Manejo en entornos de Alto Rendimiento para el Sistema de Entorno Virtual de Aprendizaje MOODLE

Moodle is an Open Source Course Management System (CMS), aiso known as a Learning Management System (LMS) or a Virtual Learning Environment (VLE). It has become very popular among educators around the worid as a tool for creating oniine dynamic web sites for their students. To work, it needs to be installed on a web server somewhere, either on one of your own computers or one at a web hosting company Moodle es un Sistema de Gestión de Cursos de Código Abierto (Open Source Course Management System, CMS),conocido también como Sistema de Gestión del Apren dizaje (Learning Management System, LMS) o como Entorno de Aprendizaje Virtual (Virtual Learning Environment, VLE). Es muy popular entre los educadores de todo el mundo como una herramienta para crear sitios web dinámicos en línea para sus estudiantes. Para utilizarlo, necesita ser instalado en un servidor web, puede ser instalado tanto en un ordenador personal como en un servidor proporcionado por una compañía de hospedaje de páginas we

Diseño del proceso de una bebida líquida a base de cereales ecuatorianos: soya y cebada, como complemento alternativo en dietas de alto gasto energético

El presente artículo describe el desarrollo y diseño del proceso de una bebida líquida a base de leche de soya con pinol. El objetivo es utilizar un cereal ancestral autóctono de nuestro país como la cebada, la cual será combinada con la soya. La aplicación es la de ser un complemento alternativo a la alimentación diaria de personas que practiquen deportes de alto consumo energético. Basaremos nuestra investigación en pruebas y ensayos de los puntos más importantes del proceso de elaboración del producto: Estudio del tratamiento térmico usando los métodos analíticos, con la finalidad de obtener la temperatura óptima para la eliminación del microorganismo termoresistente. Diseño experimental, se desarrollará el estudio de la solubilidad y estabilidad del pinol en la leche de soya, mediante los siguientes ensayos: saturación de la leche, temperatura de disolución, velocidad y tiempo de agitación y estabilidad natural. Evaluación del valor nutricional del producto, para su inserción dentro de la dieta diaria como un complemento para deportistas con un consumo energético de 4000 a 6000 calorías. Evaluación sensorial de la bebida, se realizará un panel de degustación de consumidores no entrenados con el perfil para el cual se desarrolla este producto

Effect of dialysate temperature on central hemodynamics and urea kinetics

Effect of dialysate temperature on central hemodynamics and urea kinetics. Use of cool dialysate is associated with increased intradialytic blood pressure, but the hemodynamic mechanism is unknown. Whether changes in dialysate temperature affect muscle blood flow, which may the alter the degree of urea compartmentalization, also is unknown. We measured hemodynamics and blood and dialysate-side urea kinetic indices in nine hemodialysis patients during two cool (35.0°C) versus two warm (37.5°C) dialysate treatments. The % change in mean arterial pressure was different when using the cool (+6.5 ± 9.7 mm Hg) versus the warm (-13.4 ± 3.6) dialysate (P < 0.01), despite comparable amounts of fluid removal. Percent changes in cardiac output were similar with the two dialysates, and thus the blood pressure effect was due primarily to changes in total peripheral resistance (%ΔTPR, cool +26 ± 13.6, warm +8.6 ± 14.5; P < 0.02). During cool dialysate use tympanic membrane temperature changed by -0.51 ± 0.23°C, whereas body temperature increased by 0.52 ± 0.14°C during use of warm dialysate. Measured urea recovery normalized to the predialysis urea nitrogen concentration was similar with the two treatments: cool 31.3 ± 0.039 liter-1; warm 29.7 ± 0.021; P = NS. In a second study, post-dialysis urea rebound values from 15 seconds to 30 minutes, expressed as the percent of the post-dialysis SUN, were similar after the two treatments: cool 11.79 ± 1.4; warm 12.21 ± 2.27, P = NS. The results suggest that increased blood pressure associated with use of cool dialysate is due to an increased TPR, and that this alteration in hemodynamics has no clinically important effects on either the amount of urea removal or the extent of post-dialysis urea rebound

Linked patterns of biological and environmental covariation with brain structure in adolescence : a population-based longitudinal study

