Recent advances in asymmetric catalysis

CHAPTER ONE reviews the literature, discussing aspects of transition metal mediated asymmetric catalysis in the presence of enantiomerically pure ligands. CHAPTER TWO discusses the asymmetric addition of dialkyl-zinc reagents to aromatic aldehydes. The work presented is particularly concerned with the design and construction of enantiomerically pure oxazoline ligands tethered to alcohols These ligands have proved effective in the acceleration of the alkylation reaction and are able to influence good levels of asymmetric induction in the resultant secondary alcohol products CHAPTER THREE examines the electronic (and steric) effects of enantiomerically pure oxazoline ligands for the palladium catalysed allylic substitution reaction. Using ligands possessing two electronically different donor atoms, it is possible to create electronic distortion upon the intermediate allyl complex. In doing so it is possible to direct nucleophilic addition to one carbon centre preferentially to the other, resulting in asymmetric induction. Manipulation of these ligands enables control in the extent of electron distortion inflicted upon the allyl complex and consequently influences the levels of enantioselectivity observed. CHAPTER FOUR investigates the ability of hydrolytic enzymes to kinetically resolve a series of allylic acetates, under varying conditions. Lipases appeared superior to esterases for the substrates employed. In particular cis-3-acetoxy-5-carbomethoxycyclohexene was smoothly resolved m high yield and enantioselectivity. CHAPTER FIVE reports on the potentiality of a dynamic resolution of allylic acetates, using hydrolytic enzymes in the presence of a palladium catalyst. A proposed mechanism is discussed. Initial results are promising, however, the sensitivity of the reaction is realised and optimisation of conditions still needs to be addressed

A Qualitative Study Examining the Leadership of the Executive Board of the Black Ministerial Alliance of Greater Boston

The purpose of this study was to examine leadership in the faith-based community from the perspective of six members of the Executive Board of the Black Ministerial Alliance of Greater Boston. Using portraiture methodology the research qualitatively examined leadership through the lived experiences of four male, and two female members of the board by: • defining leadership. • examining the role of the Black Church as an institution. • investigating the personal and professional influences that affect leadership. • examining the role the Black Ministerial Alliance of Greater Boston as an organization has on ones leadership. • determining what, in terms of leadership, led to development of the Victory Generation After-School Program. The study found common treads, which formed the leadership of these six men and women, and made recommendation on how the faith-based community can enhance its role in the development of leaders and its leadership

Whole Child Development Mapping Project in Western Europe and North America: The UK (1)

Visualization 1 Originally published in Optics Express on 28 November 2016 (oe-24-24-27785

I-LEEP Newsletter Volume 1, Issue 4

https://digitalcommons.lasalle.edu/ileep_newsletter/1003/thumbnail.jp

Understanding eScience: Reflections on a Houston Symposium

EScience is a research methodology combining data collection, storage and networking on a massive scale. By its very nature, eScience presents new and diverse opportunities in librarianship. While various academic institutions such as Cornell, Georgia Tech, and the University of Massachusetts are already engaged in well-established projects at their libraries, eScience is still relatively new to many others. To explain eScience and its implications for medical librarians within the Texas Medical Center, The Texas Medical Center (TMC) Library hosted an event on February 13, 2012, called Understanding eScience: A Symposium for Medical Librarians. Funded in part by the National Network of Libraries of Medicine--South Central Region (NN/LM-SCR), this symposium’s core was a panel of scientists and librarians serving various roles in eScience research. These experts described their work to identify concrete opportunities and challenges for libraries hoping to take on similar roles. Designed with an emphasis on medical librarians, the symposium provided an educational and collaborative opportunity for librarians of all specialties. Within this article, the authors share their experiences in planning and hosting an eScience event and the catalyst it provided for The TMC Library’s on-going involvement in eScience research and collaborations

Mix and Match: Promoting Interdisciplinary Teaching, Learning, and Community through Classroom-Level Partnerships

Developed at the University of British Columbia (UBC), UBC Mix creates interdisciplinary learning experiences for students by developing partnerships between existing courses, and between existing courses and other learning opportunities. UBC Mix connects faculty members interested in making their courses more interdisciplinary, and facilitates the creation of shared learning activities that mix” students together. The UBC Mix project provides a model for facilitating interdisciplinary teaching and learning within existing courses and programs at colleges and universities

Figurative language and aggression after traumatic brain injury: Does sarcasm have a role in modulating aggressive behaviour?

