630 research outputs found
Suppressing decoherence of quantum algorithms by jump codes
The stabilizing properties of one-error correcting jump codes are explored
under realistic non-ideal conditions. For this purpose the quantum algorithm of
the tent-map is decomposed into a universal set of Hamiltonian quantum gates
which ensure perfect correction of spontaneous decay processes under ideal
circumstances even if they occur during a gate operation. An entanglement gate
is presented which is capable of entangling any two logical qubits of different
one-error correcting code spaces. With the help of this gate simultaneous
spontaneous decay processes affecting physical qubits of different code spaces
can be corrected and decoherence can be suppressed significantly
Calculations of the moon's heat history at different concentrations of radioactive elements taking account of the material differentiation with melting
A mathematical procedure for analyzing the heat conductivity of the lunar surface is discussed. The solution is based on homogeneous and laminated moon models and considers the effects of radioactive elements conveyed to the lunar surface by melting. The various parameters which introduce uncertainties into the numerical analysis are identified. The application of data obtained from radio astronomy and from analyses of lunar samples returned by the Apollo flights is explained. Tables of data are included to show the types and amounts of radioactive materials which have been identified
Calculations of the moon's thermal history at different concentrations of radioactive elements, taking into account differentiation on melting
Calculations of the thermal history of the moon were done by solving the thermal conductivity equation for the case in which the heat sources are the long lived radioactive elements Th, U, and K-40. The concentrations of these elements were adjusted to give 4 variations of heat flow. Calculations indicated that the moon's interior was heated to melting during the first 0.7 to 2.3 x 10 to the 9th power years. The maximum fusion involved practically the entire moon to a distance from 15 to 45 km beneath the surface, and started 3.5 to 4.0 x 10 to the 9th power years ago, or 2.5 x 3.0 x 10 to the 9th power years ago and continued for 1 to 2 x 10 to the 9th power years. The moon today is cooling. The current thickness of the solid crust is from 150 to 200 km and the heat flow exceeds the stationary value 1.5 fold
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Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis.
During epithelial ovarian cancer (EOC) progression, intraperitoneally disseminating tumor cells and multicellular aggregates (MCAs) present in ascites fluid adhere to the peritoneum and induce retraction of the peritoneal mesothelial monolayer prior to invasion of the collagen-rich submesothelial matrix and proliferation into macro-metastases. Clinical studies have shown heterogeneity among EOC metastatic units with respect to cadherin expression profiles and invasive behavior; however, the impact of distinct cadherin profiles on peritoneal anchoring of metastatic lesions remains poorly understood. In the current study, we demonstrate that metastasis-associated behaviors of ovarian cancer cells and MCAs are influenced by cellular cadherin composition. Our results show that mesenchymal N-cadherin-expressing (Ncad+) cells and MCAs invade much more efficiently than E-cadherin-expressing (Ecad+) cells. Ncad+ MCAs exhibit rapid lateral dispersal prior to penetration of three-dimensional collagen matrices. When seeded as individual cells, lateral migration and cell-cell junction formation precede matrix invasion. Neutralizing the Ncad extracellular domain with the monoclonal antibody GC-4 suppresses lateral dispersal and cell penetration of collagen gels. In contrast, use of a broad-spectrum matrix metalloproteinase (MMP) inhibitor (GM6001) to block endogenous membrane type 1 matrix metalloproteinase (MT1-MMP) activity does not fully inhibit cell invasion. Using intact tissue explants, Ncad+ MCAs were also shown to efficiently rupture peritoneal mesothelial cells, exposing the submesothelial collagen matrix. Acquisition of Ncad by Ecad+ cells increased mesothelial clearance activity but was not sufficient to induce matrix invasion. Furthermore, co-culture of Ncad+ with Ecad+ cells did not promote a 'leader-follower' mode of collective cell invasion, demonstrating that matrix remodeling and creation of invasive micro-tracks are not sufficient for cell penetration of collagen matrices in the absence of Ncad. Collectively, our data emphasize the role of Ncad in intraperitoneal seeding of EOC and provide the rationale for future studies targeting Ncad in preclinical models of EOC metastasis
Controlling quantum systems by embedded dynamical decoupling schemes
