Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages

<p>Abstract</p> <p>Background</p> <p>Toll-like receptors (TLRs) are present on monocytes and alveolar macrophages that form the first line of defense against inhaled particles. The importance of those cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) has well been documented. Cigarette smoke contains high concentration of oxidants which can stimulate immune cells to produce reactive oxygen species, cytokines and chemokines.</p> <p>Methods</p> <p>In this study, we evaluated the effects of cigarette smoke medium (CSM) on TLR4 expression and interleukin (IL)-8 production by human macrophages investigating the involvement of ROS.</p> <p>Results and Discussion</p> <p>TLR4 surface expression was downregulated on short term exposure (1 h) of CSM. The downregulation could be explained by internalization of the TLR4 and the upregulation by an increase in TLR4 mRNA. IL-8 mRNA and protein were also increased by CSM. CSM stimulation increased intracellular ROS-production and decreased glutathione (GSH) levels. The modulation of TLR4 mRNA and surface receptors expression, IRAK activation, IκB-α degradation, IL-8 mRNA and protein, GSH depletion and ROS production were all prevented by antioxidants such as N-acetyl-L-cysteine (NAC).</p> <p>Conclusion</p> <p>TLR4 may be involved in the pathogenesis of lung emphysema and oxidative stress and seems to be a crucial contributor in lung inflammation.</p

Collecting and mapping soundscape data across the 15 UK National Parks

The soundscape approach, as understood by the ISO 12913 series, is most applied in urban settings, aiming beyond noise control in order to holistically employ its quantitative and qualitative facets. On the other side, the current understanding of the soundscape concept in bioacoustics and acoustic ecology is less focused on perception. There is generally a lot of public interest in how to preserve the opportunity for people to experience the “natural quiet” and “the sounds of nature”, and the need to balance that with the protection of the natural areas and national parks from the noise that the visitors themselves generate while on site. However, specific investigations in these environments are scarce in the United Kingdom. Moreover, while there might be acoustic environments and sound sources that people identify with national parks, they are not systematically documented nor implemented in the national parks' management plans. Therefore, we propose a framework starting with a quasi-crowd-sourced acquisition of soundscape data and mapping those to a freely accessible GIS platform such as Google Earth, leading towards identifying soundscape conservation targets and management tools for the UK national parks, further raising the awareness of the value of sound as a resource

A Psychoacoustic Investigation on the Effect of External Shading Devices on Building Facades

Due to energetic and natural lighting factors, building facades often present external shading devices, but the acoustic properties of such devices have not yet been well studied. This study was carried out using a full-scale model of a portion of a shading device, in a semi-anechoic chamber, using traditional and sound absorbing louvres. The psychoacoustic effects produced by the shading system were evaluated through comparisons between averaged values of loudness, roughness and sharpness levels, as well as sound pressure levels as reference. Results highlighted that the sound absorbing shading device offers good attenuation in terms of loudness, roughness and sound pressure level, with a small reduction in sharpness. The traditional shading system studied does not efficiently reduce the analysed parameters, or even worsens the situation. Several analyses of variance were carried out, one for each situation studied. The sound source position and the louvres’ tilt angle both produce statistically significant effects on almost all of the variations of the parameters studied. The analyses of the partial eta squared factors highlighted that source position and louvre tilt angle affect the variations of the parameters studied to a different degree in respect of the two types of louvres

Combined Spectroscopy and Electrical Characterization of La:BaSnO3_\text{3} Thin Films and Heterostructures

For La-doped BaSnO$_\text{3}$ thin films grown by pulsed laser deposition, we combine chemical surface characterization and electronic transport studies to probe the evolution of electronic states in the band structure for different La-doping content. Systematic analyses of spectroscopic data based on fitting the core electron line shapes help to unravel the composition of the surface as well as the dynamics associated with increasing doping. This dynamics is observed with a more pronounced signature in the Sn 3d core level, which exhibits an increasing asymmetry to the high binding energy side of the peak with increasing electron density. The present results expand the current understanding of the interplay between the doping concentration, electronic band structure and transport properties of epitaxial La:BaSnO$_\text{3}$ films.Comment: 7 Figures, 4 Tables in manuscript; and 6 Figures and 1 Table in the Supplementary Informatio

Building Performance Evaluation of a New Hospital Building in the UK: Balancing Indoor Environmental Quality and Energy Performance

Hospitals are controlled yet complex ecosystems which provide a therapeutic environment that promotes healing, wellbeing and work efficiency for patients and staff. As these buildings accommodate the sick and vulnerable, occupant wellbeing and good indoor environmental quality (IEQ) that deals with indoor air quality (IAQ), thermal comfort, lighting and acoustics are important objectives. As the specialist nature of hospital function demands highly controlled indoor environments, this makes them energy intensive buildings due to the complex and varying specifications for their functions and operations. This paper reports on a holistic building performance evaluation covering aspects of indoor air quality, thermal comfort, lighting, acoustics, and energy use. It assesses the performance issues and inter-relationships between IEQ and energy in a new building on a hospital campus in the city of Bristol, United Kingdom. The empirical evidence collated from this case study and the feedback received from the hospital staff help identify the endemic issues and constraints related to hospital buildings, such as the need for robust ventilation strategies in hospitals in urban areas that mitigate the effect of indoor and outdoor air pollution and ensuring the use of planned new low-carbon technologies. Whilst the existing guidelines for building design provide useful instructions for the protection of hospital buildings against ingress of particulate matter from outdoors, more advanced filtration strategies may be required to enact chemical reactions required to control the concentration levels of pollutants such as nitrogen dioxide and benzene. Further lessons for improved performance in operation and maintenance of hospitals are highlighted. These include ensuring that the increasingly available metering and monitoring data in new buildings, through building management systems, is used for efficient and optimal building operations for better IEQ and energy management. Overall, the study highlights the need for an integrated and holistic approach to building performance to ensure that healthy environments are provided while energy efficiency targets are me

