La chancellerie du roi d’Aragon vers 1345-1356 : les effectifs

International audienc

Évaluation d’un logiciel éducatif dans deux contextes de communication : face à face et synchrone à distance

In this paper, we compare peer interactions in two collaborative contexts (synchronous textual communication and face-to-face communication) involving either 14-year-old students or students, who had to build a concept map with an educational software (ModellingSpace). The first study involved 22 pairs of students ; half of them communicated face-to-face and the other group used computer-supported communication. The distant communication condition has been experimented in the second study, with 16 pairs of secondary school students. The structure and content of verbal interactions were the focus of analysis. Results show that the mode of communication has an impact on the structure of the interactions, but not on the content and on the quality of the concept maps. The adults and teenagers’ exchanges present the same structure but differ in their content. These results are discussed in relation with the issue of the assessment of educational software.Cette recherche compare les échanges entre pairs dans différentes situations de collaboration (en face à face ou à distance) impliquant des collégiens, ou des étudiants confrontés à une tâche de construction d’une carte conceptuelle à l’aide du logiciel ModellingSpace. La première étude a impliqué 11 dyades d’étudiants ; la moitié des dyades communique en face à face, et l’autre moitié à distance. Dans la seconde étude, la modalité de communication à distance a été répliquée auprès d’élèves d’une classe de 4 e (âgés de 14 ans en moyenne), 8 dyades au total. Les analyses concernent la structure et le contenu des échanges. Il s’avère que, chez les étudiants, le mode de communication a un impact sur les échanges enregistrés du point de vue de la structure des échanges, mais pas de leur contenu, sans incidence sur la qualité des productions. Les échanges des adultes et des adolescents communiquant à distance présentent le même type de structure mais les contenus des échanges sont différents. Ces résultats font l’objet d’une discussion en relation avec des préoccupations liées à l’évaluation des logiciels éducatifs.Lainé Aurélie, Ortiz Wallner Alexandra, Weil-Barais Annick. Évaluation d’un logiciel éducatif dans deux contextes de communication : face à face et synchrone à distance. In: Sciences et Technologies de l'Information et de la Communication pour l'Éducation et la Formation, volume 13, 2006. Forum de Discussion en Education. pp. 97-128

Évaluation d’un logiciel éducatif dans deux contextes de communication : face à face et synchrone à distance

In this paper, we compare peer interactions in two collaborative contexts (synchronous textual communication and face-to-face communication) involving either 14-year-old students or students, who had to build a concept map with an educational software (ModellingSpace). The first study involved 22 pairs of students ; half of them communicated face-to-face and the other group used computer-supported communication. The distant communication condition has been experimented in the second study, with 16 pairs of secondary school students. The structure and content of verbal interactions were the focus of analysis. Results show that the mode of communication has an impact on the structure of the interactions, but not on the content and on the quality of the concept maps. The adults and teenagers’ exchanges present the same structure but differ in their content. These results are discussed in relation with the issue of the assessment of educational software.Cette recherche compare les échanges entre pairs dans différentes situations de collaboration (en face à face ou à distance) impliquant des collégiens, ou des étudiants confrontés à une tâche de construction d’une carte conceptuelle à l’aide du logiciel ModellingSpace. La première étude a impliqué 11 dyades d’étudiants ; la moitié des dyades communique en face à face, et l’autre moitié à distance. Dans la seconde étude, la modalité de communication à distance a été répliquée auprès d’élèves d’une classe de 4 e (âgés de 14 ans en moyenne), 8 dyades au total. Les analyses concernent la structure et le contenu des échanges. Il s’avère que, chez les étudiants, le mode de communication a un impact sur les échanges enregistrés du point de vue de la structure des échanges, mais pas de leur contenu, sans incidence sur la qualité des productions. Les échanges des adultes et des adolescents communiquant à distance présentent le même type de structure mais les contenus des échanges sont différents. Ces résultats font l’objet d’une discussion en relation avec des préoccupations liées à l’évaluation des logiciels éducatifs.Lainé Aurélie, Ortiz Wallner Alexandra, Weil-Barais Annick. Évaluation d’un logiciel éducatif dans deux contextes de communication : face à face et synchrone à distance. In: Sciences et Technologies de l'Information et de la Communication pour l'Éducation et la Formation, volume 13, 2006. Forum de Discussion en Education. pp. 97-128

Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors

Endometrial cancer (EC) is the seventh most common tumor in women, and prognosis of recurrent and metastatic disease is poor. Cervical cancer (CC) represents the fifth most common gynecological cancer. While ECs are more common in developed countries, the incidence of CC has decreased due to the recent implementation of large screening and vaccination programs. Until very recently, patients with advanced or unresectable EC or CC had very limited treatment options and were receiving in first line setting platinum/taxane-based chemotherapy (CT). Significant progress in the treatment of gynecological cancers has occurred in the last few years, with the use of innovative targeted therapies and immunotherapy. However, targeting the immune system in patients with gynecological tumors remains challenging and is not always successful. In ovarian cancer, several immunotherapy treatment regimens have been investigated (as monotherapy and combination therapy in first and subsequent lines of treatment) and showed poor responses. Therefore, we specifically focused our review on EC and CC for their specific immune-related features and therapeutic results demonstrated with immunotherapy. We report recent and current immunotherapy-based clinical trials and provide a review of emerging data that are likely to impact immunotherapy development based on increased biomarkers’ identification to monitor response and overcome resistance