A dynamical decoupling method is presented which is based on embedding a
deterministic decoupling scheme into a stochastic one. This way it is possible
to combine the advantages of both methods and to increase the suppression of
undesired perturbations of quantum systems significantly even for long
interaction times. As a first application the stabilization of a quantum memory
is discussed which is perturbed by one-and two-qubit interactions
Foam-like compression behavior of fibrin networks
The rheological properties of fibrin networks have been of long-standing
interest. As such there is a wealth of studies of their shear and tensile
responses, but their compressive behavior remains unexplored. Here, by
characterization of the network structure with synchronous measurement of the
fibrin storage and loss moduli at increasing degrees of compression, we show
that the compressive behavior of fibrin networks is similar to that of cellular
solids. A non-linear stress-strain response of fibrin consists of three
regimes: 1) an initial linear regime, in which most fibers are straight, 2) a
plateau regime, in which more and more fibers buckle and collapse, and 3) a
markedly non-linear regime, in which network densification occurs {{by bending
of buckled fibers}} and inter-fiber contacts. Importantly, the spatially
non-uniform network deformation included formation of a moving "compression
front" along the axis of strain, which segregated the fibrin network into
compartments with different fiber densities and structure. The Young's modulus
of the linear phase depends quadratically on the fibrin volume fraction while
that in the densified phase depends cubically on it. The viscoelastic plateau
regime corresponds to a mixture of these two phases in which the fractions of
the two phases change during compression. We model this regime using a
continuum theory of phase transitions and analytically predict the storage and
loss moduli which are in good agreement with the experimental data. Our work
shows that fibrin networks are a member of a broad class of natural cellular
materials which includes cancellous bone, wood and cork
Quantum error correction of coherent errors by randomization
A general error correction method is presented which is capable of correcting
coherent errors originating from static residual inter-qubit couplings in a
quantum computer. It is based on a randomization of static imperfections in a
many-qubit system by the repeated application of Pauli operators which change
the computational basis. This Pauli-Random-Error-Correction (PAREC)-method
eliminates coherent errors produced by static imperfections and increases
significantly the maximum time over which realistic quantum computations can be
performed reliably. Furthermore, it does not require redundancy so that all
physical qubits involved can be used for logical purposes.Comment: revtex 4 pages, 3 fig
IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study.
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in these patients. We carried out a rigorous analysis of the associations between IgG anti-apoA-1 levels and disease activity, drug therapy, serology, damage, mortality and CVD events in a large British SLE cohort
Excitation of weakly bound Rydberg electrons by half-cycle pulses
The interaction of a weakly bound Rydberg electron with an electromagnetic
half-cycle pulse (HCP) is described with the help of a multidimensional
semiclassical treatment. This approach relates the quantum evolution of the
electron to its underlying classical dynamics. The method is nonperturbative
and is valid for arbitrary spatial and temporal shapes of the applied HCP. On
the basis of this approach angle- and energy-resolved spectra resulting from
the ionization of Rydberg atoms by HCPs are analyzed. The different types of
spectra obtainable in the sudden-impact approximation are characterized in
terms of the appearing semiclassical scattering phenomena. Typical
modifications of the spectra originating from finite pulse effects are
discussed.Comment: Submitted to Phys. Rev.
Peakons, R-Matrix and Toda-Lattice
The integrability of a family of hamiltonian systems, describing in a
particular case the motionof N ``peakons" (special solutions of the so-called
Camassa-Holm equation) is established in the framework of the -matrix
approach, starting from its Lax representation. In the general case, the
-matrix is a dynamical one and has an interesting though complicated
structure. However, for a particular choice of the relevant parameters in the
hamiltonian (the one corresponding to the pure ``peakons" case), the -matrix
becomes essentially constant, and reduces to the one pertaining to the finite
(non-periodic) Toda lattice. Intriguing consequences of such property are
discussed and an integrable time discretisation is derived.Comment: 12 plain tex page
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