System of Pressure Detection with IoT for Pins in Tail Pinch Test

Internet of Things (IoT) allows to interconnect and to interchange objects data through Internet. This component is part of a global term denominated Industry 4.0 that involved cyber-physical components for automation in industry. But IoT can be applied to different fields in research and technological developing as laboratory automation. Thus, it was developed a system that measure and classify pins used on Tail Pinch Test automatically. Our objective was to create a system that allow to categorize automatically instruments that are used in experiments. Thus, measurements variations are reduced, and the reliability of experiments grows. The system was based on Arduino ADK and resistive sensor to acquire pressure data. Also, a WIFI network and cloud computing service was used in the system. The application layer processed 100 pressure measurements and classified in linguistic values a pin using an Artificial Neural Network.Resumen—El Internet de las Cosas (IoT) permite a los objetos conectarse e intercambiar datos de todo tipo usando Internet. Se trata de uno de los componentes de la denominada Industria 4.0, cuyo campo de trabajo son los sistemas ciber-físicos para la automatización de procesos. Pero IoT tiene aplicaciones en muchos otros campos además de la industria, como lo son la investigación y el desarrollo tecnológico en la automatización de laboratorios. Así se creó un sistema que mide y clasifica de manera automática la presión de pinzas usadas en la prueba Tail-Pinch. El objetivo fue crear un sistema que permitiera categorizar instrumentos de experimentación. De tal manera que las variaciones de medición se reduzcan mientras crece la confiabilidad del experimento. Para ello, se empleó una tarjeta Arduino ADK y un sensor resistivo de presión. Se empleó una red WIFI y un servicio de almacenamiento de datos en nube. La aplicación final utilizó 100 medidas de presión y una Red Neuronal Artificial para dar una categoría lingüística de salida a la pinza seleccionada

avaliação não-invasiva do desenvolvimento muscular de atletas

Muscles contribute to the movement, in addition to providing protection to the bones, veins, arte-ries and organs, besides they shape the body. In this article, we describe a non-invasive method to evaluate the functional status of muscles based on muscle temperature, used to track the performance of athletes. The study was developed with different groups of subjects, each with a different sport activity (runners and physicist-constructivists) and, in turn, often with different training frequency (intense and moderate), to which a non-invasive muscle test was applied; with the statistical analysis of the obtained data it was possible to characterize, in a differential way, the muscular behavior in terms of heat released, corresponding to each experimental group.Los músculos contribuyen al movimiento, además de proporcionar protección a los huesos, venas, arterias y órganos, además dan forma al cuerpo. En el presente artículo, se describe un método no invasivo para evaluar el estado funcional de los músculos con base en la tempe-ratura muscular, usada para dar seguimiento al desempeño de atletas. El estudio se desarrolló con diferentes grupos de sujetos, cada uno con una actividad deportiva distinta (corredores y físico-constructivistas) y, a su vez, con frecuencia de entrenamiento distinto (intensa y mode-rada), a los que se aplicó una prueba muscular no invasiva; con el análisis estadístico de los datos obtenidos fue posible caracterizar, de manera diferencial, el comportamiento muscular en términos de calor liberado, correspondientes a cada grupo experimental.Os músculos contribuem para o movimento, além de fornecer proteção aos ossos, veias, arté-rias e órgãos, além de moldarem o corpo. Neste artigo, descrevemos um método não invasivo para avaliar o estado funcional dos músculos baseado na temperatura muscular, usado para rastrear o desempenho de atletas. O estudo foi desenvolvido com diferentes grupos de sujeitos, cada um com uma atividade esportiva diferente (corredores e físico-construtivistas) e, por sua vez, muitas vezes com treinamento diferente (intenso e moderado), aos quais foram aplicados um teste muscular não invasivo; com a análise estatística dos dados obtidos foi possível carac-terizar, de forma diferencial, o comportamento muscular em termos de calor liberado, corres-pondendo a cada grupo experimental

