5,480 research outputs found
Analysis of Fascin-1 in Relation to Gleason Risk Classification and Nuclear ETS-Related Gene Status of Human Prostate Carcinomas:An Immunohistochemical Study of Clinically Annotated Tumours From the Wales Cancer Bank
Although prostate-specific antigen (PSA) testing can identify early-stage prostate cancers, additional biomarkers are needed for risk stratification. In one study, high levels of the actin-bundling protein, fascin-1, were correlated with lethal-phase, hormone-refractory prostate cancer. Analyses of independent samples are needed to establish the value of fascin-1 as a possible biomarker. We examined fascin-1 by immunohistochemistry in tumour specimens from the Wales Cancer Bank in comparison with nuclear-located ETS-related gene (ERG), an emerging marker for aggressive prostate cancer. Fascin-1 was elevated in focal areas of a minority of tumours, yet fascin-1-positivity did not differentiate tumours of low-, intermediate-, or high-risk Gleason scores and did not correlate with PSA status or biochemical relapse after surgery. Stromal fascin-1 correlated with high Gleason score. Nuclear ERG was upregulated in tumours but not in stroma. The complexities of fascin-1 status indicate that fascin-1 is unlikely to provide a suitable biomarker for prediction of aggressive prostate cancer
Inflammation in benign prostate tissue and prostate cancer in the finasteride arm of the Prostate Cancer Prevention Trial
BACKGROUND: A previous analysis of the placebo arm of the Prostate Cancer Prevention Trial (PCPT) reported 82% overall prevalence of intraprostatic inflammation and identified a link between inflammation and higher-grade prostate cancer and serum PSA. Here we studied these associations in the PCPT finasteride arm. METHODS: Prostate cancer cases (N=197) detected either on a clinically indicated biopsy or on protocol-directed end-of-study biopsy, and frequency-matched controls (N=248) with no cancer on an end-of-study biopsy were sampled from the finasteride arm. Inflammation in benign prostate tissue was visually assessed using digital images of H&E stained sections. Logistic regression was used for statistical analysis. RESULTS: In the finasteride arm, 91.6% of prostate cancer cases and 92.4% of controls had at least one biopsy core with inflammation in benign areas; p < 0.001 for difference compared to placebo arm. Overall, the odds of prostate cancer did not differ by prevalence (OR=0.90, 95% CI 0.44-1.84) or extent (P-trend=0.68) of inflammation. Inflammation was not associated with higher-grade disease (prevalence: OR=1.07, 95% CI 0.43-2.69). Furthermore, mean PSA concentration did not differ by the prevalence or extent of inflammationin either cases or controls. CONCLUSION: The prevalence of intraprostatic inflammation was higher in the finasteride than placebo arm of the PCPT, with no association with higher-grade prostate cancer. IMPACT: Finasteride may attenuate the association between inflammation and higher-grade prostate cancer. Moreover, the missing link between intraprostatic inflammation and PSA suggests that finasteride may reduce inflammation-associated PSA elevation
Series Expansion Calculation of Persistence Exponents
We consider an arbitrary Gaussian Stationary Process X(T) with known
correlator C(T), sampled at discrete times T_n = n \Delta T. The probability
that (n+1) consecutive values of X have the same sign decays as P_n \sim
\exp(-\theta_D T_n). We calculate the discrete persistence exponent \theta_D as
a series expansion in the correlator C(\Delta T) up to 14th order, and
extrapolate to \Delta T = 0 using constrained Pad\'e approximants to obtain the
continuum persistence exponent \theta. For the diffusion equation our results
are in exceptionally good agreement with recent numerical estimates.Comment: 5 pages; 5 page appendix containing series coefficient
Physical Properties of Emission-Line Galaxies at z ~ 2 from Near-Infrared Spectroscopy with Magellan FIRE
We present results from near-infrared spectroscopy of 26 emission-line
galaxies at z ~ 2 obtained with the FIRE spectrometer on the Magellan Baade
telescope. The sample was selected from the WISP survey, which uses the
near-infrared grism of the Hubble Space Telescope Wide Field Camera 3 to detect
emission-line galaxies over 0.3 < z < 2.3. Our FIRE follow-up spectroscopy
(R~5000) over 1.0-2.5 micron permits detailed measurements of physical
properties of the z~2 emission-line galaxies. Dust-corrected star formation
rates for the sample range from ~5-100 M_sun yr-1. We derive a median
metallicity for the sample of ~0.45 Z_sun, and the estimated stellar masses
range from ~10^8.5 - 10^9.5 M_sun. The average ionization parameters measured
for the sample are typically much higher than what is found for local
star-forming galaxies. We derive composite spectra from the FIRE sample, from
which we infer typical nebular electron densities of ~100-400 cm^-3. Based on
the location of the galaxies and composite spectra on BPT diagrams, we do not
find evidence for significant AGN activity in the sample. Most of the galaxies
as well as the composites are offset in the BPT diagram toward higher [O
III]/H-beta at a given [N II]/H-alpha, in agreement with other observations of
z > 1 star-forming galaxies, but composite spectra derived from the sample do
not show an appreciable offset from the local star-forming sequence on the [O
III]/H-beta versus [S II]/H-alpha diagram. We infer a high nitrogen-to-oxygen
abundance ratio from the composite spectrum, which may contribute to the offset
of the high-redshift galaxies from the local star-forming sequence in the [O
III]/H-beta versus [N II]/H-alpha diagram. We speculate that the elevated
nitrogen abundance could result from substantial numbers of Wolf-Rayet stars in
starbursting galaxies at z~2. (Abridged)Comment: Accepted for publication in Ap
Social behaviour and collective motion in plant-animal worms
© 2016 The Author(s) Published by the Royal Society. All rights reserved. Social behaviour may enable organisms to occupy ecological niches that would otherwise be unavailable to them. Here, we test this major evolutionary prin- ciple by demonstrating self-organizing social behaviour in the plant-animal, Symsagittifera roscoffensis. These marine aceol flat worms rely for all of their nutrition on the algae within their bodies: hence their common name. We show that individual worms interact with one another to coordinate their movements so that even at low densities they begin to swim in small polarized groups and at increasing densities such flotillas turn into circular mills. We use computer simulations to: (i) determine if real worms interact socially by com- paring them with virtual worms that do not interact and (ii) show that the social phase transitions of the real worms can occur based only on local inter- actions between and among them. We hypothesize that such social behaviour helps the worms to form the dense biofilms or mats observed on certain sun- exposed sandy beaches in the upper intertidal of the East Atlantic and to become in effect a super-organismic seaweed in a habitat where macro-algal seaweeds cannot anchor themselves. Symsagittifera roscoffensis, a model organ- ism in many other areas in biology (including stem cell regeneration), also seems to be an ideal model for understanding how individual behaviours can lead, through collective movement, to social assemblages
Effect of NASA Light-emitting Diode Irradiation on Wound Healing
Objective: The purpose of this study was to assess the effects of hyperbaric oxygen (HBO) and near-infrared light therapy on wound healing.
