An All Optical Fibre Quantum Controlled-NOT Gate

We report the first experimental demonstration of an optical controlled-NOT gate constructed entirely in fibre. We operate the gate using two heralded optical fibre single photon sources and find an average logical fidelity of 90% and an average process fidelity of 0.83<F<0.91. On the basis of a simple model we are able to conclude that imperfections are primarily due to the photon sources, meaning that the gate itself works with very high fidelity.Comment: 4 pages, 4 figures, comments welcom

Dynamics of cognitive function in older patients after intravenous anestesia

To define the effect of various drugs for total intravenous anesthesia (TIVA) on cognitive function (CF) in older patients

Hybrid photonic circuit for multiplexed heralded single photons

A key resource for quantum optics experiments is an on-demand source of single and multiple photon states at telecommunication wavelengths. This letter presents a heralded single photon source based on a hybrid technology approach, combining high efficiency periodically poled lithium niobate waveguides, low-loss laser inscribed circuits, and fast (>1 MHz) fibre coupled electro-optic switches. Hybrid interfacing different platforms is a promising route to exploiting the advantages of existing technology and has permitted the demonstration of the multiplexing of four identical sources of single photons to one output. Since this is an integrated technology, it provides scalability and can immediately leverage any improvements in transmission, detection and photon production efficiencies.Comment: 5 pages, double column, 3 figure

Fast and accurate semantic annotation of bioassays exploiting a hybrid of machine learning and user confirmation

Bioinformatics and computer aided drug design rely on the curation of a large number of protocols for biological assays that measure the ability of potential drugs to achieve a therapeutic effect. These assay protocols are generally published by scientists in the form of plain text, which needs to be more precisely annotated in order to be useful to software methods. We have developed a pragmatic approach to describing assays according to the semantic definitions of the BioAssay Ontology (BAO) project, using a hybrid of machine learning based on natural language processing, and a simplified user interface designed to help scientists curate their data with minimum effort. We have carried out this work based on the premise that pure machine learning is insufficiently accurate, and that expecting scientists to find the time to annotate their protocols manually is unrealistic. By combining these approaches, we have created an effective prototype for which annotation of bioassay text within the domain of the training set can be accomplished very quickly. Well-trained annotations require single-click user approval, while annotations from outside the training set domain can be identified using the search feature of a well-designed user interface, and subsequently used to improve the underlying models. By drastically reducing the time required for scientists to annotate their assays, we can realistically advocate for semantic annotation to become a standard part of the publication process. Once even a small proportion of the public body of bioassay data is marked up, bioinformatics researchers can begin to construct sophisticated and useful searching and analysis algorithms that will provide a diverse and powerful set of tools for drug discovery researchers

Integrated spatial multiplexing of heralded single photon sources

The non-deterministic nature of photon sources is a key limitation for single photon quantum processors. Spatial multiplexing overcomes this by enhancing the heralded single photon yield without enhancing the output noise. Here the intrinsic statistical limit of an individual source is surpassed by spatially multiplexing two monolithic silicon correlated photon pair sources, demonstrating a 62.4% increase in the heralded single photon output without an increase in unwanted multi-pair generation. We further demonstrate the scalability of this scheme by multiplexing photons generated in two waveguides pumped via an integrated coupler with a 63.1% increase in the heralded photon rate. This demonstration paves the way for a scalable architecture for multiplexing many photon sources in a compact integrated platform and achieving efficient two photon interference, required at the core of optical quantum computing and quantum communication protocols.Comment: 10 pages, 3 figures, comments welcom

Money, Well-Being, and Loss Aversion: Does an Income Loss Have a Greater Effect on Well-Being Than an Equivalent Income Gain?

Higher income is associated with greater well-being, but do income gains and losses affect well-being differently? Loss aversion, whereby losses loom larger than gains, is typically examined in relation to decisions about anticipated outcomes. Here, using subjective-well-being data from Germany (N = 28,723) and the United Kingdom (N = 20,570), we found that losses in income have a larger effect on well-being than equivalent income gains and that this effect is not explained by diminishing marginal benefits of income to well-being. Our findings show that loss aversion applies to experienced losses, challenging suggestions that loss aversion is only an affective-forecasting error. By failing to account for loss aversion, longitudinal studies of the relationship between income and well-being may have overestimated the positive effect of income on well-being. Moreover, societal well-being might best be served by small and stable income increases, even if such stability impairs long-term income growth