Integrating ecosystem services and disservices: insights from plant invasions

There is growing interest in ecosystem disservices, i.e. the negative effects of ecosystems on humans. The focus on disservices has been controversial because of the lack of clarity on how to disentangle ecosystem services and disservices related to human wellbeing. A perspective that considers both services and disservices is needed to inform objective decision-making. We propose a comprehensive typology of ecosystem disservices, and present a framework for integrating ecosystem services and disservices for human wellbeing linked to ecosystem functioning. Our treatment is underpinned by three key assumptions: (1) ecosystem attributes and functions are value-free; (2) the perception of benefits or nuisances are however dependent on societal context, and preferences and actions by societal actors may trigger, enhance or alleviate benefits or nuisances derived from ecosystems; and (3) the notion of disservices must account for the role of human management in assessments of ecosystem values, i.e. the social and technological measures that identify, protect, promote or restore desirable levels of services, and concurrently minimise, mitigate or adapt to disservices. We illustrate our ideas with examples from plant invasions as a complex social-ecological phenomenon

Building performance evaluation: Balancing energy and indoor environmental quality in a UK school building

There is a policy-driven focus, at present, on improving the energy performance of buildings. However, energy-related issues alone do not capture the full impact of buildings on occupants and the wider environment. The performance of a building also includes occupant wellbeing and indoor environmental quality. Specifically, in schools, indoor environmental quality (thermal comfort, indoor air quality, lighting and acoustics) is an important aspect. Additionally, the issue of the ‘performance gap’, generally focused on energy, also affects indoor environmental quality parameters and needs to be addressed holistically. This paper reports on a holistic building performance evaluation covering aspects of energy, thermal comfort, indoor air quality, lighting and acoustics. It assesses the performance issues and inter-relationships between energy and indoor environmental quality in a recently built school campus in London. Based on the evidence collated from this case study and supplementary literature, the endemic issues and constraints within the construction industry are explored, such as inappropriate design calculations and resistance to new low-carbon technologies. Further, lessons for improved performance in the design, operation and maintenance of schools are highlighted such as factoring in the changing building use trends during design and the significance of optimal operations and maintenance of building systems for better energy and indoor environmental quality performance. This study shows that if the building design focus primarily remains on energy, unintended consequence of indoor environmental quality underperformance may occur where there are conflicts between energy and indoor environmental quality objectives. An integrated approach to building performance can help address this issue. PRACTICAL APPLICATION: There are often conflicts between energy efficiency and indoor environmental quality (IEQ) objectives in building design and operation. Most building performance evaluations are primarily focused on one set of these performance criteria. This building performance evaluation was done with an integrated energy and IEQ perspective. The study identifies the causes of underperformance in energy and IEQ in a recently built school in London. Some of the findings from this study provide lessons that are relevant across the industry for the delivery of low-carbon and healthy buildings. These lessons include methods to further strengthen the policy frameworks and design protocols along with overall improvements in the processes followed during design, construction and operation of schools and other non-domestic buildings. The paper can also inform building designers, contractors and facility managers about the ways to reduce the performance gap and achieve energy targets without unintended consequences for indoor environment

Ten questions on the soundscapes of the built environment

Soundscape research represents a paradigm shift from noise control policies towards a new multidisciplinary approach as it involves not only physical measurements but also the cooperation of humanity and social sciences to account for the diversity of soundscapes across countries and cultures, with more focus on how people actually experience the acoustic environments; and it considers environmental sounds as a ‘resource’ rather than a ‘waste’. The ten questions presented in this paper range from the very basic definitions underlying the emerging soundscape ‘science’, to more applied topics about how to use soundscape as a design approach for the planning and management of the built environments. Although significant research activity has been conducted so far, there is still a need to systematically provide the underpinning science and practical guidance in soundscaping. Thus, the last question aims to identify the most crucial gaps in soundscape research and set the agenda for future advancements in the field

The Effect of Soundscapes and Lightscapes on the Perception of Safety and Social Presence Analyzed in a Laboratory Experiment

The present study evaluates the effect of soundscape and lightscape variations on the perceived safety and perceived social presence in a pedestrian area through laboratory experiments. Thirty-one participants were presented with nine different virtual scenarios, in which the same underpass was reproduced under different soundscape and lightscape conditions. The participants were asked to assess each scenario considering 10 items related to perceived safety and perceived social presence. A principal component analysis allowed the 10 items to be reduced to two principal components, namely “perceived safety” and “perceived social presence”. A two-way repeated measures ANOVA analysis was conducted to assess the effect of modifications of both the soundscape and lightscape on the two components. The obtained results showed that the soundscape had an effect on both the perceived safety (p < 0.05) and perceived social presence (p < 0.05), while the lightscape variations implemented in this experiment only had a statistically significant effect on the latter (p < 0.05). The results of such studies may be of interest for public design and management as they may be conducted by means of non-intrusive and cost-effective techniques