Adolescence is a period of major brain reorganization shaped by biologically timed and by environmental factors. We sought to discover linked patterns of covariation between brain structural development and a wide array of these factors by leveraging data from the IMAGEN study, a longitudinal population-based cohort of adolescents. Brain structural measures and a comprehensive array of non-imaging features (relating to demographic, anthropometric, and psychosocial characteristics) were available on 1476 IMAGEN participants aged 14 years and from a subsample reassessed at age 19 years (n = 714). We applied sparse canonical correlation analyses (sCCA) to the cross-sectional and longitudinal data to extract modes with maximum covariation between neuroimaging and non-imaging measures. Separate sCCAs for cortical thickness, cortical surface area and subcortical volumes confirmed that each imaging phenotype was correlated with non-imaging features (sCCA r range: 0.30-0.65, all P-FDR <0.001). Total intracranial volume and global measures of cortical thickness and surface area had the highest canonical cross-loadings (|rho| = 0.31-0.61). Age, physical growth and sex had the highest association with adolescent brain structure (|rho| = 0.24-0.62); at baseline, further significant positive associations were noted for cognitive measures while negative associations were observed at both time points for prenatal parental smoking, life events, and negative affect and substance use in youth (|rho| = 0.10-0.23). Sex, physical growth and age are the dominant influences on adolescent brain development. We highlight the persistent negative influences of prenatal parental smoking and youth substance use as they are modifiable and of relevance for public health initiatives.Peer reviewe

Call center “mitad del mundo”

El Call Center Mitad del Mundo se establecerá en la ciudad de Guayaquil, provincia del Guayas; esta ciudad es el principal polo económico del país y el centro urbano más grande de la nación, lo cual presenta especiales cualidades para el desarrollo de la actividad de nuestro proyecto. La ciudad de Guayaquil cuenta con la infraestructura suficiente de telecomunicaciones para soportar el desarrollo de nuestra actividad

Developing a 3U CubeSat Engineering Model - FlatSat & Chassis Design

WUSAT-3 is a 3U CubeSat being designed to carry an experimental RF signal direction finding payload in Low Earth Orbit (LEO). Successful outcome of this experiment could lead to significant benefits for the field of wildlife monitoring from Space. Commercial adoption of this process would enable the development and use of much smaller, lighter RF tracking tags, which in turn would considerably increase the potential range of species that could be tracked by Satellites. The effect of the Covid-19 pandemic lockdowns has limited physical progress over the past 18 months, but the team continues to gain enormous experience and motivation from pursuing this exciting project with a very real-world mission. A recent return to near-normal working patterns has enabled the team to fully engage with the practicalities of progressing the previously produced WUSAT-3 Configuration Model, towards a testable Engineering Model. This paper outlines the development of both the initial chassis prototype (including mechanisms) and a subsystem FlatSat as a first stage towards building the complete Engineering Model. The chassis prototype was required to meet all the requirements of the FYS Design Specification [1], the NanoRacks CubeSat ICD [2], the CubeSat Design Specification [3] and those features identified by the outcomes of the WUSAT-3 Configuration Model. The FlatSat was required to include all subsystems capable of being constructed and tested without the availability of certain proprietary items that will be purchased later. The function and interface of these items, where it was necessary for the purpose of testing the assembled subsystem units that were available, was met by the design and inclusion of temporary substitute arrangements that provided similar performance. Systems Engineering methodologies were employed throughout as a means of ensuring that the design features of both chassis and FlatSat met all necessary requirement

