The Status of Web 2.0 in Iran’s LIS Education / Maryam Sarrafzadeh, Afsaneh Hazeri and Soheila Alavi

The present paper discusses results of a study which aimed to explore the knowledge and use of Web 2.0 technologies by LIS academics in Iran and to explore the challenges they face for using these technologies. More specifically, the study was to find answers to the following questions: 1. How do Iran‘s LIS educators rate their awareness of Web 2.0 tools? 2. How and in what ways Iran‘s LIS educators use Web 2.0 tools and services for academic purposes? 3. What are the problems that inhibit Iran‘s LIS educators from using Library 2.0 applications? The research method was explorative and empirical. Data was collected through a web-based survey questionnaire containing both open and close ended questions. The results show that LIS academics in Iran had good level of familiarity with some Web 2.0 tools such as blog, wiki, YouTube and Facebook. However, their familiarity with some other Web 2.0 tools such as RSS feeds, Twitter, Flickr, Delicious and podcast was limited. Blog, discussion groups, chat tools, file sharing tools, Wikis and SMS, video sharing tools and forum were used respectively by LIS academics in their teaching. Internet filtering was identified as the most inhibiting barrier to the use of Web 2.0 tools. Lack of access to high speed internet and lack of training were pointed as the other identified barriers. Authors suggest that to reap the benefits of Web 2.0, LIS academics need to find alternative non filtered Web 2.0 tools to employ in their teaching and research

The Status of Web 2.0 in Iran’s LIS Education / Maryam Sarrafzadeh, Afsaneh Hazeri and Soheila Alavi

The present paper discusses results of a study which aimed to explore the knowledge and use of Web 2.0 technologies by LIS academics in Iran and to explore the challenges they face for using these technologies. More specifically, the study was to find answers to the following questions: 1. How do Iran‘s LIS educators rate their awareness of Web 2.0 tools? 2. How and in what ways Iran‘s LIS educators use Web 2.0 tools and services for academic purposes? 3. What are the problems that inhibit Iran‘s LIS educators from using Library 2.0 applications? The research method was explorative and empirical. Data was collected through a web-based survey questionnaire containing both open and close ended questions. The results show that LIS academics in Iran had good level of familiarity with some Web 2.0 tools such as blog, wiki, YouTube and Facebook. However, their familiarity with some other Web 2.0 tools such as RSS feeds, Twitter, Flickr, Delicious and podcast was limited. Blog, discussion groups, chat tools, file sharing tools, Wikis and SMS, video sharing tools and forum were used respectively by LIS academics in their teaching. Internet filtering was identified as the most inhibiting barrier to the use of Web 2.0 tools. Lack of access to high speed internet and lack of training were pointed as the other identified barriers. Authors suggest that to reap the benefits of Web 2.0, LIS academics need to find alternative non filtered Web 2.0 tools to employ in their teaching and research

The effect of supportive group therapy on menopause mental health

Background & Objective: Menopause effect on women quality of life and mental health. This study performed to determine the effect of supportive group therapy on menopause mental health condition in Sharekord. Materials & Methods: This study is a quasi experimental research. 46 menopause women who had research condition divided in case and control group. We used GHQ28 and demographic questionnaire in 3 stages for data gathering. group therapy session perform for case group. Data was analysed with SPSS soft ware..

27630 Assessing signs and symptoms of hidradenitis suppurativa from the patient perspective

Background: Qualitative research was conducted to develop a patient reported outcome (PRO) measure assessing symptoms/signs of hidradenitis suppurativa (HS), the HS Symptom Diary (HSSD). Methods: Concept elicitation (CE) and combined CE/cognitive debriefing (CD) interviews were conducted with adult patients with moderate-to-severe HS from 5 dermatology practices in North America. The CE portion of the interview sought to fully understand important concepts of HS. Subjects then completed the draft HSSD, and answered questions to evaluate its content, clarity, and relevance. Revisions were made iteratively to the HSSD. The study received institutional review board approval; subjects provided written informed consent. Results: 36 subjects were interviewed [6 = CE and 30 = CE/CD, 65% female; mean age = 39]. The most commonly reported lesion locations were armpits (81%), groin (75%), or under the breasts (31%). Subjects reported pain (100%), drainage (100%), itching (100%), swelling/ inflammation (94%), odor (86%), tenderness (81%), heat (64%), and pressure (64%) related to their lesions. The most bothersome symptoms were pain (94%), drainage (50%), swelling/inflammation (42%), and itching (33%). Pain was the most difficult symptom to manage (53%). In general, respondents were able to paraphrase each item and found the content to be clear and relevant. The final HSSD, developed as a daily diary with a 24-hour recall period, contains 8 items evaluating severity of each symptom/sign using an 11-point numeric rating scale. A 7-day version was also developed. Conclusion: Content validity of the HSSD in patients with moderate-to-severe HS has been demonstrated. Its measurement properties will be assessed using data from upcoming clinical studies

