CONTROLE DOS COMUNICANTES DE PACIENTES COM TUBERCULOSE PULMONAR EM UMA UNIDADE DE TRATAMENTO DE SÃO LUÍS (MA) EM 2008 e 2009

Este é um estudo descritivo sobre as ações de controle dos comunicantes de pacientes com tuberculose pulmonar em uma unidade de tratamento de São Luís (MA) em 2008 e 2009. Foram utilizados dados secundários das fchas de controle de comunicantes. Dos comunicantes de casos novos de tuberculose pulmonar, apenas 17% foram examinados. Os exames solicitados a esses comunicantes foram: 85 baciloscopias de escarro (70,2%), 48 testes tuberculínicos (39,7%) e 4 radiografas de tórax (3,3%). A unidade de tratamento não atingiu a meta de quatro comunicantes examinados por caso diagnosticado de tuberculose pulmonar. Não houve diagnóstico de casos novos de tuberculose nesses comunicantes. A avaliação da unidade de saúde mostrou a fragilidade do Programa de Controle de Tuberculose em São Luís, evidenciando a necessidade de padronização de condutas de controle e reformulação periódica das ações.descritores: Tuberculose Pulmonar; Comunicante; Frequência.Abstract: It is a descriptive study about the control actions of pulmonary tuberculosis patients’ contacts in a treatment unit of Sao Luis (MA) in 2008 and 2009. Secondary data were obtained from control chart of contacts. Among the contacts of new pulmonary tuberculosis cases, only 17% of them were examined. The required examinations to these contacts were 85 sputum smear microscopy (70.2%), 48 tuberculin skin tests (39.7%) and 4 chests X-ray (3.3%). The treatment unit has not achieved the goal of contacts examined per four diagnosed case of pulmonary tuberculosis. There were not new cases of TB diagnosed among those contacts. The evaluation of the health unit showed the fragility of the Tuberculosis Control Program in São Luís, highlighting the need for standard practices for controlling and periodic reformulation of the actions.descriptors: Pulmonary Tuberculosis; Contact; Frequency

Evidence of validity of the Stress-Producing Life Events (SPLE) instrument

OBJECTIVE: Evaluate the construct validity of a list of eight Stressful Life Events in pregnant women. METHODS: A cross-sectional study was conducted with 1,446 pregnant women in São Luís, MA, and 1,364 pregnant women in Ribeirão Preto, SP (BRISA cohort), from February 2010 to June 2011. In the exploratory factorial analysis, the promax oblique rotation was used and for the calculation of the internal consistency, we used the compound reliability. The construct validity was determined by means of the confirmatory factorial analysis with the method of estimation of weighted least squares adjusted by the mean and variance. RESULTS: The model with the best fit in the exploratory analysis was the one that retained three factors with a cumulative variance of 61.1%. The one-factor model did not obtain a good fit in both samples in the confirmatory analysis. The three-factor model called Stress-Producing Life Events presented a good fit (RMSEA < 0.05; CFI/TLI > 0.90) for both samples. CONCLUSIONS: The Stress-Producing Life Events constitute a second order construct with three dimensions related to health, personal and financial aspects and violence. This study found evidence that confirms the construct validity of a list of stressor events, entitled Stress-Producing Life Events Inventory.OBJETIVO: Avaliar a validade de construto de uma lista com oito Eventos de Vida Estressantes em gestantes. MÉTODOS: Foi conduzido um estudo transversal com 1.446 gestantes em São Luís, MA, e 1.364 em Ribeirão Preto, SP (coorte BRISA), de fevereiro de 2010 a junho de 2011. Na análise fatorial exploratória, utilizou-se a rotação oblíqua promax e para o cálculo da consistência interna, a confiabilidade composta. A validade de construto foi determinada por meio da análise fatorial confirmatória com o método de estimação dos mínimos quadrados ponderados ajustados pela média e variância. RESULTADOS: O modelo com o melhor ajuste na análise exploratória foi o que reteve três fatores com uma variância acumulada de 61,1%. O modelo com um fator não obteve um bom ajuste em ambas as amostras na análise confirmatória. O modelo com três fatores denominado Eventos de Vida Produtores de Estresse apresentou um bom ajuste (RMSEA < 0,05; CFI/TLI > 0,90) para as duas amostras. CONCLUSÕES: Os Eventos de Vida Produtores de Estresse constituem um construto de segunda ordem com três dimensões relacionadas à saúde, aos aspectos pessoais e financeiros e à violência. Este estudo encontrou evidências que confirmam a validade de construto de uma lista de eventos estressores, intitulado Inventário de Eventos de Vida Produtores de Estresse

