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Epigenetic Applications in Adverse Outcome Pathways and Chemical Risk Evaluation
Control of light transmission through opaque scattering media in space and time
We report the first experimental demonstration of combined spatial and
temporal control of light trajectories through opaque media. This control is
achieved by solely manipulating spatial degrees of freedom of the incident
wavefront. As an application, we demonstrate that the present approach is
capable to form bandwidth-limited ultrashort pulses from the otherwise randomly
transmitted light with a controllable interaction time of the pulses with the
medium. Our approach provides a new tool for fundamental studies of light
propagation in complex media and has potential for applications for coherent
control, sensing and imaging in nano- and biophotonics
Transmission channels for light in absorbing random media: from diffusive to ballistic-like transport
While the absorption of light is ubiquitous in nature and in applications,
the question remains how absorption modifies the transmission channels in
random media. We present a numerical study on the effects of optical absorption
on the maximal transmission and minimal reflection channels in a
two-dimensional disordered waveguide. In the weak absorption regime, where the
system length is less than the diffusive absorption length, the maximal
transmission channel is dominated by diffusive transport and it is equivalent
to the minimal reflection channel. Its frequency bandwidth is determined by the
underlying quasimode width. However, when the absorption is strong, light
transport in the maximal transmission channel undergoes a sharp transition and
becomes ballistic-like transport. Its frequency bandwidth increases with
absorption, and the exact scaling varies with the sample's realization. The
minimal reflection channel becomes different from the maximal transmission
channel and becomes dominated by absorption. Counterintuitively, we observe in
some samples that the minimum reflection eigenvalue increases with absorption.
Our results show that strong absorption turns open channels in random media
from diffusive to ballistic-like.Comment: 11 pages, 7 figure
A library of near-infrared integral field spectra of young M-L dwarfs
We present a library of near-infrared (1.1-2.45 microns) medium-resolution
(R~1500-2000) integral field spectra of 15 young M6-L0 dwarfs, composed of
companions with known ages and of isolated objects. We use it to (re)derive the
NIR spectral types, luminosities and physical parameters of the targets, and to
test (BT-SETTL, DRIFT-PHOENIX) atmospheric models. We derive infrared spectral
types L0+-1, L0+-1, M9.5+-0.5, M9.5+-0.5, M9.25+-0.25, M8+0.5-0.75, and
M8.5+-0.5 for AB Pic b, Cha J110913-773444, USco CTIO 108B, GSC 08047-00232 B,
DH Tau B, CT Cha b, and HR7329B, respectively. BT-SETTL and DRIFT-PHOENIX
models yield close Teff and log g estimates for each sources. The models seem
to evidence a 600-300+600 K drop of the effective temperature at the M-L
transition. Assuming the former temperatures are correct, we derive new mass
estimates which confirm that DH Tau B, USco CTIO 108B, AB Pic b, KPNO Tau 4,
OTS 44, and Cha1109 lay inside or at the boundary of the planetary mass range.
We combine the empirical luminosities of the M9.5-L0 sources to the Teff to
derive semi-empirical radii estimates that do not match "hot-start"
evolutionary models predictions at 1-3 Myr. We use complementary data to
demonstrate that atmospheric models are able to reproduce the combined optical
and infrared spectral energy distribution, together with the near-infrared
spectra of these sources simultaneously. But the models still fail to represent
the dominant features in the optical. This issue casts doubts on the ability of
these models to predict correct effective temperatures from near-infrared
spectra alone. We advocate the use of photometric and spectroscopic data
covering a broad range of wavelengths to study the properties of very low mass
young companions to be detected with the planet imagers (Subaru/SCExAO,
LBT/LMIRCam, Gemini/GPI, VLT/SPHERE).Comment: 27 pages, 14 tables, 19 figures, accepted for publication in
Astronomy & Astrophysic
Comparison of cloud models for Brown Dwarfs
A test case comparison is presented for different dust cloud model approaches
applied in brown dwarfs and giant gas planets. We aim to achieve more
transparency in evaluating the uncertainty inherent to theoretical modelling.
