Reconstructing axion-like particles from beam dumps with simulation-based inference

Axion-like particles (ALPs) that decay into photon pairs pose a challenge for experiments that rely on the construction of a decay vertex in order to search for long-lived particles. This is particularly true for beam-dump experiments, where the distance between the unknown decay position and the calorimeter can be very large. In this work we use machine learning to explore the possibility to reconstruct the ALP properties, in particular its mass and lifetime, from such inaccurate observations. We use a simulation-based inference approach based on conditional invertible neural networks to reconstruct the posterior probability of the ALP parameters for a given set of events. We find that for realistic angular and energy resolution, such a neural network significantly outperforms parameter reconstruction from conventional high-level variables while at the same time providing reliable uncertainty estimates. Moreover, the neural network can quickly be re-trained for different detector properties, making it an ideal framework for optimizing experimental design.Comment: 34 pages, 18 figures, code available at https://github.com/amorandini/SBI_axio

Searching for dark radiation at the LHC

In this work we explore the intriguing connections between searches for long-lived particles (LLPs) at the LHC and early universe cosmology. We study the non-thermal production of ultra-relativistic particles (i.e. dark radiation) in the early universe via the decay of weak-scale LLPs and show that the cosmologically interesting range ∆Neff ~ 0.01–0.1 corresponds to LLP decay lengths in the mm to cm range. These decay lengths lie at the boundary between prompt and displaced signatures at the LHC and can be comprehensively explored by combining searches for both. To illustrate this point, we consider a scenario where the LLP decays into a charged lepton and a (nearly) massless invisible particle. By reinterpreting searches for promptly decaying sleptons and for displaced leptons at both ATLAS and CMS we can then directly compare LHC exclusions with cosmological observables. We find that the CMB-S4 target value of ∆Neff = 0.06 is already excluded by current LHC searches and even smaller values can be probed for LLP masses at the electroweak scale

Searching for dark radiation at the LHC

In this work we explore the intriguing connections between searches for long-lived particles (LLPs) at the LHC and early universe cosmology. We study the non-thermal production of ultra-relativistic particles (i.e. dark radiation) in the early universe via the decay of weak-scale LLPs and show that the cosmologically interesting range $\Delta N_\text{eff} \sim 0.01-0.1$ corresponds to LLP decay lengths in the mm to cm range. These decay lengths lie at the boundary between prompt and displaced signatures at the LHC and can be comprehensively explored by combining searches for both. To illustrate this point, we consider a scenario where the LLP decays into a charged lepton and a (nearly) massless invisible particle. By reinterpreting searches for promptly decaying sleptons and for displaced leptons at both ATLAS and CMS we can then directly compare LHC exclusions with cosmological observables. We find that the CMB-S4 target value of $\Delta N_\text{eff}=0.06$ is already excluded by current LHC searches and even smaller values can be probed for LLP masses at the electroweak scale.Comment: 15 pages, 4 figure

Engineering of a CMC aeronautical muffler

This work explores the feasibility of adopting an LSI produced C/SiC composite to build an aeronautical Auxiliary Power Unit system muffler. The study first covers the experimental material characterization through tensile and compressive tests. The material properties are characterized also after exposing the samples to an oxidizing atmosphere, that is typical for the proposed application. The material response is characterized by significant non-linearities and a pseudo plastic response, which were numerically modeled using a Drucker-Prager model. The detailed design of the muffler is described and verified, for different loading conditions, using a Finite Element model. Finally, a full-scale prototype is produced and assembled, thus proving the technological feasibility of the design. The manufacturing phase required to study and understand the phenomena that were leading to defects in the proposed closed axial symmetric shape, and to implement suitable technological solutions in order to get an acceptable prototype

Forecasting dark showers at Belle II

Dark showers from strongly interacting dark sectors that confine at the GeV scale can give rise to novel signatures at e$^+$e$^−$ colliders. In this work, we study the sensitivity of B factory experiments to dark showers produced through an effective interaction arising from a heavy off-shell mediator. We show that a prospective search for displaced vertices from GeV-scale long-lived particles at Belle II can improve the sensitivity to dark showers substantially compared to an existing search at BaBar. We compare the sensitivity of searches for displaced signals to searches for promptly produced resonances at BaBar and KLOE and calculate sensitivity projections for a single-photon search at Belle II to invisible dark showers produced through an effective interaction. The underlying structure of the effective interaction can be resolved at higher-energy experiments, where the mediator can be produced on-shell. To study the resulting constraints, we update electroweak precision bounds on kinetically mixed Z′ bosons and reinterpret a search for low-mass di-muon resonances at LHCb in terms of dark showers. We find that LHCb and Belle II are most sensitive to different particle decay lengths, underscoring the complementarity of LHC and intensity frontier experiments

Assessment of immunostimulatory responses to the antimiR-22 oligonucleotide compound RES-010 in human peripheral blood mononuclear cells

microRNA-22 (miR-22) is a key regulator of lipid and energy homeostasis and represents a promising therapeutic target for NAFLD and obesity. We have previously identified a locked nucleic acid (LNA)-modified antisense oligonucleotide compound complementary to miR-22, designated as RES-010 that mediated robust inhibition of miR-22 function in cultured cells and in vivo. In this study we investigated the immune potential of RES-010 in human peripheral blood mononuclear cells (PBMCs). We treated fresh human peripheral blood mononuclear cells isolated from six healthy volunteers with different concentrations of the RES-010 compound and assessed its proinflammatory effects by quantifying IL-1β, IL-6, IFN-γ, TNF-α, IFN-α2a, IFN-β, IL-10, and IL-17A in the supernatants collected 24 h of treatment with RES-010. The T-cell activation markers, CD69, HLA-DR, and CD25 were evaluated by flow cytometry after 24 and 144 h of treatment, respectively, whereas cell viability was assessed after 24 h of treatment with RES-010. Our results show that RES-010 compound does not induce any significant immunostimulatory responses in human PBMCs in vitro compared to controls, implying that the proinflammatory potential of RES-010 is low.</p

Russell-like bodies in plant seeds share common features with prolamin bodies and occur upon recombinant protein production

Although many recombinant proteins have been produced in seeds at high yields without adverse effects on the plant, endoplasmic reticulum (ER) stress and aberrant localization of endogenous or recombinant proteins have also been reported. The production of murine interleukin-10 (mIL-10) in Arabidopsis thaliana seeds resulted in the de novo formation of ER-derived structures containing a large fraction of the recombinant protein in an insoluble form. These bodies containing mIL-10 were morphologically similar to Russell bodies found in mammalian cells. We confirmed that the compartment containing mIL-10 was enclosed by ER membranes, and 3D electron microscopy revealed that these structures have a spheroidal shape. Another feature shared with Russell bodies is the continued viability of the cells that generate these organelles. To investigate similarities in the formation of Russell-like bodies and the plant-specific protein bodies formed by prolamins in cereal seeds, we crossed plants containing ectopic ER-derived prolamin protein bodies with a line accumulating mIL-10 in Russell-like bodies. This resulted in seeds containing only one population of protein bodies in which mIL-10 inclusions formed a central core surrounded by the prolamin-containing matrix, suggesting that both types of protein aggregates are together removed from the secretory pathway by a common mechanism. We propose that, like mammalian cells, plant cells are able to form Russell-like bodies as a self-protection mechanism, when they are overloaded with a partially transport-incompetent protein, and we discuss the resulting challenges for recombinant protein production