Computer simulation of field ion images of nanoporous structure in the irradiated materials

Computer simulation and interpretation of field ion microscopy images of ion irradiated platinum are discussed. Field ion microscopy technique provides direct precise atomic scale investigation of crystal lattice defects of atomically pure surface of material; at the same time it allows to analyze the structural defects in volume by controlled and sequential removal of surface atoms by electric field. Defects identification includes the following steps: at the first stage the type of crystalline structure and spatial orientation of crystallographic directions were determined. Thus, we obtain the data about exact position of all atoms of the given volume, i.e. the model image of an ideal crystal. At the second stage, the ion image was processed used the program to obtain the data about real arrangement of atoms of the investigated sample. At the third stage the program compares these two data sets, with a split-hair accuracy revealing a site of all defects in a material. Results of the quantitative analysis show that shape of nanopores are spherical or cylindrical, diameter on nanopores was varied from 1 to 5 run, their depth was fond to be from 1 to 9 nm. It was observed that nearly 40% of nanopores are concentrated in the subsurface layer 10 nm thick, the concentration of nanopores decreased linearly with the distance from the irradiated surface

Absorption et désorption du dioxyde de souffre par des gouttes d'eau de fort diamètre en chute.

Cet article concerne l’absorption et la désorption du SO2 par des gouttes d’eau de diamètre supérieur à 1mm en chute libre dans un mélange air-SO2 à faible et moyenne concentrations. Dans ce cas, le transfert résulte du couplage des résistances interne et externe à la goutte. Dans la phase liquide, un modèle local basé sur la vitesse de frottement inter faciale et le diamètre de la goutte permet le calcul du coefficient de transfert interne kl. Le coefficient de transfert externe kg dans la phase gazeuse est déterminé à l’aide d’une expression plus classiqueAfin de valider le modèle, des investigations expérimentales sont menées en absorption et en désorption sur une colonne de 2.3 m de hauteur dans laquelle le temps de séjour des gouttes est de l’ordre de la seconde. Le présent modèle simule fort bien l’ensemble de ces expériences réalisées pour différents diamètres de goutte [2.04 ; 4.31] mm et différentes concentrations [100 ; 2000] ppm. Le modèle proposé est aussi comparé avec succès à des résultats expérimentaux de la littérature à faible et moyenne concentrations pour des temps de contact beaucoup plus grands.Son domaine d’application couvre donc désormais l’absorption et la désorption du SO2 pour des concentrations comprises entre quelques ppm et quelque %.Mass transfer in dispersed media is of interest to fields such as nuclear engineering, process engineering and environmental engineering. It occurs when two phases, not under chemical equilibrium, are in contact. Knowledge of mass transfer mechanisms in the case of gas absorption from and/or into droplets is necessary to understand the scavenging of trace gases in clouds, rain and wet scrubbers. Our studies focus on absorption and desorption phenomena involving free falling water droplets in a mixture of air and gas. For example, acid rain is formed when a drop of rain falls through an atmosphere contaminated with gaseous acid precursors. A similar phenomenon occurs in specific atmospheric scrubbers, where pollution is trapped at the source. In all cases, the transfer of trace gases from the air into the falling droplets is controlled by molecular diffusion and by convection outside and inside the drops.For droplets, falling inside a soluble gas medium, the main transfer resistance is located in the gas phase. A survey of published studies shows that a number of good numerical models exist, as well as experimental correlations for predictions of the mass transfer coefficient in the gas film. For the liquid phase controlled resistance, Saboni (1991) proposed a model based on local scales, interfacial liquid friction velocity and drop diameter. The model was validated experimentally by Amokrane et al. (1994). The experimental study and model validation in the case of sulfur dioxide absorption by water droplets falling through air with a high gas concentration (few %) has been described previously in detail by Amokrane et al. (1994).The purpose of the present article was to extend our previous model to predict SO2 absorption and desorption by droplets (1-5 mm) falling in air with a low gas concentration. In the liquid phase, a model based on local scales, interfacial liquid friction velocity and droplet size diameter was used. In the continuous gas phase a more classical model was applied. To support the model, two types of experiments were carried out. The first type was adapted to measure the absorption of gas by droplets of known diameter. A second set of experiments gave the desorption rate from droplets with an initial concentration of sulfur dioxide falling through SO2 -free air. Absorption occurred during the fall through a 2.3 m long column for various gas concentrations and for various droplet diameters. A sketch of the experimental equipment is presented schematically in Figure 1. It consists of a cylindrical column 2.3 m in height and 0.104 m in diameter. Before each experiment, a gas mixture with the desired SO2 concentration in air, ranging between 100 and 2000 ppm, was introduced into the column. The SO2 concentration was set at the desired value by regulating the volumetric flow rates of sulfur dioxide and air with calibrated rotameters. The gas concentration in the column was measured continuously by a chemical cell analyzer. The air temperature and humidity were continually measured at the top, in the middle and at the bottom of the column. They ranged from 18°C to 20°C and from 40% to 50%, respectively. Droplets were generated using a specific injector consisting of a demineralized water tank at the base of which identical thin needles were placed. In the case of the smallest droplets, seven needles, 300 µm in diameter, were used. For the largest droplets, one needle of about 1 mm was used. The artificial rain was started by exerting an overpressure in the tank and it was stopped by exerting a depression. This device allowed the generation of almost identical water drops at a controlled rate. Droplets fell with zero initial velocity. Their diameters were determined by collecting a known number of droplets and weighing them on a precision balance. The droplets were collected in a special glass cup placed at the bottom of the rain shaft. This collector initially contained a known volume of kerosene. The presence of this organic compound allowed the creation of a film to prevent additional absorption of SO2 during the experiment and natural desorption of sulfur after the experiment. An experiment consisted of dropping 10 to 20 mL of rain. This amount is enough to precisely measure the sulfur concentration.For reversible desorption, experimentation was undertaken directly in a lab atmosphere. For these experiments, the 4.31 mm diameter droplets free fall occurred over 16.3 m. Three intermediate levels were also examined with falling times varying from 0.7 to 2.4 s. The ambient temperature was measured in the surrounding area of both the injector and the collector and the maximum variation was 2°C. Various initial sulfurous acid concentrations were obtained as a result of various contact times of demineralized water with air-SO2 mixtures. Initial concentrations ranged from 0.5 10-3 mol·L-1 to 1.8 10-3 mol·L-1. In this case, the collector initially contained a known volume of hydrogen peroxide to immediately convert sulfurous acid into sulfuric acid. This avoided additional desorption of sulfurous acid during and after the experiments. In this case, the presence of the organic film was not necessary.The results achieved with the theoretical model were compared to the experimental results. The present model was successful in correlating the experimental results carried out for various droplet diameters ranging between 2.04 and 4.31 mm, and gas concentrations ranging between 100 and 2000 ppm. The model also compared successfully with experimental results from the literature in the case of much longer contact times. The applicability of the model thus covers the absorption and desorption of SO2 for concentrations ranging between ppm to a few %