PESO E VELOCIDADE DE GANHO PONDERAL EM CRIANÇAS ACOMPANHADAS EM PROGRAMA DE INCENTIVO À AMAMENTAÇÃO / WEIGHT AND WEIGHT GAIN VELOCITY IN CHILDREN FOLLOWED IN A PROGRAM TO ENCOURAGE BREASTFEEDING

Introdução: O aleitamento materno exclusivo, nos primeiros seis meses de vida, promove o crescimento infantil saudável. Objetivo: Analisar peso e velocidade do ganho ponderal, com relação ao padrão World Health Organization (WHO)/2006, em crianças amamentadas exclusivamente até o sexto mês, acompanhadas em um programa de incentivo à amamentação. Métodos: Estudo longitudinal realizado em Banco de Leite Humano (BLH), de outubro/2007 a novembro/2008. Amostra não probabilística, com 328 crianças a termo, peso ao nascer igual ou superior a 2,5kg e inferior ou igual a 4,0kg, em aleitamento exclusivo, do nascimento ao sexto mês. Avaliou-se o crescimento por meio de médias, desvio padrão; a velocidade do ganho ponderal, por meio de percentis. Finalizaram o estudo 181 crianças. Resultados: Meninos foram mais pesados que meninas, do primeiro ao sexto mês. Meninos e meninas dobraram peso médio de nascimento por volta do terceiro e quarto meses, respectivamente. A maior velocidade no ganho ponderal médio mensal ocorreu nos dois primeiros meses, em ambos os sexos, sendo mais expressiva nos meninos. A desaceleração na velocidade do ganho ponderal diário iniciou-se no segundo mês. O peso médio mostrou-se acima do padrão a partir do 3º mês. A velocidade de ganho ponderal acompanhou o percentil 50 do padrão, porém com desempenho melhor. Conclusão: O crescimento e a velocidade de ganho ponderal, em crianças amamentadas exclusivamente, assemelhou-se ao modelo WHO/2006.Palavras-chave: Crescimento. Ganho ponderal. Amamentação.AbstractIntroduction: Exclusive breastfeeding in the first six months of life promotes the infant growth. Objective: To evaluate weigh and velocity in weight gain, according to the standard of WHO / 2006, in infants that are exclusively breastfed till six months in a breastfeeding promotion program. Methods: Longitudinal research carried out at the Human Milk Bank from October/2007 to November/2008. A non-probability sample of 328 full term infants, with birth weight equal to or over 2.5 kg and lower or equal to 4.0kg who were exclusively breastfed since their birth. The growth was evaluated through mean standard deviation; the velocity in weight gain, through percentiles. 181 infants concluded the study. Results: Males weighed more than females from the first to the sixth month. Both males and females doubled their mean birth weight around the third and fourth months, respectively. The highest velocity of the mean monthly weight gain occurred in the first two months of life for both genders being more expressively in males. The slowdown in velocity of the daily weight gain started in the second month. The mean weight was superior to the standard value from the third month. The velocity of weight gain followed the 50th percentile curve of the standard value, however, with a better result. Conclusion. The growth and the velocity of weight gain in exclusively breastfed infants were alike the standards of WHO/2006.Keywords: Growth. Weight gain. Breastfeeding

