Evolución de la posición del consejo de estado frente a la aplicación del principio de planeación en la contratación estatal en Colombia

El análisis de la evolución de la posición del consejo de estado frente a la aplicación del principio de planeación en la contratación estatal en Colombia, permitió determinar de acuerdo a la norma la interpretación en cuanto al concepto, alcance y finalidad del mismo; igualmente, se examinaron las posiciones que ha fijado el consejo de estado frente a la aplicación de éste postulado; y, finalmente, se identificaron las diferencias entre la sección tercera y cuarta del consejo de estado frente a la aplicación de dicho fundamento. lo anterior, considerando que se trató de una investigación jurídica, con enfoque cualitativo, de tipo documental, apoyada en la hermenéutica, la cual permitió interpretar la normativa y jurisprudencia.The analysis of the evolution of the position of the council of state in front of the application of the principle of planning in the state contracting in Colombia, allowed to determine according to the norm the interpretation regarding the concept, scope and purpose of the same; likewise, the positions that the council of state has set before the application of this postulate were examined; and, finally, the differences between the third and fourth sections of the council of state in the face of the application of said foundation were identified. the foregoing, considering that it was a legal research, with a qualitative approach, of a documentary type, supported by hermeneutics, which allowed interpreting the regulations and jurisprudence

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

Twenty nine original 3-nitroimidazo[1,2-a]pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized. In vitro evaluation highlighted compound 5 as an antiparasitic hit molecule displaying low cytotoxicity for the human HepG2 cell line (CC50 > 100 mu M) alongside good antileishmanial activities (IC50 = 1-2.1 mu M) against L. donovani, L. infantum, and L. major; and good antitrypanosomal activities (IC50 = 1.3-2.2 mu M) against T. brucei brucei and T. cruzi, in comparison to several reference drugs such as miltefosine, fexinidazole, eflornithine, and benznidazole (IC50 = 0.6 to 13.3 mu M). Molecule 5, presenting a low reduction potential (E degrees = -0.63 V), was shown to be selectively bioactivated by the L. donovani type 1 nitroreductase (NTR1). Importantly, molecule 5 was neither mutagenic (negative Ames test), nor genotoxic (negative comet assay), in contrast to many other nitroaromatics. Molecule 5 showed poor microsomal stability; however, its main metabolite (sulfoxide) remained both active and nonmutagenic, making 5 a good candidate for further in vivo studies

Preoccupazione ambientale e praxis ecologista : I vari rapporti delle Magliette Gialle all'ecologia

National audienc

Preoccupazione ambientale e praxis ecologista : I vari rapporti delle Magliette Gialle all'ecologia

National audienc

Inquiétude environnementale et praxis écologique populaire : les différents rapports à l’écologie au sein des Gilets jaunes

À partir d'un enquête à la fois qualitative et quantitative auprès du mouvement des Gilets Jaunes, la présentation cherche à montrer la critique écologique portée par les Gilets Jaunes ainsi que la manière dont les écologies populaires en son sein s'incarnent dans des pratiques spécifiques

Preoccupazione ambientale e praxis ecologista : I vari rapporti delle Magliette Gialle all'ecologia

Les Gilets jaunes : approches pluridisciplinaires des mobilisations et politisations populaire

Preoccupazione ambientale e praxis ecologista : I vari rapporti delle Magliette Gialle all'ecologia

Les Gilets jaunes : approches pluridisciplinaires des mobilisations et politisations populaire

Preoccupazione ambientale e praxis ecologista : I vari rapporti delle Magliette Gialle all'ecologia

National audienc

Clinical Relevance of Liquid Biopsy in Melanoma and Merkel Cell Carcinoma

International audienceMelanoma and Merkel cell carcinoma are two aggressive skin malignancies with high disease-related mortality and increasing incidence rates. Currently, invasive tumor tissue biopsy is the gold standard for their diagnosis, and no reliable easily accessible biomarker is available to monitor patients with melanoma or Merkel cell carcinoma during the disease course. In these last years, liquid biopsy has emerged as a candidate approach to overcome this limit and to identify biomarkers for early cancer diagnosis, prognosis, therapeutic response prediction, and patient follow-up. Liquid biopsy is a blood-based non-invasive procedure that allows the sequential analysis of circulating tumor cells, circulating cell-free and tumor DNA, and extracellular vesicles. These innovative biosources show similar features as the primary tumor from where they originated and represent an alternative to invasive solid tumor biopsy. In this review, the biology and technical challenges linked to the detection and analysis of the different circulating candidate biomarkers for melanoma and Merkel cell carcinoma are discussed as well as their clinical relevance