614 research outputs found
Chapter Per la conoscenza della terminologia delle arti fuori di Toscana fra Tre e Quattrocento. Con alcune spigolature da documenti bolognesi e ferraresi
The article is divided into three parts. In the first part, after referring to an ongoing project of an online re-release of artistic documents coming mainly from Tuscany (and Siena in particular) dating back to the XIVth and XVth centuries, and of creation of a glossary of the artistic and architectural terminology contained therein, the author announces his intention to expand the investigation to the extra-Tuscan terminologies in use in the centres or areas that played an important role in the domain of figurative arts in the period under consideration, to study the timeframe and means of their emergence and diffusion. For this purpose, the author believes that the archives of the Fabbricerie, related to the construction of large churches, could be fertile ground for documentary investigation. In the second part, the results of a first survey in the Archivio della Fabbrica di San Petronio, in Bologna, are followed by the examination of a few words extracted from two documents dating back to the end of the XIVth century. In the third part, the focus is on a rich anthology of artistic documents made available to experts by Adriano Franceschini, Artisti a Ferrara in etĂ umanistica e rinascimentale, through which it is possible to know better the artistic vocabulary in Ferrara; also in this case, some lexical examples are provided
1H-NMR-Based Metabolomics in Autism Spectrum Disorder and Pediatric Acute-Onset Neuropsychiatric Syndrome
We recently described a unique plasma metabolite profile in subjects with pediatric acute-onset neuropsychiatric syndrome (PANS), suggesting pathogenic models involving specific patterns of neurotransmission, neuroinflammation, and oxidative stress. Here, we extend the analysis to a group of patients with autism spectrum disorder (ASD), as a consensus has recently emerged around its immune-mediated pathophysiology with a widespread involvement of brain networks. This observational case-control study enrolled patients referred for PANS and ASD from June 2019 to May 2020, as well as neurotypical age and gender-matched control subjects. Thirty-four PANS outpatients, fifteen ASD outpatients, and twenty-five neurotypical subjects underwent physical and neuropsychiatric evaluations, alongside serum metabolomic analysis with 1H-NMR. In supervised models, the metabolomic profile of ASD was significantly different from controls (p = 0.0001), with skewed concentrations of asparagine, aspartate, betaine, glycine, lactate, glucose, and pyruvate. Metabolomic separation was also observed between PANS and ASD subjects (p = 0.02), with differences in the concentrations of arginine, aspartate, betaine, choline, creatine phosphate, glycine, pyruvate, and tryptophan. We confirmed a unique serum metabolomic profile of PANS compared with both ASD and neurotypical subjects, distinguishing PANS as a pathophysiological entity per se. Tryptophan and glycine appear as neuroinflammatory fingerprints of PANS and ASD, respectively. In particular, a reduction in glycine would primarily affect NMDA-R excitatory tone, overall impairing downstream glutamatergic, dopaminergic, and GABAergic transmissions. Nonetheless, we found metabolomic similarities between PANS and ASD that suggest a putative role of N-methyl-D-aspartate receptor (NMDA-R) dysfunction in both disorders. Metabolomics-based approaches could contribute to the identification of novel ASD and PANS biomarkers
Intrinsic time resolution of 3D-trench silicon pixels for charged particle detection
In the last years, high-resolution time tagging has emerged as the tool to
tackle the problem of high-track density in the detectors of the next
generation of experiments at particle colliders. Time resolutions below 50ps
and event average repetition rates of tens of MHz on sensor pixels having a
pitch of 50m are typical minimum requirements. This poses an important
scientific and technological challenge on the development of particle sensors
and processing electronics. The TIMESPOT initiative (which stands for TIME and
SPace real-time Operating Tracker) aims at the development of a full prototype
detection system suitable for the particle trackers of the next-to-come
particle physics experiments. This paper describes the results obtained on the
first batch of TIMESPOT silicon sensors, based on a novel 3D MEMS (micro
electro-mechanical systems) design. Following this approach, the performance of
other ongoing silicon sensor developments has been matched and overcome, while
using a technology which is known to be robust against radiation degradation. A
time resolution of the order of 20ps has been measured at room temperature
suggesting also possible improvements after further optimisations of the
front-end electronics processing stage.Comment: This version was accepted to be published on JINST on 21/07/202
f0(980) production in inelastic pp collisions at s = 5.02 TeV