Pontos de corte da circunferência do pescoço e da relação cintura-estatura como preditores da obesidade e risco cardiovascular em adolescentes

OBJECTIVE: To determine neck circumference (NC) and waist-to-height ratio (WHtR) cut-off points as predictors of obesity and cardiovascular risk in adolescents. METHODS: Cross-sectional study developed with a subsample of 648 adolescents aged 18 and 19 years belonging to the third phase of the “RPS” cohort (Ribeirão Preto, Pelotas and São Luís) carried out in 2016. The area under the ROC curve (AUC) was identified to assess the predictive capacity of NC and WHtR in relation to the percentage of body fat (%BF), obtained by air displacement plethysmography (ADP), and the cardiovascular risk estimated by the Pathobiological Determinants of Atherosclerosis in Youth (PDAY). RESULTS: The prevalence of obesity by %BF was 7.6% in males and 39.4% in females (p-value <0.001), and the high PDAY risk was 13.8% and 10.9%, respectively.  For males, NC cut-off point was 44.0 cm and the AUCs were 0.70 (95%CI 0.58-0.83) to predict obesity and 0.71 (95%CI 0.62-0.80) to predict high cardiovascular risk; for females, NC cut-off point was 40 cm and the AUCs were 0.75 (95%CI 0.69-0.80) and 0.63 (95%CI 0.53-0.73), respectively. WHtR cut-off point was 0.50 for both sexes; for males, the AUCs to predict obesity and high risk according to PDAY were 0.90 (95%CI 0.80-0.99) and 0.73 (95%CI 0.63-0.82), respectively; for females, they were 0.87 (95%CI 0.83-0.90) and 0.55 (95%CI 0.45-0.65), respectively.  CONCLUSION: WHtR and NC are good discriminators to assess obesity and cardiovascular risk in adolescents, especially in males.OBJETIVO: Determinar os pontos de corte da circunferência do pescoço (CP) e da relação cintura-estatura (RCEst) para a predição da obesidade e do risco cardiovascular em adolescentes. MÉTODOS: Estudo transversal desenvolvido com uma subamostra de 634 adolescentes de 18 e 19 anos de idade pertencentes à terceira fase da coorte “RPS” (Ribeirão Preto, Pelotas e São Luís) realizada em 2017. Identificou-se a área sob a curva ROC (AUC) para avaliar a capacidade preditiva da CP e RCE em relação ao percentual de gordura corporal (%GC), obtido pela pletismografia por deslocamento de ar (PDA), e do risco cardiovascular estimado pelo Phatobiological Determinants of Atherosclerosis in Youth (PDAY). RESULTADOS: A prevalência de obesidade pelo %GC foi de 7,6% no sexo masculino e 39,4% no sexo feminino (p-valor < 0,001) e o alto risco para PDAY foi de 13,8% e 10,9%, respectivamente. Para a CP, o ponto de corte identificado para o sexo masculino foi de 44,0 cm e as AUC foram de 0,70 (IC95% 0,58-0,83) para predição de obesidade e de 0,71 (IC95% 0,62-0,80) para predição do alto risco cardiovascular; e para o sexo feminino foi de 40 cm e as AUC foram de 0,75 (IC95% 0,69-0,80) e de 0,63 (IC95% 0,53-0,73), respectivamente. Para a RCEst, o ponto de corte identificado foi de 0,50 para ambos os sexos e as AUC para a predição da obesidade e do alto risco segundo o PDAY foram de 0,90 (IC95% 0,80-0,99) e 0,73 (IC95% 0,63-0,82), respectivamente, para o sexo masculino; e de 0,87 (IC95% 0,83-0,90) e 0,55 (IC95% 0,45-0,65), respectivamente, para o sexo feminino. CONCLUSÃO: RCEst e CP como bons discriminadores para avaliar a obesidade e risco cardiovascular em adolescentes, especialmente no sexo masculino

