Differences in the prognosis of HPV16-positive patients with squamous cell carcinoma of head and neck according to viral load and expression of P16

Purpose To evaluate the impact of HPV16 load (VL-the number of virus genome copies per cell) and P16 expression on prognosis of patients with squamous cell carcinomas (SCCs) of head and neck (HN). Materials and methods HPV16 presence was assessed in the group of 109 patients with HNSCCs by quantitative polymerase chain reaction (qPCR). VL (assessed by qPCR) and P16 expression (evaluated by immunohistochemistry) were analysed only in the subgroup of HPV16-positive tumours. These features were correlated with 5-year overall survival (OS) and disease-free survival (DFS). Results HPV16 infection was found in 36 tumours (33.0%). Virus-positive patients had better OS and DFS than those without infection (P = 0.041 and 0.005). Among HPV16-positive HNSCCs, 18 (50.0%) had higher VL (median value > 6764.3 copies/cell) and 25 (73.5%) P16 over expression. The significant differences in OS and DFS (P = 0.008 and 0.004) were noticed according to VL, wherein 100% DFS was found for patients with higher VL. According to P16 expression, significant difference was found only for OS (P = 0.020). In multivariate analysis, VL (P = 0.045; HR = 2.795; CI 0.121-1.060) and the level of smoking (P = 0.023, HR = 2.253; CI 1.124-4.514) were independent factors affecting DFS of HPV16-positive patients. Conclusion On the basis of viral load, it is possible to differentiate prognosis of patients with HPV16-positive HNSCCs. In this subgroup, viral load has stronger prognostic potential than P16 expression

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Księga poświęcona Profesorowi Hieronimowi Kubiakowi w 75. rocznicę urodzin. Tom ofiarowany przez przyjaciół i uczniów

Multidifferential study of identified charged hadron distributions in ZZ-tagged jets in proton-proton collisions at s=\sqrt{s}=13 TeV

Jet fragmentation functions are measured for the first time in proton-proton collisions for charged pions, kaons, and protons within jets recoiling against a $Z$ boson. The charged-hadron distributions are studied longitudinally and transversely to the jet direction for jets with transverse momentum 20 $< p_{\textrm{T}} < 100$ GeV and in the pseudorapidity range $2.5 < \eta < 4$. The data sample was collected with the LHCb experiment at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 1.64 fb$^{-1}$. Triple differential distributions as a function of the hadron longitudinal momentum fraction, hadron transverse momentum, and jet transverse momentum are also measured for the first time. This helps constrain transverse-momentum-dependent fragmentation functions. Differences in the shapes and magnitudes of the measured distributions for the different hadron species provide insights into the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb public pages

Study of the B−→Λc+Λˉc−K−B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-} decay

The decay $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ is studied in proton-proton collisions at a center-of-mass energy of $\sqrt{s}=13$ TeV using data corresponding to an integrated luminosity of 5 $\mathrm{fb}^{-1}$ collected by the LHCb experiment. In the $\Lambda_{c}^+ K^{-}$ system, the $\Xi_{c}(2930)^{0}$ state observed at the BaBar and Belle experiments is resolved into two narrower states, $\Xi_{c}(2923)^{0}$ and $\Xi_{c}(2939)^{0}$, whose masses and widths are measured to be $$m(\Xi_{c}(2923)^{0}) = 2924.5 \pm 0.4 \pm 1.1 \,\mathrm{MeV}, \\ m(\Xi_{c}(2939)^{0}) = 2938.5 \pm 0.9 \pm 2.3 \,\mathrm{MeV}, \\ \Gamma(\Xi_{c}(2923)^{0}) = \phantom{000}4.8 \pm 0.9 \pm 1.5 \,\mathrm{MeV},\\ \Gamma(\Xi_{c}(2939)^{0}) = \phantom{00}11.0 \pm 1.9 \pm 7.5 \,\mathrm{MeV},$$ where the first uncertainties are statistical and the second systematic. The results are consistent with a previous LHCb measurement using a prompt $\Lambda_{c}^{+} K^{-}$ sample. Evidence of a new $\Xi_{c}(2880)^{0}$ state is found with a local significance of $3.8\,\sigma$, whose mass and width are measured to be $2881.8 \pm 3.1 \pm 8.5\,\mathrm{MeV}$ and $12.4 \pm 5.3 \pm 5.8 \,\mathrm{MeV}$, respectively. In addition, evidence of a new decay mode $\Xi_{c}(2790)^{0} \to \Lambda_{c}^{+} K^{-}$ is found with a significance of $3.7\,\sigma$. The relative branching fraction of $B^{-} \to \Lambda_{c}^{+} \bar{\Lambda}_{c}^{-} K^{-}$ with respect to the $B^{-} \to D^{+} D^{-} K^{-}$ decay is measured to be $2.36 \pm 0.11 \pm 0.22 \pm 0.25$, where the first uncertainty is statistical, the second systematic and the third originates from the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb public pages

Measurement of the ratios of branching fractions R(D∗)\mathcal{R}(D^{*}) and R(D0)\mathcal{R}(D^{0})

