DIAGNÓSTICO INTEGRAL DEL ÁREA DE INFLUENCIA DE LA UNIVERSIDAD NACIONAL DE LUJÁN. Una herramienta para la gestión.

Se presenta en esta ponencia el trabajo de configuración del programa “DIAGNÓSTICO INTEGRAL DEL AREA DE INFLUENCIA DE LA UNIVERSIDAD NACIONAL DE LUJAN: Evaluación e impacto de acciones y servicios hacia la comunidad”. La labor en equipo, que está avalada por disposición 688/06 del Consejo Directivo Departamental de Ciencias Sociales de la Universidad Nacional de Luján (UNLu.), tiene como meta perfilar el área de influencia de la UNLu para establecer un diagnóstico de los territorios involucrados, y evaluar las acciones y servicios realizados desde el ámbito universitario. A partir de la caracterización de la relación universidad-área de influencia, se delinearán distintas tácticas de base para la planificación y gestión de servicios a la comunidad. Los servicios se pensarán en función de las demandas de los distintos sectores sociales: extrínsecos (comunidad) e intrínsecos (UNLu). Se da cuenta también aquí, del sistema de relaciones entre los distintos proyectos del programa que intentan dimensionar la vinculación entre: • crecimiento vegetativo de la población y crecimiento vegetativo del alumnado; • creación de carreras y necesidades de la comunidad; • sistema de transporte y servicios académicos; • investigación y desarrollo local; • extensión y vinculación sectorial

Information competencies for initial teacher training courses in Uruguay: proposal for the curricula based on a systematic review of the literature

Los cursos de grado de formación inicial del profesorado resultan ser claves para enfrentar los desafíos de la educación dentro de una sociedad actual cultural y tecnológicamente compleja. Entre estos, un profesorado atravesado por el cambio continuo y por una gran cantidad de información digital disponible. Este artículo pretende plantear una guía para el desarrollo de competencias en información a ser integrada en los planes de estudio de la formación inicial de profesores en Uruguay. Se realizó una revisión bibliográfica sistemática de las competencias en información y de programas para el desarrollo de las mismas. Como resultado, fue elaborada una guía que sugiere lineamientos para el desarrollo de estrategias de búsqueda, de evaluación y selección de la información, de comunicación de la información y de uso ético de la misma. La propuesta pretende así, contribuir para la sistematización del desarrollo de competencias en información para los profesores que están iniciando su formación.Initial teacher training courses are key to face the challenges of education in today's culturally and technologically complex society. Among these, a teaching profession that faces constant changes and a large amount of digital information available. This article aims to propose a guide for the development of information competencies to be integrated into the curricula of initial teacher training in Uruguay. A systematic bibliographic review of information competencies and programs for their development was carried out. As a result, a guide was elaborated suggesting guidelines for the development of strategies for search, evaluation and selection, communication and ethical use of the information. The proposal thus aims to contribute for the systematization of the development of information competencies for teachers who are beginning their training process.Facultad de Humanidades y Ciencias de la Educació

A traçabilidade do conceito de competências em informação nos marcos de referência digitais docentes

Este artículo presenta la trazabilidad del concepto de competencias en información dentro de varios marcos de referencia digitales orientados a docentes. Se realizó un análisis documental basado en un relevamiento bibliográfico en el que se cruzaron los datos de los diferentes textos seleccionados. Se eligieron ocho trabajos que responden a organismos internacionales (Unesco, Unión Europea, ISTE) y a instituciones educativas nacionales de América Latina, España y Reino Unido. Se discuten las diversas terminologías que dichos marcos utilizan en relación al uso de tecnologías digitales en la educación, analizando los conceptos de competencias digitales que estos presentan e identificando los elementos propios de las competencias en información que en ellos se incluyen. Se elaboró una tabla con los aspectos comunes hallados que sirven de insumo para la discusión. Si bien en algunos marcos no figuran de forma explícita las competencias en información, se lograron identificar las siguientes: búsqueda de información, selección y evaluación crítica, y uso ético. Estas se encuentran atravesadas por la capacidad de pensar en forma crítica al momento de generar nuevo conocimiento.This article presents the traceability of the concept of information competences in several digital frameworks oriented to teachers. A documentary analysis was carried out based on a bibliographic survey where data from different selected texts were cross-checked. Eight works from international organizations (Unesco, European Union, ISTE) and national educational institutions in Latin America, Spain and the United Kingdom were selected. The different terminologies used by these frameworks in relation to the use of digital technologies in education are discussed, analyzing the concepts of digital competences that they present and identifying the elements of information competences included in them. A table was elaborated with the common aspects found that serve as input for discussion. Although some frameworks do not explicitly include information competences, the following were identified: information search, selection and critical evaluation, and ethical use. These are crossed by the ability to think critically when generating new knowledge.Este artigo apresenta a traçabilidade do conceito de competências em informação dentro de vários marcos de referência digitais docentes. Foi realizada uma análise documental baseada em uma pesquisa bibliográfica na qual se realizou um cruzamento dos dados dos diferentes textos selecionados. Foram escolhidos oito trabalhos de organizações internacionais (Unesco, União Europeia, ISTE) e instituições educacionais nacionais da América Latina, Espanha e Reino Unido. Neste trabalho são discutidas as diferentes terminologias que os marcos utilizam em relação ao uso das tecnologias digitais na educação, analisando os conceitos de competências digitais que eles apresentam e identificando os elementos próprios das competências em informação incluídos neles. Uma tabela foi elaborada com os aspectos comuns encontrados que servem como insumo para a discussão. Embora estas competências não estejam explicitamente incluídas em alguns desses marcos, as de busca de informações, seleção e avaliação crítica e uso ético são identificadas. Elas se encontram atravessadas pela capacidade de pensar de forma crítica al momento de gerar novo conheciment

