A taxonomy of explanations in a general practitioner clinic for patients with persistent “medically unexplained” physical symptoms

MSS1 and MSS2 were supported by grants from the Chief Scientist Office of the Scottish Government (references CZG/2/412 and CZH/4/945). We are grateful to the general practitioners and patients who participated in these studies.Peer reviewedPostprin

Curatorial Practice as Production of Visual & Spatial Knowledge: Panel Discussion, October 4, 2014

The following is a transcription of a conversation between curators of art, science, and digital data about how their practice creates knowledge in their respective fields. Drawn from Pittsburgh’s rich institutional resources, the panelists include Dan Byers, (then) Richard Armstrong Curator of Contemporary Art, Carnegie Museum of Art; Dr. Alison Langmead, Director, Visual Media Workshop, Department of History of Art and Architecture, and Assistant Professor, School of Information Scienes, University of Pittsburgh; Dr. Cynthia Morton, Associate Curator of Botany, Carnegie Museum of Natural History; and Dr. Terry Smith, Andrew W. Mellon Professor of Contemporary Art History and Theory, University of Pittsburgh. Moderated by Nicole Scalissi, PhD candidate, Department of History of Art and Architecture, University of Pittsburgh. The panel took place as a part of Debating Visual Knowledge, a symposium organized by graduate students in Information Science and History of Art and Architecture at the University of Pittsburgh, October 3-5, 2014. The transcription has been edited for clarity.Curatorial Practice as Production of Visual &amp; Spatial Knowledge</jats:p

Double-difference waveform inversion of 4D ocean bottom cable data: Application to Valhall, North Sea

Changes in reservoir properties resulting from extracting hydrocarbons and injecting fluid are critical to optimize production. These properties can be characterized using waveform inversions of time-lapse seismic data. The conventional approach for analysis using waveform tomography is to take the difference of seismic inversion obtained using baseline and subsequent time-lapse datasets that are imaged independently. By contrast, double-difference waveform inversion (DDWI) jointly inverts time-lapse seismic datasets for reservoir changes. We use a 2D synthetic example to demonstrate the advantage of DDWI in mitigating spurious estimates of property changes. We then apply both conventional full waveform inversion(FWI) and DDWI to time-lapse datasets collected by ocean bottom cables (OBC) in the Valhall field in the North Sea. The data sets are acquired one year apart. DDWI gives a cleaner and more easily interpreted image of the model changes, as compared to that obtained with the conventional FWI scheme

Time-lapse full-waveform inversion with ocean-bottom-cable data: Application on Valhall field

Knowledge of changes in reservoir properties resulting from extracting hydrocarbons or injecting fluid is critical to future production planning. Full-waveform inversion (FWI) of time-lapse seismic data provides a quantitative approach to characterize the changes by taking the difference of the inverted baseline and monitor models. The baseline and monitor data sets can be inverted either independently or jointly. Time-lapse seismic data collected by ocean-bottom cables (OBCs) in the Valhall field in the North Sea are suitable for such time-lapse FWI practice because the acquisitions are of a long offset, and the surveys are well-repeated. We have applied independent and joint FWI schemes to two time-lapse Valhall OBC data sets, which were acquired 28 months apart. The joint FWI scheme is double-difference waveform inversion (DDWI), which inverts differenced data (the monitor survey subtracted by the baseline survey) for model changes. We have found that DDWI gave a cleaner and more easily interpreted image of the reservoir changes compared with that obtained with the independent FWI schemes. A synthetic example is used to demonstrate the advantage of DDWI in mitigating spurious estimates of property changes and to provide cross validations for the Valhall data results

Longitudinal and cross-sectional modelling of health related quality of life in people with cystic fibrosis

People with cystic fibrosis (CF) must endure up to four hours treatment per day to maintain health and are vulnerable to complications. The Cystic Fibrosis Quality of Life Questionnaire was developed to measure health related quality of life (HRQoL) in the UK. Most studies on HRQoL are cross-sectional in design with HRQoL measured once per patient. However, the Cystic Fibrosis Quality of Life Questionnaire has been used to monitor HRQoL longitudinally with measures taken over a 12 year period at one clinic in the UK. These data were modelled with a binomial distribution for a domain score and with fixed and random coefficients for the patient-level clinical and demographic variables. The longitudinal study included 182 patients whose HRQoL was first measured within a single calendar year and were then followed-up. These data provided an opportunity to compare, directly and by simulation, the modelling of a cross-sectional with the modelling of a longitudinal study and so provided insights into the statistical merits of longitudinal studies compared to cross-sectional studies in HRQoL

WS9.3 Reduced physical activity participation is associated with increased need for hospitalisation in adults with cystic fibrosis

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Clinical investigation of the novel iron-chelating agent, CP94, to enhance topical photodynamic therapy of nodular basal cell carcinoma.

