81 research outputs found
A European arena for joint innovation in healthcare: The Platform for Innovation of Procurement and Procurement of Innovation (PiPPi)
Digital health; Health innovation; University hospitalSalut digital; Innovació sanitària; Hospital universitariSalud digital; Innovación en salud; Hospital universitarioBy 2000 the European Union (EU) had recognized that its innovation capacity was underperforming in comparison to similar competitors and trading partners. Although the EU has made an effort to stimulate public research and development (R&D) through policy tools like Pre-Commercial Procurement (PCP) and Public Procurement of Innovation (PPI), starting with the 2000 Lisbon strategy and continuing through the 2021 updated Guidance on Innovation Procurement, there has remained a gap in knowledge of and use of these tools, in particular within healthcare. The past decades have seen an explosion in the number and use of digital technologies across the entire spectrum of healthcare. Demand-driven R&D has lagged here, while new digital health R&D has largely been driven by the supply side in a linear fashion, which can have disappointing results. PCP and PPI could have big impacts on the development and uptake of innovative health technology. The Platform for Innovation of Procurement and Procurement of Innovation (PiPPi) project was a Horizon 2020-funded project that ran from December 2018 to May 2022 with a consortium including seven of Europe's premier research hospitals and the Catalan Agency for Health Information. To promote PCP and PPI, PiPPi established a virtual Community of Practice (CoP) that brings together all stakeholder groups to share and innovate around unmet healthcare needs. This perspective presents a brief history of PCP and PPI in Europe with a focus on digital innovation in healthcare before introducing the PiPPi project and its value proposition.This project received funding from the European Union's Horizon 2020 Research and Innovation Programme under Grant Agreement No. 826157
Rapid malignant progression of an intraparenchymal choroid plexus papillomas
Background: Choroid plexus tumors (CPTs) are rare neoplasms accounting for only 0.3-0.6% of all brain tumors in adults and 2-5% in children. The World Health Organization (WHO) classification describes three histological grades: grade I is choroid plexus papilloma (CPP), grade II is atypical papilloma, and grade III is the malignant form of carcinoma. In adults, CPTs rarely have a supratentorial localization. Case Description: Here we report a very rare case of an intraparenchymal parietal CPP with a rapid histological transition from grade I to grade III WHO in a 67-year-old man, in <7 months. Conclusion: Because of the rarity of these oncotypes, descriptions of each new case are useful, mostly to consider this diagnostic entity in extraventricular brain tumors of adults, despite an unusual location
On the alpha activity of natural tungsten isotopes
The indication for the alpha decay of 180-W with a half-life
T1/2=1.1+0.8-0.4(stat)+-0.3(syst)x10^18 yr has been observed for the first time
with the help of the super-low background 116-CdWO_4 crystal scintillators. In
conservative approach the lower limit on half-life of 180-W has been
established as T1/2>0.7x10^18 yr at 90% C.L. Besides, new T1/2 bounds were set
for alpha decay of 182-W, 183-W, 184-W and 186-W at the level of 10^20 yr.Comment: 16 pages, 8 figures, accepted in Phys. Rev.
SICANE: a Detector Array for the Measurement of Nuclear Recoil Quenching Factors using Monoenergetic Neutron Beam
SICANE is a neutron scattering multidetector facility for the determination
of the quenching factor (ratio of the response to nuclear recoils and to
electrons) of cryogenic detectors used in direct WIMP searches. Well collimated
monoenergetic neutron beams are obtained with inverse (p,n) reactions. The
facility is described, and results obtained for the quenching factors of
scintillation in NaI(Tl) and of heat and ionization in Ge are presented.Comment: 30 pages, Latex, 11 figures. Submitted to NIM
Peripheral facial palsy following ventriculoperitoneal shunt. The lesson we have learned
The most frequent complications after shunt surgery are infective and obstructive. Other types are less common, and eventually occur due to technical errors during brain ventricular puncture, opening the intraperitoneal cavity or the tunnelling of the catheter between the two points. Although rare, there are well-reported complications related to the poor positioning of the distal catheter, with perforation of organs and tissues. We report a very rare case of a male patient with normal pressure hydrocephalus submitted to ventriculoperitoneal shunt. During tunnelling of the shunt stylet, a peripheral facial palsy due to injury to the extra cranial segment of the facial nerve occurred. To the best of our knowledge this is the second case described in Literature. The patient and the surgeon should be aware of this very rare but possible complication in shunt surgery being careful to the course of the facial nerve in the mastoid region
A Cryogenic Underground Observatory for Rare Events: Cuore, an Update
CUORE is a proposed tightly packed array of 1000 TeO_{2} bolometers, each
being a cube 5 cm on a side with a mass of 750 gms. The array consists of 25
vertical towers, arranged in a square, of 5 towers by 5 towers, each containing
10 layers of 4 crystals. The design of the detector is optimized for ultralow-
background searches for neutrinoless double beta decay of ^{130}Te (33.8%
abundance), cold dark matter, solar axions, and rare nuclear decays. A
preliminary experiment involving 20 crystals of various sizes (MIBETA) has been
completed, and a single CUORE tower is being constructed as a smaller scale
experiment called CUORICINO. The expected performance and sensitivity, based on
Monte Carlo simulations and extrapolations of present results, are reported.Comment: in press: Nucl. Phys. of Russian Academy of Sc
Measurement of the response of heat-and-ionization germanium detectors to nuclear recoils
The heat quenching factor Q' (the ratio of the heat signals produced by
nuclear and electron recoils of equal energy) of the heat-and-ionization
germanium bolometers used by the EDELWEISS collaboration has been measured. It
is explained how this factor affects the energy scale and the effective
quenching factor observed in calibrations with neutron sources. This effective
quenching effect is found to be equal to Q/Q', where Q is the quenching factor
of the ionization yield. To measure Q', a precise EDELWEISS measurement of Q/Q'
is combined with values of Q obtained from a review of all available
measurements of this quantity in tagged neutron beam experiments. The
systematic uncertainties associated with this method to evaluate Q' are
discussed in detail. For recoil energies between 20 and 100 keV, the resulting
heat quenching factor is Q' = 0.91+-0.03+-0.04, where the two errors are the
contributions from the Q and Q/Q' measurements, respectively. The present
compilation of Q values and evaluation of Q' represent one of the most precise
determinations of the absolute energy scale for any detector used in direct
searches for dark matter.Comment: 28 pages, 7 figures. Submitted to Phys. Rev.
Neutrinoless Double Beta Decay within QRPA with Proton-Neutron Pairing
We have investigated the role of proton-neutron pairing in the context of the
Quasiparticle Random Phase approximation formalism. This way the neutrinoless
double beta decay matrix elements of the experimentally interesting A= 48, 76,
82, 96, 100, 116, 128, 130 and 136 systems have been calculated. We have found
that the inclusion of proton-neutron pairing influences the neutrinoless double
beta decay rates significantly, in all cases allowing for larger values of the
expectation value of light neutrino masses. Using the best presently available
experimental limits on the half life-time of neutrinoless double beta decay we
have extracted the limits on lepton number violating parameters.Comment: 16 RevTex page
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