Análise espacial dos óbitos por tuberculose em um estado do nordeste brasileiro

Introduction: Tuberculosis  is an important public health problem that affects different geographical areas. Objective: To analyze the spatial distribution of deaths from tuberculosis in Maranhão (Brazil) and its association with socioeconomic indicators. Method: Ecological study of tuberculosis deaths in Maranhão, from 2010 to 2015, using municipalities as the unit of analysis. The global Moran index, the correlogram, and the spread of the Moran index were used, and to assess the spatial association of tuberculosis deaths with socioeconomic indicators, different conditional autoregressive spatial models (CAR) were adjusted. Results: During the chosen period, 949 deaths from tuberculosis were reported. A strong spatial dependence was identified in the occurrence of deaths. Using the adjusted conditional autoregressive spatial model, it was found that approximately 12 % of the municipalities have more than a 75 % chance of death from tuberculosis and that the north and central parts of the state have the highest probability of death from tuberculosis. Conclusion: There was a strong spatial dependence on the occurrence of deaths from tuberculosis, which was affected by the rates in neighboring areas. The municipal human development index was negatively associated with the rate of deaths from tuberculosis and the average per capita income showed a positive association.Introducción: La tuberculosis  es un importante problema de salud pública y afecta a diferentes áreas geográficas. Objetivo: Analizar la distribución espacial de las muertes por tuberculosis en Maranhão (Brasil) y su asociación con indicadores socioeconómicos. Método: Estudio ecológico de las muertes por tuberculosis en Maranhão con municipios como unidad de análisis, entre 2010 y 2015. Se utilizaron el índice global de Moran, el correlograma y la dispersión del índice de Moran. Además, para evaluar la asociación espacial de las muertes por tuberculosis con los indicadores socioeconómicos, se ajustaron diferentes modelos espaciales autorregresivos condicionales. Resultados: Durante el período, se reportaron 949 muertes por tuberculosis. Se identificó una fuerte dependencia espacial en la ocurrencia de muertes. Utilizando el modelo espaciales autorregresivos condicionales ajustado, se encontró que, aproximadamente, el 12 % de los municipios tienen más del 75 % de probabilidad de muerte por tuberculosis. Además, que el norte y centro del estado son las regiones con mayor probabilidad de muerte por tuberculosis. Conclusión: Existió una fuerte dependencia espacial de la ocurrencia de muertes por tuberculosis, la cual fue afectada por las tasas en las áreas vecinas. El índice de desarrollo humano municipal se asoció negativamente con la tasa de muertes por tuberculosis y el ingreso per cápita promedio mostró una asociación positiva.Introdução: A tuberculose é um importante problema de saúde pública e atinge de maneira dessemelhante os espaços geográficos. Objetivo: analisar a distribuição espacial dos óbitos por tuberculose no Maranhão (Brasil) e sua associação com indicadores socioeconômicos. Método: Estudo ecológico dos óbitos por tuberculose no Maranhão, no período de 2010 a 2015, com unidade de análise, os municípios. Utilizou-se o índice de Moran global, correlograma e espalhamento do índice de Moran e para avaliar a associação espacial de óbitos por tuberculose com os indicadores socioeconômicos foram ajustados diferentes modelos espaciais condicionais autoregressivos. Resultados: No período, foram notificados 949 óbitos por tuberculose. Identificou-se uma forte dependência espacial na ocorrência dos óbitos. Por meio do modelo autoregressivo ajustado, constatou-se que aproximadamente 12% dos municípios possuem mais que 75% de chance de ocorrer um óbito por tuberculose e que o norte e a parte central do Estado são as regiões que concentram as maiores probabilidades de óbito. Conclusão: Houve forte dependência espacial na ocorrência de óbitos por TB, sendo esta afetada pelas taxas das áreas vizinhas. O índice de desenvolvimento humano municipal esteve negativamente associado com a taxa de óbitos por tuberculose e a renda média per capita apresentou associação positiva

