Transport Layer solution for bulk data transfers over Heterogeneous Long Fat Networks in Next Generation Networks

Aquesta tesi per compendi centra les seves contribucions en l'aprenentatge i innovació de les Xarxes de Nova Generació. És per això que es proposen diferents contribucions en diferents àmbits (Smart Cities, Smart Grids, Smart Campus, Smart Learning, Mitjana, eHealth, Indústria 4.0 entre d'altres) mitjançant l'aplicació i combinació de diferents disciplines (Internet of Things, Building Information Modeling, Cloud Storage, Ciberseguretat, Big Data, Internet de el Futur, Transformació Digital). Concretament, es detalla el monitoratge sostenible del confort a l'Smart Campus, la que potser es la meva aportació més representativa dins de la conceptualització de Xarxes de Nova Generació. Dins d'aquest innovador concepte de monitorització s'integren diferents disciplines, per poder oferir informació sobre el nivell de confort de les persones. Aquesta investigació demostra el llarg recorregut que hi ha en la transformació digital dels sectors tradicionals i les NGNs. Durant aquest llarg aprenentatge sobre les NGN a través de les diferents investigacions, es va poder observar una problemàtica que afectava de manera transversal als diferents camps d'aplicació de les NGNs i que aquesta podia tenir una afectació en aquests sectors. Aquesta problemàtica consisteix en el baix rendiment durant l'intercanvi de grans volums de dades sobre xarxes amb gran capacitat d'ample de banda i remotament separades geogràficament, conegudes com a xarxes elefant. Concretament, això afecta al cas d'ús d'intercanvi massiu de dades entre regions Cloud (Cloud Data Sharing use case). És per això que es va estudiar aquest cas d'ús i les diferents alternatives a nivell de protocols de transport,. S'estudien les diferents problemàtiques que pateixen els protocols i s'observa per què aquests no són capaços d'arribar a rendiments òptims. Deguda a aquesta situació, s'hipotetiza que la introducció de mecanismes que analitzen les mètriques de la xarxa i que exploten eficientment la capacitat de la mateixa milloren el rendiment dels protocols de transport sobre xarxes elefant heterogènies durant l'enviament massiu de dades. Primerament, es dissenya l’Adaptative and Aggressive Transport Protocol (AATP), un protocol de transport adaptatiu i eficient amb l'objectiu de millorar el rendiment sobre aquest tipus de xarxes elefant. El protocol AATP s'implementa i es prova en un simulador de xarxes i un testbed sota diferents situacions i condicions per la seva validació. Implementat i provat amb èxit el protocol AATP, es decideix millorar el propi protocol, Enhanced-AATP, sobre xarxes elefant heterogènies. Per això, es dissenya un mecanisme basat en el Jitter Ràtio que permet fer aquesta diferenciació. A més, per tal de millorar el comportament del protocol, s’adapta el seu sistema de fairness per al repartiment just dels recursos amb altres fluxos Enhanced-AATP. Aquesta evolució s'implementa en el simulador de xarxes i es realitzen una sèrie de proves. A l'acabar aquesta tesi, es conclou que les Xarxes de Nova Generació tenen molt recorregut i moltes coses a millorar causa de la transformació digital de la societat i de l'aparició de nova tecnologia disruptiva. A més, es confirma que la introducció de mecanismes específics en la concepció i operació dels protocols de transport millora el rendiment d'aquests sobre xarxes elefant heterogènies.Esta tesis por compendio centra sus contribuciones en el aprendizaje e innovación de las Redes de Nueva Generación. Es por ello que se proponen distintas contribuciones en diferentes ámbitos (Smart Cities, Smart Grids, Smart Campus, Smart Learning, Media, eHealth, Industria 4.0 entre otros) mediante la aplicación y combinación de diferentes disciplinas (Internet of Things, Building Information Modeling, Cloud Storage, Ciberseguridad, Big Data, Internet del Futuro, Transformación Digital). Concretamente, se detalla la monitorización sostenible del confort en el Smart Campus, la que se podría considerar mi aportación más representativa dentro de la conceptualización de Redes de Nueva Generación. Dentro de este innovador concepto de monitorización se integran diferentes disciplinas, para poder ofrecer información sobre el nivel de confort de las personas. Esta investigación demuestra el recorrido que existe en la transformación digital de los sectores tradicionales y las NGNs. Durante este largo aprendizaje sobre las NGN a través de las diferentes investigaciones, se pudo observar una problemática que afectaba de manera transversal a los diferentes campos de aplicación de las NGNs y que ésta podía tener una afectación en estos sectores. Esta problemática consiste en el bajo rendimiento durante el intercambio de grandes volúmenes de datos sobre redes con gran capacidad de ancho de banda y remotamente separadas geográficamente, conocidas como redes elefante, o Long Fat Networks (LFNs). Concretamente, esto afecta al caso de uso de intercambio de datos entre regiones Cloud (Cloud Data Data