22,090 research outputs found
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Implication of Sialidases in Salmonella Infection: Genome Release of Sialidase Knockout Strains from Salmonella enterica Serovar Typhimurium LT2.
Sialidases, which are widely distributed in nature, cleave the α-ketosidic bond of terminal sialic acid residue. These emerging virulence factors degrade the host glycan. We report here the release of seven sialidase and one sialic acid transporter deletion in Salmonella enterica serovar Typhimurium strain LT2, which are important in cellular invasion during infection
High-Speed Projects in the United States: Identifying the Elements for Success-Part 1, MTI Report 05-01
For almost half a century, high-speed ground transportation (HSGT) has held the promise of fast, convenient, and environmentally sound travel for distances between 40 and 600 miles. While a number of HSGT systems have been developed and deployed in Asia and Europe, none has come close to being implemented in the United States. Yet this is not for lack of trying. There have been several efforts around the country, most of which have failed, some of which are still in the early stages, and a few of which might come to pass.
The goal of this study was to identify lessons learned for successfully developing and implementing high-speed rail (HSR) in the United States. Through a broad literature review, interviews, and three specific case studies—Florida, California, and the Pacific Northwest—this study articulates those lessons and presents themes for future consideration
Design evaluation criteria for commercial STOL transports
Handling qualities criteria and operational performance margins have been determined for the landing phase of commercial short-takeoff-and-landing airplanes. The requirements are the result of a literature survey, analysis of areas found to be inadequately covered by current criteria, and a subsequent piloted simulator investigation of critical criteria requiring substantiation. Three complete simulator models were used, each describing the characteristics of a different high-lift system, the externally blown flap, the augmentor flap, and the internally blown flap. The proposed criteria are presented with substantiating discussions from currently available data or directly from the results of this simulation work where it is applicable
β-diketonate versus β-ketoiminate:the importance of a ferrocenyl moiety on improving the anticancer potency
Herein we present a library of fully characterized beta-diketonate and beta-ketoiminate compounds that are functionalized with a ferrocenyl moiety. Their cytotoxic potential has been determined by screening against human breast adenocarcinomas (MCF-7 and MDA-MB-231), human colorectal carcinoma p53 wild type (HCT116 p53(+/+)) and normal human prostate (PNT2) cell lines. The ferrocenyl beta-diketonate compounds are more than 18 times more cytotoxic than the ferrocenyl beta-ketoiminate analogues. Against MCF-7, compounds functionalized at the meta position are up to nine times more cytotoxic than when functionalized at the para position. The ferrocenyl beta-diketonate compounds have increased selectivity towards MCF-7 and MDA-MB-231, with several complexes having selectivity index (SI) values that are more than nine times (MCF-7) and more than six times (MDA-MB-231) that of carboplatin. The stability of these compounds in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF) has been assessed by NMR spectroscopy and mass spectrometry studies, and the compounds show no oxidation of the iron center from Fe-II to Fe-III. Cytotoxicity screening was performed in both DMSO and DMF, with no significant differences observedin their potency
Draft Genome Sequences of Campylobacter jejuni Strains That Cause Abortion in Livestock.
Campylobacter jejuni is an intestinal bacterium that can cause abortion in livestock. This publication announces the public release of 15 Campylobacter jejuni genome sequences from isolates linked to abortion in livestock. These isolates are part of the 100K Pathogen Genome Project and are from clinical cases at the University of California (UC) Davis
Draft Genome Sequence of Multidrug-Resistant Abortive Campylobacter jejuni from Northern California.
Campylobacter jejuni is an enteric bacterium that can cause abortion in livestock. This is the release of a multidrug-resistant Campylobacter jejuni genome from an isolate that caused an abortion in a cow in northern California. This isolate is part of the 100K Pathogen Genome Project
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Shigella Draft Genome Sequences: Resources for Food Safety and Public Health.
Shigella is a major foodborne pathogen that infects humans and nonhuman primates and is the major cause of dysentery and reactive arthritis worldwide. This is the initial public release of 16 Shigella genome sequences from four species sequenced as part of the 100K Pathogen Genome Project
Swarm-Oscillators
Nonlinear coupling between inter- and intra-element dynamics appears as a
collective behaviour of elements. The elements in this paper denote symptoms
such as a bacterium having an internal network of genes and proteins, a
reactive droplet, a neuron in networks, etc. In order to elucidate the
capability of such systems, a simple and reasonable model is derived. This
model exhibits the rich patterns of systems such as cell membrane, cell fusion,
cell growing, cell division, firework, branch, and clustered clusters
(self-organized hierarchical structure, modular network). This model is
extremely simple yet powerful; therefore, it is expected to impact several
disciplines.Comment: 9 pages, 4 figure
As-built design specification for LACIE phase 3 automatic status and tracking system
There are no author-identified significant results in this report
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