523 research outputs found
Cyclopentenyl ethylamines active on CNS
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine
Igualdade como diversidade no direito à educação : erradicando a discriminação étnico-racial no sistema de ensino brasileiro
Tese (doutorado)—Universidade de BrasĂlia, Faculdade de Direito, Programa de PĂłs-Graduação em Direito, 2017.Esta tese de doutorado na área do direito apresenta uma análise sobre a discriminação, as desigualdades Ă©tnico-raciais, o direito Ă educação e a implementação do direito internacional e de leis e polĂticas pĂşblicas no Brasil para promover a igualdade Ă©tnico-racial, sobretudo na educação. Uma pesquisa de campo foi realizada em cinco Estados do Brasil (Rio de Janeiro, Alagoas, Pará, Distrito Federal e Rio Grande do Sul). Foram visitadas dez escolas pĂşblicas de ensino mĂ©dio - duas em cada estado, sendo uma rural e outra urbana. O fator Ă©tnico-racial no Brasil Ă© um fator fundamental que ajuda a explicar os fenĂ´menos das desigualdades socioeconĂ´micas e educacionais no paĂs. Diversos indicadores de socioeconĂ´micos e de desempenho escolar, desagregados por etnia-raça, mostram que há desigualdade, principalmente, entre as populações branca e afrodescendente. A maioria da população brasileira - especialmente a maioria dos afrodescendentes e indĂgenas - goza de seus direitos humanos de forma limitada. Tais desigualdades explĂcitas e persistentes podem ser consideradas como uma violação indireta e uma nĂŁo realização de direitos humanos e/ou um ato de discriminação que aponta para a falta de leis e polĂticas pĂşblicas adequadas e efetivas para melhorar os padrões e as condições de vida da maioria dessas populações no Brasil. As desigualdades comprometem o desenvolvimento sustentável e a distribuição dos benefĂcios entre as regiões e classes sociais. Os indicadores socioeconĂ´micos e educacionais analisados nesta tese sugerem que ainda há necessidade de melhorar a execução das leis e polĂticas pĂşblicas socioeconĂ´micas e educacionais no Brasil, especialmente para alcançar os grupos e indivĂduos mais marginalizados e vulneráveis. O direito internacional Ă© uma ferramenta neste sentido e deve continuar evoluindo para ser mais inclusivo, emancipatĂłrio e multicultural, a fim de contribuir mais adequadamente para a redução das desigualdades e reverter os padrões hierárquicos de dominação e exploração etnocĂŞntricos. Esta tese visa a contribuir para uma definição mais inclusiva do direito Ă educação, destacando os princĂpios universais de diversidade e multiculturalismo. Para um mundo sustentável, mais justo, pacĂfico e tolerante, a educação e o direito devem refletir e praticar critĂ©rios e princĂpios universais mĂnimos baseados na paz, na diversidade e no multiculturalismo.This doctoral thesis presents a comprehensive analysis of ethnic-racial discrimination and inequalities, the right to education and the implementation of the international legal framework and national laws and policies in Brazil to promote ethnic-racial equality, especially in education. Field research was carried out in five States of Brazil (Rio de Janeiro, Alagoas, Pará, Distrito Federal, and Rio Grande do Sul). Ten public high schools were visited two in each State, of which one in a rural area and one in an urban area. The ethnic-racial factor is a fundamental factor that helps explain the phenomena of socioeconomic and educational inequalities in Brazil. Socioeconomic and education performance indicators, disaggregated by ethnicityrace, show that a structural ethnic-racial inequality exists amongst the white and afrodescendant populations. Majority of the Brazilian population especially majority of afrodescendants and indigenous - enjoy their human rights in a limited way. In general, such explicit and persistent inequalities can be considered as an indirect violation and non realization of the respective human rights, and/or as an act of discrimination that points to the lack of adequate and effective laws and public policies aiming to improve the living standards and conditions of majority of these populations in Brazil. Inequalities compromise sustainable development and the distribution of benefits across regions and social classes. The socioeconomic and educational indicators analyzed in this thesis suggest that there is still a need to improve the execution of socioeconomic and educational laws and public policies in Brazil, to reach marginalized and vulnerable groups and individuals. International law is an instrument towards this and must continue evolving to become more inclusive, emancipatory and multicultural to contribute more adequately to the reduction of inequalities and reverse the hierarchical patterns of ethnocentric domination and exploitation. This thesis aims to contribute to a more inclusive definition of the right to education by emphasizing the universal principles of diversity and multiculturalism. For a sustainable world that is more just, peaceful and tolerant, education and law must reflect and practice minimum universal criteria and principles based on peace, diversity and multiculturalism
Identification of toxigenic fungal species associated with maize ear rot: Calmodulin as single informative gene