New limonene-hybrid derivatives with anti-T. cruzi activity

The development of hybrid compounds containing limonene- and recognized anti-T. cruzi-heterocycle-frameworks is described. The six new compounds displayed broad antitrypanosomal activities having 5-nitrofuran and 5-nitroindazole derivatives, the best profiles. In addition, a 5-nitroindazole derivative evaluated against a panel of fungi exhibited relevant activities. Knowing that free-radical-production operates as one of the mechanisms of action on these heterocycles, we studied a potential extra-mechanism, membrane-sterols changes. Non-relevant T. cruzi squalene accumulation was observed for any of the tested hybrid-limonene derivatives. © 2010 Bentham Science Publishers Ltd.Fil: Alvarez, Guzmán. Universidad de la República; UruguayFil: Gerpe, Alejandra. Universidad de la República; UruguayFil: Benitez, Diego. Universidad de la República; UruguayFil: Garibotto, Francisco Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Zacchino, Susana Alicia Stella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; ArgentinaFil: Graebin, Cedric Stephan. Universidade Federal do Rio Grande do Sul; BrasilFil: Gomes da Rosa, Ricardo. Universidade Federal do Rio Grande do Sul; BrasilFil: Eifler Lima, Vera. Universidade Federal do Rio Grande do Sul; BrasilFil: González, Mercedes. Universidad de la República; UruguayFil: Cerecetto, Hugo. Universidad de la República; Urugua

The characterization of Escherichia coli CpdB as a recombinantpProtein reveals that, besides having the expected 3´-nucleotidase and 2´,3´-cyclic mononucleotide phosphodiesterase activities, it is also active as cyclic dinucleotide phosphodiesterase

Endogenous cyclic diadenylate phosphodiesterase activity was accidentally detected in lysates of Escherichia coli BL21. Since this kind of activity is uncommon in Gram-negative bacteria, its identification was undertaken. After partial purification and analysis by denaturing gel electrophoresis, renatured activity correlated with a protein identified by fingerprinting as CpdB (cpdB gene product), which is annotated as 3´-nucleotidase / 2´,3´- cyclicmononucleotide phosphodiesterase, and it is synthesized as a precursor protein with a signal sequence removable upon export to the periplasm. It has never been studied as a recombinant protein. The coding sequence of mature CpdB was cloned and expressed as a GST fusion protein. The study of the purified recombinant protein, separated from GST, confirmed CpdB annotation. The assay of catalytic efficiencies (kcat/Km) for a large substrate set revealed novel CpdB features, including very high efficiencies for 3´-AMP and 2´,3´- cyclic mononucleotides, and previously unknown activities on cyclic and linear dinucleotides. The catalytic efficiencies of the latter activities, though low in relative terms when compared to the major ones, are far from negligible. Actually, they are perfectly comparable to those of the ‘average’ enzyme and the known, bona fide cyclic dinucleotide phosphodiesterases. On the other hand, CpdB differs from these enzymes in its extracytoplasmic location and in the absence of EAL, HD and DHH domains. Instead, it contains the domains of the 5´-nucleotidase family pertaining to the metallophosphoesterase superfamily, although CpdB lacks 5´-nucleotidase activity. The possibility that the extracytoplasmic activity of CpdB on cyclic dinucleotides could have physiological meaning is discussed.Trabajo financiado por: Junta de Extremadura y Fondos FEDER. Ayudas GR10133 y GR15143 Donación privada para María Jesús Costas Vázquez. Contrato 2015/00481/001peerReviewe

Diversity, systematic and conservation of rodents from the southwestern end of the Interior Atlantic Forest

