Spindle cell carcinoma: Two instances mistaken for vocal polyps

Spindle cell carcinoma is a variant of squamous carcinoma, with behavior that is apparently more aggressive than that of squamous carcinoma and that can produce distant lymphatic metastasis. It was first described by Virchow in 1864 [1], but the origin of the tumor is still not clear. The tumor is biphasic, with an epidermal component and a sarcomatous component involving spindle cells; transition zones between these components can be found [2–5]. In part due to this peculiar and complex nature, the tumor has accumulated various names since it was first described: sarcomatoid tumor, carci- nosarcoma, pleomorphic carcinoma, collision tumor, etc. [2,5,6]

Reconstrucción de defectos faríngeos

Reconstruction of pharyngeal defects continues to present a clinical challenge for the head and neck surgeon. We have different reconstructive options to preserve speech, airway, and swallowing functions. Reconstructive surgery implies a balance between oncologic cure, patient morbidity, and quality of life. Classical reconstructive techniques include pedicled cervical cutaneous or myocutaneous flaps and distal myocutaneous flaps such as from the pectoralis major. Current microvascular techniqu

Characterization of the shallow subsurface structure across the Carrascoy Fault System (SE Iberian Peninsula) using P-wave tomography and Multichannel Analysis of Surface Waves

The seismicity in the SE Iberian Peninsula is distributed parallel to the coast in a well-developed strike-slip fracture system known as the Eastern Betic Shear Zone (EBSZ). This work focuses on the characterization of the shallow subsurface structure of the Algezares-Casas Nuevas Fault, within the Carrascoy Fault System of the EBSZ. The Carrascoy Fault borders the Guadalentín Depression to the south, which is a densely populated area with extensive agricultural activity. Therefore, this faults system represents a seismic hazard with significant social and economic implications. We have constructed two velocity-depth models based on P-wave tomography and Multichannel Analysis of Surface Waves (MASW) acquired from seismic reflection data. The resulting velocity models have allowed us to interpret the first ~250m depth and have revealed: i) the thickness of the critical zone; ii) the geometry of the Algezares-Casas Nuevas Fault; iii) the depth of the Messinian/Tortonian contact and iv) the presence of blind thrusts and damage zones under the Guadalentín Depression. Our results have also helped us to estimate an apparent vertical slip rate of 0.66±0.06m/ky for the Algezares-Casas Nuevas Fault since 209.1±6.2ka. Our results provide a methodological and backflow protocol to study the shallow subsurface of active faults, complementing previous geological models based on paleoseismological trenches, and can be used to improve the seismic hazard assessment of tectonically active regions around the world.The authors would like to acknowledge the project INTERGEO (CGL2013-47412-C2-1-P) GEO3BCNCSIC for the data access. Data are public access through SeisDARE (DeFelipe et al., 2021), dataset Martí et al. (2015). The Ministry of Education and Culture of the Republic of Indonesia is thanked for the main author’s Ph.D. scholarship (D3.2/KD.02.01/2019). JA is funded by MICINN (IJC2018-026335-I). I.P. is funded by the Spanish Government and the Universidad de Salamanca (Beatriz Galindo grant BEGAL 18/00090). IDF is funded by a FEDER-Junta de Castilla y León Postdoctoral contract (SA0084P20). We thank the GIPP-GFZ, (Germany) and Lisbon University (Portugal) for the instrumentation provided. Generalitat de Catalunya (AGAUR) grant 2017SGR1022 (GREG); EU (H2020) 871121 (EPOSSP); and EIT-RawMaterias 17024 (SIT4ME). WPeer reviewe

Fault interpretation in seismic reflection data: an experiment analysing the impact of conceptual model anchoring and vertical exaggeration

The use of conceptual models is essential in the in- terpretation of reflection seismic data. It allows interpreters to make geological sense of seismic data, which carries inherent uncertainty. However, conceptual models can create powerful anchors that prevent interpreters from reassessing and adapting their interpretations as part of the interpretation process, which can subsequently lead to flawed or erroneous outcomes. It is therefore critical to understand how conceptual models are generated and applied to reduce unwanted effects in interpretation results. Here we have tested how interpretation of vertically exaggerated seismic data influenced the creation and adoption of the conceptual models of 161 participants in a paper-based interpretation experiment. Participants were asked to interpret a series of faults and a horizon, offset by those faults, in a seismic section. The seismic section was randomly presented to the participants with different horizontal-vertical exaggeration (1 : 4 or 1 : 2). Statistical analysis of the results indicates that early anchoring to specific conceptual models had the most impact on interpretation outcome, with the degree of vertical exaggeration having a subdued influence. Three different conceptual models were adopted by participants, constrained by initial observations of the seismic data. Interpreted fault dip angles show no evidence of other constraints (e.g. from the application of accepted fault dip models). Our results provide evidence of biases in interpretation of uncertain geological and geophysical data, including the use of heuristics to form initial conceptual models and anchoring to these models, confirming the need for increased understanding and mitigation of these biases to improve interpretation outcomes

