Development of an Equivalent Porous Medium Model for a Tubular Receiver Equipped With Raschig Rings

The porous insert has become one of the promising methods for heat transfer enhancement in many industrial applications ranging from small electronic devices to nuclear reactors, and large solar fields. For the assessment of such systems, the CFD numerical studies are usually employed by scientists to investigate the heat and mass transfer inside the region in micro or macro scales. Although micro studies are accurate and provide a detailed analysis of the process, they cannot be used for every study due to complex and costly computational resource they may demand for the case under study. Therefore, sometimes macro-scale simulations become more favorable thanks to the reduction in time and cost as well as the simplification over the morphology of the porous medium they offer. For these reasons, this study aims at developing a macro model for a novel porous disc made of Raschig Rings, to be applied to the tubular solar absorber for future simulations. The methodology devised in this study was to exploit detailed micro-scale simulations, achieving the macro properties and then developing a new equivalent macro model of a porous medium, based on the obtained properties. Numerical data indicated that when the developed macro model is compared to the micro simulations, the thermo-hydraulic results are in good agreement. Applying the macro model to a solar absorber working under linear Fresnel heating showed that the proposed porous disc could reduce the temperature rise on the tube wall by 40%

Experimental and numerical investigation of a porous receiver equipped with Raschig Rings for CSP applications

In the context of central solar tower systems, tubular receivers are among the most appealing absorber solutions: the absorbed solar radiation is transferred from the tube external surface to the heat transfer fluid (HTF) flowing within the absorber. In the case of air as HTF, very high temperatures of the coolant can be obtained in principle, thus increasing the efficiency of the downstream thermodynamic cycle. To explore the possible applicability of a porous medium made of Raschig Rings (RRs), already successfully adopted in the heat removal from the resonant cavity of a technological device, the gyrotron, where the heat flux can go up to 20–25 MW/m2 and removed by subcooled water, a mock-up of a planar receiver equipped with RRs has been tested in a solar furnace, using air as coolant. The test results are presented here and analyzed1. Furthermore, a numerical model of the mock-up, where the RRs are modeled in detail by the Discrete Element Method, is presented and its capability to reproduce the measured data demonstrated. The model shows, for the tested configuration, an enhancement of the heat transfer of a factor of ~5 with respect to a plain channel with the same envelope, and a Performance Evaluation Criteria of 2–2.5 when the device is compared to the same receiver configuration, but without RRs

Test and modeling of the hydraulic performance of high-efficiency cooling configurations for gyrotron resonance cavities

The design and manufacturing of different full-size mock-ups of the resonance cavity of gyrotrons, relevant for fusion applications, were performed according to two different cooling strategies. The first one relies on mini-channels, which are very promising in the direction of increasing the heat transfer in the heavily loaded cavity, but which could face an excessively large pressure drop, while the second one adopts the solution of Raschig rings, already successfully used in European operating gyrotrons. The mock-ups, manufactured with conventional techniques, were hydraulically characterized at the Thales premises, using water at room temperature. The measured pressure drop data were used to validate the corresponding numerical computational fluid dynamics (CFD) models, developed with the commercial software STAR-CCM+ (Siemens PLM Software, Plano TX, U.S.A.) and resulting in excellent agreement with the test results. When the validated models were used to compare the two optimized cooling configurations, it resulted that, for the same water flow, the mini-channel strategy gave a pressure drop was two-fold greater than that of the Raschig rings strategy, allowing a maximum flow rate of 1 × 10–3 m3/s to meet a maximum allowable pressure drop of 0.5 MPa

Calibration of the KIT test setup for the cooling tests of a gyrotron cavity full-size mock-up equipped with mini-channels