Clinical TrialMulticenter StudyThis is the peer reviewed version of the article which has been published in final form at DOI: 10.1111/j.1365-2133.2008.08668.x This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.© 2008 The AuthorsJournal Compilation © 2008 British Association of DermatologistsBACKGROUND: Photodynamic therapy (PDT) involves the activation of a photosensitizer by visible light to produce activated oxygen species within target cells, resulting in their destruction. Evidence-based guidelines support the efficacy of PDT using topical 5-aminolaevulinic acid (ALA-PDT) in actinic keratoses, Bowen disease and basal cell carcinoma (BCC). Efficacy for nodular BCC appears inferior to that for superficial BCC unless prior debulking or repeat treatments are performed. Objectives The aim of this study was to assess the safety and efficacy of adding a novel iron-chelating agent, CP94 (1,2-diethyl-3-hydroxypyridin-4-one hydrochloride), to topical ALA, to temporarily increase the accumulation of the photosensitizer in the tumour. METHODS: A mixed topical formulation of ALA + increasing concentrations of CP94 was used to carry out PDT on previously biopsied nodular BCC with no prior lesion preparation using standard light delivery. The area was assessed clinically and surgically excised 6 weeks later for histological examination. RESULTS: Enhanced PDT using 40% CP94 resulted in significantly greater clearance rates in nodular BCC than with ALA-PDT alone, in our protocol of single-treatment PDT with no lesion preparation. CONCLUSIONS: The results of this study demonstrate the safe and effective use of an enhanced ALA-PDT protocol for nodular BCC using CP94, with no adverse reactions to this modification. This is the first time this formulation has been used in patients. This formulation is now the focus of further study

Vocal behaviour as an indicator of lamb vigour

The viability and survival of the neonate lamb relies on its ability to communicate and maintain a strong attachment with its dam. To date there has been little concise information available about the role of the lamb's behaviour, and in particular the importance of acoustic cues, in this relationship as greater attention has been focused on maternal attributes important in facilitating the maternal-young bond. In human and rodent neonates, acoustic features of the distress vocalisation are used as indices of neurological deficit and integrity both at birth and in infant acoustic cry analysis. The aim of this thesis was to investigate potential behavioural indicators of lamb vigour, with a particular focus on vocal behaviour, within the first 12 hours of life. Such measures could provide valuable information for development of reproductive breeding objectives, and provide clarity regarding the role of the lamb in failed maternal-young interactions. Delayed vocalisation initiation in response to a separation stimulus was found to be associated with poor vigour-related behaviour reflecting the capacity of the lamb to reunite and follow the dam over 12 hours postpartum. Vocalisation delay was also associated with risk factors related to poor lamb survival including longer parturition duration, male sex, first parity, heavier birth weight and sire-related conformational attributes likely to result in a more difficult birth. Blood assay markers reflecting fetal distress including poor blood oxygenation, and elevated plasma glucose and lactate levels sampled at birth were also demonstrated to be correlated with vocalisation latency. These associations were concluded to reflect impacts on the lamb's neurological system rather than genetic influences because of evidence provided by within-litter comparisons, and to demonstrate neuroregenerative processes over a 12 hour measurement period. An analysis of lamb distress signals modelled on acoustic cry analysis of the human neonate was also undertaken to compare vocalisation characteristics of lambs with delayed responses to those with rapid responses indicating vigour. Signal features of delayed response lambs were more likely to demonstrate acoustic parameters reflecting glottal instability, lower amplitude and reduced repetition rate. These lambs were more likely to emit inefficient or inappropriate signals in the context of isolation. A significantly higher fundamental frequency, an indicator of pathology in the human infant, was not clearly demonstrated to be associated with compromised lambs in this study. It was also found in a two-choice test, where sheep dams were required to demonstrate a preference for signals of their own co-twins, that ewes preferred acoustic signals of lambs correlated with rapid vocalisation response, higher pitch and greater signal stability. The results indicate that delayed vocalisation responsiveness and other acoustic measures are associated with fetal compromise in the neonate lamb, as shown in the human and rodent models. It was concluded that delayed vocal initiation is a marker for poor postnatal outcome characterised by diminished responsiveness to a distress condition. This research has important implications for understanding failed maternal-young relationships and the consequences for survival in mammalian neonates

Summary [January 1978]

This brief provides a summary of the world, UK and Scottish economic outlook. The upward movement in the Scotland/UK unemployment relative over the past few quarters is unlikely to portend a return to the poor relative performance of the Scottish economy which occurred in the early nineteen sixties. Nevertheless the outlook for the Scottish economy in 1978 is not very encouraging

Long term care and the coronavirus pandemic: a new role for environmental design in a changing context

First paragraph: It took more than three decades of championing the principles of environmental design for dementia and developing the research evidence base on how the physical environment can support the independence and wellbeing of people with dementia to reach a point where cognitively supportive design should be the default requirement for new and existing long term residential care facilities. It has taken a fraction of that time for an emerging coronavirus to displace concern with residents’ lived experience in favour of strict transmission and infection control measures, forcing a return to more institutionalised and medicalised environments and care practices