The measurement of the production of f0(980) in inelastic pp collisions at sqrt(s) = 5.02 TeV is presented. This is the first reported measurement of inclusive f0(980) yield at LHC energies. The production is measured at midrapidity, |y| pi+pi- hadronic decay channel using the ALICE detector. The pT-differential yields are compared to those of pions, protons and Ï mesons as well as to predictions from the HERWIG 7.2 QCD-inspired Monte Carlo event generator and calculations from a coalescence model that uses the AMPT model as an input. The ratio of the pT-integrated yield of f0(980) relative to pions is compared to measurements in e+e- and pp collisions at lower energies and predictions from statistical hadronisation models and HERWIG 7.2. A mild collision energy dependence of the f0(980) to pion production is observed in pp collisions from SPS to LHC energies. All considered models underpredict the pT-integrated 2f0(980)/(pi+ + pi-) ratio. The prediction from the canonical statistical hadronisation model assuming a zero total strangeness content of f0(980) is consistent with the data within 1.9Ï and is the closest to the data. The results provide an essential reference for future measurements of the particle yield and nuclear modification in pâPb and PbâPb collisions, which have been proposed to be instrumental to probe the elusive nature and quark composition of the f0(980) scalar meson
Light (anti)nuclei production in Pb-Pb collisions at sNN=5.02Â TeV
The measurement of the production of deuterons, tritons and 3 He and their antiparticles in Pb-Pb collisions
at âs NN = 5.02 TeV is presented in this article. The measurements are carried out at midrapidity (|y| <
0.5) as a function of collision centrality using the ALICE detector. The pT -integrated yields, the coalescence
parameters and the ratios to protons and antiprotons are reported and compared with nucleosynthesis models. The
comparison of these results in different collision systems at different center-of-mass collision energies reveals a
suppression of nucleus production in small systems. In the Statistical Hadronisation Model framework, this can
be explained by a small correlation volume where the baryon number is conserved, as already shown in previous
fluctuation analyses. However, a different size of the correlation volume is required to describe the proton yields
in the same data sets. The coalescence model can describe this suppression by the fact that the wave functions
of the nuclei are large and the fireball size starts to become comparable and even much smaller than the actual
nucleus at low multiplicities
Inclusive and multiplicity dependent production of electrons from heavy-flavour hadron decays in pp and p-Pb collisions
Measurements of the production of electrons from heavy-flavour hadron decays in pp collisions at root s = 13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (p(T)) of 0.2 GeV/c and up to p(T) = 35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In p-Pb collisions, the production cross section and the nuclear modification factor of electrons from heavy-flavour hadron decays are measured in the p(T) range 0.5 < p(T) < 26 GeV/c at root s(NN) = 8.16 TeV. The nuclear modification factor is found to be consistent with unity within the statistical and systematic uncertainties. In both collision systems, first measurements of the yields of electrons from heavy-flavour hadron decays in different multiplicity intervals normalised to the multiplicity-integrated yield (self-normalised yield) at midrapidity are reported as a function of the self-normalised charged-particle multiplicity estimated at midrapidity. The self-normalised yields in pp and p-Pb collisions grow faster than linear with the self-normalised multiplicity. A strong p(T) dependence is observed in pp collisions, where the yield of high-p(T) electrons increases faster as a function of multiplicity than the one of low-p(T) electrons. The measurement in p-Pb collisions shows no p(T) dependence within uncertainties. The self-normalised yields in pp and p-Pb collisions are compared with measurements of other heavy-flavour, light-flavour, and strange particles, and with Monte Carlo simulations
Production of pions, kaons, and protons as a function of the relative transverse activity classifier in pp collisions at = 13 TeV
Abstract: The production of ϱ, K±, and ( p )p is measured in pp collisions at âs = 13 TeV
in different topological regions of the events. Particle transverse momentum (pT) spectra are
measured in the âtowardâ, âtransverseâ, and âawayâ angular regions defined with respect
to the direction of the leading particle in the event. While the toward and away regions
contain the fragmentation products of the near-side and away-side jets, respectively, the
transverse region is dominated by particles from the Underlying Event (UE). The relative
transverse activity classifier, RT = NT/ăNTă, is used to group events according to their UE
activity, where NT is the measured charged-particle multiplicity per event in the transverse
region and ăNTă is the mean value over all the analysed events. The first measurements
of identified particle pT spectra as a function of RT in the three topological regions are
reported. It is found that the yield of high transverse momentum particles relative to the
RT-integrated measurement decreases with increasing RT in both the toward and the away
regions, indicating that the softer UE dominates particle production as RT increases and
validating that RT can be used to control the magnitude of the UE. Conversely, the spectral
shapes in the transverse region harden significantly with increasing RT. This hardening
follows a mass ordering, being more significant for heavier particles. Finally, it is observed
that the pT-differential particle ratios (p + p )/(Ï+ + Ïâ) and (K+ + Kâ)/(Ï+ + Ïâ) in
the low UE limit (RT â 0) approach expectations from Monte Carlo generators such as
PYTHIA 8 with Monash 2013 tune and EPOS LHC, where the jet-fragmentation models
have been tuned to reproduce e+eâ results
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