Productivity, Technical eficiency and internationalisation of the Spanish chemical sector

relationship between productivity and international position of Spanish chemical firms in the period 2005-2011. The goal is to determine whether companies that follow and international strategy, either with exports or by investment in foreign countries obtain greater productivity growth than these that do not operate in global market. For this purpose a panel data set with microdata has been created. A preliminary analysis of the evolution of productivity growth in the sector is carried out. The measurement of Total Factor Productivity is performed. With the estimated TFP we analyze the differentials in productivity growth, comparing the effects of export and investment behavior with non-international firms

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and production of essential lipid-derived molecules. Interest in the organelle's cell biology has exponentially increased over the last decade due to the link between LDs and prevalent human diseases and the discovery of new and unexpected functions of LDs. As a result, there has been significant recent progress toward understanding where and how LDs are formed, and the specific lipid pathways that coordinate LD biogenesis

Spreads as international business productivity position the case of spanish chemical sector

Universidad Autónoma del Carib

Avaliação da eficiência técnica e hotel e camping sector em espanha /

Universidad Autónoma del Carib

Combustibles alternativos y análisis operativo de la introducción de GNL en formato de combustible dual

Estudio de los recientes combustibles alternativos aplicados a buques convencionales marcados por las estrictas legislaciones relacionadas con el control de las emisiones nocivas para el medio ambiente y la implementación de tecnologías de combustible dual para dichos buques que puedan afrontar las crecientes restricciones de forma económica, efectiva y plausible para sus armadores.Objectius de Desenvolupament Sostenible::7 - Energia Assequible i No Contaminan

Conocimiento y competitividad. Una visión desde la política pública

In the analysis of conceptual approaches to knowledge, it is observed how this radically modifies the economic structure (micro and macro) of national, territorial and local economies. That is why we must consider how there is a link between knowledge, competitiveness and public policy. Thus, competitiveness becomes a link between knowledge and public policy because it is a fundamental economic result in the sense that it represents the set of factors, institutions and policies that explain productivity.En el análisis de las aproximaciones conceptuales al conocimiento se observa cómo éste modifica radicalmente la estructura económica (micro y macro) de las economías nacionales, territoriales y locales. Es por ello que se debe considerar como existe un vínculo entre conocimiento, competitividad y política pública. Así mismo, la competitividad se convierte en un nexo de unión entre el conocimiento y la política pública porque es un resultado económico fundamental en el sentido de que representa al conjunto de factores, instituciones y políticas que explican la productividad

Insights Into the Biogenesis and Emerging Functions of Lipid Droplets From Unbiased Molecular Profiling Approaches.

Lipid droplets (LDs) are spherical, single sheet phospholipid-bound organelles that store neutral lipids in all eukaryotes and some prokaryotes. Initially conceived as relatively inert depots for energy and lipid precursors, these highly dynamic structures play active roles in homeostatic functions beyond metabolism, such as proteostasis and protein turnover, innate immunity and defense. A major share of the knowledge behind this paradigm shift has been enabled by the use of systematic molecular profiling approaches, capable of revealing and describing these non-intuitive systems-level relationships. Here, we discuss these advances and some of the challenges they entail, and highlight standing questions in the field.MS-Á acknowledges support from the Tec4Bio consortium (of which MD is co-coordinator; ref. S2018/NMT4443, Actividades de I+D entre Grupos de Investigación en Tecnologías, Comunidad Autónoma de Madrid/FEDER, Spain) and a CNIC-IPP COFUND MSCA fellowship, and is currently a recipient of a Ramón y Cajal research contract from the Spanish Ministry of Science and Innovation (RYC2020-029690-I). MAdP is an elected EMBO member, and research at his lab is supported by grants from the Spanish Ministry of Science and Innovation (PID2020-118658RB-I00, SAF2017-83130-R), La Caixa Health Research Programme (HR20-00075, AtheroConvergence), La Marató TV3 (201936-30-31) and the Asociación Española Contra el Cáncer (PROYE20089DELP). AP is an ICREA research professor and was supported by the Ministerio de Ciencia e Investigacion (MICINN, RTI2018-098593-B-I00) and the CERCA Programme/Generalitat de Catalunya. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovacion (MCIN) and the Pro CNIC Foundation), and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/ AEI/10.13039/501100011033).S

A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance

Recent studies have indicated a role for caveolin in regulating cholesterol-dependent signaling events. In the present study we have analyzed the role of caveolins in intracellular cholesterol cycling using a dominant negative caveolin mutant. The mutant caveolin protein, cav-3DGV, specifically associates with the membrane surrounding large lipid droplets. These structures contain neutral lipids, and are accessed by caveolin 1–3 upon overexpression. Fluorescence, electron, and video microscopy observations are consistent with formation of the membrane-enclosed lipid rich structures by maturation of subdomains of the ER. The caveolin mutant causes the intracellular accumulation of free cholesterol (FC) in late endosomes, a decrease in surface cholesterol and a decrease in cholesterol efflux and synthesis. The amphiphile U18666A acts synergistically with cavDGV to increase intracellular accumulation of FC. Incubation of cells with oleic acid induces a significant accumulation of full-length caveolins in the enlarged lipid droplets. We conclude that caveolin can associate with the membrane surrounding lipid droplets and is a key component involved in intracellular cholesterol balance and lipid transport in fibroblasts

Cellubrevin is present in the basolateral endocytic compartment of hepatocytes and follows the transcytotic pathway after IgA internalization

The endocytic compartment of polarized cells is organized in basolateral and apical endosomes plus those endocytic structures specialized in recycling and transcytosis, which are still poorly characterized. The complexity of the various populations of endosomes has been demonstrated by the exquisite repertoire of endogenous proteins. In this study we examined the distribution of cellubrevin in the endocytic compartment of hepatocytes, since its intracellular location and function in polarized cells are largely unknown. Highly purified rat liver endosomes were isolated from estradiol-treated rats, and the early/sorting endosomal fraction was further subfractionated in a multistep sucrose density gradient, and studied. Analysis of dissected endosomal fractions showed that cellubrevin was located in early/sorting endosomes, with Rab4, annexins II and VI, and transferrin receptor, but in a specific subpopulation of these early endosomes with the same density range as pIgA and Raf-1. Interestingly, only in those isolated endosomal fractions, endosomes enriched in transcytotic structures (of livers loaded with IgA), the polymeric immunoglobulin receptor specifically co-immunoprecipitated with cellubrevin. In addition, confocal and immuno-electron microscopy identification of cellubrevin in tubular structures underneath the sinusoidal plasma membrane together with the re-organization of cellubrevin, in the endocytic compartment, after the IgA loading, strongly suggest the involvement of cellubrevin in the transcytosis of pIgA