Surfactants: Role in biofilm management and cellular behaviour

Appropriate and effective wound cleaning represents an important process that is necessary for preparing the wound for improved wound healing and for helping to dislodge biofilms. Wound cleaning is of paramount importance to wound bed preparation for helping to enhance wound healing. Surfactant applications in wound care may represent an important area in the cleaning continuum. However, understanding of the role and significance of surfactants in wound cleansing, biofilm prevention and control, and enhancing cellular viability and proliferation is currently lacking. Despite this, some recent evidence on poloxamer-based surfactants where the surfactants are present in high concentration have been shown to have an important role to play in biofilm management; matrix metalloproteinase modulation; reducing inflammation; and enhancing cellular proliferation, behaviour, and viability. Consequently, this review aims to discuss the role, mode of action, and clinical significance of the use of medically accepted surfactants, with a focus on concentrated poloxamer-based surfactants, to wound healing but, more specifically, the role they may play in biofilm management and effects on cellular repair

Efficacy and Safety of Adalimumab in Conjunction With Surgery in Moderate to Severe Hidradenitis Suppurativa:The SHARPS Randomized Clinical Trial

IMPORTANCE: Surgery is a mainstay in the management of hidradenitis suppurativa (HS). Adalimumab is the first drug approved for HS. OBJECTIVE: To investigate the efficacy and safety of adalimumab in combination with wide-excision surgery followed by secondary intention healing. DESIGN, SETTING, AND PARTICIPANTS: The Safety and Efficacy of Adalimumab for Hidradenitis Suppurativa Peri-Surgically (SHARPS) trial was a phase 4, randomized, double-blind, placebo-controlled study of adalimumab in conjunction with surgery. Patients were enrolled in 45 sites across 20 countries from July 18, 2016, to February 2, 2019, with the last patient visit on October 16, 2019. Eligible patients (aged 18-65 years) had moderate to severe HS that required radical surgery in an axillary or inguinal region and had 2 other anatomical regions affected, with 1 or more regions at Hurley stage II or III. Analysis was conducted in November 2019. INTERVENTIONS: Patients were randomized 1:1 to receive continuous adalimumab, 40 mg, or placebo during presurgery (12 weeks), perioperative (2 weeks), and postoperative (10 weeks) periods. MAIN OUTCOMES AND MEASURES: The primary end point was the proportion of patients achieving HS clinical response across all body regions at week 12. RESULTS: Overall, 103 patients were randomized to adalimumab and 103 to matching placebo. Among all patients, 51% (n = 106) were women, 94% (n = 193) were White, and the mean (SD) age was 37.6 (11.3) years. At week 12, significantly more patients receiving adalimumab (49 of 103 [48%]) vs placebo (35 of 103 [34%]; P = .049) achieved HS clinical response across all body regions (treatment difference, 14% [95% CI, 0%-27%]). Treatment-emergent adverse events were reported in 74 of 103 patients (72%) and 69 of 103 patients (67%) in the adalimumab and placebo groups, respectively. No increased risk of postoperative wound infection, complication, or hemorrhage was observed with adalimumab vs placebo. Two deaths occurred in the adalimumab group; neither was considered as having a reasonable possibility of relationship to study drug. CONCLUSIONS AND RELEVANCE: Adalimumab was efficacious in conjunction with wide-excision surgery followed by secondary intention healing, with no need to interrupt treatment prior to surgery. These data support further investigation of adalimumab as an adjuvant therapy to surgery in patients with moderate to severe HS. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT0280897

Role of the complement pathway in inflammatory skin diseases: a focus on hidradenitis suppurativa

Although the role of immune dysregulation in hidradenitis suppurativa (HS) has yet to be elucidated, recent studies identified several complement abnormalities in patients with HS. The complement system serves a critical role in the modulation of immune response and regulation of cutaneous commensal bacteria. Complement is implicated in several inflammatory skin diseases including systemic lupus erythematosus, angioedema, pemphigus, bullous pemphigoid, and HS. A model of HS pathogenesis is proposed, integrating the role of commensal bacteria, cutaneous immune responses, and complement dysregulation. The role of complement in disease pathogenesis has led to the development of novel anticomplement agents and clinical trials investigating the efficacy of such treatments in HS

