Giancarlo De Carlo y la participación: El caso del villaggio Matteotti. Terni, Italia

The description of the process of participation of the users of the villaggio Matteotti is toured through the different moments and various ways in which it is carried out: questionnaires, interviews, debates, publications, exhibitions, guided tours. The narration of the events, which are followed for six years from the establishment of the urban study to the delivery of the departments, seeks to clarify the effective power of decision of the users and how their needs influence in the building finally constructed. This history cannot go without the spaces of the previous complex, the clients, the inhabitants, the managers, the financing programs for the workers, the state companies involved in the construction or the contributions of the sociologist, the curator and the graphic designer of the exhibitions, as well as the company’s magazines or the support of the operators.La descripción del proceso de participación de los usuarios del villaggio Matteotti se recorre a través de los diferentes momentos y varios modos en los cuales se realiza: cuestionarios, entrevistas, debates, publicaciones, exposiciones, visitas guiadas. La narración de los eventos, que se siguen por seis años desde el establecimiento del estudio urbanístico hasta la entrega de los departamentos, busca aclarar el efectivo poder de decisión de los usuarios y cómo sus necesidades influyen sobre el edificio finalmente construido. Esta historia no puede prescindir de los espacios del complejo precedente, de los clientes, de los habitantes, de los encargados, de los programas de financiamiento para los trabajadores, de las empresas del Estado involucradas en la construcción o las contribuciones del sociólogo, del curador y del diseñador gráfico de las exposiciones, así como de las revistas de la empresa o el apoyo de los operadores

The importance of live binary evolution in numerical simulations of binaries embedded in circumbinary discs

The shrinking of a binary orbit driven by the interaction with a gaseous circumbinary disc, initially advocated as a potential way to catalyze the binary merger, has been recently debated in the case of geometrically thick (i.e. with $H/R\gtrsim 0.1$) discs. However, a clear consensus is still missing mainly owing to numerical limitations, such as fixed orbit binaries or lack of resolution inside the cavity carved by the binary in its circumbinary disc. In this work, we asses the importance of evolving the binary orbit by means of hydrodynamic simulations performed with the code {\sc gizmo} in meshless-finite-mass mode. In order to model the interaction between equal mass circular binaries and their locally isothermal circumbinary discs, we enforce hyper-Lagrangian resolution inside the cavity. We find that fixing the binary orbit ultimately leads to an overestimate of the gravitational torque that the gas exerts on the binary, and in an underestimate of the torque due to the accretion of material onto the binary components. Furthermore, we find that the modulation of the accretion rate on the binary orbital period is strongly suppressed in the fixed orbit simulation, while it is clearly present in the live binary simulations. This has potential implications for the prediction of the observable periodicities in massive black hole binary candidates.Comment: 7 pages, 8 figures, accepted for publication in MNRA

Anomalous diffusion in the Long-Range Haken-Strobl-Reineker model

We analyze the propagation of excitons in a $d$-dimensional lattice with power-law hopping $\propto 1/r^\alpha$ in the presence of dephasing, described by a generalized Haken-Strobl-Reineker model. We show that in the strong dephasing (quantum Zeno) regime the dynamics is described by a classical master equation for an exclusion process with long jumps. In this limit, we analytically compute the spatial distribution, whose shape changes at a critical value of the decay exponent $\alpha_{\rm cr} = (d+2)/2$. The exciton always diffuses anomalously: a superdiffusive motion is associated to a L\'evy stable distribution with long-range algebraic tails for $\alpha\leq\alpha_{\rm cr}$, while for $\alpha > \alpha_{\rm cr}$ the distribution corresponds to a surprising mixed Gaussian profile with long-range algebraic tails, leading to the coexistence of short-range diffusion and long-range L\'evy-flights. In the many-exciton case, we demonstrate that, starting from a domain-wall exciton profile, algebraic tails appear in the distributions for any $\alpha$, which affects thermalization: the longer the hopping range, the faster equilibrium is reached. Our results are directly relevant to experiments with cold trapped ions, Rydberg atoms and supramolecular dye aggregates. They provide a way to realize an exclusion process with long jumps experimentally.Comment: 5 pages, 2 figure

Cortisol in hair: a comparison between wild and feral cats in the north-eastern Alps

