Escenario actual de la resistencia a la colistina mediada por plásmidos en América Latina

Colistin resistance can occur by chromosomal mutations and by acquisition of plasmid-carrying determinants, mainly mcr-1. In the recent years, we have observed the outburst of this resistance gene in our region. Due to the risk of the rapid dissemination of mcr-1, this finding has worried and alerted different actors from the health field and has become one of the most prolific topics. Our review compiles available reports of well-documented mcr-1-positive strains of Enterobacteriaceae, obtained from different samples in Argentina and other countries of Latin America. Furthermore, it addresses the association of mcr-1 with ESBL resistance markers and outlines the platforms involved in their dissemination.Fil: Quiroga, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Di Conza, José Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentin

Plasma Activity of the Broad-snouted Caiman (Caiman latirostris)

Crocodilians exhibit well-defined social behaviors, which frequently result in serious wounds as a consequence of social disputes including the loss of entire limbs. Despite the severity of many wounds, there is typically little sign of infection. A common question is how these animals survive with serious wounds without showing obvious signs of illness, particularly when living in environments containing potentially pathogenic microbes. In this study we determined in vitro plasma antibacterial activity of the Broad-snouted caiman (Caiman latirostris) against Escherichia coli and compared it to that in hen (Gallus gallus) and human plasma. Colony forming units were measured at different exposure times (0, 1, 3, and 6 h). The antibacterial activity of Broad-snouted caiman plasma was consistently superior to those of human and hen plasma, and hen plasma had greater activity than human plasma except at 3 h of exposure. Only C. latirostris plasma completely inhibited E. coli proliferation at 6 h.Fil: Siroski, Pablo Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Proyecto Yacaré; Argentina. Secretaría de Estado de Medio Ambiente y Desarrollo Sustentable de la Provincia de Santa Fe; ArgentinaFil: Piña, Carlos Ignacio. Provincia de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Universidad Autónoma de Entre Ríos. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones Científicas y Transferencia de Tecnología a la Producción; Argentina. Proyecto Yacaré; ArgentinaFil: Larriera, Alejandro. Proyecto Yacaré; Argentina. Secretaría de Estado de Medio Ambiente y Desarrollo Sustentable de la Provincia de Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias; ArgentinaFil: Merchant, Mark. McNeese State University; Estados UnidosFil: Di Conza, José Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Cátedra de Microbiología General; Argentin

Corrosion Resistance of Steel/Zinc with Silicate Nanoparticles/Polyurethane Paint Systems in NaCl Solution

Surface characteristics and corrosion behaviour of bare electrogalvanized steel coated with polymer/nano-silicate particles added to the electrogalvanizing bath were studied by scanning electron microscopy (SEM), energy dispersive spectrometer (EDXS) and electrochemical impedance spectroscopy (EIS). After applying a barrier polyurethane paint, the paint hardness, porosity, flexibility, colour, gloss, blistering and rusting degrees, and anticorrosive protective properties in 0.05 mol·L-1 NaCl solution were also evaluated. The results correlated well and, being demonstrative of the very slow deterioration rate of the immersed coated electrogalvanized steel, they enabled to assume that if a chemically analogous but thicker coating system was applied; it could be an acceptable alternative in real service conditions.Fil: Célia R. Tomachuk. Energy And Nuclearresearch Institute; BrasilFil: Elsner, Cecilia Ines. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Di Sarli, Alejandro Ramón. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentin

Valeur ajoutée dans le modèle régional canadien du climat : comparaison de la précipitation aux échelles du modèle global canadien du climat

La modélisation du climat à haute résolution est nécessaire pour une meilleure compréhension des impacts des changements climatiques. Les modèles régionaux du climat (MRC) constituent une des principales sources de ce type de données puisque les modèles de circulation générale (MCG) ne fonctionnent toujours pas à une résolution suffisante pour répondre à ces besoins.\ud Une fois que les MRC sont devenus des outils capables de générer des simulations physiquement réalistes, un effort important a été fait pour évaluer leur capacité de mise à l'échelle, en se concentrant principalement sur des variables moyennées temporellement. Cet effort ne s'est pas traduit par des améliorations sans équivoque par rapport aux simulations produites par les MCG.\ud L'objectif principal de cette étude est d'examiner l'existence de la valeur ajoutée dans les simulations du modèle régional Canadien du climat (MRCC) par rapport à celles du modèle de circulation général canadien (MCGC) utilisé comme pilote. Dans cette première étape, il a été nécessaire d'analyser les échelles temporelles et spatiales communes aux deux modèles, le MRCC et le MCGC. Une comparaison est effectuée en ramenant les données à haute résolution des stations météorologiques et du MRCC à la résolution du MCGC. L'évaluation se base sur la comparaison des histogrammes d'intensités de précipitation et des 95e centiles des distributions afin de caractériser les événements extrêmes. On estime le degré de chevauchement entre les distributions simulées et observées en utilisant la mesure S définie par Perkins et al. (2007). Cette dernière reflète principalement le comportement des intensités faibles et modérées. Les résultats montrent que les statistiques quotidiennes des précipitations simulées par le MGCC et le MRCC sont généralement très similaires. En comparant les résultats des deux modèles, il n'existe aucune preuve de l'existence de la valeur ajoutée. En outre, pendant l'été, les données simulées par le modèle MCGC sont plus proches des observations que celles générées par le MRCC. Cette amélioration provient d'une meilleure simulation de la fréquence des jours secs. Pour les événements quotidiens les plus intenses, le MCGC produit aussi des résultats plus proches des valeurs observées que le MRCC. Ce dernier montre une sous-estimation constante de la fréquence d'occurrence des événements intenses. C'est aussi le cas dans les régions caractérisées par d'importants forçages de surface, où la différence entre les topographies des deux modèles pourrait avoir un impact. ______________________________________________________________________________ MOTS-CLÉS DE L’AUTEUR : MRCC, Mise à l'échelle, Précipitation, Valeur ajoutée, Histogrammes