Depression and anxiety in adults with hidradenitis suppurativa

Importance Previous studies suggest that depression and anxiety are common in patients with hidradenitis suppurativa (HS), more so than other dermatological conditions. Yet, to the authors’ knowledge, no previous systematic review or meta-analysis has estimated the prevalence or odds ratio (OR) for those psychiatric comorbidities in this population. Objective To assess the prevalence and odds for depression and anxiety in patients with HS. Data Sources From July 25 to September 30, 2018, observational studies investigating the prevalence and odds for depression and anxiety in adults with HS were systematically searched without language restriction from the inception of each database to July 25, 2018, in PubMed/MEDLINE, Embase, and PsycINFO databases. Searches used various configurations of the terms hidradenitis suppurativa; acne inversa; depressive disorder; depression; anxiety; anxiety disorders; phobia, social; suicide; and suicide, attempted. In addition, the reference lists of included references were screened manually. Study Selection Two investigators independently screened references that measured prevalence rates and odds for depressive and anxiety symptoms in patients with HS. Of 136 unique references, 10 ultimately met inclusion criteria. Data Extraction and Synthesis Relevant data were extracted from eligible references. Authors were contacted to provide further information when necessary. Methodological quality of included studies was assessed through a modified version of the Newcastle-Ottawa Scale. Random-effects models were used to synthesize available evidence. Main Outcomes and Measures Prevalence rates and ORs for depression and anxiety in adults with HS were the primary outcome measures. Heterogeneity across studies was assessed with the I2 statistic. Sources of heterogeneity were explored through subgroup and meta-regression analyses. Results Ten studies comprising 40 307 participants with HS met inclusion criteria. The overall prevalence of depression was 16.9% (95% CI, 9.9%-27.2%). Heterogeneity was large. In the subgroup of studies that considered a clinical criteria–based diagnosis of depression, the prevalence of depression was 11.9% (95% CI, 4.9%-26.2%), compared with 26.8% (95% CI, 20.4%-34.5%) in studies that used a screening instrument. The methodological quality of included studies moderated those findings. The OR for depression in individuals with HS compared with individuals without HS was 1.84 (95% CI, 1.57-2.15). The prevalence of anxiety was 4.9% (95% CI, 1.7%-13.2%); there were insufficient data to determine an odds ratio for anxiety in persons with HS because 2 studies included a comparison group. Conclusions and Relevance This systematic review and meta-analysis indicates that depression and anxiety are common comorbid conditions in patients with HS. Results suggest that the development of strategies to recognize and treat those psychiatric comorbidities in patients with HS is warranted

The Global Hidradenitis Suppurativa Atlas (GHiSA) methodology: Combining global proportions in a pooled analysis

Introduction: Data concerning the global burden of Hidradenitis Suppurativa (HS) are limited. Reported prevalence estimates vary between 0.0003% and 4.1%, and data from various geographical regions are still to be collected. Previously reported prevalence rates have been limited by the methodological approach and source of data. This has resulted in great heterogeneity as prevalence data from physician-diagnosed cases poorly match those of self-reported apparent HS disease. Methods: The Global Hidradenitis Suppurativa Atlas (GHiSA) introduces an innovative approach to determine the global prevalence of HS. This approach involves using a previously validated questionnaire to screen apparently healthy adults accompanying a patient to a non-dermatological outpatient clinic visit in a hospital. The screening questionnaire (i.e., the index test) is combined with a subsequent physician-based in-person validation (i.e., the reference standard) of the participants who screen positive. Ten percent of the screen-negative participants are also clinically assessed to verify the diagnostic precision of the test. The local prevalence (pi) will be estimated from each country that submits the number of patients who are HS positive according to the index test and clinical examination (n), and the corresponding total number of observations (N). Conclusion: The GHiSA Global Prevalence studies are currently running simultaneously in 58 countries across six continents (Africa, Europe, Australia, North America, South America, and Asia). The goal of the combined global proportion is the generation of a single summary (i.e., proportional meta-analysis), which will be done after a logit transformation, and synthesized using a random-effects model. The novel standardization of the Global Prevalence studies conducted through GHiSA enables direct international comparisons, which were previously not possible due to substantial heterogeneity in past HS prevalence studies