The quantification of glucocorticoid metabolites in hair is a non-invasive tool that provides important information regarding the endocrine status and represents a valuable method for studying potential stressors that may affect carnivores under both natural and non-natural conditions. Cortisol is the main glucocorticoid hormone of the hypothalamic-pituitary-adrenal gland axis and is considered a standard stress indicator for animal welfare. The current study aimed to compare cortisol levels extracted from hair of both dead, frozen European wildcats (Felis silvestris silvestris) and living feral individuals (Felis silvestris catus) living in different environmental conditions. The results obtained revealed that wild individuals exhibited a significantly (p < 0.001) higher cortisol concentration (n = 15, mean \ub1 SD = 8.91 \ub1 4.48 pg/mg) than feral ones (n = 10, mean \ub1 SD = 3.57 \ub1 1.25 pg/mg), probably as a result of both the physiological and/or environmental factors to which each subspecies was subject. This is the first study in which cortisol concentrations have been compared within the Felis silvestris subspecies, thus enriching the scarce information available for the Felidae. Nevertheless, further research is needed to better understand the various physiological and ecological factors affecting the adrenocortical activity of species or populations living in different environmental contexts

The role of slab geometry in the exhumation of cordilleran-type orogens and their forelands: Insights from northern Patagonia

In cordilleran-type orogens, subduction geometry exerts a fundamental control on the tectonic behavior of the overriding plate. An integrated low-temperature, large thermochronological data set is used in this study to investigate the burial and exhumation history of the overriding plate in northern Patagonia (40°–45°S). Thermal inverse modeling allowed us to establish that a ~2.5–4-km-thick section originally overlaid the Jurassic–Lower Cretaceous successions deposited in half-graben systems that are presently exposed in the foreland. Removal of the sedimentary cover started in the late Early Cretaceous. This was coeval with an increase of the convergence rate and a switch to a westward absolute motion of the South American Plate that was accompanied by shallowing of the subducting slab. Unroofing was probably further enhanced by Late Cretaceous to early Paleogene opening of a slab window beneath the overriding plate. Following a tectonically quiescent period, renewed exhumation occurred in the orogen during relatively fast Neogene plate convergence. However, even the highly sensitive apatite (U-Th)/He thermochronometer does not record any coeval cooling in the foreland. The comparison between Late Cretaceous and Neogene exhumation patterns provides clear evidence of the fundamental role played by inter-plate coupling associated with shallow slab configurations in controlling plate-scale deformation. Our results, besides highlighting for the first time how the whole northern Patagonia foreland was affected by an exhumation of several kilometers since the Late Cretaceous, provide unrivalled evidence of the link between deep geodynamic processes affecting the slab and the modes and timing of unroofing of different sectors of the overriding plate.Fil: Genge, Marie C.. Università di Padova; Italia. Centre National de la Recherche Scientifique; Francia. Université de Lille; Francia. Université du Littoral; FranciaFil: Zattin, Massimiliano. Università di Padova; ItaliaFil: Savignano, Elisa. Università di Padova; ItaliaFil: Franchini, Marta Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Confluencia; Argentina. Universidad Nacional de Río Negro. Sede Alto Valle. Instituto de Investigaciones en Paleobiología y Geología; Argentina. Universidad Nacional del Comahue; ArgentinaFil: Gautheron, Cécile. Université Paris Sud; Francia. Centre D'etudes de Saclay; Francia. Centre National de la Recherche Scientifique; FranciaFil: Ramos, Victor Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Mazzoli, Stefano. Università degli Studi di Camerino; Itali

Itaconic-Acid-Based Sustainable Poly(ester amide) Resin for Stereolithography

Material science is recognized as a frontrunner in achieving a sustainable future, owing to its primary reliance upon petroleum-based chemical raw materials. Several efforts are made to implement common renewable feedstocks as an alternative to common fossil resources. For this purpose, additive manufacturing (AM) represents promising and effective know-how for the replacement of high energy- and resource-demanding processes with more environmentally friendly practices. This work presents a novel biobased ink for stereolithography, which has been formulated by mixing a photocurable poly(ester amide) (PEA) obtained from renewable resources with citrate and itaconate cross-linkers and appropriate photopolymerization initiators, terminators, and dyes. The mechanical features and the relative biocompatibility of 3D-printed objects have been carefully studied to evaluate the possible resin implementation in the field of the textile fashion industry.9 página