Análise da estrutura fatorial do Audit em adolescentes entre 18 e 19 anos

OBJETIVO: Determinar a estrutura fatorial do instrumento Alcohol Use Disorders Identification Test (Audit) em uma amostra representativa de adolescentes de 18 a 19 anos. MÉTODOS: Estudo transversal realizado com adolescentes nascidos em São Luís (MA). A consistência interna do instrumento foi determinada pelo coeficiente alfa de Cronbach e a validade do construto foi avaliada por meio da Análise Fatorial Confirmatória (AFC). O índice de Kaiser-Meyer-Olkin (KMO) foi calculado para analisar a adequação da amostra. A qualidade de ajuste do modelo fatorial foi analisada de acordo com os índices dos testes qui-quadrado de ajustamento, comparative fit index (CFI), Tucker-Lewis index (TLI) e root mean square error of approximation (RMSEA). RESULTADOS: A amostra do estudo foi composta por 1.002 adolescentes entre 18 e 19 anos, sendo 56,8% meninas, 68,5% com 18 anos, 63,3% pardos ou mulatos, 48,6% pertencentes à classe C, 15,4% não trabalhavam e não estudavam e 52,1% tinham pais separados. A amostra foi adequada para a análise fatorial confirmatória (KMO = 0,79) e o coeficiente do alfa de Cronbach foi de 0,70, demostrando consistência interna satisfatória com cargas fatoriais acima de 0,5, com exceção do item 9 “Ficou ferido ou ficou alguém ferido por ter bebido”. A análise fatorial confirmatória revelou a validade do modelo de três fatores para a amostra em estudo com base nos índices de ajustes psicométricos. CONCLUSÃO: A estrutura fatorial do Audit com três fatores foi confirmada para a população de adolescentes entre 18 e 19 anos residentes em São Luís, ratificando os domínios conceituais originais propostos pela Organização Mundial da Saúde. O Audit apresentou-se como um instrumento confiável para a identificação do consumo de álcool.OBJECTIVE: To determine the factor structure of the instrument Alcohol Use Disorders Identification Test (AUDIT) in a representative sample of adolescents aged 18 to 19 years. METHODS: Cross-sectional study performed with adolescents born in São Luís (MA). The internal consistency of the instrument was determined by the Cronbach's alpha coefficient, and the validity of the construct was assessed by Confirmatory Factor Analysis (CFA). The Kaiser-Meyer-Olkin (KMO) was estimated to analyze the adequacy of the sample. The fit quality of the factor model was analyzed according to the indexes of the Chi-square adjustment test, comparative fit index (CFI), Tucker-Lewis index (TLI) and root mean square error of approximation (RMSEA). RESULTS: The sample of the study was composed of 1,002 adolescents aged from 18 to 19 years, being 56.8% girls, 68.5% with 18 years, 63.3% brown, 48.6% belonging to class C, 15.4% did not work or did not study, and 52.1% had divorced parents. The sample was suitable for confirmatory factor analysis (KMO = 0.79); Cronbach's alpha coefficient was 0.70, demonstrating satisfactory internal consistency with factor loads above 0.5, except for item 9, “was injured or someone else was injured due to drinking.” Confirmatory factor analysis revealed the validity of the three-factor model for the studied sample based on the indices of psychometric adjustments. CONCLUSION: The three-factor AUDIT factor structure was confirmed for the population of adolescents between 18 and 19 years old living in São Luís, ratifying the original conceptual domains proposed by the World Health Organization. AUDIT proved to be a reliable instrument to identify the consumption of alcohol

Analysis of dengue cases according to clinical severity, São Luís, Maranhão, Brazil

