Elicitation and representation of expert knowledge for computer aided diagnosis in mammography

To study how professional radiologists describe, interpret and make decisions about micro-calcifications in mammograms. The purpose was to develop a model of the radiologists' decision making for use in CADMIUM II, a computerized aid for mammogram interpretation that combines symbolic reasoning with image processing

86, 43, and 22 GHz VLBI Observations of 3C120

We present the first 86 GHz VLBI observations of the radio galaxy 3C~120, together with contemporaneous 43 and 22 GHz polarimetric VLBA observations. The very high angular resolution obtained at 86 GHz provides an upper limit to the size of the core of 54 $\mu$as (0.025 $h^{-1}$pc). This represents a direct determination of the base of the jet which is independent of variability arguments (which depend on uncertain estimates of the Doppler factor), and places it below approximately one light-month. Comparison with previous VLBA observations after a one-year interval shows pronounced changes in the structure and polarization of the jet. Most of the components are found to follow a curved path while undergoing a steepening of their spectra accompanied by a decrease in total and polarized emission. However, at least one component is observed to follow a quasi-ballistic motion, accompanied by a flattening of its spectrum, as well as an increase in total and polarized flux. This may be explained by its interaction with the external medium, resulting in a shock that enhances the emission and aligns the magnetic field perpendicular to the component motion, thereby producing an increase of the degree of polarization from undetected values to as high as 15%. A second strong component, with the highest degree of polarization (23%), is found to have experienced a displacement from the ridge line of the structural position angle of the jet as it moved downstream. We have found a mean swing to the south of the position angle of the innermost components of $\sim 6^{\circ}$ between late 1996 and 1997, which may be responsible for the jet curvature observed at parsec and kiloparsec scales.Comment: 12 pages, 1 figure. Accepted for publication in ApJ Letter

Effects of incorrect computer-aided detection (CAD) output on human decision-making in mammography

To investigate the effects of incorrect computer output on the reliability of the decisions of human users. This work followed an independent UK clinical trial that evaluated the impact of computer-aided detection(CAD) in breast screening. The aim was to use data from this trial to feed into probabilistic models (similar to those used in "reliability engineering") which would detect and assess possible ways of improving the human-CAD interaction. Some analyses required extra data; therefore, two supplementary studies were conducted. Study 1 was designed to elucidate the effects of computer failure on human performance. Study 2 was conducted to clarify unexpected findings from Study 1

How to discriminate between computer-aided and computer-hindered decisions: a case study in mammography

Background. Computer aids can affect decisions in complex ways, potentially even making them worse; common assessment methods may miss these effects. We developed a method for estimating the quality of decisions, as well as how computer aids affect it, and applied it to computer-aided detection (CAD) of cancer, reanalyzing data from a published study where 50 professionals (“readers”) interpreted 180 mammograms, both with and without computer support. Method. We used stepwise regression to estimate how CAD affected the probability of a reader making a correct screening decision on a patient with cancer (sensitivity), thereby taking into account the effects of the difficulty of the cancer (proportion of readers who missed it) and the reader’s discriminating ability (Youden’s determinant). Using regression estimates, we obtained thresholds for classifying a posteriori the cases (by difficulty) and the readers (by discriminating ability). Results. Use of CAD was associated with a 0.016 increase in sensitivity (95% confidence interval [CI], 0.003–0.028) for the 44 least discriminating radiologists for 45 relatively easy, mostly CAD-detected cancers. However, for the 6 most discriminating radiologists, with CAD, sensitivity decreased by 0.145 (95% CI, 0.034–0.257) for the 15 relatively difficult cancers. Conclusions. Our exploratory analysis method reveals unexpected effects. It indicates that, despite the original study detecting no significant average effect, CAD helped the less discriminating readers but hindered the more discriminating readers. Such differential effects, although subtle, may be clinically significant and important for improving both computer algorithms and protocols for their use. They should be assessed when evaluating CAD and similar warning systems