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity is essential to control faithful DNA replication and to prevent accumulation of deleterious DNA double-strand breaks. In humans, hypomorphic mutations in these genes lead to DNA damage response (DDR)-defective and cancer-prone syndromes. Moreover, MRN complex dysfunction dramatically affects the nervous system, where MRE11 is required to restrain MYCN-dependent replication stress, during the rapid expansion of progenitor cells. MYCN activation, often due to genetic amplification, represents the driving oncogenic event for a number of human tumors, conferring bad prognosis and predicting very poor responses even to the most aggressive therapeutic protocols. This is prototypically exemplified by neuroblastoma, where MYCN amplification occurs in about 25% of the cases. Intriguingly, MRE11 is highly expressed and predicts bad prognosis in MYCN-amplified neuroblastoma. Due to the lack of direct means to target MYCN, we explored the possibility to trigger intolerable levels of replication stress-dependent DNA damage, by inhibiting MRE11 in MYCN-amplified preclinical models. Indeed, either MRE11 knockdown or its pharmacological inhibitor mirin induce accumulation of replication stress and DNA damage biomarkers in MYCN-amplified cells. The consequent DDR recruits p53 and promotes a p53-dependent cell death, as indicated by p53 loss- and gain-of-function experiments. Encapsulation of mirin in nanoparticles allowed its use on MYCN-amplified neuroblastoma xenografts in vivo, which resulted in a sharp impairment of tumor growth, associated with DDR activation, p53 accumulation, and cell death. Therefore, we propose that MRE11 inhibition might be an effective strategy to treat MYCN-amplified and p53 wild-type neuroblastoma, and suggest that targeting replication stress with appropriate tools should be further exploited to tackle MYCN-driven tumors

Efeito das classes de peso sobre o rendimento de processamento de tucunaré (Cichla sp.)

The study aimed to examine the carcass yield, fillet of animal by-products and to establish standards of weight economically viable for the marketing and consumption. We used 60 copies of tucunar&eacute; divided into six weight classes: 0 to 500g (C1) 501 to 1.000g (C2); 1001 to 1500g (C3), 1501 will 2.000g (C4), 2001 to 2,500 g (C5 ) 2.501g above (C6). We measured the following parameters: PCE - gutted body weight; PF - weight of the fillet; PS - weight of the carcass + viscera + gills; CP - = standard length measured from tip of snout to caudal peduncle; AC - body height ( AC) = measured from the base of the dorsal fin to the ventral part, the width of the fillet, the fillet length, thickness of the fillet. Later calculated the parameters of income. It is concluded that the fish of the C3 stood out due to a better yield of fillet. Already the C1 is more advantages over the other, provide a good income because of steak.O trabalho teve como objetivo analisar o rendimento de carca&ccedil;a, fil&eacute; e subprodutos do tucunar&eacute;, a fim de estabelecer padr&otilde;es de peso economicamente vi&aacute;veis para a comercializa&ccedil;&atilde;o e consumo. Foram utilizados 60 exemplares de tucunar&eacute; divididos em seis classes de peso: 0 &aacute; 500g (C1); 501 &aacute; 1.000g (C2); 1.001 &aacute; 1.500g (C3); 1.501 &aacute; 2.000g (C4); 2.001 &aacute; 2.500g (C5); 2.501g acima (C6). Foram aferidos os seguintes par&acirc;metros: PCE - peso do corpo eviscerado; PF - peso do fil&eacute;; PS - peso das v&iacute;sceras + br&acirc;nquias + carca&ccedil;a; CP - comprimento padr&atilde;o = aferido desde a ponta do focinho at&eacute; o ped&uacute;nculo caudal; AC - altura corporal = aferido desde a base da nadadeira dorsal at&eacute; a parte ventral; largura do fil&eacute;; comprimento do fil&eacute;; espessura do fil&eacute;. Posteriormente calculado os par&acirc;metros de rendimentos. Conclui-se que os peixes da C3 se destacaram devido a um melhor rendimento de fil&eacute;. J&aacute; a categoria C1 apresenta maiores vantagens sobre as demais, devido proporcionar um bom rendimento de fil&eacute;