Comment on ``Confirmation of the Sigma Meson''

We comment on the recent paper by N.A. Tornqvist and M. Roos published in Phys. Rev. Lett. 76, 1575 (1996).Comment: 3 pages (LaTeX), 1 PostScript Figur

Dynamics of Cognitive Functions in Patients With Parasellar Meningiomas Undergoing Radiotherapy

This study was focused on neuropsychological analysis of the cognitive functions in patients with parasellar meningiomas undergoing radiation therapy. In these patients, the unilateral hippocampus adjacent to the tumor was partially exposed to irradiation. A novel approach was used to assess particular memory functionsincluding pattern separation, in subpopulations of subjects prior to the course of radiotherapy, immediately after the course, and 1–2 years after therapy. Our results show a tendency for pattern separation decline in the long-term follow-up. A possible association of these disorders with the effect of the hippocampal region irradiation and inhibition of adult neurogenesis is discussed. Keywords: cognitive functions, radiation therapy, hippocampus, parasellar meningioma, pattern separation, adult neurogenesi

Trajectories of the internal control system in the management of agricultural organizations

Purpose: The article aims to investigate the current situation of the agricultural sector, as well as its normative-legal regulation in the Russian Federation. Currently, in the context of the economic development, the importance of the agricultural sector is undeniable. Design/Methodology/Approach: It is necessary to determine the trajectory of the internal control system in the management of agricultural organizations, to investigate the current situation of the agricultural sector in the Russian Federation, as well as to systematize the normative regulation in the agricultural sector and to identify the groups of problems of the internal control system. Findings: The article presents the stages of the implementation of the state policy in the field of a sustainable development of rural areas. There are identified the main directions of the development of the agricultural sector. Having analyzed the industry features in agriculture, determined by different scientists and practitioners, the authors identified features that affect the organization of the internal control system. There are analyzed and allocated enlarged groups of problems of internal control system in the agricultural organizations: normative-legal; organizational-methodical; informational; methodological; software and hardware. Practical Implications: The results of the study can be implemented into the practice of organization, functioning and improvement of the internal control system of agricultural organizations. Originality/Value: The main contribution of this study is to clarify and develop the theoretical and methodological aspects of the internal control system in agricultural organizations in the context of digitalization.peer-reviewe

Informed consent to medical intervention: the figure and role of a doctor

Informed consent reflects a patient’s right to decide whether to receive or refuse medical intervention. Ideally, the patient receives all the necessary information from a physician and, consciously, allows the treatment or refuses it. However, in routine practice, a doctor may influence the patient’s decision: both because of professional knowledge, and because of the very fact that a patient seeks medical help. It follows from this that voluntary basis of a patient’s consent can hardly be absolute, since a doctor often influences his decision to a greater or lesser degree. The article proposes criteria for assessing the admissibility of doctor’s influence on a patient when deciding whether to sign informed consent to medical intervention or to refuse it, using the example of cardiac surgery.

Exclusive pp→nnπ+π+pp \to nn \pi^{+}\pi^{+} reaction at LHC and RHIC

We evaluate differential distributions for the four-body $p p \to n n \pi^+ \pi^+$ reaction. The amplitude for the process is calculated in the Regge approach including many diagrams. We make predictions for possible future experiments at RHIC and LHC energies. Very large cross sections are found which is partially due to interference of a few mechanisms. Presence of several interfering mechanisms precludes extraction of the elastic $\pi^+ \pi^+$ scattering cross section. Absorption effects are estimated. Differential distributions in pseudorapidity, rapidity, invariant two-pion mass, transverse-momentum and energy distributions of neutrons are presented for proton-proton collisions at $\sqrt{s}$ = 500 GeV (RHIC) and $\sqrt{s}$ = 0.9, 2.36 and 7 TeV (LHC). Cross sections with experimental cuts are presented.Comment: 22 pages, 18 figures, calculations have been corrected, new processes added, discussion expanded in print in Phys. Rev.

Association of the rs2167270 polymorphism of the leptin gene (LEP) with the intensity of pain in patients with osteoarthritis of the knee

Background: Osteoarthritis (OA) is a significant social problem as it is the most common disease of the joints. OA is a multifactorial disease in which great attention is paid to hereditary factors. Recently, a number of studies have demonstrated the contribution of a number of genes to the subjective assessment of pain in OA, which is the main symptom of this disease. The association of P2X7, TRPV1 and TACR1 genes and some others with pain sensitivity has been shown. One of the risk factors of pain among many others, is the increased weight. Abdominal adipose tissue is a source of release of pro-inflammatory adipokines that cause systemic inflammation associated with damage to many tissues, including subchondral bone, synovial membrane. Leptin is an endogenous hormone from the adipokine family encoded by the obesity gene leptin (LEP) and which is synthesized primarily in adipocytes.Aims: To investigate the possible association of rs2167270 (A19G) polymorphism of the LEP gene with pain intensity in ­patients with knee OA.Materials and methods: The study was conducted among women diagnosed with OA. Using the VAS scale (Visual analog scale), patients with mild knee pain — group 1 (VAS ≤ 40 mm) and patients with moderate or severe pain — group 2 (VAS>40 mm) were selected for pain assessment. Genetic variants of A19G leptin gene polymorphism were studied by polymerase chain reaction followed by restriction fragment length analysis (PCR-RFLP) method.Results: In the group of patients with moderate or severe pain intensity (group 2, n=61), a statistically significant association was shown with a higher body mass index (p=0.006) and an increased frequency of carriers of the 19GG genotype (p=0,051) compared to group 1 (n=36). Carriers of the 19GG genotype statistically significantly had a higher rate of knee pain and an early age of OA debut compared to carriers of the 19AA genotype (p=0,035 and p=0,015, respectively).Conclusions: The findings open up new possibilities for predicting pain symptoms in patients with knee OA by genetic testing of A19G polymorphic variants of the leptin gene