The ratios of branching fractions $\mathcal{R}(D^{*})\equiv\mathcal{B}(\bar{B}\to D^{*}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(\bar{B}\to D^{*}\mu^{-}\bar{\nu}_{\mu})$ and $\mathcal{R}(D^{0})\equiv\mathcal{B}(B^{-}\to D^{0}\tau^{-}\bar{\nu}_{\tau})/\mathcal{B}(B^{-}\to D^{0}\mu^{-}\bar{\nu}_{\mu})$ are measured, assuming isospin symmetry, using a sample of proton-proton collision data corresponding to 3.0 fb${ }^{-1}$ of integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The tau lepton is identified in the decay mode $\tau^{-}\to\mu^{-}\nu_{\tau}\bar{\nu}_{\mu}$. The measured values are $\mathcal{R}(D^{*})=0.281\pm0.018\pm0.024$ and $\mathcal{R}(D^{0})=0.441\pm0.060\pm0.066$, where the first uncertainty is statistical and the second is systematic. The correlation between these measurements is $\rho=-0.43$. Results are consistent with the current average of these quantities and are at a combined 1.9 standard deviations from the predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb public pages

Glosses for ontological aspects of radio-play

The article focuses on inaccuracy of terms which has appeared in the radio drama literature. According to propounded thesis, original radio drama is a kind of adaptation, because its existence in proper auditory form always requires a specific intersemiotic translation which involves at least acoustic scenario fruition. The thesis was verified on the material of Drugi pokój – Zbigniew Herbert’s radio-play directed by Waldemar Modestowicz. Terms ‘original radio drama’ and ‘radio-play adaptation’ have the same basis, which demands analysis of radio drama’s features. ‘Subject’ and ‘recipient’ of an audio work focus on issues of perception, which is a starting point for deliberation

The analysis of Mexican Spanish based on some Televisa’s telenovelas

Celem niniejszej pracy jest wyjaśnienie kilku kluczowych różnic między językiem kastylijskim a jego meksykańską odmianą. Ponadto, na podstawie czterech wybranych telenowel zaprezentowano, jak ważną rolę w każdej z tych produkcji pełnią meksykanizmy oraz jak ich obecność wpływa na zróżnicowanie słownictwa. Część teoretyczna pracy została poświęcona na wyjaśnienie, czym jest telenowela, między innymi, poprzez wskazanie jej charakterystycznych cech. Niemniej jednak, jej głównym zamierzeniem było obalenie dosyć powszechnego przekonania o tym, że telenowela jest synonimem opery mydlanej.The aim of this thesis is to demonstrate some of the most important differences with respect to Castilian and Mexican Spanish. Moreover, in our analysis, based on four chosen telenovelas, we would like to indicate the importance of mexicanisms in each of these productions and the variety of vocabulary created by them. However, the thesis focuses also on explaining what a telenovela is by presenting, among others, some characteristic features of this genre. Most of all, it proves that telenovela is not a synonym for the soap opera.El objetivo principal de esta memoria consiste en indicar algunas diferencias más importantes en cuanto al castellano y el español de México. Además, a través de cuatro telenovelas elegidas se muestra la gran importancia de mexicanismos en cada una de las producciones y la diversidad de vocabulario construida con base en ellos. No obstante, el trabajo se concentra también en explicar qué es una telenovela, entre otros, indica sus rasgos más característicos pero, sobre todo, refuta la convicción bastante común de que la telenovela es uno de los sinónimos de soap opera

Translator in Wonderland

Celem niniejszej pracy jest omówienie charakterystycznych cech literatury dziecięcej oraz kluczowych aspektów związanych z jej tłumaczeniem. Ponadto, wytłumaczona została perspektywa dziecka oraz jego oczekiwania wobec książki. Na postawie dzieła Lewisa Carrolla Alice’s Adventures in Wonderland pokazano, dlaczego humor w literaturze dziecięcej jest tak istotny oraz omówiono język, którym powieść została napisana. Następnie, dokonano analizy treści, aby móc jednoznacznie wskazać prawdziwego odbiorcę książki. Na koniec, została omówiona rola ilustracji w książkach dla dzieci. To doświadczenie ukazało nam różnorakie przedstawienia Alicji oraz udowodniło, że każda z nich jest wyjątkowa na swój sposób.The aim of this thesis is to demonstrate the main features of children’s literature. Thus, we comment on different aspects connected with the theory of translation of children’s literature. First of all, we explain a child´s perspective and their expectations as a reader. Then, based on Alice´s Adventures in Wonderland by Lewis Carroll we underline the importance of the humour in books for children and we comment on the language that is used therein. Moreover, we comment on the contents of this book to indicate its real reader. Finally, we comment on the role of illustration in children´s literature to show numerous faces of Alice.El presente trabajo tiene como objetivo demostrar las características principales de la literatura infantil. De ahí, se comentan diferentes aspectos relacionados con la teoría de la traducción de la literatura infantil. Primero, se explica la perspectiva de un niño y sus expectativas como lector. Luego, con base en la obra Alice´s Adventures in Wonderland de Lewis Carroll se subraya la importancia de comicidad en los libros destinados a los niños y se comenta el lenguaje que se utiliza. Además, se analiza el contenido de la obra para indicar su verdadero destinatario. Finalmente, se comenta el rol de la imagen en la literatura infantil para demostrar los múltiples rostros de Alicia