Aggressive behaviour after traumatic brain injury (TBI) has been associated with general language impairments (Alderman, 2007). Figurative language has an important role in modulating emotional intensity (Dews & Winner, 1995), and sarcasm, a form of figurative language heavily linked to social cognition, is considered a socially appropriate communication of aggression (Haiman, 1998). The present research aimed to investigate the processing of sarcasm in individuals with TBI, and in healthy adults, in an attempt to explore whether possible deficits in linguistic performance may contribute to aggressive behaviour. A novel, auditory-visual, computer-based task was developed to test comprehension of factual and attitude (others’ intentions) information in sarcastic and literal contexts. Experiment One compared the performance of seven participants with severe TBI with seven matched, healthy control participants. Experiment Two compared 20 low aggressive with 20 moderately aggressive healthy young adults. Reaction time and accuracy data were statistically analysed with parametric and non-parametric tests, and the TBI data was also correlated with neuropsychological and behavioural data. In Experiment One, results suggested that TBI participants were as able as healthy control participants to comprehend sarcasm, given explicit prosodic and contextual cues, though they struggled with drawing literal inferences and did not benefit as much from priming when comprehending questions. Correlations suggested that their difficulties inferring others’ literal intentions related to poor emotion identification, and these difficulties also linked to aggressive behaviour. In Experiment Two, reaction times were significantly faster in literal contexts, on factual questions and on the second of the two questions presented. No statistically significant differences were found between the low and moderate aggression groups on their reaction times or error rates. Overall, these findings shed more light on the appreciation of sarcasm after TBI and the role that language, and in particular sarcasm, plays in modulating aggressive behaviour

What factors enable mid-life carers to re-enter the labour market in New Zealand?

Objective.- To assess the characteristics of carers and the caregiving situation associated with return to paid employment among older unemployed carers in New Zealand. Methods.- A baseline sample of 280 unemployed carers was identified from responses by people aged 55-70 to the 2012-2016 biennial waves of the New Zealand Health, Work and Retirement longitudinal survey. Multiple logistic regression analysis was used to assess characteristics uniquely predicting employment status at two-year follow-up. Results.- Sixteen percent were employed at follow-up. Economic living standards, physical health and preference to be in paid employment were positively associated with being employed at follow-up. There were no statistical differences according to age, gender, ethnicity, marital status, education and care characteristics. Conclusion.- Individual preferences were the strongest predictor of return to paid employment. Despite New Zealand employment legislation allowing all employees to request flexible working arrangements, economic and health differences in workforce retention among carers persist

The Ursinus Weekly, May 11, 1953

Ed Abramson elected prexy by thespians • Spirit Committee to hold election • Ursinus debaters triumph over LaSalle team, on FEPC • J. Alfred Kaye to speak at commencement, June 1 • Clubs elect 1953-54 heads • Cast receives high praise for Two blind mice production • New Y cabinet installed Sunday; Dance planned • Day Study elections decide new officers • Ruth Reed is May queen; Crowned under sunny sky • Seniors win study awards • Quartets present program, Tuesday • MSGA elections to be held Tuesday • Career offer for grads • Freshmen women elect soph rulers; Nesta Lewis to head committee • Editorials: But who shall decide? • Letters to the editor • Time machine • Mr. all-college visits U.C. and finds a way of life • To all happy drivers: We struggle for survival • Rittenhouse places in intercollegiates • Taylor hurls one-hitter; Belles defeat Beaver, 3-2 • PMC tops tracksters; Bears win 880, discus • Tennis team wins; Tops Albright, 5-4 • Baseball team wins, 5-4; Burger, Anderson star • Swarthmore wins meet 76-50; Swett, Eshbach win again • Sororities close year with dinner dances, shore tripshttps://digitalcommons.ursinus.edu/weekly/1520/thumbnail.jp