Feasibility report of conservative surgery, perioperative high-dose-rate brachytherapy (PHDRB), and low-to-moderate dose external beam radiation therapy (EBRT) in pediatric sarcomas

This study was undertaken to determine the feasibility of perioperative high-dose-rate brachytherapy (PHDRB) as an accelerated boost in patients with pediatric sarcomas. METHODS AND MATERIALS: Five pediatric patients (ages 7-16) with soft tissue sarcomas (STS) or soft tissue recurrences of previously treated osteosarcomas were treated with surgical resection and PHDRB (16-24 Gy) for R0-R1 resections. Patients with STS and osteosarcomas received 27 Gy and 45 Gy of EBRT postoperatively. RESULTS: After a median follow-up of 27 months (range, 12-50) all the patients remain locally controlled. Only 1 patient developed regrowth of pulmonary metastases and died of distant disease at 16 months. CONCLUSIONS: The use of PHDRB is safe in the short-term in this pediatric population. Only 1 patient suffered a partial wound dehiscence that may not be entirely related to PHDRB. Patients with recurrent osteosarcomas can be treated in a fashion similar to their adult soft tissue counterparts and avoid limb amputation. Younger patients with STS may achieve local control and prevent growth retardation with a combination of PHDRB and moderate doses of EBR

Lacrimal Diversion Devices (Sinopsys Lacrimal Stent): Sharing our Experience with Patients with Chronic Rhinosinusitis without Polyposis

Introduction: Chronic rhinosinusitis (CRS) is a highly prevalent pathology in our society. Due to the prevalence of this condition and to the persisting symptoms despite an appropriate medical treatment, surgical techniques are often required. Lately, minimal invasive techniques have been described, such as lacrimal diversion devices (LDDs). This technique offers a fast and convenient choice for delivery of sinus irrigation and topical medication. Objective: We aimed to describe our experience with LDDs and evaluate the safety and effectiveness of the procedure in patients with moderate to severe CRS without nasal polyposis (CRSsNP) and persistent symptomatology despite medical therapy. Methods: A total of 7 patients underwent bilateral lacrimal stents placement in the operating room. A retrospective observational study was conducted. The Sino-Nasal Outcome Test-20 (SNOT-20) survey was performed and the score obtained was compared before and 1 month after the procedure. Results: The LDDs were used for an average of 80 days. During the follow-up, only three patients had a mild complication with the device (granuloma in the punctum, obstruction, and early extrusion). The mean baseline SNOT-20 score dropped significantly (p ¼ 0.015) from 25.85 to 11.57 (mean: - 14.29) 1 month after the procedure. Conclusion: According to our experience and results, the use of LDD is a novel, feasible, and less invasive technique to treat refractory CRS. It reduces the risk of mucosal stripping, provides short-term outcomes, and the surgical procedure does not require advanced training in endoscopic sinus surgery. Moreover, it can be performed in-office under local anesthesia or sedation

A criteria-driven approach to the CO2 storage site selection of East Mey for the acorn project in the North Sea

Carbon Capture and Storage (CCS) is an essential tool in the fight against climate change. Any prospective storage site must meet various criteria that ensure the effectiveness, safety and economic viability of the storage operations. Finding the most suitable site for the storage of the captured CO2 is an essential part of the CCS chain of activity. This work addresses the site selection of a second site for the Acorn CCS project, a project designed to develop a scalable, full-chain CCS project in the North Sea (offshore northeast Scotland). This secondary site has been designed to serve as a backup and upscaling option for the Acorn Site, and has to satisfy pivotal project requirements such as low cost and high storage potential. The methodology followed included the filtering of 113 input sites from the UK CO2Stored database, according to general and project-specific criteria in a multi-staged approach. This criteria-driven workflow allowed for an early filtering out of the less suitable sites, followed by a more comprehensive comparison and ranking of the 15 most suitable sites. A due diligence assessment was conducted of the top six shortlisted sites to produce detailed assessment of their storage properties and suitability, including new geological interpretation and capacity calculations for each site. With the new knowledge generated during this process, a critical comparison of the sites led to selection of East Mey as the most suitable site, due to its outstanding storage characteristics and long-lasting hydrocarbon-production history, that ensure excellent data availability to risk-assess storage structures. A workshop session was held to present methods and results to independent stakeholders; feedback informed the final selection criteria. This paper provides an example of a criteria-driven approach to site selection that can be applied elsewhere.Project ACT-Acorn is gratefully thanked for funding this study. ACT Acorn, project 271500, received funding from BEIS (UK), RCN (Norway) and RVO (Netherland), and was co-funded by the European Commission under the ERA-Net instrument of the Horizon 2020 programme. ACT Grant number 691712. J. Alcalde is funded by MICINN (Juan de la Cierva fellowship - IJC2018-036074-I). S. Ghanbari is currently supported by the Energi Simulation. Energi Simulation is also thanked for funding the chair in reactive transport simulation held by E. Mackay.Peer reviewe

