Radiation constraints from cosmic strings

We show that it is possible to evolve a network of global strings numerically including the effects of radiative backreaction, using the renormalised equations for the Kalb-Ramond action. We calculate radiative corrections to the equations of motion and deduce the effect on a network of global strings. We also discuss the implications of this work for the cosmological axion density.Comment: 4 Pages, UUencoded postscript file, to appear in 'Trends in Astro-Particle Physics - Nuclear Physics B, Proceedings Supplement

Chitinase and Fizz family members are a generalized feature of nematode infection with selective Upregulation of Ym1 and F10.1 by antigen-presenting cells

Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model. Here, we show that their expression is a generalized feature of nematode infection and that they are induced at the site of infection with both the tissue nematode Litomosoides sigmodontis and the gastrointestinal nematode Nippostrongylus brasiliensis. At the sites of infection with N. brasiliensis, we also observed induction of other chitinase and Fizz family members (ChaFFs): acidic mammalian chitinase (AMCase) and Fizz2. The high expression of both Ym1 and AMCase in the lungs of infected mice suggests that abundant chitinase production is an important feature of Th2 immune responses in the lung. In addition to expression of ChaFFs in the tissues, Ym1 and Fizz1 expression was observed in the lymph nodes. Expression both in vitro and in vivo was restricted to antigen-presenting cells, with the highest expression in B cells and macrophages. ChaFFs may therefore be important effector or wound-repair molecules at the site of nematode infection, with potential regulatory roles for Ym1 and Fizz1 in the draining lymph nodes

A dedicated haem lyase is required for the maturation of a novel bacterial cytochrome c with unconventional covalent haem binding

In bacterial c-type cytochromes, the haem cofactor is covalently attached via two cysteine residues organized in a haem c-binding motif. Here, a novel octa-haem c protein, MccA, is described that contains only seven conventional haem c-binding motifs (CXXCH), in addition to several single cysteine residues and a conserved CH signature. Mass spectrometric analysis of purified MccA from Wolinella succinogenes suggests that two of the single cysteine residues are actually part of an unprecedented CX15CH sequence involved in haem c binding. Spectroscopic characterization of MccA identified an unusual high-potential haem c with a red-shifted absorption maximum, not unlike that of certain eukaryotic cytochromes c that exceptionally bind haem via only one thioether bridge. A haem lyase gene was found to be specifically required for the maturation of MccA in W. succinogenes. Equivalent haem lyase-encoding genes belonging to either the bacterial cytochrome c biogenesis system I or II are present in the vicinity of every known mccA gene suggesting a dedicated cytochrome c maturation pathway. The results necessitate reconsideration of computer-based prediction of putative haem c-binding motifs in bacterial proteomes

The psychological wellbeing outcomes of nonpharmacological interventions for older persons with insomnia symptoms: a systematic review and meta-analysis

Nonpharmacological treatment of insomnia in older persons has been associated with reduced insomnia symptoms and increased psychological wellbeing. This systematic review and meta-analysis examined whether nonpharmacological interventions can promote wellbeing indicators in older persons who experience insomnia symptoms and investigated the components of these interventions. Twenty studies met inclusion criteria. Psychological wellbeing outcomes included symptoms of depression, anxiety, mental health-related quality of life, and fatigue. Interventions significantly reduced depression and fatigue symptoms in most of the studies that included these outcomes. Findings of our qualitative analysis suggest that mindfulness-based interventions in particularcan potentially reduce depression symptoms in older persons with insomnia symptoms. Meta-analyses of studies that included psychological wellbeing outcomes showed small-medium weighted mean effects indicating reductions in symptoms of depression, anxiety, and fatigue. The results suggest that nonpharmacological interventions for older persons with insomnia symptoms can potentially reduce depression and fatigue symptoms and highlight interventions that may be particularly valuable for this purpose