use case). Es por ello que se estudió este caso de uso y las diferentes alternativas a nivel de protocolos de transporte. Se estudian las diferentes problemáticas que sufren los protocolos y se observa por qué no son capaces de alcanzar rendimientos óptimos. Debida a esta situación, se hipotetiza que la introducción de mecanismos que analizan las métricas de la red y que explotan eficientemente la capacidad de la misma mejoran el rendimiento de los protocolos de transporte sobre redes elefante heterogéneas durante el envío masivo de datos. Primeramente, se diseña el Adaptative and Aggressive Transport Protocol (AATP), un protocolo de transporte adaptativo y eficiente con el objetivo maximizar el rendimiento sobre este tipo de redes elefante. El protocolo AATP se implementa y se prueba en un simulador de redes y un testbed bajo diferentes situaciones y condiciones para su validación. Implementado y probado con éxito el protocolo AATP, se decide mejorar el propio protocolo, Enhanced-AATP, sobre redes elefante heterogéneas. Además, con tal de mejorar el comportamiento del protocolo, se mejora su sistema de fairness para el reparto justo de los recursos con otros flujos Enhanced-AATP. Esta evolución se implementa en el simulador de redes y se realizan una serie de pruebas. Al finalizar esta tesis, se concluye que las Redes de Nueva Generación tienen mucho recorrido y muchas cosas a mejorar debido a la transformación digital de la sociedad y a la aparición de nueva tecnología disruptiva. Se confirma que la introducción de mecanismos específicos en la concepción y operación de los protocolos de transporte mejora el rendimiento de estos sobre redes elefante heterogéneas.This compendium thesis focuses its contributions on the learning and innovation of the New Generation Networks. That is why different contributions are proposed in different areas (Smart Cities, Smart Grids, Smart Campus, Smart Learning, Media, eHealth, Industry 4.0, among others) through the application and combination of different disciplines (Internet of Things, Building Information Modeling, Cloud Storage, Cybersecurity, Big Data, Future Internet, Digital Transformation). Specifically, the sustainable comfort monitoring in the Smart Campus is detailed, which can be considered my most representative contribution within the conceptualization of New Generation Networks. Within this innovative monitoring concept, different disciplines are integrated in order to offer information on people's comfort levels. . This research demonstrates the long journey that exists in the digital transformation of traditional sectors and New Generation Networks. During this long learning about the NGNs through the different investigations, it was possible to observe a problematic that affected the different application fields of the NGNs in a transversal way and that, depending on the service and its requirements, it could have a critical impact on any of these sectors. This issue consists of a low performance operation during the exchange of large volumes of data on networks with high bandwidth capacity and remotely geographically separated, also known as Elephant networks, or Long Fat Networks (LFNs). Specifically, this critically affects the Cloud Data Sharing use case. That is why this use case and the different alternatives at the transport protocol level were studied. For this reason, the performance and operation problems suffered by layer 4 protocols are studied and it is observed why these traditional protocols are not capable of achieving optimal performance. Due to this situation, it is hypothesized that the introduction of mechanisms that analyze network metrics and efficiently exploit network’s capacity meliorates the performance of Transport Layer protocols over Heterogeneous Long Fat Networks during bulk data transfers. First, the Adaptive and Aggressive Transport Protocol (AATP) is designed. An adaptive and efficient transport protocol with the aim of maximizing its performance over this type of elephant network.. The AATP protocol is implemented and tested in a network simulator and a testbed under different situations and conditions for its validation. Once the AATP protocol was designed, implemented and tested successfully, it was decided to improve the protocol itself, Enhanced-AATP, to improve its performance over heterogeneous elephant networks. In addition, in order to upgrade the behavior of the protocol, its fairness system is improved for the fair distribution of resources among other Enhanced-AATP flows. Finally, this evolution is implemented in the network simulator and a set of tests are carried out. At the end of this thesis, it is concluded that the New Generation Networks have a long way to go and many things to improve due to the digital transformation of society and the appearance of brand-new disruptive technology. Furthermore, it is confirmed that the introduction of specific mechanisms in the conception and operation of transport protocols improves their performance on Heterogeneous Long Fat Networks

