845 research outputs found
Obesity, metabolic syndrome and diabetes: cardiovascular implications and therapy
Obesity, metabolic syndrome, and type-2 diabetes
mellitus are 3 interrelated conditions that share a number
of pathophysiological mechanisms and that are frequently
observed to lead, in succession, to cardiovascular
complications. The fact that their prevalence is increasing
alarmingly should prompt all healthcare professionals
urgently to implement measures to prevent these
complications. The most effective, though also the least
adopted, are those related to lifestyle modification. Drug
treatment targeted at controlling risk factors (eg,
hypertension, dyslipidemia, and thrombophilia), metabolic
abnormalities, and excess weight is also necessary
Monitoring of biophysicochemical changes in a silty clay soil contaminated with LNAPLs
The interdependence between time domain induced polarization measurements at uncontaminated and
artificially contaminated soil samples with diesel and biophysicochemical alterations caused by diesel
degradation was investigated during 12 months. The research was performed on a slightly alkaline soil,
with high content of organic matter (148 g/kg) and silty clay texture. Soil clay mineralogy was mainly
composed of plagioclase, amphibole, biotite, interstratified mica-smectite, goethite and some vestigial
kaolinite. A decrease on resistivity and induced polarization (IP) in contaminated soil was observed during
the 12 months. This reduction on geoelectrical parameters was related to: 1) the increase on the electrolyte
conductivity; 2) the increase on interfacial surface area, as result of biotite transformation and weathering of
other ferromagnesian minerals and 3) a slight increase in soil aggregation, caused by diesel-degrading
microorganisms (a significant increase of the numbers of specific carbon degraders was observed). After
4 months, the IP response was lowest in the contaminated soil which was explained by inhibition of the
cation exchange capacity due to two possible processes: 1) clay particles coating by organic molecules and
2) attachment of microbial cells (biofilms) to clay particles and/or soil aggregates. The results suggest that
the content and mineralogy of the clay fraction as well as the aggregation state of the soils contaminated
with LNAPL's affect the IP response. This response is a diagnostic of the biophysicochemical alterations
occurring during diesel degradation as a result of biological activit
Safety of the Deferral of Coronary Revascularization on the Basis of Instantaneous Wave-Free Ratio and Fractional Flow Reserve Measurements in Stable Coronary Artery Disease and Acute Coronary Syndromes.
OBJECTIVES:
The aim of this study was to investigate the clinical outcomes of patients deferred from coronary revascularization on the basis of instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute coronary syndromes (ACS).
BACKGROUND:
Assessment of coronary stenosis severity with pressure guidewires is recommended to determine the need for myocardial revascularization.
METHODS:
The safety of deferral of coronary revascularization in the pooled per-protocol population (n = 4,486) of the DEFINE-FLAIR (Functional Lesion Assessment of Intermediate Stenosis to Guide Revascularisation) and iFR-SWEDEHEART (Instantaneous Wave-Free Ratio Versus Fractional Flow Reserve in Patients With Stable Angina Pectoris or Acute Coronary Syndrome) randomized clinical trials was investigated. Patients were stratified according to revascularization decision making on the basis of iFR or FFR and to clinical presentation (SAP or ACS). The primary endpoint was major adverse cardiac events (MACE), defined as the composite of all-cause death, nonfatal myocardial infarction, or unplanned revascularization at 1 year.
RESULTS:
Coronary revascularization was deferred in 2,130 patients. Deferral was performed in 1,117 patients (50%) in the iFR group and 1,013 patients (45%) in the FFR group (p < 0.01). At 1 year, the MACE rate in the deferred population was similar between the iFR and FFR groups (4.12% vs. 4.05%; fully adjusted hazard ratio: 1.13; 95% confidence interval: 0.72 to 1.79; p = 0.60). A clinical presentation with ACS was associated with a higher MACE rate compared with SAP in deferred patients (5.91% vs. 3.64% in ACS and SAP, respectively; fully adjusted hazard ratio: 0.61 in favor of SAP; 95% confidence interval: 0.38 to 0.99; p = 0.04).