Atorvastatin: old friend in the light of novel coronavirus infection’s pandemia

The COVID-19 (COronaVIrus Disease 2019) pandemic caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome CoronaVirus 2) continues to be a global threat to people and health systems. As of March 21, 2022, there are more than 460 million cases and more than 6 million deaths worldwide, and more than 17 million and 360,000 respectively in the Russian Federation. Due to the rapid spread of the new coronavirus infection, since the beginning of the pandemic, tremendous efforts have been made to create new pharmacological agents to reduce morbidity and mortality, and tactics have been used to repurpose existing medications in treatment regimens for patients with COVID-19, particularly statins. Statins represent one of the most widely used and prescribed classes of drugs in the world. The hypolipidemic properties of statins are actively used to treat hyperlipidemia and primary and secondary prevention of cardiovascular diseases and their complications. Statins have a known safety profile, are inexpensive and accessible. In addition to their hypolipidemic effects, statins have a wide range of pleiotropic anti-inflammatory, antiviral, and antithrombotic effects potentially useful in the treatment of COVID-19. Presumably, the use of statins can reduce SARS-CoV-2-induced organ and tissue damage and improve lung function. The use of statins, particularly atorvastatin, as one of the most effective, widely prescribed and studied drugs in this class, as a safe, affordable and relatively inexpensive therapy may be a promising therapeutic approach in the fight against a new coronavirus infection

The+basic+algorithm+for+the+design+and+construction+of+a+monocultural+innovation+organization

Algorithmization of management activities in the transition to the digital economy is one of the most important tasks of modern management science. Sketch design is defined by the algorithm creation tool. This algorithmization method is applied to the processes of choosing the type of a homogeneous product, its quality and other consumer properties, utility for the consumer and manufacturer. Products are classified according to their purpose and the resources for their production. The quality of the product is defined as the ratio of the actual properties of the product to the normative ones, while it is necessary to take into account the influence of manufacturing defects, which entails a transition from linear to non-linear quality functions. The cumulative assessment of the product for the consumer is determined taking into account his subjective assessment of the properties of the product, expressed in the weight of the quality of individual utilities. For a manufacturer, the aggregate assessment of product quality directly depends on the main properties of the product, taking into account its other properties, and inversely depends on the cost of purchasing it, taking into account their functional elasticity. The algorithm is recommended for use by specialists dealing with algorithmic management activities

Analyticity, Crossing Symmetry and the Limits of Chiral Perturbation Theory

The chiral Lagrangian for Goldstone boson scattering is a power series expansion in numbers of derivatives. Each successive term is suppressed by powers of a scale, $\Lambda_\chi$, which must be less than of order $4\pi f/\sqrt{N}$ where $f$ is the Goldstone boson decay constant and $N$ is the number of flavors. The chiral expansion therefore breaks down at or below $4 \pi f/\sqrt{N}$. We argue that the breakdown of the chiral expansion is associated with the appearance of physical states other than Goldstone bosons. Because of crossing symmetry, some ``isospin'' channels will deviate from their low energy behavior well before they approach the scale at which their low energy amplitudes would violate unitarity. We argue that the estimates of ``oblique'' corrections from technicolor obtained by scaling from QCD are untrustworthy.Comment: harvmac, 18 pages (3 figures), HUTP-92/A025, BUHEP-92-18, new version fixes a TeX problem in little mod

Pain as one of the risk factors for progression of knee osteoarthrosis

Objective: to study the impact of pain intensity on the progression of knee osteoarthrosis (OA). Subjects and methods. One hundred and ten patients with knee OA were examined at a 5-year interval. All the patients underwent a questionnaire survey and knee joint pain assessment using a visual analog scale (VAS) and standard radiography. Results. After 5-year follow-up, radiographic OA progression was seen in 40 patients (Group 2); its stage remained the same in 70 patients (Group 1). In both groups, the patients were matched for age (59.2+9.5 and 59.0+8.1 years) and disease duration (11.1+10.6 and 13.7+9.9 years). During the first examination, pain on walking was more severe in Group 1 than in Group 2: 57.8+16.6 and 48.7+13.3 mm by VAS (р=0.002), as well as severe joint pain was predominant in these patients: 22.5 and 11.4%, respectively. Over the 5-year period, there was an increase in pain intensity. At the end of the follow-up, the patients with progressive OA rated their knee joint pain as severe in 35% of cases whereas in this index the non-progression group was only 12.9 (p = 0.012). Conclusion. In the OA progression group, pain intensity was initially statistically higher than that in the non-progression group. During 5-year follow-up, Group 1 showed an increase in knee joint pain intensity on walking, which can be considered as one of the predictors of gonarthrosis progression