In high-power fusion gyrotrons, the maximum heat-load on the wall of the interaction section is in the order of 2 kW/cm2, which is the major limiting technological factor for output power and pulse-length of the tube. The ongoing gyrotron development demands a very effective cavity cooling system for optimum gyrotron operation. In this work, the experimental investigation of a mini-channel cavity cooling using a mock-up test set-up is described. The mock-up test set-up will be used to experimentally validate the predictive simulation results and verify the mini-channel cooling performance. It is crucial for validation of the mini-channel cooling properties to determine the amount of the heat load introduced in the cavity wall by an induction heater. In order to estimate that heat load, full 3D electromagnetic simulations have been performed using the CST Studio Suite® software. A suitable calibration factor for the load deposited in the mock-up inner wall is identified after numerical investigation by a 3D thermal model. Calorimetry measurements are performed and the experimental results are compared with the simulation results obtained with a 3D thermal-hydraulic model, using the commercial software STAR-CCM+. When the calibration factor is applied, the experimental calorimetry is well reproduced by the simulations

Reduced availability of voltage-gated sodium channels by depolarization or blockade by tetrodotoxin boosts burst firing and catecholamine release in mouse chromaffin cells

KEY POINTS: Mouse chromaffin cells (MCCs) of the adrenal medulla possess fast-inactivating Nav channels whose availability alters spontaneous action potential firing patterns and the Ca2+ -dependent secretion of catecholamines. Here, we report MCCs expressing large densities of neuronal fast-inactivating Nav1.3 and Nav1.7 channels that carry little or no subthreshold pacemaker currents and can be slowly inactivated by 50% upon slight membrane depolarization. Reducing Nav1.3/Nav1.7 availability by tetrodotoxin or by sustained depolarization near rest leads to a switch from tonic to burst-firing patterns that give rise to elevated Ca2+ -influx and increased catecholamine release. Spontaneous burst firing is also evident in a small percentage of control MCCs. Our results establish that burst firing comprises an intrinsic firing mode of MCCs that boosts their output. This occurs particularly when Nav channel availability is reduced by sustained splanchnic nerve stimulation or prolonged cell depolarizations induced by acidosis, hyperkalaemia and increased muscarine levels. ABSTRACT: Action potential (AP) firing in mouse chromaffin cells (MCCs) is mainly sustained by Cav1.3 L-type channels that drive BK and SK currents and regulate the pacemaking cycle. As secretory units, CCs optimally recruit Ca2+ channels when stimulated, a process potentially dependent on the modulation of the AP waveform. Our previous work has shown that a critical determinant of AP shape is voltage-gated sodium channel (Nav) channel availability. Here, we studied the contribution of Nav channels to firing patterns and AP shapes at rest (-50 mV) and upon stimulation (-40 mV). Using quantitative RT-PCR and immunoblotting, we show that MCCs mainly express tetrodotoxin (TTX)-sensitive, fast-inactivating Nav1.3 and Nav1.7 channels that carry little or no Na+ current during slow ramp depolarizations. Time constants and the percentage of recovery from fast inactivation and slow entry into closed-state inactivation are similar to that of brain Nav1.3 and Nav1.7 channels. The fraction of available Nav channels is reduced by half after 10 mV depolarization from -50 to -40 mV. This leads to low amplitude spikes and a reduction in repolarizing K+ currents inverting the net current from outward to inward during the after-hyperpolarization. When Nav channel availability is reduced by up to 20% of total, either by TTX block or steady depolarization, a switch from tonic to burst firing is observed. The spontaneous occurrence of high frequency bursts is rare under control conditions (14% of cells) but leads to major Ca2+ -entry and increased catecholamine release. Thus, Nav1.3/Nav1.7 channel availability sets the AP shape, burst-firing initiation and regulates catecholamine secretion in MCCs. Nav channel inactivation becomes important during periods of high activity, mimicking stress responses

Improving Risk Regulation

Confronted with the challenge of improving regulatory performance, many governments in the world are looking for ways to better manage risks, in particular those risks that develop in complex systems, with stakeholders from various sectors, and that are marked by uncertainty. This report includes five authored pieces about: The contribution of transnational private regulation to revisiting risk regulation (Scott), Emerging strategies to manage system-level risks: an examination of private sector, government and non-governmental organization initiative (Yosie), Potential scope and challenges of behaviourally informed regulation (Renn and Florin), and Managing uncertainty in drug development and use, by enhancing adaptability and flexibility in pharmaceuticals regulation (Oye et al.)