Selective recovery of tropane alkaloids applying liquid membrane technique

A tropine recovery from its solutions applying a liquid membrane technique was studied. Among several studied organic solvents, chloroform showed best extraction ability towards atropine. Pertraction studies were carried out in a laboratory bulk liquid membrane contactor with agitation of all three phases. Both, aqueous solutions of pure atropine and extract of Atropa Belladonna L. roots were used as feed solutions, as well as chloroform and diluted sulphuric acid as a liquid membrane and a stripping liquor, respectively. The effect of phase agitation on alkaloid pertraction was studied for the cases when pure atropine solutions were used as feed phase. A pertraction process carried out with native liquid extracts from A. Belladonna provided selective alkaloid recovery and its concentration in the acceptor solutio

Anisotropy of Solar Wind Turbulence between Ion and Electron Scales

The anisotropy of turbulence in the fast solar wind, between the ion and electron gyroscales, is directly observed using a multispacecraft analysis technique. Second order structure functions are calculated at different angles to the local magnetic field, for magnetic fluctuations both perpendicular and parallel to the mean field. In both components, the structure function value at large angles to the field S_perp is greater than at small angles S_par: in the perpendicular component S_perp/S_par = 5 +- 1 and in the parallel component S_perp/S_par > 3, implying spatially anisotropic fluctuations, k_perp > k_par. The spectral index of the perpendicular component is -2.6 at large angles and -3 at small angles, in broad agreement with critically balanced whistler and kinetic Alfven wave predictions. For the parallel component, however, it is shallower than -1.9, which is considerably less steep than predicted for a kinetic Alfven wave cascade.Comment: 4 pages, 4 figures, replaced to match published versio

From random to rational: improving enzyme design through electric fields, second coordination sphere interactions, and conformational dynamics