Measuring patient's expectation and the perception of quality in LASIK services

<p>Abstract</p> <p>Background</p> <p>LASIK is the use of excimer lasers to treat therapeutic and refractive visual disorders, ranging from superficial scars to nearsightedness (myopia), and from astigmatism to farsightedness (hyperopia). The purposes of this study are to checking the applicability and psychometric properties of the SERVQUAL on Lasik surgery population. Second, use SEM methods to investigate the loyalty, perceptions and expectations relationship on LASIK surgery.</p> <p>Methods</p> <p>The method with which this study was conducted was questionnaire development. A total of 463 consecutive patients, attending LASIK surgery affiliated with Chung Shan Medical University Eye Center, enrolled in this study. All participants were asked to complete revised SERVQUAL questionnaires. Student t test, correlation test, and ANOVA and factor analyses were used to identify the characters and factors of service quality. Paired t test were used to test the gap between expectation and perception scores and structural equation modeling was used to examine relationships among satisfaction components.</p> <p>Results</p> <p>The effective response rate was 97.3%. Validity was verified by several methods and internal reliability Cronbach's alpha was > 0.958. The results from patient's scores were very high with an overall score of 6.41(0.66), expectations at 6.68(0.47), and perceptions at 6.51(0.57). The gap between expectations and perceptions was significant, however, (t = 6.08). Furthermore, there were significant differences in the expectation scores among the different jobs. Also, the results showed that the higher the education of the patient, the lower their perception score (r = -0.10). The factor loading results of factor analysis showed 5 factors of the 22 items of the SERVQUAL model. The 5 factors of perception explained 72.94% of the total variance there; and on expectations it explained 77.12% of the total variance of satisfaction scores.</p> <p>The goodness-of-fit summary, of structure equation modeling, showed trends in concept on expectations, perceptions, and loyalty.</p> <p>Conclusion</p> <p>The results of this research appear to show that the SERVQUAL instrument is a useful measurement tool in assessing and monitoring service quality in LASIK service, and enabling staff to identify where improvements are needed, from the patients' perspective. There were service quality gaps in the reliability, assurance, and empathy. This study suggested that physicians should increase their discussions with patients; which has, of course, already been proven to be an effective way to increase patient's satisfaction with medical care, regardless of the procedure received.</p

Is telemedicine the answer to rural expansion of medication treatment for opioid use disorder? Early experiences in the feasibility study phase of a National Drug Abuse Treatment Clinical Trials Network Trial

Telemedicine (TM) enabled by digital health technologies to provide medical services has been considered a key solution to increasing health care access in rural communities. With the immediate need for remote care due to the COVID-19 pandemic, many health care systems have rapidly incorporated digital technologies to support the delivery of remote care options, including medication treatment for individuals with opioid use disorder (OUD). In responding to the opioid crisis and the COVID-19 pandemic, public health officials and scientific communities strongly support and advocate for greater use of TM-based medication treatment for opioid use disorder (MOUD) to improve access to care and have suggested that broad use of TM during the pandemic should be sustained. Nevertheless, research on the implementation and effectiveness of TM-based MOUD has been limited. To address this knowledge gap, the National Drug Abuse Treatment Clinical Trials Network (CTN) funded (via the NIH HEAL Initiative) a study on Rural Expansion of Medication Treatment for Opioid Use Disorder (Rural MOUD; CTN-0102) to investigate the implementation and effectiveness of adding TM-based MOUD to rural primary care for expanding access to MOUD. In preparation for this large-scale, randomized controlled trial incorporating TM in rural primary care, a feasibility study is being conducted to develop and pilot test implementation procedures. In this commentary, we share some of our experiences, which include several challenges, during the initial two-month period of the feasibility study phase. While these challenges could be due, at least in part, to adjusting to the COVID-19 pandemic and new workflows to accommodate the study, they are notable and could have a substantial impact on the larger, planned pragmatic trial and on TM-based MOUD more broadly. Challenges include low rates of identification of risk for OUD from screening, low rates of referral to TM, digital device and internet access issues, workflow and capacity barriers, and insurance coverage. These challenges also highlight the lack of empirical guidance for best TM practice and quality remote care models. With TM expanding rapidly, understanding implementation and demonstrating what TM approaches are effective are critical for ensuring the best care for persons with OUD

Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

Protein-protein interactions are critical determinants in biological systems. Engineered proteins binding to specific areas on protein surfaces could lead to therapeutics or diagnostics for treating diseases in humans. But designing epitope-specific protein-protein interactions with computational atomistic interaction free energy remains a difficult challenge. Here we show that, with the antibody-VEGF (vascular endothelial growth factor) interaction as a model system, the experimentally observed amino acid preferences in the antibody-antigen interface can be rationalized with 3-dimensional distributions of interacting atoms derived from the database of protein structures. Machine learning models established on the rationalization can be generalized to design amino acid preferences in antibody-antigen interfaces, for which the experimental validations are tractable with current high throughput synthetic antibody display technologies. Leave-one-out cross validation on the benchmark system yielded the accuracy, precision, recall (sensitivity) and specificity of the overall binary predictions to be 0.69, 0.45, 0.63, and 0.71 respectively, and the overall Matthews correlation coefficient of the 20 amino acid types in the 24 interface CDR positions was 0.312. The structure-based computational antibody design methodology was further tested with other antibodies binding to VEGF. The results indicate that the methodology could provide alternatives to the current antibody technologies based on animal immune systems in engineering therapeutic and diagnostic antibodies against predetermined antigen epitopes