Background Data: Light-emitting diodes (LED), originally developed for NASA plant growth experiments in space show promise for delivering light deep into tissues of the body to promote wound healing and human tissue growth. In this paper, we review and present our new data of LED treatment on cells grown in culture, on ischemic and diabetic wounds in rat models, and on acute and chronic wounds in humans.
Materials and Methods: In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation.
Results: LED produced in vitro increases of cell growth of 140–200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155–171% of normal human epithelial cells. Wound size decreased up to 36% in conjunction with HBO in ischemic rat models. LED produced improvement of greater than 40% in musculoskeletal training injuries in Navy SEAL team members, and decreased wound healing time in crew members aboard a U.S. Naval submarine. LED produced a 47% reduction in pain of children suffering from oral mucositis.
Conclusion: We believe that the use of NASA LED for light therapy alone, and in conjunction with hyperbaric oxygen, will greatly enhance the natural wound healing process, and more quickly return the patient to a preinjury/ illness level of activity. This work is supported and managed through the NASA Marshall Space Flight Center–SBIR Program
Bronchopulmonary Dysplasia: Executive Summary of a Workshop
Comment in
Bronchopulmonary Dysplasia: The Ongoing Search for One Definition to Rule Them All. [J Pediatr. 2018]
Midlife crisis? In its 50th year, BPD redefines itself. [J Pediatr. 2018
Unstable decay and state selection II
The decay of unstable states when several metastable states are available for
occupation is investigated using path-integral techniques. Specifically, a
method is described which allows the probabilities with which the metastable
states are occupied to be calculated by finding optimal paths, and fluctuations
about them, in the weak noise limit. The method is illustrated on a system
described by two coupled Langevin equations, which are found in the study of
instabilities in fluid dynamics and superconductivity. The problem involves a
subtle interplay between non-linearities and noise, and a naive approximation
scheme which does not take this into account is shown to be unsatisfactory. The
use of optimal paths is briefly reviewed and then applied to finding the
conditional probability of ending up in one of the metastable states, having
begun in the unstable state. There are several aspects of the calculation which
distinguish it from most others involving optimal paths: (i) the paths do not
begin and end on an attractor, and moreover, the final point is to a large
extent arbitrary, (ii) the interplay between the fluctuations and the leading
order contribution are at the heart of the method, and (iii) the final result
involves quantities which are not exponentially small in the noise strength.
This final result, which gives the probability of a particular state being
selected in terms of the parameters of the dynamics, is remarkably simple and
agrees well with the results of numerical simulations. The method should be
applicable to similar problems in a number of other areas such as state
selection in lasers, activationless chemical reactions and population dynamics
in fluctuating environments.Comment: 28 pages, 6 figures. Accepted for publication in Phys. Rev.
Evolution of the Rate and Mode of Star Formation in Galaxies since z=0.7
We present the star formation rate (SFR) and starburst fraction (SBF) for a
sample of field galaxies from the ICBS intermediate-redshift cluster survey. We
use [O II] and Spitzer 24 micron fluxes to measure SFRs, and 24 micron fluxes
and H-delta absorption to measure of SBFs, for both our sample and a
present-epoch field sample from the Sloan Digital Sky Survey (SDSS) and Spitzer
Wide-area Infrared Extragalactic (SWIRE) survey. We find a precipitous decline
in the SFR since z=1, in agreement with other studies, as well as a
corresponding rapid decline in the fraction of galaxies undergoing
long-duration moderate-amplitude starbursts. We suggest that the change in both
the rate and mode of star formation could result from the strong decrease since
z=1 of gas available for star formation.Comment: ApJ Letters in pres
Survival-Time Distribution for Inelastic Collapse
In a recent publication [PRL {\bf 81}, 1142 (1998)] it was argued that a
randomly forced particle which collides inelastically with a boundary can
undergo inelastic collapse and come to rest in a finite time. Here we discuss
the survival probability for the inelastic collapse transition. It is found
that the collapse-time distribution behaves asymptotically as a power-law in
time, and that the exponent governing this decay is non-universal. An
approximate calculation of the collapse-time exponent confirms this behaviour
and shows how inelastic collapse can be viewed as a generalised persistence
phenomenon.Comment: 4 pages, RevTe
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