Presentamos una síntesis del conocimiento actual de los roedores de la provincia de Misiones, Argentina, con énfasis en aspectos taxonómicos, cromosómicos, biogeográficos y de conservación. En esta provincia, el orden está representado por 7 familias: Sciuridae (1 género, 1 especie), Cricetidae (17, 24), Caviidae (2, 2), Cuniculidae (1, 1), Dasyproctidae (1, 1), Echymyidae (3, 3) y Erethizontidae (1, 1). De 1 a 5 especies -dependiendo de la autoridad taxonómica usada- son endémicas de Misiones. Discutimos brevemente algunas problemáticas taxonómicas, destacando aquellos interrogantes que aún persisten (e.g., la compleja situación del género Brucepattersonius). Para varias especies aportamos datos cromosómicos novedosos y los comparamos con aquellos disponibles para Brasil. Un análisis de la riqueza a nivel provincial indica que los mayores valores para ese parámetro ocurren hacia el centro-sur del territorio, en un área de interdigitación entre el Bosque Atlántico Interior y la ecorregión de los Campos y Malezales. Discutimos el rol de los grandes ríos de la región como barrera para la dispersión de la fauna (e. g., el Paraná entre Argentina y el este Paraguay). Por lo menos 9 especies de roedores con distribución en la provincia de Misiones han sido referidas bajo alguna categoría de amenaza o cercana a la amenaza. En todos los casos, la supervivencia de esos taxones depende de que se mantenga la integridad y conectividad entre los remanentes boscosos.We present a synthesis of the current knowledge of the rodents from the provinceof Misiones, Argentina, with emphasis on taxonomic, chromosomal, biogeographic and conservation issues. In this province, the order is represented by 7 families: Sciuridae (1 genus, 1 species), Cricetidae (17, 24), Caviidae(2, 2), Cuniculidae (1, 1), Dasyproctidae (1, 1), Echymyidae (3, 3) and Erethizontidae (1, 1). From 1 to 5 species -depending on taxonomic authorities- are endemic to Misiones. We briefly discuss some taxonomic problems, highlighting those questions that still persist (e.g., the complex situation of the genus Brucepattersonius). For several species, we provide novel chromosome data and compare it with the information available for Brazil. An analysis of the species richness at the provincial level indicates that the highest values for this parameter occur towards the south-central portion of the territory, in an area of interdigitation between the Interior Atlantic Forest and the ecoregion of Campos y Malezales. We discuss the role of large rivers in the region as barriers to the dispersal of this fauna (e.g., the Paraná between Argentina and eastern Paraguay). At least 9 species of rodents with distribution in the province of Misiones have been classified under some category of threat or near to the threat. In all cases, the survival of these taxa depends on maintaining the integrity and connectivity between forest remnants.Fil: Lanzone, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Labaroni, Carolina Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Formoso, Anahí Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Centro para el Estudio de Sistemas Marinos; ArgentinaFil: Buschiazzo, Leandro Maciel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Da Rosa, Fernando Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Teta, Pablo. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Zoología de Vertebrados. Sección de Mastozoología; Argentin

Diversity, systematic and conservation of rodents from the southwestern end of the Interior Atlantic Forest

Presentamos una síntesis del conocimiento actual de los roedores de la provincia de Misiones, Argentina, con énfasis en aspectos taxonómicos, cromosómicos, biogeográficos y de conservación. En esta provincia, el orden está representado por 7 familias: Sciuridae (1 género, 1 especie), Cricetidae (17, 24), Caviidae (2, 2), Cuniculidae (1, 1), Dasyproctidae (1, 1), Echymyidae (3, 3) y Erethizontidae (1, 1). De 1 a 5 especies -dependiendo de la autoridad taxonómica usada- son endémicas de Misiones. Discutimos brevemente algunas problemáticas taxonómicas, destacando aquellos interrogantes que aún persisten (e.g., la compleja situación del género Brucepattersonius). Para varias especies aportamos datos cromosómicos novedosos y los comparamos con aquellos disponibles para Brasil. Un análisis de la riqueza a nivel provincial indica que los mayores valores para ese parámetro ocurren hacia el centro-sur del territorio, en un área de interdigitación entre el Bosque Atlántico Interior y la ecorregión de los Campos y Malezales. Discutimos el rol de los grandes ríos de la región como barrera para la dispersión de la fauna (e. g., el Paraná entre Argentina y el este Paraguay). Por lo menos 9 especies de roedores con distribución en la provincia de Misiones han sido referidas bajo alguna categoría de amenaza o cercana a la amenaza. En todos los casos, la supervivencia de esos taxones depende de que se mantenga la integridad y conectividad entre los remanentes boscosos.We present a synthesis of the current knowledge of the rodents from the provinceof Misiones, Argentina, with emphasis on taxonomic, chromosomal, biogeographic and conservation issues. In this province, the order is represented by 7 families: Sciuridae (1 genus, 1 species), Cricetidae (17, 24), Caviidae(2, 2), Cuniculidae (1, 1), Dasyproctidae (1, 1), Echymyidae (3, 3) and Erethizontidae (1, 1). From 1 to 5 species -depending on taxonomic authorities- are endemic to Misiones. We briefly discuss some taxonomic problems, highlighting those questions that still persist (e.g., the complex situation of the genus Brucepattersonius). For several species, we provide novel chromosome data and compare it with the information available for Brazil. An analysis of the species richness at the provincial level indicates that the highest values for this parameter occur towards the south-central portion of the territory, in an area of interdigitation between the Interior Atlantic Forest and the ecoregion of Campos y Malezales. We discuss the role of large rivers in the region as barriers to the dispersal of this fauna (e.g., the Paraná between Argentina and eastern Paraguay). At least 9 species of rodents with distribution in the province of Misiones have been classified under some category of threat or near to the threat. In all cases, the survival of these taxa depends on maintaining the integrity and connectivity between forest remnants.Facultad de Ciencias Naturales y Muse

