Instability of flood embankments due to pore water pressure build-up at the toe : lesson learned from the Adige river case study

A case study is presented of the Adige River embankment, a segment of which experienced instability of the landside slope due to the development of uplift pressures. Soil profile and hydromechanical properties of the embankment and foundation materials have been assessed via site investigation, laboratory testing, and field monitoring for two cross sections, within and outside the failure segment. The hydromechanical model developed thereof was first validated against its ability to reproduce the probability of failure for the two sections with a first-order, second-moment (FOSM)-based approach. Comparison of water flow regimes between the two sections was then used to highlight the importance of the hydraulic properties of the material on the landside for the development of uplift pressures at the toe of the embankment. The lesson learnt from this case study is that the hydraulic response of the ground on the landside may play a critical role on the stability of flood embankments and its characterization should therefore not be overlooked when planning site investigation

ERMES: Design and preliminary simulations for an autonomous docking manoeuvre

In the last decades, small satellites have played an important role in space missions. Due to their reduced dimension and costs, they became affordable to smaller companies and research laboratories to conduct scientific experiments and technological demonstrations in space. In addition, the number of these satellites has considerably increased due to their wide use in technological, scientific and commercial domains. In this scenario, autonomous architectures, as well as miniaturized mechanical subsystems for small satellites, are continuously investigated. Experimental Rendezvous in Microgravity Environment Study (ERMES) is a student project that focuses on the simulation of an autonomous docking manoeuvres between two CubeSats mock-ups equipped with miniaturized Guidance Navigation and Control systems and mechanical docking interfaces. ERMES aims to integrate different subsystems for autonomous docking, to increase the Technology Readiness Level and to study possible applications for in-orbit servicing. This paper deals with the design and development of the tests for autonomous docking manoeuvres between two CubeSats mock-ups to be performed in a reduced-gravity environment during a parabolic flight. A Target-Chaser configuration has been selected, where the Chaser is fully active and the Target is cooperative. The Chaser is equipped with a miniaturized cold gas propulsion system with eight thrusters to control its attitude and position; in contrast, the Target has a set of three reaction wheels to control only its attitude. The tested miniaturized mechanical docking interfaces employs a probe-drogue configuration. The most demanding aspect of the development phase will be the dedicated software for the proximity navigation. The reduced-gravity conditions will be achieved during a campaign of parabolic flights thanks to the participation to the European Space Agency “Fly Your Thesis!” programme 2022

Advances in the monitoring of geo-structure subjected to climate loading

The paper presents results achieved within the project MAGIC, a project funded by the European Commission under the Marie-Curie Industry Academia Partnerships and Pathways (IAPP) scheme. The project MAGIC aims to advance the state-of-the art in the monitoring of geo-structures subjected to climate loading by filling some of the gaps in current monitoring technologies. The project involves a partnership between academic and industrial partners to boost knowledge transfer and promote the development of ‘industrial’ instruments and services. The paper presents developments concerning the measurement of pore-water tension (suction in excess of 100 kPa) and the integration of geotechnical and geophysical monitoring

Lessons learned from dike failures in recent decades

The paper describes five different dike failures that occurred in recent decades. The case histories were located on different rivers and involved different loading conditions. The observed failure mechanisms involved erosion and stability problems. The types of erosion observed were both internal erosion due to extreme groundwater flow and external erosion caused by the river flow and wave action. The case involving instability was caused by uplift, i.e., increased hydraulic head led to a sharp reduction in maximum shear strength between subsoil layers. Two cases demonstrate the importance of dike management and maintenance. Despite the variations in the loading conditions and failure mechanisms, all the cases show that the strength of a dike depends not only on the material used to build the dike but also on the strength of the subsoil

COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)

Objective To estimate the incidence and describe clinical characteristics and outcome of GBS in COVID-19 patients (COVID19-GBS) in one of the most hit regions during the frst pandemic wave, Lombardia. Methods Adult patients admitted to 20 Neurological Units between 1/3–30/4/2020 with COVID19-GBS were included as part of a multi-center study organized by the Italian society of Hospital Neuroscience (SNO). Results Thirty-eight COVID19-GBS patients had a mean age of 60.7 years and male frequency of 86.8%. CSF albuminocytological dissociation was detected in 71.4%, and PCR for SARS-CoV-2 was negative in 19 tested patients. Based on neurophysiology, 81.8% of patients had a diagnosis of AIDP, 12.1% of AMSAN, and 6.1% of AMAN. The course was favorable in 76.3% of patients, stable in 10.5%, while 13.2% worsened, of which 3 died. The estimated occurrence rate in Lombardia ranges from 0.5 to 0.05 GBS cases per 1000 COVID-19 infections depending on whether you consider positive cases or estimated seropositive cases. When we compared GBS cases with the pre-pandemic period, we found a reduction of cases from 165 to 135 cases in the 2-month study period in Lombardia. Conclusions We detected an increased incidence of GBS in COVID-19 patients which can refect a higher risk of GBS in COVID-19 patients and a reduction of GBS events during the pandemic period possibly due to a lower spread of more common respiratory infectious diseases determined by an increased use of preventive measures

