A DINÂMICA DO CONHECIMENTO SOBRE O ESCOAMENTO PELO TRONCO: UMA REVISÃO SISTEMÁTICA

A importância do escoamento pelo tronco para a hidrologia e biogeoquímica dos ecossistemas florestais é destacada pelo crescente interesse da comunidade científica desde os anos 1970. Para resumir as principais contribuições dos estudos de escoamento pelo tronco (Sf) dos últimos anos, este trabalho apresenta uma revisão sistemática da literatura, incluindo 375 publicações científicas de 2006 e 2019. O Sf em arbustos demonstrou uma eficiência superior (11,1%) ao escoamento pelo tronco em espécies arbóreas (3,6%). Galhos, textura e composição das cascas, capacidade de saturação das folhas e intensidade dos ventos foram identificados como os fatores que mais influenciam o Sf. No entanto, apesar do crescente número de publicações sobre o tema, a maioria concentra-se em regiões semiáridas da Ásia, principalmente na China e em regiões temperadas. Assim, para as regiões tropical e semiequatorial, ainda há um desconhecimento sobre o papel das diferentes espécies no ciclo biogeoquímico em relação ao Sf

THE DYNAMICS OF THE SUBSTRATE RECOVERY OF WASTE DUMPS IN CALCARY MINING UNDER NATURAL REGENERATION

<div><p>ABSTRACT This study aimed to evaluate the dynamics of the physical and chemical recovery of the substrates of waste dumps of different ages undergoing natural regeneration, in a calcary mining in Salto de Pirapora - SP, Brazil. Characterization of the vegetation, vegetation and physical and chemical cover of the substrates of the abandoned waste dumps since 1994 and 2013 and the soil of a native forest fragment adjacent to the mining was carried out. Twelve plots of 10x10m were allocated in each environment. It was verified that the soil cover rate with herbaceous, grassy, regenerating and litter of the sterile stacks are similar to the native forest fragment. The same was observed for the physical characterization of soil resistance to penetration, soil moisture content and relative light index. For the chemical characteristics, in all areas sampled there is aluminum deficiency which, consequently, presented low potential acidity and alkaline pH. The CEC of the substrates of the waste dumps presented values similar to the CEC of the native forest fragment, with abundance in some essential nutrients, indicating the possibility of vegetation development in the sterile stacks and the contribution of the natural regeneration to the substrates. Thus, the plant-soil relationship via natural regeneration in the sterile piles contributed to the improvement of the edaphic quality of the substrates over time, being a potential form of recovery in calcary mining. Thereby, the Fabaceae predominated on the waste dumps, especially Leucaena leucocephala, which, despite being an exotic species, is relevant for the current recovery stage of the substrates.</p></div

Whole-genome sequencing reveals host factors underlying critical COVID-19

Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease