NNLOPS accurate Drell-Yan production

We present a next-to-next-to-leading order accurate description of Drell-Yan lepton pair production processes through $\gamma^*/Z$ or $W$ exchange that includes consistently parton shower effects. Results are obtained by upgrading the vector-boson plus one jet NLO calculation in POWHEG with the MiNLO procedure and by applying an appropriate reweighting procedure making use of the DYNNLO program. We compare to existing data and to accurate resummed calculations.Comment: 31 pages, 17 figures, 1 tabl

Variation in Loblolly Pine Cross-Sectional Microfibril Angle With Tree Height and Physiographic Region

The effect of height and physiographic region on whole disk cross-sectional microfibril angle (CSMFA) in loblolly pine (Pinus taeda L.) in the southern United States was evaluated. Whole disk CSMFA was determined at 1.4, 4.6, 7.6, 10.7, and 13.7 m up the stem of 59 trees, representing five physiographic regions. A mixed-effects analysis of variance was performed to test the significance of height, region, and the height by region interaction on CSMFA. Height, region, and the height by region interaction terms were all found to be significant at the 0.10 level. Significant differences were found in CSMFA between 1.4 m and all other height levels in all regions. However, there was no difference between CSMFA at 1.4 m and 13.7 m in the Gulf Coastal Plain. No significant difference was found in CSMFA between 4.5, 7.6, and 10.7 meter-height levels in all regions. CSMFA was found to be significantly larger in the north Atlantic and Piedmont regions compared to the south Atlantic, Gulf, and Hilly regions at all heights. The analysis of variance also indicated that significant variation exists among trees within stands and across stands within regions. This is an indicator that aside from the distinct patterns of CSMFA within trees, other factors including site quality, length of growing season, rainfall, and genetics could possibly play a key role in CSMFA development

Air-spun PLA nanofibers modified with reductively-sheddable hydrophilic surfaces for vascular tissue engineering : synthesis and surface modification

Polylactide (PLA) is a class of promising biomaterials that hold great promise for various biological and biomedical applications, particularly in the field of vascular tissue engineering where it can be used as a fibrous mesh to coat the inside of vascular prostheses. However, its hydrophobic surface providing nonspecific interactions and its limited ability to further modifications are challenges that need to be overcome. Here, the development of new air-spun PLA nanofibers modified with hydrophilic surfaces exhibiting reduction response is reported. Surface-initiated atom transfer radical polymerization allows for grafting pendant oligo(ethylene oxide)-containing polymethacrylate (POEOMA) from PLA air-spun fibers labeled with disulfide linkages. The resulting PLA-ss-POEOMA fibers exhibit enhanced thermal stability and improved surface properties, as well as thiol-responsive shedding of hydrophilic POEOMA by the cleavage of its disulfide linkages in response to reductive reactions, thus tuning the surface properties

The role of cyclone clustering during the stormy winter of 2013/2014

The winter season of 2013/2014 was the stormiest on record for the British Isles. In this article we show that there was an unprecedented amount of cyclone clustering during this season, corresponding to an average of one intense cyclone affecting the country every 2.5 days. An intensely clustered period from 6 to 13 February 2014 that was associated with one specific cyclone family is analysed in detail. This cyclone family is shown to be associated with a strong and straight upper level jet that is flanked by Rossby wave breaking on both its northern and southern sides for the duration of the clustering event. This mechanism is also identified for other periods in this season. The persistence of these conditions resulted in the clustered cyclone activity, and it was accompanied by record-breaking rainfall, widespread flooding and large socio-economic losses

Plasma levels of apelin are reduced in patients with liver fibrosis and cirrhosis but are not correlated with circulating levels of bone morphogenetic protein 9 and 10

Background: The peptide apelin is expressed in human healthy livers and is implicated in the development of hepatic fibrosis and cirrhosis. Mutations in the bone morphogenetic protein receptor type II (BMPR-II) result in reduced plasma levels of apelin in patients with heritable pulmonary arterial hypertension. Ligands for BMPR-II include bone morphogenetic protein 9 (BMP9), highly expressed in liver, and BMP10, expressed in heart and to a lesser extent liver. However, it is not known whether reductions in BMP9 and/or BMP10, with associated reduction in BMPR-II signalling, correlate with altered levels of apelin in patients with liver fibrosis and cirrhosis. Methods: Plasma from patients with liver fibrosis (n = 14), cirrhosis (n = 56), and healthy controls (n = 25) was solid-phase extracted using a method optimised for recovery of apelin, which was measured by ELISA. Results: Plasma apelin was significantly reduced in liver fibrosis (8.3 ± 1.2 pg/ml) and cirrhosis (6.5 ± 0.6 pg/ml) patients compared with controls (15.4 ± 2.0 pg/ml). There was no obvious relationship between apelin and BMP 9 or BMP10 previously measured in these patients. Within the cirrhotic group, there was no significant correlation between apelin levels and disease severity scores, age, sex, or treatment with β-blockers. Conclusions: Apelin was significantly reduced in plasma of patients with both early (fibrosis) and late-stage (cirrhosis) liver disease. Fibrosis is more easily reversible and may represent a potential target for new therapeutic interventions. However, it remains unclear whether apelin signalling is detrimental in liver disease or is beneficial and therefore, whether an apelin antagonist or agonist have clinical use

Bulk Mediated Surface Diffusion: Non Markovian Desorption with Finite First Moment

Here we address a fundamental issue in surface physics: the dynamics of adsorbed molecules. We study this problem when the particle's desorption is characterized by a non Markovian process, while the particle's adsorption and its motion in the bulk are governed by a Markovian dynamics. We study the diffusion of particles in a semi-infinite cubic lattice, and focus on the effective diffusion process at the interface $z = 1$. We calculate analytically the conditional probability to find the particle on the $z=1$ plane as well as the surface dispersion as functions of time. The comparison of these results with Monte Carlo simulations show an excellent agreement.Comment: 16 pages, 7 figs. European Physical Journal B (in press

The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection.

Journal ArticleTGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68) infection on the background of pre-existing bleomycin-induced pulmonary fibrosis. Assessment of total lung collagen levels in combination with ex vivo micro-computed tomography (µCT) analysis of whole lungs demonstrated that MHV-68 infection did not enhance lung collagen deposition in this two-hit model but led to a persistent and exacerbated inflammatory response. Moreover, µCT reconstruction and analysis of the two-hit model revealed distinguishing features of diffuse ground-glass opacities and consolidation superimposed on pre-existing fibrosis that were reminiscent of those observed in acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF). Virally-infected murine fibrotic lungs further displayed evidence of extensive inflammatory cell infiltration and increased levels of CCL2, TNFα, IL-1β and IL-10. Blockade of TGFβ-ALK5 signalling attenuated lung collagen accumulation in bleomycin-alone injured mice, but this anti-fibrotic effect was reduced in the presence of concomitant viral infection. In contrast, inhibition of TGFβ-ALK5 signalling in virally-infected fibrotic lungs was associated with reduced inflammatory cell aggregates and increased levels of the antiviral cytokine IFNγ. These data reveal newly identified intricacies for the TGFβ-ALK5 signalling axis in experimental lung fibrosis, with different outcomes in response to ALK5 inhibition depending on the presence of viral infection. These findings raise important considerations for the targeting of TGFβ signalling responses in the context of pulmonary fibrosis.MRCNovartis CASE studentshi

Third-Order Fiducial Predictions for Drell-Yan Production at the LHC

The Drell-Yan process at hadron colliders is a fundamental benchmark for the study of strong interactions and the extraction of electroweak parameters. The outstanding precision of the LHC demands very accurate theoretical predictions with a full account of fiducial experimental cuts. In this Letter we present a state-of-the-art calculation of the fiducial cross section and of differential distributions for this process at third order in the strict fixed-order expansion in the strong coupling, as well as including the all-order resummation of logarithmic corrections. Together with these results, we present a detailed study of the subtraction technique used to carry out the calculation for different sets of experimental cuts, as well as of the sensitivity of the fiducial cross section to infrared physics. We find that residual theory uncertainties are reduced to the percent level and that the robustness of the predictions can be improved by a suitable adjustment of fiducial cuts