Basement structure of the Hontomín CO2 Geological storage facility (Burgos, Spain): integration of microgravity & 3D seismic reflection data

The structure of the Hontomín CO2 geological storage research facility has been addressed combining 3D seismic reflection data, borehole information and microgravity data. The integrated interpretation constrains the basement structural setting geometry and that of the sedimentary succession. The study unravels the deep structure and topography of the basement and quantifies the thickness of the Triassic Keuper evaporites. We describe a half-graben setting filled with Keuper evaporites (up to 2000 m) forming an extensional forced fold. Three set of faults are identified with two main fault systems compartmentalizing the area into three differentiated blocks. These faults have been interpreted to be reactivated normal faults that have led to the formation of the Hontomín dome.The datasets in this work have been funded by Fundación Ciudad de la Energía (Spanish Government, www.ciuden.es) and by the European Union through the “European Energy Programme for Recovery” and the Compostilla OXYCFB300 project. Dr. Juan Alcalde is currently funded by NERC grant NE/M007251/1.Peer Reviewe

Basement structure of the Hontomín CO2 Geological storage facility (Burgos, Spain): integration of microgravity & 3D seismic reflection data

The structure of the Hontomín CO2 geological storage research facility has been addressed combining 3D seismic reflection data, borehole information and microgravity data. The integrated interpretation constrains the basement structural setting geometry and that of the sedimentary succession. The study unravels the deep structure and topography of the basement and quantifies the thickness of the Triassic Keuper evaporites. We describe a half-grabensetting filled with Keuper evaporites (up to 2000 m) forming an extensional forced fold. Three set of faults are identified with two main fault systems compartmentalizing the area into three differentiated blocks. These faults have been interpreted to be reactivated normal faults that have led to the formation of the Hontomín dome.The datasets in this work have been funded by Fundación Ciudad de la Energía (Spanish Government, www.ciuden.es) and by the European Union throughthe “European Energy Programme for Recovery” and the Compostilla OXYCFB300 project. Dr. Juan Alcalde is currently funded by NERC grant NE/M007251/1.Peer Reviewe

Summer truffle in the Iberian Peninsula: current status and crop potential

La trufa de verano (Tuber aestivum, incluyendo Tuber uncinatum) es una especie de un gran valor económico y social, que se produce de modo silvestre en toda Europa, norte de África y parte de Oriente medio. Los esfuerzos de cultivo de esta especie en la península ibérica han permanecido en un segundo plano debido a las condiciones adecuadas de ciertos terrenos para cultivar especies de mayor valor económico, como la trufa negra (Tuber melanosporum). Sin embargo, la trufa de verano es una alternativa viable y muy productiva para zonas de dudosa aptitud para T. melanosporum. En este trabajo, mediante revisión bibliográfica, se ponen de manifiesto los siguientes aspectos: la distribución y ecología de T. aestivum, la situación actual del cultivo, así como las perspectivas de futuro propias de esta especie en la península ibérica. En rasgos generales, se ha constatado su mayor amplitud ecológica y geográfica en relación a la trufa negra y se ha observado que es un cultivo incipiente pero en crecimiento. Sin embargo, se ha deducido que aún es necesario realizar un gran esfuerzo para dar a conocer este producto tanto a cultivadores como a consumidores potenciales en España así como divulgar aspectos técnicos sobre la gestión de su cultivo.Summer truffle (Tuber aestivum, including Tuber uncinatum) is a species of great economic and social value. Wild summer truffles are produced all over Europe, North Africa and part of the Middle East. This species has been underutilized in the Iberian Peninsula due to ability of certain areas to cultivate species of greater economic value, such as the black truffle (Tuber melanosporum). However, the summer truffle is an alternative species for areas where the black truffle is not well adapted. In this paper, the distribution and ecology of T. aestivum, the current situation and the future prospects of this crop in the Iberian Peninsula is reviewed. Summer truffle is a growing crop, well adapted in greater ecological and geographical areas than black truffle. However, it is still necessary to carry out further efforts to publicize it to both growers and consumers in Spain and to spread technical aspects of its managementPublishe