Severe dengue cases have increased in Brazil since 2001, with the first records in Maranhão dating back to 2002. The aim of this study was to determine the prevalence of severe dengue cases by age group and the possible risk factors. This was a study of secondary data on dengue in residents of São Luís, Maranhão, Brazil, using probable cases notified to the National Mandatory Reporting System (SINAN) from 2002 to 2011. The diagnosis and classification of dengue were based on the Brazilian Ministry of Health criteria: dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue fever with complications (DWC). DHF and DWC were considered severe dengue, and DF was classified as non-severe dengue. A logistic regression analysis was performed with severe dengue as the outcome. During the study period, 1,229 cases of severe dengue were reported; of these, 812 in patients under the age of 15 (66%). Among the risk factors evaluated, age under 15 years old (OR = 3.10, 95% CI = 2.69-3.57, p-value = 0.001) was associated with severe dengue. The prevalence of severe dengue in children under the age of 15 was higher, and only this age group was associated with the occurrence of severe dengue

Epidemiological and sociodemographic characterization of women and men with cancer in a State in the Brazilian Amazon

Objective: Objective: Analyzes the epidemiological and sociodemographic characterization of women and men with cancer in the State of Rondônia, Western Amazon (Brazil), diagnosed over a period of 2 (two) years. Materials and Methods: It is a documentary, cross-sectional and descriptive study, with the systematization of primary data, according to the methodological model recommended by Paraguassú-Chaves et al [25]. We used an instrument developde by Paraguassu-Chaves et al [26], semi-structured, divided into two blocks: (a) Block I – sociodemographic profile and (b) Block II – epidemiological profile. The Ethics Committee on Human Research at the reference hospital was asked to waive the Informed Consent Form. The research project is in accordance with Resolution 196/96 of the National Health Council of Brazil. Results: Of the 3.333 new cases of cancer, 53.4% ​​were female and 46.5% male. The 10 (ten) most common types of cancer among men and women in Rondônia over a 2-year period were non-melanoma skin (C44), breast (C50), prostate (C61), cervix (C53), stomach (C16), thyroid gland (C73), bronchi and lungs (C33-C34), colon (C18), reticuloendothelial hematopoietic system (C42) and rectal cancer (C20). An age range of 50 to 69 years was predominant in both sexes and patients with low educational level. The highest frequency was for married patients. There was a predominance of brown skin, patients born in the State of Rondônia (22.6%) and agricultural workers. The Unified Health System - SUS was responsible for the entry for treatment of 99.5% of patients. Most patients underwent “other isolated therapeutic procedures” and with the disease in advanced stages. Conclusions: The estimate of new cancer cases in Rondônia follows an increasing trend. The scenarios selected from the variables of the sociodemographic and epidemiological indicators of the research require the public health authorities of Rondônia, urgent redirection of actions and strategies for the prevention, control, assistance and treatment of cancer in women and men in Rondônia

Epidemiological, Sociodemographic And Clinical Profile of Men With Cancer in Rondônia, Brazilian Amazon

Objective: to analyze the epidemiological, sociodemographic and clinical profile of men in Rondônia, Western Amazonia (Brazil), diagnosed with the main types of cancer, during a period of 2 (two) years. Materials and Methods: it is an epidemiological, descriptive, cross-sectional and quantitative study, with the systematization of primary data according to the methodological model recommended by Paraguassu-Chaves et al [6]. We used an instrument developed by Paraguassu-Chaves et al [5], semi-structured composed of a series of epidemiological, clinical and sociodemographic variables. The research project is in compliance with Resolution 196/96 of the National Health Council of Brazil, taking into account the ethical aspects of research in Brazil. Main results: the 10 (ten) main types of cancer diagnosed by the location of the primary tumor in men were analyzed, corresponding to 1,163 (74.9%) cases of cancer in men, over a period of 2 (two) years. The 10 (ten) most common types of cancer in men were: prostate (30.9%), non-melanoma skin (22.9%), stomach (11.7%), bronchi and lungs (6.7%), colon (5.8%), leukemia (5.8%), esophagus (4.4%), central nervous system (4.2%), rectum (3.9%) and bladder (3.6%). The age group of 50 to 79 years old reaches 76.4% of the 10 main types of cancer in men. They are more frequent in brown (64.6%) and white (28%) men and with low education. 73.2% of men with cancer are married. 44.9% of men with cancer work in agriculture. 45.6% of men with cancer have a family history of cancer. The sum of smokers and ex-smokers reaches a relative frequency of 43.7%. 19.5% consume alcoholic beverages and 17.2% are ex-consumers. In 40.1%, "other isolated therapeutic procedures" were applied in the first treatment. 14.2% of diagnosed patients died from the disease. Conclusions: The scenario of cancer projection in men in Rondônia is worrying and requires an urgent redirection of actions and strategies for cancer prevention, control, assistance and treatment