MANTENIMIENTO AUTOMOTRIZ BASADO EN UN DIAGNOSTICO TRIBOLÓGICO

En este trabajo se presenta un plan de mantenimiento automotriz basado en un diagnóstico tribológico del aceite lubricante de origen mineral grado SAE 20W50 multigrado, utilizado en la lubricación de un motor de combustión interna de cuatro cilindros, 1800 cm3, motor en posición diagonal, enfriado por anticongelante, con un sistema de lubricación por bomba mecánica. Las muestras se obtuvieron bajo diferentes condiciones de uso: 0km, 1000km, 5000km y 8500km; mismas que se sometieron a diversos ensayos, tales como: Viscosidad cinemática a 40°C y 100°C (Norma ASTM-D445), Desgaste (Norma ASTM G99-05), Timken (Norma ASTM-D-2782-17) y Análisis de Aceite; esto con la finalidad de diagnosticar la degradación del aceite lubricante y el desgaste generado, considerando estos resultados, se formuló un plan de mantenimiento automotriz basado en un diagnostico tribológico del aceite lubricante del motor en estudio

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Evaluación no invasiva del desarrollo muscular de deportistas

Muscles contribute to the movement, in addition to providing protection to the bones, veins, arte-ries and organs, besides they shape the body. In this article, we describe a non-invasive method to evaluate the functional status of muscles based on muscle temperature, used to track the performance of athletes. The study was developed with different groups of subjects, each with a different sport activity (runners and physicist-constructivists) and, in turn, often with different training frequency (intense and moderate), to which a non-invasive muscle test was applied; with the statistical analysis of the obtained data it was possible to characterize, in a differential way, the muscular behavior in terms of heat released, corresponding to each experimental group.Os músculos contribuem para o movimento, além de fornecer proteção aos ossos, veias, arté-rias e órgãos, além de moldarem o corpo. Neste artigo, descrevemos um método não invasivo para avaliar o estado funcional dos músculos baseado na temperatura muscular, usado para rastrear o desempenho de atletas. O estudo foi desenvolvido com diferentes grupos de sujeitos, cada um com uma atividade esportiva diferente (corredores e físico-construtivistas) e, por sua vez, muitas vezes com treinamento diferente (intenso e moderado), aos quais foram aplicados um teste muscular não invasivo; com a análise estatística dos dados obtidos foi possível carac-terizar, de forma diferencial, o comportamento muscular em termos de calor liberado, corres-pondendo a cada grupo experimental.Los músculos contribuyen al movimiento, además de proporcionar protección a los huesos, venas, arterias y órganos, además dan forma al cuerpo. En el presente artículo, se describe un método no invasivo para evaluar el estado funcional de los músculos con base en la tempe-ratura muscular, usada para dar seguimiento al desempeño de atletas. El estudio se desarrolló con diferentes grupos de sujetos, cada uno con una actividad deportiva distinta (corredores y físico-constructivistas) y, a su vez, con frecuencia de entrenamiento distinto (intensa y mode-rada), a los que se aplicó una prueba muscular no invasiva; con el análisis estadístico de los datos obtenidos fue posible caracterizar, de manera diferencial, el comportamiento muscular en términos de calor liberado, correspondientes a cada grupo experimental

Sistema mecánico abre bolsas: un ejemplo práctico para la enseñanza

En este artículo se presenta la manera de obtener un modelo matemático simplificado de un sistema mecánico abre bolsas, con la finalidad de ejemplificar los conocimientos que se obtienen usualmente en el curso de dinámica de mecanismos, tales como: equilibrio dinámico de partículas, movimiento de proyectiles y fuerzas de fricción. Con la ayuda de este modelo, se puede llevar a cabo el diseño mecánico del sistema abre bolsas para que sea posteriormente implementado en una planta de reciclaje de residuos sólidos