Accurate identification of fungi occurring on agrofood products is the key aspect of any prevention and pest management program, offering valuable information in leading crop health and food safety. Fungal species misidentification can dramatically impact biodiversity assessment, ecological studies, management decisions, and, concerning toxigenic fungi, health risk assessment, since they can produce a wide range of toxic secondary metabolites, referred to as mycotoxins. Since each toxigenic fungal species can have its own mycotoxin profile, a correct species identification, hereby attempted with universal DNA barcoding approach, could have a key role in mycotoxins prevention strategies. Currently, identification of single marker for species resolution in fungi has not been achieved and the analysis of multiple genes is used, with the advantage of an accurate species identification and disadvantage of difficult setting up of PCR-based diagnostic assays. In the present paper, we describe our strategy to set up a DNA-based species identification of fungal species associated with maize ear rot, combining DNA barcoding approach and species-specific primers design for PCR based assays. We have (i) investigated the appropriate molecular marker for species identification, limited to mycobiota possibly occurring on maize, identifying calmodulin gene as single taxonomically informative entity; (ii) designed 17 sets of primers for rapid identification of 14 Fusarium, 10 Aspergillus, 2 Penicillium, and 2 Talaromyces species or species groups, and finally (iii) tested specificity of the 17 set of primers, in combination with 3 additional sets previously developed
Porta Valbona in Urbino: its representation between history and restoration
[EN] The Porta Valbona study is part of a complex project of conservation and valorisation of the defensive
walls of Urbino that the research group, of the School of Conservation and Restoration of the University
of Urbino Carlo Bo, has developed in recent years. Built in 1621 it is the most important gate of the city
both because it is connected to Via Mazzini, one of the main streets of the historic centre, and for its
spectacular architectural appearance created for the wedding of Prince Federico Ubaldo della Rovere
with Princess Claudia de Medici. The two eagles, in limestone, placed at the sides of the door, date back
to the mid-eighteenth century and are the work of the Rimini architect Giovan Francesco Buonamici. It
is also the only Gate of Urbino which has a monumental facing facing outwards, or towards Piazza del
Mercatale. Despite having undergone several restorations and consolidations over the centuries, it has
not been modified in its original appearance. Porta Valbona, together with the city walls, represents a
real urban palimpsest, an exceptional case of sedimentation and stratification which, despite the events,
still allows us to reconstruct its historical events. The applied design method was based on the following
analyzes: a) urban analysis: knowledge of the characteristics and urban potential of the door; b) historical analysis: knowledge of the historical evolution and of the specific qualities of the door; c) geometric
analysis: metric and architectural survey; d) material analysis, study of materials and forms of deterioration; e) structural analysis: identification of the morphological and constructive organization from the
structural point of view. All the large amount of information obtained from the analysis was managed
thanks to the use of GIS systems. Thus it was possible to identify the shape and character of the monument and its testimonial, constructive and architectural values were recognized. On the basis of an internal analysis of the cultural asset and an external analysis of the context in which it is located, it was possible to define the strengths, weaknesses, opportunities and threats.Baratin, L.; Cattaneo, A.; Moretti, E. (2020). Porta Valbona a Urbino: la sua rappresentazione tra storia e restauro. Editorial Universitat Politècnica de València. 1045-1052. https://doi.org/10.4995/FORTMED2020.2020.11401OCS1045105
Bronchiolitis. Analysis of 10 consecutive epidemic seasons
Bronchiolitis is the leading cause of hospitalization in infants under 12 months. Our aims were to analyze epidemiological characteristics of infants with bronchiolitis over 10 consecutive seasons and to evaluate whether there are any clinical differences between infants hospitalized for bronchiolitis during epidemic peak months and infants in non-peak months. We enrolled consecutive enrolled 723 previously healthy term infants hospitalized at the Paediatric Emergency Department, "Sapienza" University of Rome over the period 2004-2014. Fourteen respiratory viruses were detected from nasopharyngeal aspirates by molecular methods. Clinical and demographic data were extracted from clinical charts. Viruses were detected in 351 infants (48.5%): RSV in 234 (32.4%), RV in 44 (6.1%), hBoV in 11 (1.5%), hMPV in 12 (1.6%), co-infections in 39 (5.4%), and other viruses in 11 (1.5%). Analyzing the 10 epidemic seasons, we found higher incidence for bronchiolitis every 4 years with a peak during the months December-January. Infants hospitalized during peak months had lower family history for asthma (P = 0.003), more smoking mothers during pregnancy (P = 0.036), were slightly higher breastfed (0.056), had lower number of blood eosinophils (P = 0.015) and had a higher clinical severity score (P = 0.017). RSV was detected mostly during peak months, while RV was equally distributed during the seasons. We found some variations in bronchiolitis incidence during epidemics, and discriminative characteristics in infants hospitalized for bronchiolitis during peak months and in non-peak months, that might reflect two different populations of children. Pediatr Pulmonol. 2016; 9999:XX-XX. © 2016 Wiley Periodicals, Inc
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