Time-Dependent Z-R Relationships for Estimating Rainfall Fields from Radar Measurements

Abstract. The operational use of weather radars has become a widespread and useful tool for estimating rainfall fields. The radar-gauge adjustment is a commonly adopted technique which allows one to reduce bias and dispersion between radar rainfall estimates and the corresponding ground measurements provided by rain gauges. This paper investigates a new methodology for estimating radar-based rainfall fields by recalibrating at each time step the reflectivity-rainfall rate (Z-R) relationship on the basis of ground measurements provided by a rain gauge network. The power-law equation for converting reflectivity measurements into rainfall rates is readjusted at each time step, by calibrating its parameters using hourly Z-R pairs collected in the proximity of the considered time step. Calibration windows with duration between 1 and 24 h are used for estimating the parameters of the Z-R relationship. A case study pertaining to 19 rainfall events occurred in the north-western Italy is considered, in an area located within 25 km from the radar site, with available measurements of rainfall rate at the ground and radar reflectivity aloft. Results obtained with the proposed method are compared to those of three other literature methods. Applications are described for a posteriori evaluation of rainfall fields and for real-time estimation. Results suggest that the use of a calibration window of 2–5 h yields the best performances, with improvements that reach the 28% of the standard error obtained by using the most accurate fixed (climatological) Z-R relationship

GridCertLib: a Single Sign-on Solution for Grid Web Applications and Portals

This paper describes the design and implementation of GridCertLib, a Java library leveraging a Shibboleth-based authentication infrastructure and the SLCS online certificate signing service, to provide short-lived X.509 certificates and Grid proxies. The main use case envisioned for GridCertLib, is to provide seamless and secure access to Grid/X.509 certificates and proxies in web applications and portals: when a user logs in to the portal using Shibboleth authentication, GridCertLib can automatically obtain a Grid/X.509 certificate from the SLCS service and generate a VOMS proxy from it. We give an overview of the architecture of GridCertLib and briefly describe its programming model. Its application to some deployment scenarios is outlined, as well as a report on practical experience integrating GridCertLib into portals for Bioinformatics and Computational Chemistry applications, based on the popular P-GRADE and Django softwares.Comment: 18 pages, 1 figure; final manuscript accepted for publication by the "Journal of Grid Computing

redesign and manufacturing of a metal towing hook via laser additive manufacturing with powder bed

Abstract An approach to redesign and manufacture a metal towing hook via Selective Laser Melting is discussed. Some reference criteria and general guidelines are considered step-by-step to concurrently address lightening, manufacturability and job planning. Grounds are given for the application of Additive Manufacturing for complex components to the purpose of material saving and increased safety factor

Tailoring treatment of salivary duct carcinoma (SDC) by liquid biopsy: ARv7 expression in circulating tumor cells

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Nutritional vitamin D in renal transplant patients : speculations and reality

Reduced levels of nutritional vitamin D are commonly observed in most chronic kidney disease (CKD) patients and particularly in patients who have received a kidney transplant (KTx). In the complex clinical scenario characterizing the recipients of a renal graft, nutritional vitamin D deficiency has been put in relation not only to the changes of mineral and bone metabolism (MBM) after KTx, but also to most of the medical complications which burden KTx patients. In fact, referring to its alleged pleiotropic (non-MBM related) activities, vitamin D has been claimed to play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic and infectious complications commonly observed in KTx recipients. Furthermore, low nutritional vitamin D levels have also been connected with graft dysfunction occurrence and progression. In this review, we will discuss the purported and the demonstrated effects of native vitamin D deficiency/insufficiency in most of the above mentioned fields, dealing separately with the MBM-related and the pleiotropic effects