CONCLUSIONS:
Overall, deferral of revascularization is equally safe with both iFR and FFR, with a low MACE rate of about 4%. Lesions were more frequently deferred when iFR was used to assess physiological significance. In deferred patients presenting with ACS, the event rate was significantly increased compared with SAP at 1 year.info:eu-repo/semantics/publishedVersio
Genética Molecular e Citogenética
XXXII Congresso Brasileiro de Zoologia, Foz do Iguaçu, 2018. Tema: Desafios e perspectivas para a Zoologia na América LatinaCaderno de Resumos de Trabalhos da Área temática Genética Molecular e Citogenética, do XXXII Congresso Brasileiro de ZoologiaSociedade Brasileira de Zoologia (SBZ) e Universidade Federal da Integração Latino-Americana (Unila
An Unexpected Association in a Patient with Heart Failure Presenting a Surgical Challenge
Bicuspid aortic valve (BAV) is the most common form of congenital heart disease and frequently leads to premature valvular dysfunction. BAV is associated with aortic wall abnormalities and a high prevalence of ascending aorta dilatation and coarctation of the aorta (CoA). Consequently, in patients with BAV a careful assessment of the valve, and also of the aortic root and the ascending aorta, should be performed. The most feared complication is aortic dissection, however, the actual incidence of this complication is low. We report the case of a 58-year-old man who presented with New York Heart Association class III heart failure. The work-up revealed BAV with severe stenosis and severe compromise of left ventricle systolic function. In addition, CoA in the isthmus region, and type B dissection of the aorta were diagnosed.info:eu-repo/semantics/publishedVersio
Avances en la cardiopatía isquémica aguda y crónica
Atherothrombosis is a key concept in our new pathophysiologic understanding of cardiovascular disease. It has led to new preventive strategies, both pharmacologic and lifestyle-related, to more specific treatments and to emerging imaging modalities
Prevalencia del síndrome metabólico en población laboral española: registro MESYAS
Introducción y objetivos. Estudiar la prevalencia del
síndrome metabólico (SM) en la población laboral activa
española y analizar sus diferencias según las categorías
laborales.
Sujetos y método. Se recogieron los datos de 7.256
trabajadores activos (un 82,4% varones), con una edad
media de 45,4 ± 9,8 años, empleados en una factoría de
coches y unos grandes almacenes. El diagnóstico del SM
se realizó mediante los criterios modificados del ATP-III
(se utilizó el índice de masa corporal en lugar del perímetro
abdominal).
Resultados. La prevalencia bruta del SM fue del
10,2%. Ajustada por edad y sexo en una población plana
(20-60 años) fue del 5,8% (intervalo de confianza [IC] del
95%, 4,1-7,6%), significativamente más alta en varones
que en mujeres (el 8,7%; IC del 95%, 7,3-10,0 frente al
3,0%; IC del 95%, 0,8-5,1). Todos los componentes del
SM fueron significativamente más prevalentes en varones,
excepto las concentraciones de lipoproteínas de alta
densidad, que fueron más bajas. La prevalencia aumentó
con la edad y el sexo masculino (odds ratio [OR] = 1,7),
la obesidad (OR = 9,6), la hipertensión (OR = 3,4) y la
diabetes (OR = 15,4). Los trabajadores manuales presentaron
la mayor prevalencia de SM (11,8%), seguidos por
EPIDEMIOLOGÍA Y PREVENCIÓN
Prevalencia del síndrome metabólico en población laboral
española: registro MESYAS
Eduardo Alegríaa, Alberto Corderoa, Martín Laclaustrab, Alberto Grimac, Montserrat Leónb,
José A. Casasnovasb, Emilio Luengod, Alfonso del Ríob e Ignacio Ferreirab, en representación
de los investigadores del registro MESYAS*
aDepartamento de Cardiología. Clínica Universitaria de Navarra. Pamplona. Navarra. España.
bUnidad de Investigación Cardiovascular. Hospital Clínico Universitario. Zaragoza. España.
cServicio de Cardiología Preventiva. Asepeyo. Valencia. España.
dServicio de Cardiología. Hospital Militar. Zaragoza. España.
*Al final del artículo se relacionan los miembros del equipo de
investigación MESYAS.
Martín Laclaustra está contratado como investigador en el Instituto
Aragonés de Ciencias de la Salud dentro del programa de ayudas a
contratos para investigadores que han finalizado su formación médica
especializada del Instituto de Salud Carlos III.
El registro MESYAS cuenta con una beca de la Sociedad Española de
Cardiología (Sevilla, 2003) y la Sección de Cardiología Preventiva y
Rehabilitadora.
Correspondencia: Dr. E. Alegría Ezquerra.
Departamento de Cardiología. Clínica Universitaria de Navarra.
Avda. Pío XII, 36. 31008 Pamplona. Navarra. España.
Correo electrónico: [email protected]
Recibido el 5 de octubre de 2004.
Aceptado para su publicación el 18 de marzo de 2005.
los trabajadores de oficina (9,3%) y los directivos (7,7%)
(gradiente social inverso). Los trabajadores manuales tienen
un riesgo superior de presentar SM, con independencia
de la edad y el sexo (OR = 1,3); este efecto parece
depender de las concentraciones de triglicéridos.