Enzymes are versatile and efficient biological catalysts that drive numerous cellular processes, motivating the development of enzyme design approaches to tailor catalysts for diverse applications. In this perspective, we investigate the unique properties of natural, evolved, and designed enzymes, recognizing their strengths and shortcomings. We highlight the challenges and limitations of current enzyme design protocols, with a particular focus on their limited consideration of long-range electrostatic and dynamic effects. We then delve deeper into the impact of the protein environment on enzyme catalysis and explore the roles of preorganized electric fields, second coordination sphere interactions, and protein dynamics for enzyme function. Furthermore, we present several case studies illustrating successful enzyme-design efforts incorporating enzyme strategies mentioned above to achieve improved catalytic properties. Finally, we envision the future of enzyme design research, spotlighting the challenges yet to be overcome and the synergy of intrinsic electric fields, second coordination sphere interactions, and conformational dynamics to push the state-of-the-art boundaries

Violation of the Hormonal Spectrum in Polycystic Ovaries in Combination with Insulin Resistance. What is the Trigger: Insulin Resistance or Polycystic Ovary Disease?

متلازمة المبيض متعدد التكيسات هي السبب الرئيس للعقم لدى النساء. حيث يناقش البحث دور مقاومة الأنسولين في تطور تكيس المبايض. تم تحليل الطيف الهرموني للمرضى الذين يعانون من متلازمة تكيس المبايض و / أو مقاومة الأنسولين. اشتملت الدراسة على مرضى يعانون من متلازمة تكيس المبايض دون مقاومة الأنسولين (عددهم = 48) ومقاومة الأنسولين (عددهم = 39). كانت مجموعات المقارنة من المرضى الذين ليس لديهم تاريخ من متلازمة تكيس المبايض: مجموعة تحكم بدون مقاومة الأنسولين (عددهم = 46) ومجموعة من المرضى الذين يعانون من مقاومة الأنسولين (عددهم = 45). تم تحديد المعلمات التالية في المرضى: FSH ، LH ، TSH ، T3f ، T4f، PRL ، E2 ، 17-OHd ، Pr ، AMH ، مجموع الاختبار ، Testf ، DHEAS ، DHEAS ، SHBG ، ACTH ، الكورتيزول ، IRI ، IGF-1 ، C- الببتيد ، ومستوى الجلوكوز. تم حساب مؤشر HOMA-IR ونسبة LH / FSH واختبار إجمالي / SHBG. تم إجراء تحليل الارتباط أيضًا بين HOMA IR ومؤشرات المظهر الهرموني و IGF-1 و C-peptide. تم العثور على تغيرات أحادية الاتجاه في مستويات الهرمونات التالية في مقاومة الأنسولين و / أو متلازمة تكيس المبايض و / أو مقاومة الأنسولين بالنسبة لقيم التحكم: استراديول ، هرمون التستوستيرون الكلي ، الكورتيزول ، البرولاكتين ، AMG ، و SHBG. نتيجة لتحليل الارتباط ، تم إنشاء علاقات سلبية بين مؤشر HOMA .IR ومستويات E2 والكورتيزول و AMH في المرضى (باستثناء المجموعة الضابطة) تفترض الدراسة أن تكوين النمط الظاهري للمبيض المتعدد الكيسات مع مزيج من مقاومة الأنسولين يمكن أن يتشكل في المرضى الذين يعانون من مقاومة الأنسولين نتيجة لانخفاض مستوى الاستراديول ، SHBG وزيادة محتوى التستوستيرون الكلي و AMH.Polycystic ovary syndrome (PCOS) is the main cause of female infertility. The role of insulin resistance in the development of polycystic ovary is actively discussed here. The study included patients with PCOS without insulin resistance (n = 48) and with insulin resistance (n = 39). The comparison groups were patients with no history of PCOS: a control group without insulin resistance (n = 46) and a group of patients with insulin resistance (n = 45). The following parameters were determined in patients: FSH, LH, TSH, T3f, T4f, PRL, E2, 17-OHd, Pr, AMH, Test total, Testf, DHEAS, DHEASs, SHBG, ACTH, cortisol, IRI, IGF-1, C-peptide, and glucose level. The HOMA-IR index and the LH / FSH ratio and the total / SHBG test were calculated. Correlation analysis was also performed between HOMA IR and indicators of the hormonal profile, IGF-1, and C-peptide.Unidirectional changes in the levels of the following hormones were found in insulin resistance, PCOS and / or insulin resistance relative to control values: estradiol, total testosterone, cortisol, prolactin, AMG, and SHBG. As a result of the correlation analysis, negative relationships were established between the HOMA IR Index and the levels of E2, cortisol and AMH in patients (except for the control group).We assume that the formation of the phenotype of polycystic ovary with a combination of insulin resistance can be formed in patients with insulin resistance as a result of a decrease in the level of estradiol, SHBG and an increase in the content of total testosterone and AMH