Profile and migration of members of Residency Programs in Family Medicine

OBJETIVO Caracterizar o perfil sociodemográfico e analisar as características migratórias dos integrantes dos Programas de Residência em Medicina de Família e Comunidade em 2020 no Brasil. MÉTODOS O estudo segue um delineamento observacional transversal de natureza quantitativa a partir da perspectiva dos integrantes dos Programas de Residência em Medicina de Família e Comunidade. Foram desenvolvidos questionários adaptados para cada grupo participante, aplicados por meio de plataforma on-line. RESULTADOS A maioria dos participantes é do sexo feminino e de cor branca. A maioria dos supervisores e preceptores foi residente de Programas de Residência em Medicina de Família e Comunidade, contudo, há alguns que não são especialistas na área. A maior parte dos participantes está vinculada às capitais ou regiões metropolitanas. Em relação à fixação, 41,1% dos supervisores e 73,1% dos preceptores estão vinculados a um programa no mesmo município onde foram residentes. Para a maioria dos médicos residentes, o local da residência coincide com o local de nascimento e/ou graduação (57,4%), sendo que 48,5% estão no mesmo local de graduação. CONCLUSÕES A pesquisa reforça a necessidade de políticas de promoção da migração de residentes para Programas de Residência em Medicina de Família e Comunidade fora das capitais e regiões metropolitanas, bem como estimula a fixação dos egressos formados fora dos grandes centros urbanos para que eles possam contribuir com a distribuição e com o provimento de médicos onde ainda é necessário.OBJECTIVE To describe the sociodemographic profile and analyze the migratory characteristics of the members of the Residency Programs in Family Medicine in 2020 in Brazil. METHODS The study follows a cross-sectional observational design of a quantitative nature from the perspective of the members of the Residency Programs in Family Medicine. Questionnaires adapted for each participating group were developed, applied through an online platform. RESULTS Most participants are female and white. Most supervisors and preceptors were residents of Residency Programs in Family Medicine, however, there are some who are not specialists in the field. Most participants are based in capitals or metropolitan regions. In relation to retention, 41.1% of supervisors and 73.1% of preceptors are affiliated to a program in the same municipality where they lived. For most resident physicians, the place of residence coincides with the place of birth and/or graduation (57.4%), and 48.5% are in the same place of graduation. CONCLUSIONS The research reinforces the need for policies to promote the migration of residents to Residency Programs in Family Medicine outside capital cities and metropolitan regions, as well as encouraging the retention of graduates trained outside large urban centers so that they can contribute to distribution and provision of doctors where they are still needed

Transcriptomic analysis reveals that mTOR pathway can be modulated in macrophage cells by the presence of cryptococcal cells

Cryptococcus neoformans and Cryptococcus gattii are the etiological agents of cryptococcosis, a high mortality disease. The development of such disease depends on the interaction of fungal cells with macrophages, in which they can reside and replicate. In order to dissect the molecular mechanisms by which cryptococcal cells modulate the activity of macrophages, a genome-scale comparative analysis of transcriptional changes in macrophages exposed to Cryptococcus spp. was conducted. Altered expression of nearly 40 genes was detected in macrophages exposed to cryptococcal cells. The major processes were associated with the mTOR pathway, whose associated genes exhibited decreased expression in macrophages incubated with cryptococcal cells. Phosphorylation of p70S6K and GSK-3β was also decreased in macrophages incubated with fungal cells. In this way, Cryptococci presence could drive the modulation of mTOR pathway in macrophages possibly to increase the survival of the pathogen