Harmonized tuning of nucleic acid and lectin binding properties with multivalent cyclodextrins for macrophage-selective gene delivery

Polycationic amphiphilic cyclodextrins (paCDs) have been shown to behave as efficient non-viral gene carriers paralleling the efficacy of commercial vectors towards a variety of cell lines. Their molecular framework and modular design allow the installation of saccharidic antennae to promote specific carbohydrate–protein interactions, thus potentially endowing them with selective targeting abilities. Yet, the presence of these additional functionalities onto the polycationic cluster may hamper paCD self-assembly and nucleic acid condensation. In this report we describe the influence of paCD mannosylation extent on paCD-pDNA nanocomplex stability as well as the consequences of varying glycotope density on mannose-specific lectin recognition and gene delivery capabilities. The work aims at exploring the potential of this approach to optimize both properties in order to modulate cell transfection selectivity.Ministerio de Economía y Competitividad SAF2013-44021-RJunta de Andalucía FQM-146

Recommender systems fairness evaluation via generalized cross entropy

Fairness in recommender systems has been considered with respect to sensitive attributes of users (e.g., gender, race) or items (e.g., revenue in a multistakeholder setting). Regardless, the concept has been commonly interpreted as some form of equality – i.e., the degree to which the system is meeting the information needs of all its users in an equal sense. In this paper, we argue that fairness in recommender systems does not necessarily imply equality, but instead it should consider a distribution of resources based on merits and needs.We present a probabilistic framework based ongeneralized cross entropy to evaluate fairness of recommender systems under this perspective, wherewe showthat the proposed framework is flexible and explanatory by allowing to incorporate domain knowledge (through an ideal fair distribution) that can help to understand which item or user aspects a recommendation algorithm is over- or under-representing. Results on two real-world datasets show the merits of the proposed evaluation framework both in terms of user and item fairnessThis work was supported in part by the Center for Intelligent Information Retrieval and in part by project TIN2016-80630-P (MINECO

Association between grain yield, grain quality and morpho-physiological traits along ten cycles of recurrent selection in bread wheat (triticum aestivum L.)

The objective of the present investigation was to examine the relationships between agronomical behavior and grain quality along ten cycles of a recurrent selection program performed under rainfed condition. Twenty-four lines, four for each one of the 0, 2, 4, 6, 8 and 10 cycles of recurrent selection, were evaluated for two consecutive years (2011 and 2012). The experimental lines were evaluated under conventional (CT) and no tillage (NT) systems. Grain yield and grain weight were determined and harvest index and grain number estimated. Flour protein content, sodium dodecyl sulphate sedimentation (IS-SDS) and lactic acid SRC (LASRC) were considered as end-use quality predictive tests. The Spearman correlation coefficient was used to measure the relationships among yield, its components and grain quality parameters. Within the context of CT, flour protein content was negatively associated with all the agronomic variables. The IS-SDS has a negative association with the grain weight; meanwhile, LASRC associated positively with all the agronomic variables. When wheat was grown in NT, the relationship between IS-SDS and harvest index, like LASRC with all agronomic traits, was positive. Confining the discussion to the CT results, after ten cycles of recurrent selection the highest grain yield achieved was accompanied by a decrease in protein percentage. However, the decrease in the percentage of protein in more advanced selection cycles was offset by an improvement of its quality.Fil: Maich, Ricardo Héctor. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Steffolani, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Di Rienzo, Julio Alejandro. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Leon, Alberto Edel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentin

(Uncontrolled) Aggregate shocks or vertical tax interdependence? Evidende from gasoline and cigarettes

Besley and Rosen (1998) were the first authors to empirically estimate the presence of vertical tax externalities. They tested it on gasoline and tobacco unitary taxes. However, they did not take into account the difference in cost of living across states: high cost areas pay less in real terms than low cost areas, since the nominal unit tax on cigarettes and gasoline does not differ according to the state in which it is applied. Consequently, we propose that vertical tax competition can be estimated by deflating all financial variables using the House Price Index (HPI), which is disaggregated by states. This produces a federal tax variable that is expressed in real terms and shows crosssectional variation. This empirical strategy enabled us to disentangle the vertical interdependence between state and federal tax rates from aggregate shocks over time, using US data from 1975 to 2006 on gasoline and tobacco. We found significant horizontal tax competition, which was higher for cigarettes, but no vertical tax reaction. The results were robust to the period analyzed.tax setting, vertical tax externality

Massive Schwinger model at finite θ\theta

Using the approach developed in [V. Azcoiti, G. Di Carlo, A. Galante, V. Laliena, \textit{Phys. Lett.} \textbf{B563}, (2003) 117], we are able to reconstruct the behavior of the massive 1-flavor Schwinger model with a $\theta$ term and a quantized topological charge. We calculate the full dependence of the order parameter with $\theta$. Our results at $\theta = \pi$ are compatible with Coleman's conjecture on the phase diagram of this model.Comment: 8 pages, 8 figure