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Background: Additional safe and efficacious vaccines are needed to control the COVID-19 pandemic. We aimed to analyse the efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate. Methods: HERALD is a randomised, observer-blinded, placebo-controlled, phase 2b/3 clinical trial conducted in 47 centres in ten countries in Europe and Latin America. By use of an interactive web response system and stratification by country and age group (18–60 years and ≥61 years), adults with no history of virologically confirmed COVID-19 were randomly assigned (1:1) to receive intramuscularly either two 0·6 mL doses of CVnCoV containing 12 μg of mRNA or two 0·6 mL doses of 0·9% NaCl (placebo) on days 1 and 29. The primary efficacy endpoint was the occurrence of a first episode of virologically confirmed symptomatic COVID-19 of any severity and caused by any strain from 15 days after the second dose. For the primary endpoint, the trial was considered successful if the lower limit of the CI was greater than 30%. Key secondary endpoints were the occurrence of a first episode of virologically confirmed moderate-to-severe COVID-19, severe COVID-19, and COVID-19 of any severity by age group. Primary safety outcomes were solicited local and systemic adverse events within 7 days after each dose and unsolicited adverse events within 28 days after each dose in phase 2b participants, and serious adverse events and adverse events of special interest up to 1 year after the second dose in phase 2b and phase 3 participants. Here, we report data up to June 18, 2021. The study is registered at ClinicalTrials.gov, NCT04652102, and EudraCT, 2020–003998–22, and is ongoing. Findings: Between Dec 11, 2020, and April 12, 2021, 39 680 participants were enrolled and randomly assigned to receive either CVnCoV (n=19 846) or placebo (n=19 834), of whom 19 783 received at least one dose of CVnCoV and 19 746 received at least one dose of placebo. After a mean observation period of 48·2 days (SE 0·2), 83 cases of COVID-19 occurred in the CVnCoV group (n=12 851) in 1735·29 person-years and 145 cases occurred in the placebo group (n=12 211) in 1569·87 person-years, resulting in an overall vaccine efficacy against symptomatic COVID-19 of 48·2% (95·826% CI 31·0–61·4; p=0·016). Vaccine efficacy against moderate-to-severe COVID-19 was 70·7% (95% CI 42·5–86·1; CVnCoV 12 cases in 1735·29 person-years, placebo 37 cases in 1569·87 person-years). In participants aged 18–60 years, vaccine efficacy against symptomatic disease was 52·5% (95% CI 36·2–64·8; CVnCoV 71 cases in 1591·47 person-years, placebo, 136 cases in 1449·23 person-years). Too few cases occurred in participants aged 61 years or older (CVnCoV 12, placebo nine) to allow meaningful assessment of vaccine efficacy. Solicited adverse events, which were mostly systemic, were more common in CVnCoV recipients (1933 [96·5%] of 2003) than in placebo recipients (1344 [67·9%] of 1978), with 542 (27·1%) CVnCoV recipients and 61 (3·1%) placebo recipients reporting grade 3 solicited adverse events. The most frequently reported local reaction after any dose in the CVnCoV group was injection-site pain (1678 [83·6%] of 2007), with 22 grade 3 reactions, and the most frequently reported systematic reactions were fatigue (1603 [80·0%] of 2003) and headache (1541 [76·9%] of 2003). 82 (0·4%) of 19 783 CVnCoV recipients reported 100 serious adverse events and 66 (0·3%) of 19 746 placebo recipients reported 76 serious adverse events. Eight serious adverse events in five CVnCoV recipients and two serious adverse events in two placebo recipients were considered vaccination-related. None of the fatal serious adverse events reported (eight in the CVnCoV group and six in the placebo group) were considered to be related to study vaccination. Adverse events of special interest were reported for 38 (0·2%) participants in the CVnCoV group and 31 (0·2%) participants in the placebo group. These events were considered to be related to the trial vaccine for 14 (<0·1%) participants in the CVnCoV group and for five (<0·1%) participants in the placebo group. Interpretation: CVnCoV was efficacious in the prevention of COVID-19 of any severity and had an acceptable safety profile. Taking into account the changing environment, including the emergence of SARS-CoV-2 variants, and timelines for further development, the decision has been made to cease activities on the CVnCoV candidate and to focus efforts on the development of next-generation vaccine candidates. Funding: German Federal Ministry of Education and Research and CureVac