Gaining assurance in a voter-verifiable voting system

The literature on e-voting systems has many examples of discussion of the correctness of the computer and communication algorithms of such systems, as well as discussions of their vulnerabilities. However, a gap in the literature concerns the practical need (before adoption of a specific e-voting system) for a complete case demonstrating that the system as a whole has sufficiently high probability of exhibiting the desired properties when in use in an actual election. This paper discusses the problem of producing such a case, with reference to a specific system: a version of the Prêt à Voter scheme for voter-verifiable e-voting. We show a possible organisation of a case in terms of four main requirements – accuracy, privacy, termination and ‘trustedness’– and show some of the detailed organisation that such a case should have, the diverse kinds of evidence that needs to be gathered and some of the interesting difficulties that arise

Monthly 43 GHz VLBA Polarimetric Monitoring of 3C120 over 16 Epochs: Evidence for Trailing Shocks in a Relativistic Jet

We present a 16-month sequence of monthly polarimetric 43 GHz VLBA images of the radio galaxy 3C 120. The images probe the inner regions of the radio jet of this relatively nearby superluminal radio galaxy at a linear resolution of 0.07 $h_{65}^{-1}$ pc ($H_o= 65 h_{65}$ km s$^{-1}$ Mpc$^{-1}$). We follow the motion of a number of features with apparent velocities between 4.01$\pm$0.08 and $5.82\pm 0.13 h_{65}^{-1} c$. A new superluminal knot, moving at $4.29\pm 0.16 h_{65}^{-1} c$, is observed to be ejected from the core at a time coincident with the largest flare ever observed for this source at millimeter wavelengths. Changes in the position angle of this component, as well as a progressive rotation of its magnetic polarization vector, suggest the presence of a twisted (resembling a helix in projection) configuration of the underlying jet magnetic field and jet geometry. We identify several knots that appear in the wake of the new superluminal component, moving at proper motions $\sim 4$ times slower than any of the other moving knots observed in 3C 120. These features have properties similar to those of the ``trailing'' shocks seen in relativistic, time-dependent, hydrodynamical and emission simulations of compact jets. Such trailing compressions are triggered by pinch-mode jet-body instabilities caused by the propagation of a strong perturbation, which we associate with the new strong superluminal component.Comment: 4 pages, 5 figures, accepted for publication in Astrophysical Journal Letter

El equus stenonis cocchi como indicador biostatigráfico del plio-pleistoceno en Italia y España

[Resumen] Se esquematiza la cronoestratigrafía de los principales yacimientos de Vertebrados italianos del Plio-pleistoceno, de el Villafranquiense medio al Galerino. Se estudia, desde un punto de vista evolutivo, la presencia de las distintas formas de Equus stenonis Cocchi hasta la llegada de Equus caballus Linn. La comparación de los distintos estadios evolutivos de E. stenonis y su fauna acompañante permiten la elaboración de un Cuadro sinóptico en el cual los yacimientos españoles con Equus se correlacionan con sus sincrónicos italianos sobre una base estratigráfica comparada (BONADONNA, 1982; ARIAS et all., 1982) con los principales eventos geológicos en Europa[Abstract] The chronostratigraphy of the Plio-pleistocene marnmals italian deposits from middle Villafranchian to Galerian is surnmarized. The presence of different forms of Equus stenonis Cocchi until the appearance of the first kinds of Equus caballus Linn. is studied by an evolutive point of view. The comparison among the different evolutive levels of Equus stenonis and the associated fauna allow us to build a synoptic Table in which the spanish deposits with Equus are correlate to analogous italian ones ln a stratigraphic scale yet compared (BONADONNA, 1982; ARIAS et all., 1982) to the most important geological event ln Europ

Use of computer-aided detection (CAD) tools in screening mammography: a multidisciplinary investigation

We summarise a set of analyses and studies conducted to assess the effects of the use of a computer-aided detection (CAD) tool in breast screening. We have used an interdisciplinary approach that combines: (a) statistical analyses inspired by reliability modelling in engineering; (b) experimental studies of decisions of mammography experts using the tool, interpreted in the light of human factors psychology; and (c) ethnographic observations of the use of the tool both in trial conditions and in everyday screening practice. Our investigations have shown patterns of human behaviour and effects of computer-based advice that would not have been revealed by a standard clinical trial approach. For example, we found that the negligible measured effect of CAD could be explained by a range of effects on experts' decisions, beneficial in some cases and detrimental in others. There is some evidence of the latter effects being due to the experts using the computer tool differently from the intentions of the developers. We integrate insights from the different pieces of evidence and highlight their implications for the design, evaluation and deployment of this sort of computer tool