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis

Introduction: Severe sepsis is characterised by intravascular or extravascular infection with microbial agents, systemic inflammation and microcirculatory dysfunction, leading to tissue damage, organ failure and death. The growth factor angiopoietin (Ang-1) has therapeutic potential but recombinant Ang-1 tends to aggregate and has a short half-life in vivo. This study aimed to investigate the acute effects of the more stable Ang-1 variant matrilin-1-angiopoietin-1 (MAT.Ang-1) on the function of the microcirculation in an experimental model of sepsis, and whether any protection by MAT-Ang-1 was associated with modulation of inflammatory cytokines, angiogenic factors or the endothelial nitric oxide synthase (eNOS)-Akt and vascular endothelial (VE)-cadherin pathways. Methods: Aluminium window chambers were implanted into the dorsal skinfold of male C3H/HeN mice (7 to 10 weeks old) to expose the striated muscle microcirculation. Endotoxemia was induced by intraperitoneal injection of lipopolysaccharide (LPS, 1 mg/kg at 0 and 19 hours). MAT.Ang-1 was administered intravenously 20 hours after the onset of sepsis. Microcirculatory function was evaluated by intravital microscopy and Doppler fluximetry. Results: Endotoxemia resulted in macromolecular leak, which was ameliorated by MAT.Ang-1 post-treatment. LPS induced a dramatic reduction in tissue perfusion, which was improved by MAT.Ang-1. Proteome profiler array analysis of skeletal muscle also demonstrated increased inflammatory and reduced angiogenic factors during endotoxemia. MAT.Ang-1 post-treatment reduced the level of IL-1β but did not significantly induce the expression of angiogenic factors. MAT.Ang-1 alone did not induce leak or increase angiogenic factors but did reduce vascular endothelial growth factor expression in controls. Conclusion: Administration of MAT.Ang-1 after the onset of sepsis protects the microcirculation from endotoxemia-induced vascular dysfunction through reducing inflammation but without pro-angiogenic actions, thus representing a novel, potential pharmacotherapeutic agent for the treatment of sepsis

Septal ablation versus surgical myomectomy for hypertrophic obstructive cardiomyopathy

Patients with hypertrophic cardiomyopathy (HCM) who have left ventricular outflow tract obstruction (LVOTO) often experience severe symptoms and functional limitation. Relief of LVOTO can be achieved by two invasive interventions, i.e., surgery myectomy and alcohol septal ablation (ASA), leading in experienced hands to a dramatic improvement in clinical status. Despite extensive research, however, the choice of the best option in individual patients remains challenging and poses numerous clinical dilemmas

Utility of the two-source energy balance (TSEB) model in vine and interrow flux partitioning over the growing season

For monitoring water use in vineyards, it becomes important to evaluate the evapotranspiration (ET) contributions from the two distinct management zones: the vines and the interrow. Often the interrow is not completely bare soil but contains a cover crop that is senescent during the main growing season (nominally May–August), which in Central California is also the dry season. Drip irrigation systems running during the growing season supply water to the vine plant and re-wet some of the surrounding bare soil. However, most of the interrow cover crop is dry stubble by the end of May. This paper analyzes the utility of the thermal-based two-source energy balance (TSEB) model for estimating daytime ET using tower-based land surface temperature (LST) estimates over two Pinot Noir (Vitis vinifera) vineyards at different levels of maturity in the Central Valley of California near Lodi, CA. The data were collected as part of the Grape Remote sensing Atmospheric Profile and Evapotranspiration eXperiment (GRAPEX). Local eddy covariance (EC) flux tower measurements are used to evaluate the performance of the TSEB model output of the fluxes and the capability of partitioning the vine and cover crop transpiration (T) from the total ET or T/ET ratio. The results for the 2014–2016 growing seasons indicate that TSEB output of the energy balance components and ET, particularly, over the daytime period yield relative differences with flux tower measurements of less than 15%. However, the TSEB model in comparison with the correlation-based flux partitioning method overestimates T/ET during the winter and spring through bud break, but then underestimates during the growing season. A major factor that appears to affect this temporal behavior in T/ET is the daily LAI used as input to TSEB derived from a remote sensing product. An additional source of uncertainty is the use of local tower-based LST measurements, which are not representative of the flux tower measurement source area footprint.info:eu-repo/semantics/acceptedVersio