High energy scattering and the AdS/CFT correspondence

We consider small angle and large impact parameter high energy scattering of colourless states in SYM using the AdS/CFT correspondence. The gauge theory scattering amplitude is linked with a correlation function of tilted Wilson loops, which can be calculated by the exchange of bulk supergravity fields between the two corresponding string worldsheets. We identify the dominant contributions, which all correspond to real phase shifts. In particular, we find a contribution of the bulk graviton which gives an unexpected `gravity-like' $s^1$ behaviour of the gauge theory phase shift in a specific range of energies and (large) impact parameters.Comment: 22p, 2 figure

On the size of the smallest scales in cosmic string networks

We present a method for the calculation of the gravitational back reaction cutoff on the smallest scales of cosmic string networks taking into account that not all modes on strings interact with all other modes. This results in a small scale structure cutoff that is sensitive to the initial spectrum of perturbations present on strings. From a simple model, we compute the cutoffs in radiation- and matter-dominated universes.Comment: 4 pages, revte

Do primordial Lithium abundances imply there's no Dark Energy?

Explaining the well established observation that the expansion rate of the universe is apparently accelerating is one of the defining scientific problems of our age. Within the standard model of cosmology, the repulsive 'dark energy' supposedly responsible has no explanation at a fundamental level, despite many varied attempts. A further important dilemma in the standard model is the Lithium problem, which is the substantial mismatch between the theoretical prediction for 7-Li from Big Bang Nucleosynthesis and the value that we observe today. This observation is one of the very few we have from along our past worldline as opposed to our past lightcone. By releasing the untested assumption that the universe is homogeneous on very large scales, both apparent acceleration and the Lithium problem can be easily accounted for as different aspects of cosmic inhomogeneity, without causing problems for other cosmological phenomena such as the cosmic microwave background. We illustrate this in the context of a void model.Comment: 14 pages, 4 figures. v2: minor rearrangements in the text, comments and references expanded, results unchange

Developing young people's sense of self and place through sport

Previous research has recognized positive health implications, both physical and mental, as an outcome of participation in leisure pursuits. They provide opportunities for self-expression and stress reduction, as well as an environment in which people can socialize. Leisure activities, specifically sport activities, can play a significant role in young people's identity development. This paper explores the leisure activities in which young people in Adelaide, Australia participate. It examines the role of leisure activities in terms of young people's identity and feelings towards their hometown. This study consisted of semi-structured focus groups conducted with 24 senior high school students, followed by a survey resulting in 226 useable responses. Respondents were aged between 16 and 18 years of age. From the range of activities identified and explored, the results revealed sports activities to have the greatest impact on young people's lives. The results demonstrated that frequency of participation has a significant effect on young people's involvement levels and how they identify with the activity

Close encounters of a rotating star with planets in parabolic orbits of varying inclination and the formation of Hot Jupiters

(abbreviated) We extend the theory of close encounters of a planet on a parabolic orbit with a star to include the effects of tides induced on the central rotating star. Orbits with arbitrary inclination to the stellar rotation axis are considered. We obtain results both from an analytic treatment and numerical one that are in satisfactory agreement. These results are applied to the initial phase of the tidal circularisation problem. We find that both tides induced in the star and planet can lead to a significant decrease of the orbital semi-major axis for orbits having periastron distances smaller than 5-6 stellar radii (corresponding to periods $\sim 4-5$ days after the circularisation has been completed) with tides in the star being much stronger for retrograde orbits compared to prograde orbits. We use the simple Skumanich law for the stellar rotation with its rotational period equal to one month at the age of 5Gyr. The strength of tidal interactions is characterised by circularisation time scale, $t_{ev}$ defined as a time scale of evolution of the planet's semi-major axis due to tides considered as a function of orbital period $P_{obs}$ after the process of tidal circularisation has been completed. We find that the ratio of the initial circularisation time scales corresponding to prograde and retrograde orbits is of order 1.5-2 for a planet of one Jupiter mass and $P_{obs}\sim$ four days. It grows with the mass of the planet, being of order five for a five Jupiter mass planet with the same $P_{orb}$. Thus, the effect of stellar rotation may provide a bias in the formation of planetary systems having planets on close orbits around their host stars, as a consequence of planet-planet scattering, favouring systems with retrograde orbits. The results may also be applied to the problem of tidal capture of stars in young stellar clusters.Comment: to be published in Celestial Mechanics and Dynamical Astronom