Is the meiofauna a good indicator for climate change and anthropogenic impacts?

Our planet is changing, and one of the most pressing challenges facing the scientific community revolves around understanding how ecological communities respond to global changes. From coastal to deep-sea ecosystems, ecologists are exploring new areas of research to find model organisms that help predict the future of life on our planet. Among the different categories of organisms, meiofauna offer several advantages for the study of marine benthic ecosystems. This paper reviews the advances in the study of meiofauna with regard to climate change and anthropogenic impacts. Four taxonomic groups are valuable for predicting global changes: foraminifers (especially calcareous forms), nematodes, copepods and ostracods. Environmental variables are fundamental in the interpretation of meiofaunal patterns and multistressor experiments are more informative than single stressor ones, revealing complex ecological and biological interactions. Global change has a general negative effect on meiofauna, with important consequences on benthic food webs. However, some meiofaunal species can be favoured by the extreme conditions induced by global change, as they can exhibit remarkable physiological adaptations. This review highlights the need to incorporate studies on taxonomy, genetics and function of meiofaunal taxa into global change impact research

Down-Regulation of EBV-LMP1 Radio-Sensitizes Nasal Pharyngeal Carcinoma Cells via NF-κB Regulated ATM Expression

BACKGROUND:The latent membrane protein 1 (LMP1) encoded by EBV is expressed in the majority of EBV-associated human malignancies and has been suggested to be one of the major oncogenic factors in EBV-mediated carcinogenesis. In previous studies we experimentally demonstrated that down-regulation of LMP1 expression by DNAzymes could increase radiosensitivity both in cells and in a xenograft NPC model in mice. RESULTS:In this study we explored the molecular mechanisms underlying the radiosensitization caused by the down-regulation of LMP1 in nasopharyngeal carcinoma. It was confirmed that LMP1 could up-regulate ATM expression in NPCs. Bioinformatic analysis of the ATM ptomoter region revealed three tentative binding sites for NF-κB. By using a specific inhibitor of NF-κB signaling and the dominant negative mutant of IkappaB, it was shown that the ATM expression in CNE1-LMP1 cells could be efficiently suppressed. Inhibition of LMP1 expression by the DNAzyme led to attenuation of the NF-κB DNA binding activity. We further showed that the silence of ATM expression by ATM-targeted siRNA could enhance the radiosensitivity in LMP1 positive NPC cells. CONCLUSIONS:Together, our results indicate that ATM expression can be regulated by LMP1 via the NF-κB pathways through direct promoter binding, which resulted in the change of radiosensitivity in NPCs

An exploratory study of the determinants of the quality of strategic decision implementation in Turkish industrial firms

This paper investigates the determinants of quality of decision implementation. By drawing on a sample of 116 firms located in Turkey, the authors test whether the features of important team processes (i.e. trust and participation), of the organisation (i.e. past performance) and of implementation (i.e. its speed and uncertainty) exert an influence on the quality with which decisions are implemented. Exploratory and confirmatory factor analyses were used to test the validity of the measures, while path analysis was used in hypotheses testing. The results suggest that quality of decision implementation is positively related to trust, participation and past performance, and negatively to implementation speed and uncertainty. The implications of these findings for theory, practice and general management are discussed

“Working the System”—British American Tobacco's Influence on the European Union Treaty and Its Implications for Policy: An Analysis of Internal Tobacco Industry Documents

Katherine Smith and colleagues investigate the ways in which British American Tobacco influenced the European Union Treaty so that new EU policies advance the interests of major corporations, including those that produce products damaging to health