitive demand. This scale relates to those by Stein, Schoenfeld, and Bloom. Based on this task analysis, I have found that more tasks in the reform curricula require higher cognitive demand than tasks in the traditional curricula. These findings confirm other results that posing tasks with higher cognitive demand to students can lead to higher student achievement

The Centennial Variation of El Niño Impact on Atlantic Tropical Cyclones

Predicting tropical cyclone (TC) activity becomes more important every year while the understanding of what factors impact them continues to be complicated. El Niño–Southern Oscillation (ENSO) is one of the primary factors impacting the activities in both the Pacific and the Atlantic, but an extensive examination of the fluctuation in this system has yet to be studied in its entirety. This article analyzes the ENSO impacts on the Atlantic tropical cyclone activity during the assessed warm and cold years to show the dominant centennial-scale variation impact. This study looks to plausibly link this variation to the Southern Ocean centennial variability, which is rarely mentioned in any factors affecting the Atlantic tropical cyclone activity. This centennial variability could be used to enhance future work related to predicting tropical cyclones

Post-Occupancy Evaluation and IEQ Measurements from 64 Office Buildings: Critical Factors and Thresholds for User Satisfaction on Thermal Quality

The indoor environmental quality (IEQ) of buildings can have a strong influence on occupants’ comfort, productivity, and health. Post-occupancy evaluation (POE) is necessary in assessing the IEQ of the built environment, and it typically relies on the subjective surveys of thermal quality, air quality, visual quality, and acoustic quality. In this research, we expanded POE to include both objective IEQ measurements and the technical attributes of building systems (TABS) that may affect indoor environment and user satisfaction. The suite of three tools, including user satisfaction survey, workstation IEQ measurements, and TABS in the National Environmental Assessment Toolkit (NEAT) has been deployed in 1601 workstations in 64 office buildings, generating a rich database for statistical evaluation of possible correlations between the physical attributes of workstations, environmental conditions, and user satisfaction. Multivariate regression and multiple correlation coefficient statistical analysis revealed the relationship between measured and perceived IEQ indices, interdependencies between IEQ indices, and other satisfaction variables of significance. The results showed that overall, 55% of occupants responded as “satisfied” or “neutral”, and 45% reported being “dissatisfied” in their thermal quality. Given the dataset, air temperature in work area, size of thermal zone, window quality, level of temperature control, and radiant temperature asymmetry with façade are the critical factors for thermal quality satisfaction in the field. As a result, the outcome of this research contributes to identifying correlations between occupant satisfaction, measured data, and technical attributes of building systems. The presented integrated IEQ assessment method can further afford robust predictions of building performance against metrics and guidelines for IEQ standards to capture revised IEQ thresholds that impact building occupants’ satisfaction.</jats:p

Computational discovery and analysis of metabolic pathways

Finding novel or non-standard metabolic pathways, possibly spanning multiple species, has important applications in fields such as metabolic engineering, metabolic network analysis, and metabolic network reconstruction. Traditionally, this has been a manual process, but the large volume of metabolic data now available has created a need for computational tools to automatically identify biologically relevant pathways. This thesis presents new algorithms for automatically finding biologically meaningful linear and branched metabolic pathways in multi-genome scale metabolic networks. These algorithms utilize atom mapping data, which provides the correspondence between atoms in the substrates to atoms in the products of a chemical reaction, to find pathways which conserve a given number of atoms between desired start and target compounds. The first algorithm presented identifies atom conserving linear pathways by explicitly tracking atoms during an exploration of a graph structure constructed from the atom mapping data. The explicit tracking of atoms enables finding branched pathways because it provides automatic identification of the reactions and compounds through which atoms are lost or gained. The thesis then describes two algorithmic approaches for identifying branched metabolic pathways based upon atom conserving linear pathways. One approach takes one linear pathway at a time and attempts to add branches that connect loss and gain compounds. The other approach takes a group of linear pathways and attempts to merge pathways that move mutually exclusive sets of atoms from the start to the target compounds. Comparisons to known metabolic pathways demonstrate that atom tracking causes the algorithms to avoid many unrealistic connections, often found in previous approaches, and return biologically meaningful pathways. While the theoretical complexity of finding even linear atom conserving pathways is high, by choosing the appropriate representations and heuristics, and perhaps due to the structure of the underlying data, the algorithms in this thesis have practical running times on real data. The results also demonstrate the potential of the algorithms to find novel or non-standard pathways that may span multiple organisms

Do Physician-based or Hospital-based Provider Service Networks Better Control Medicaid Expenditures?

In a recent demonstration project, Florida Medicaid enrollees were required to pick a managed care plan that was either a Health Maintenance Organization (HMO) or a Provider Service Network (PSN). PSNs are a form of managed care very similar to Accountable Care Organizations (ACOs) that provides health care services directly through a provider or network of organizations to a defined population without a “middle man” such as a third party insurance company and health plan. There are two types of PSNs: Physician-based PSNs and Healthcare system-based PSNs. Physician-based PSNs are created and controlled by physicians groups. Healthcare system-based PSNs are based on safety net hospitals and their outpatient clinics. Health system-based PSNs are integrated delivery systems, which are organizations that combine healthcare providers into one organization and may provide more efficient care with lower cost of care due to economies of scale. The objective of this study was to examine the differences in healthcare expenditures by enrollees in physician-based and health system-based PSNs. Using a difference in difference approach our study found that compared to enrollees in physician-based PSNs, enrollees in health system-based PSNs lowered expenditures to a greater extent over time compared to physician-based PSNs. Findings from this study provide important information to states considering implementing alternative delivery models to control Medicaid costs

Unusual presentation of Kaposi sarcoma in an HIV-negative woman

Kaposi sarcoma typically presents as violaceous macules and papules in immunocompromised, specifically HIV-positive, patients. Its distinct clinical features often facilitate rapid diagnosis. In this article, we report a case of Kaposi sarcoma presenting as a concerning yet nondescript lesion in an HIV-negative woman. Although Kaposi sarcoma is frequently part of the differential diagnosis for skin lesions affecting HIV-positive patients, it is less frequently considered in HIV-negative individuals. Additionally, this case differs from the classic clinical presentation of Kaposi sarcoma by resembling a squamous cell carcinoma or superficial basal cell carcinoma. Therefore, it illustrates the importance of suspicious lesion biopsies to ensure accurate diagnosis and appropriate treatment