Politique internationale

SYL-001456 = Fascicule 1, partie 1 ;SYL-8489 = Fascicule 1, partie 2 ;SYL-001457 = Fascicule 2, partie 1 ;SYL-001458 = Fascicule 2, partie 2 ;SYL-001459 = Fascicule 3 ;SYL-001460 = Fascicule 4/5 ;SYL-001461 = Fascicule 6 ;SYL-001811 = Fascicule 7 ;SYL-001462 = Fascicule 8 ;SYL-001812 = Fascicule 9Fascicule 1, partie 1 :World Politics / Pedrag Avramovic, avec l'aide de F. Misrahi et E. Philippart -- Fascicule 1, partie 2 :World Politics / Pedrag Avramovic, avec l'aide de F. Misrahi et E. Philippart -- Fascicule 2, partie 1 :World Economy / Pedrag Avramovic avec l'aide de E. Külahci, E. Laurent -- Fascicule 2, partie 2 :World Economy / Pedrag Avramovic avec l'aide de E. Külahci, E. Laurent -- Fascicule 3 :Security issues and peace studies / Pedrag Avramovic, avec l'aide de Séverine Cirlande et Alexandra Lainé -- Fascicule 4/5 :USA and CIS / Pedrag Avramovic avec l'aide de Séverine Cirlande et Alexandra Lainé -- Fascicule 6 :Europe / Pedrag Avramovic, Erol Külahci -- Fascicule 7 :Maghreb & Middle East / S. Cirlande, E. Laurent -- Fascicule 8 :Asia & Pacific Basin -- Fascicule 9 :Latin America / Erol Külahci & Alexandra LainéSyllabus strictement réservé aux étudiants suivant les cours dans le cadre du CERIS - EXTE 000info:eu-repo/semantics/published

Politique internationale

SYL-000920 = Volume 1 Fascicule 1 ;SYL-001204 = Volume 1 Fascicule 2 ;SYL-001205 = Fascicule 2 ;SYL-001206 = Fascicule 3 ;SYL-001207 = Fascicule 4/5 ;SYL-001208 = Fascicule 6 ;SYL-001209 = Fascicule 7 ;SYL-001210 = Fascicule 8 ;SYL-001211 = Fascicule 9 ;SYL-001463 = Fascicule 10Volume 1 :World Politics. Fascicule 1 :General framework -- Volume 1 :World Politics. Fascicule 2 / F. Perl, E. Philippart -- Fascicule 2 :World Economy / M. Baptista, E. Philippart -- Fascicule 3 :Transnational issues / E. Philippart, O. Ngandu -- Fascicule 4/5 :USA & CIS / E. Cadranel, G. Mulders, E. Philippart, M. van Custem -- Fascicule 6 :The New European Architecture / E. Philippart, M. van Custem -- Fascicule 7 :Maghreb & Middle East / F. Perl -- Fascicule 8 :Asia & Pacific Basin / Gil Mulders -- Fascicule 9 :Latin America / E. Cadranel -- Fascicule 10 :Sub-Saharan Africa4e édition 1994-1995/1 ;Fascicule 10 :4e édition 1997-1998/1Maîtrise en Politique Internationale (Postgraduate Programme in International Politics). Faculté des Sciences Politiques, Economiques et Sociales; Centre d'études des Relations Internationales et stratégiques - CERISinfo:eu-repo/semantics/published

Nanoemulsions Embedded in Alginate Beads as Bioadhesive Nanocomposites for Intestinal Delivery of the Anti-Inflammatory Drug Tofacitinib

International audienceOral administration of nanoparticles (NPs) is a promising strategy to overcome solubility and stability issues of many active compounds. However, this route faces major obstacles related to the hostile gastrointestinal (GI) environment, which impairs the efficacy of orally administered nanomedicines. Here, we propose nanocomposites as a promising approach to increase the retention time of NPs in the intestinal tract by using bio-and mucoadhesive matrixes able to protect the cargo until it reaches the targeted area. A microfluidic-based approach has been applied for the production of tailored nanoemulsions (NEs) of about 110 nm, used for the encapsulation of small hydrophobic drugs such as the antiinflammatory JAK-inhibitor tofacitinib. These NEs proved to be efficiently internalized into a mucus-secreting human intestinal monolayer of Caco-2/ HT29-MTX cells and to deliver tofacitinib to subepithelial human THP-1 macrophage-like cells, reducing their inflammatory response. NEs were then successfully encapsulated into alginate hydrogel microbeads of around 300 μm, which were characterized by rheological experiments and dried to create a long-term stable system for pharmaceutical applications. Finally, ex vivo experiments on excised segments of rats′ intestine proved the bioadhesive ability of NEs embedded in alginate hydrogels compared to free NEs, showing the advantage that this hybrid system can offer for the treatment of intestinal pathologies

Regulatory T cells promote cancer immune-escape through integrin αvβ8-mediated TGF-β activation

International audienceAbstract Presence of TGFβ in the tumor microenvironment is one of the most relevant cancer immune-escape mechanisms. TGFβ is secreted in an inactive form, and its activation within the tumor may depend on different cell types and mechanisms than its production. Here we show in mouse melanoma and breast cancer models that regulatory T (Treg) cells expressing the β8 chain of αvβ8 integrin (Itgβ8) are the main cell type in the tumors that activates TGFβ, produced by the cancer cells and stored in the tumor micro-environment. Itgβ8 ablation in Treg cells impairs TGFβ signalling in intra-tumoral T lymphocytes but not in the tumor draining lymph nodes. Successively, the effector function of tumor infiltrating CD8 + T lymphocytes strengthens, leading to efficient control of tumor growth. In cancer patients, anti-Itgβ8 antibody treatment elicits similar improved cytotoxic T cell activation. Thus, this study reveals that Treg cells work in concert with cancer cells to produce bioactive-TGFβ and to create an immunosuppressive micro-environment

Cytosolic amphiregulin accumulation in malignant pleural mesothelioma cells predicts better survival of patient from the IFCT-GFPC-0701 MAPS Phase 3 trial

CERVOXY COLLNational audienc