Cistatina C e marcadores inflamatórios em receptores de transplante renal

OBJETIVO: O transplante renal é a melhor opção para pacientes renais crônicos em estágio terminal. Este estudo avaliou o perfil da cistatina C (CysC), interleucina 2 (IL-2), IL-6, e fator de necrose tumoral-α (TNF-α) como marcadores inflamatórios em 23 transplantados renais de doador vivo. MÉTODOS: Estudo descritivo, analítico e prospectivo conduzido entre 1o de janeiro (2007) e 30 de junho (2008) em 23 transplantados renais de doador vivo. Os biomarcadores foram avaliados no pré, com 30 e 180 dias do pós-transplante. RESULTADOS: A média de idade foi de 34,3 anos (± 11,7), 52% do sexo feminino e 61% de negros. Foi encontrada diferença significativa na CysC e creatinina antes do transplante e 30 dias após o procedimento (p < 0,0001) e antes do transplante e 180 dias após o procedimento (p < 0,0001). Houve uma diferença significativa na IL-2, entre 30 and 180 dias do pós-transplante (p = 0,0418) e no TNF-α antes do transplante e 30 dias após o procedimento (p = 0,0001). Foi observada uma correlação negativa entre CysC e TNF-α no pré-transplante, e entre CysC e IL-6 com 180 dias do pós-transplante. Em pacientes biopsiados houve uma diferença significante na creatinina e na CysC com 30 e 180 dias do pós-transplante. CONCLUSÃO: Em seguimento a curto prazo, não houve correlação relevante entre os níveis de CysC, IL-2, IL-6 e TNF-α em transplantados renais. Em pacientes biopsiados e não biopsiados, os níveis de CysC foram muito similares aos da creatinina, ao contrário de outros marcadores inflamatórios. Demais estudos são importantes para avaliar o perfil destes marcadores a longo prazo.OBJECTIVE: Kidney transplantation is the best option for patients with end-stage renal disease. This study evaluated the profile of cystatin C (CysC), interleukin 2 (IL-2), IL-6, and tumor necrosis factor-α (TNF-α) as inflammatory markers in 23 living donor kidney transplant recipients. METHODS: A descriptive, analytical and prospective study was conducted between January 1st, 2007 and June 30th, 2008 on 23 living donor kidney transplant recipients. The biomarkers were evaluated before and 30 and 180 days after transplantation. RESULTS: The mean age of the patients was 34.3 years (± 11.7), females (52%) and non-whites (61%). Significant difference was found in cystatin C and creatinine before and 30 days after transplantation (p < 0.0001) and before and 180 days after transplantation (p < 0.0001). There was a significant difference in IL-2 between 30 and 180 days post-transplant (p = 0.0418) and in TNF-α between pre-transplant and 30 days post-transplant (p = 0.0001). A negative correlation was observed between cystatin C and TNF-α at pre-transplant and between cystatin C and IL-6 at 180 days post-transplant. Comparison of biopsied and non-biopsied patients showed a significant difference in creatinine and cystatin C at 30 and 180 days post-transplant in biopsied patients. CONCLUSION: Our results showed no significant correlations between CysC, IL-2, IL-6 and TNF-α levels in kidney transplant recipients at short-term follow-up. Moreover, CysC levels were very similar to creatinine levels in contrast to other inflammatory markers studied in biopsied and non-biopsied patients. Further studies are important to evaluate the long-term profile of these markers