Gamma-Ray Burst observations by the high-energy charged particle detector on board the CSES-01 satellite between 2019 and 2021

In this paper we report the detection of five strong Gamma-Ray Bursts (GRBs) by the High-Energy Particle Detector (HEPD-01) mounted on board the China Seismo-Electromagnetic Satellite (CSES-01), operational since 2018 on a Sun-synchronous polar orbit at a $\sim$ 507 km altitude and 97$^\circ$ inclination. HEPD-01 was designed to detect high-energy electrons in the energy range 3 - 100 MeV, protons in the range 30 - 300 MeV, and light nuclei in the range 30 - 300 MeV/n. Nonetheless, Monte Carlo simulations have shown HEPD-01 is sensitive to gamma-ray photons in the energy range 300 keV - 50 MeV, even if with a moderate effective area above $\sim$ 5 MeV. A dedicated time correlation analysis between GRBs reported in literature and signals from a set of HEPD-01 trigger configuration masks has confirmed the anticipated detector sensitivity to high-energy photons. A comparison between the simultaneous time profiles of HEPD-01 electron fluxes and photons from GRB190114C, GRB190305A, GRB190928A, GRB200826B and GRB211211A has shown a remarkable similarity, in spite of the different energy ranges. The high-energy response, with peak sensitivity at about 2 MeV, and moderate effective area of the detector in the actual flight configuration explain why these five GRBs, characterised by a fluence above $\sim$ 3 $\times$ 10$^{-5}$ erg cm$^{-2}$ in the energy interval 300 keV - 50 MeV, have been detected.Comment: Accepted for publication in The Astrophysical Journal (ApJ

Can hippocampal neurites and growth cones climb over obstacles?

Guidance molecules, such as Sema3A or Netrin-1, can induce growth cone (GC) repulsion or attraction in the presence of a flat surface, but very little is known of the action of guidance molecules in the presence of obstacles. Therefore we combined chemical and mechanical cues by applying a steady Netrin-1 stream to the GCs of dissociated hippocampal neurons plated on polydimethylsiloxane (PDMS) surfaces patterned with lines 2 \ub5m wide, with 4 \ub5m period and with a height varying from 100 to 600 nm. GC turning experiments performed 24 hours after plating showed that filopodia crawl over these lines within minutes. These filopodia do not show staining for the adhesion marker Paxillin. GCs and neurites crawl over lines 100 nm high, but less frequently and on a longer time scale over lines higher than 300 nm; neurites never crawl over lines 600 nm high. When neurons are grown for 3 days over patterned surfaces, also neurites can cross lines 300 nm and 600 nm high, grow parallel to and on top of these lines and express Paxillin. Axons - selectively stained with SMI 312 - do not differ from dendrites in their ability to cross these lines. Our results show that highly motile structures such as filopodia climb over high obstacle in response to chemical cues, but larger neuronal structures are less prompt and require hours or days to climb similar obstacles

COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Background and objectives: It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19-related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population. Methods: Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1,362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective observational case-cohort study with population-based control. The observed vs the expected events were compared in the whole MS cohort and in different subgroups (higher risk: Expanded Disability Status Scale [EDSS] score > 3 or at least 1 comorbidity, lower risk: EDSS score ≤ 3 and no comorbidities) by the χ2 test, and the risk excess was quantified by risk ratios (RRs). Results: The risk of severe events was about twice the risk in the age- and sex-matched Italian population: RR = 2.12 for hospitalization (p < 0.001), RR = 2.19 for ICU admission (p < 0.001), and RR = 2.43 for death (p < 0.001). The excess of risk was confined to the higher-risk group (n = 553). In lower-risk patients (n = 809), the rate of events was close to that of the Italian age- and sex-matched population (RR = 1.12 for hospitalization, RR = 1.52 for ICU admission, and RR = 1.19 for death). In the lower-risk group, an increased hospitalization risk was detected in patients on anti-CD20 (RR = 3.03, p = 0.005), whereas a decrease was detected in patients on interferon (0 observed vs 4 expected events, p = 0.04). Discussion: Overall, the MS cohort had a risk of severe events that is twice the risk than the age- and sex-matched Italian population. This excess of risk is mainly explained by the EDSS score and comorbidities, whereas a residual increase of hospitalization risk was observed in patients on anti-CD20 therapies and a decrease in people on interferon