Conclusiones. Uno de cada 10 trabajadores activos
tiene SM; la prevalencia aumenta con la edad y el sexo
masculino. La obesidad y la diabetes suponen gran incremento
de la prevalencia. Los trabajadores manuales son
el colectivo con mayor prevalencia
Cardiac resynchronization therapy and valvular cardiomyopathy after corrective surgery
Cardiac resynchronization therapy (CRT) has been
shown to have clinical benefits in certain groups of
patients with advanced heart failure (HF). However,
patients with valvular cardiomyopathy are
underrepresented in randomized clinical studies. The aim
of this study was to assess the medium-term (i.e., at 6
months) effects of CRT in patients with HF exclusively
due to valvular disease. The study included 40
consecutive patients who underwent CRT device
implantation. At 6 months, there were improvements in
functional class, left ventricular remodeling, and
intraventricular dyssynchrony parameters in treated
patients. In this particular subgroup of patients, the
benefits of CRT were similar to those observed in patients
with HF due to other etiologies
Tratamiento de la insuficiencia cardíaca avanzada mediante estimulación biventricular. Experiencia inicial en una serie de 22 casos consecutivos
Recent data suggest that biventricular pacing may play
an important role in treating advanced heart failure in the presence of a
significant interventricular and/or intraventricular conduction disorder by
correcting cardiac dysynchrony. In this article, we review the initial technical
and clinical experience with cardiac resynchronization therapy in an
electrophysiology laboratory. METHODS: The first 22 consecutive patients with
severe congestive heart failure, ejection fraction < 0.35, NYHA functional class
III or IV, and QRS duration > 120 ms who were implanted biventricular pacemakers
were studied. Clinical, electrocardiographic, and echocardiographic evaluations
were made before and three months after pacemaker implantation. Acute functional
capacity testing with peak oxygen uptake was measured during biventricular pacing
and during intrinsic rhythm or right ventricular pacing three months after the
implantation procedure. RESULTS: The success rate of pacemaker implantation was
95%. Pre-discharge left ventricular pacing was achieved in 91%, with an average
pacing threshold of 1.53 (1.04) volts. NYHA functional class improved (p = 0.039)
from 3.4 (0.7) to 2.3 (0.78). The rate of hospitalization for heart failure
decreased from an average of 3.12 (0.58) three months before the procedure to
1.38 (0.34) three months after the procedure. Peak oxygen uptake was
significantly greater (p = 0.028) during biventricular pacing: 14.89 (2.1)
ml/min/kg, than during intrinsic rhythm or right ventricular pacing: 12.65 (2.3)
ml/min/kg. CONCLUSIONS: Cardiac resynchronization therapy can be performed safely
and with a high success rate in the electrophysiology laboratory. Biventricular
pacing seems to improve the symptoms of congestive heart failure in patients with
evidence of atrioventricular and/or interventricular/intraventricular
dysynchrony. An acute benefit in peak oxygen uptake was associated with
biventricular pacing after the implantation procedure
Efecto de la localización del electrodo ventricular izquierdo sobre los parámetros ecocardiográficos de asincronía en pacientes sometidos a terapia de resincronización cardíaca
Introduction and objectives. Cardiac resynchronization
therapy has been shown to be an option in the treatment
of patients with congestive heart failure. The current
indication for this treatment is based on clinical and electrocardiographic
criteria, although echocardiography has
also been shown to be a useful tool for the diagnosis of
ventricular dyssynchrony. The aim of this study was to assess
left ventricular dyssynchrony by echocardiography
and to evaluate the effect of the stimulation site on the
magnitude of resynchronization.
Patients and method. We studied 25 patients with biventricular
stimulation (left ventricular lead located in a lateral
position in 13 patients, and in an anterior position in
12). A complete echo-Doppler evaluation, including left
ventricular ejection fraction, ventricular diameters and parameters
of inter- and intraventricular dyssynchrony, was
performed before implantation and 3 months after the
procedure, with the device connected and disconnected.
Results. Left ventricular ejection fraction increased significantly
from 23.7 (6.5) to 27.8 (5.5) (P=.007) at 3
months. In the group as a whole, biventricular pacing was
associated with a significant decrease in all intraventricular
dyssynchrony parameters (septal-to-lateral wall motion
delay and septal-to-posterior wall motion delay). This decrease
in septal-to-posterior wall motion delay and septalto-
lateral wall motion delay was significantly greater in patients
with the electrode implanted in the lateral position
(58.1 ms vs 118 ms; P=.02) than with the lead in the anterior
position (39.5 ms vs 86.5 ms; P=.04). Three patients,
all with the electrode in an anterior location, were considered
non-responders.
Conclusions. Left lateral free wall stimulation provided
significantly better intraventricular resynchronization compared
to stimulation at an anterior site. Echocardiography
is a useful tool to evaluate changes in intra- and interventricular
synchrony related to the pacing site
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