We show in how far model results for characteristic dust quantities vary due to
different assumptions. We also demonstrate differences in the spectral energy
distributions resulting from our individual cloud modelling in 1D substellar
atmosphere simulationsComment: 5 pages, Proceeding to "Exoplantes: Detection, Formation, Dynamics",
eds. Ferraz-Mello et
Trapping of Rb atoms by ac electric fields
We demonstrate trapping of an ultracold gas of neutral atoms in a macroscopic
ac electric trap. Three-dimensional confinement is obtained by switching
between two saddle-point configurations of the electric field. Stable trapping
is observed in a narrow range of switching frequencies around 60 Hz. The
dynamic confinement of the atoms is directly visualized at different phases of
the ac switching cycle. We observe about 10^5 Rb atoms in the 1 mm^3 large and
several microkelvins deep trap with a lifetime of approximately 5 s.Comment: 4 pages, 4 figures; updated version, added journal referenc
Molecular phylogeny of brachiopods and phoronids based on nuclear-encoded small subunit ribosomal RNA gene sequences
Brachiopod and phoronid phylogeny is inferred from SSU rDNA sequences of 28 articulate and nine inarticulate brachiopods, three phoronids, two ectoprocts and various outgroups, using gene trees reconstructed by weighted parsimony, distance and maximum likelihood methods. Of these sequences, 33 from brachiopods, two from phoronids and one each from an ectoproct and a priapulan are newly determined. The brachiopod sequences belong to 31 different genera and thus survey about 10% of extant genus-level diversity. Sequences determined in different laboratories and those from closely related taxa agree well, but evidence is presented suggesting that one published phoronid sequence (GenBank accession UO12648) is a brachiopod-phoronid chimaera, and this sequence is excluded from the analyses. The chiton, Acanthopleura, is identified as the phenetically proximal outgroup; other selected outgroups were chosen to allow comparison with recent, non-molecular analyses of brachiopod phylogeny. The different outgroups and methods of phylogenetic reconstruction lead to similar results, with differences mainly in the resolution of weakly supported ancient and recent nodes, including the divergence of inarticulate brachiopod sub-phyla, the position of the rhynchonellids in relation to long- and short-looped articulate brachiopod clades and the relationships of some articulate brachiopod genera and species. Attention is drawn to the problem presented by nodes that are strongly supported by non-molecular evidence but receive only low bootstrap resampling support. Overall, the gene trees agree with morphology-based brachiopod taxonomy, but novel relationships are tentatively suggested for thecideidine and megathyrid brachiopods. Articulate brachiopods are found to be monophyletic in all reconstructions, but monophyly of inarticulate brachiopods and the possible inclusion of phoronids in the inarticulate brachiopod clade are less strongly established. Phoronids are clearly excluded from a sister-group relationship with articulate brachiopods, this proposed relationship being due to the rejected, chimaeric sequence (GenBank UO12648). Lineage relative rate tests show no heterogeneity of evolutionary rate among articulate brachiopod sequences, but indicate that inarticulate brachiopod plus phoronid sequences evolve somewhat more slowly. Both brachiopods and phoronids evolve slowly by comparison with other invertebrates. A number of palaeontologically dated times of earliest appearance are used to make upper and lower estimates of the global rate of brachiopod SSU rDNA evolution, and these estimates are used to infer the likely divergence times of other nodes in the gene tree. There is reasonable agreement between most inferred molecular and palaeontological ages. The estimated rates of SSU rDNA sequence evolution suggest that the last common ancestor of brachiopods, chitons and other protostome invertebrates (Lophotrochozoa and Ecdysozoa) lived deep in Precambrian time. Results of this first DNA-based, taxonomically representative analysis of brachiopod phylogeny are in broad agreement with current morphology-based classification and systematics and are largely consistent with the hypothesis that brachiopod shell ontogeny and morphology are a good guide to phylogeny
The Isoperimetric Profile of a Noncompact Riemannian Manifold for Small Volumes
In the main theorem of this paper we treat the problem of existence of
minimizers of the isoperimetric problem under the assumption of small volumes.
Applications of the main theorem to asymptotic expansions of the isoperimetric
problem are given.Comment: 33 pages, improved version after the referee comments, (Submitted
Anisotropic 2D diffusive expansion of ultra-cold atoms in a disordered potential
We study the horizontal expansion of vertically confined ultra-cold atoms in
the presence of disorder. Vertical confinement allows us to realize a situation
with a few coupled harmonic oscillator quantum states. The disordered potential
is created by an optical speckle at an angle of 30{\deg} with respect to the
horizontal plane, resulting in an effective anisotropy of the correlation
lengths of a factor of 2 in that plane. We observe diffusion leading to
non-Gaussian density profiles. Diffusion coefficients, extracted from the
experimental results, show anisotropy and strong energy dependence, in
agreement with numerical calculations
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