Evaluación in vivo del efecto de distintos fungicidas aplicados a semilla de maíz sobre la infección de Sphacelotheca reiliana.

39 p.Durante la temporada 2011/2012 se realizo un ensayo in vivo para comprobar la efectividad de un nuevo fungicida sistémico aplicado a la semilla, en el control de la infección de Sphacelotheca reiliana a plantas de maíz. Se evaluaron síntomas y signos de la enfermedad, y altura de las plantas inoculadas, al momento de floración. El ensayo se realizo en cámaras climatizadas ubicadas en el Laboratorio de Sanidad Vegetal de la Facultad de Ciencias Agrarias, Universidad de Talca. Cinco tratamientos fueron evaluados, incluyendo un control comercial, un testigo sin aplicación y el nuevo ingrediente activo en tres dosis. Las semillas con los diferentes tratamientos fueron inoculadas con teliosporas de S. reiliana, siendo luego sembradas en macetas conteniendo sustrato estéril. El ensayo fue conducido en un diseño completamente al azar con 5 tratamientos y 5 repeticiones. Los datos obtenidos fueron analizados con un programa estadístico STATGRAPHICS Centurion XV. Los resultados indican que el nuevo fungicida llamado HK510 es altamente efectivo en control de S.reiliana, ya que en los tres tratamientos en que fue evaluado, no mostraron signos ni síntomas del patógeno en estudio comparado con el testigo./ABSTRACT: During the growing season 2011/2012 an experiment under controlled conditions was conducted to verify the effectiveness of a new systemic fungicide applied to the seed in the control of Sphacelotheca reiliana infection in corn plants. The presence of symptoms and signs of the disease was recorded and the plant height was measured at blooming time. The experiment was conducted in a growing chamber of the plant pathology Laboratory, at Universidad de Talca. Five treatments were evaluated, including a commercial fungicide, a control with no application and three doses of the new active ingredient. Treated and untreated seeds of the different treatments were inoculated with teliospores of S. reiliana and sowed in pots containing sterile soil. The experiment was conducted in a completely randomized experimental design with 5 treatments and 5 replicates. The results were analyzed with a statistical program STATGRAPHICS Centurion XV. The results indicate that the new fungicide called HK510 is highly effective in controlling S.reiliana as in the three treatments was evaluated, showed no signs or symptoms of the pathogen under study compared with the control. Palabras claves: Sacapelotas reiliana- Control Químico - Control cultura

Software defined utility: A step towards a flexible, reliable and low-cost smart grid

The Smart Grid relies in Information and Communication Technologies (ICT) but usually there is still a lack of integration in their deployment. They are designed as separated systems and managed that way too. In addition, the changes in the electric network are so complex and dependable on a very rigid hardware architecture. Based on the work done in the European project FINESCE, this paper presents the “Software Defined Utility “(SDU) concept, which advocates the migration of the utility infrastructure to software systems instead of relying on complex and rigid hardware based systems. This new approach provides a prospective view on the evolution of power systems that will benefit from software systems and high-speed data network infrastructures. More concretely, as a first SDU building block, the paper proposes a data storage and management system based on a hybrid cloud infrastructure to meet the storage requirements of electric utilities. In this regard, the following dimensions have been analysed: the most appropriate methodology to select where data resources should be allocated; security requirements and threads taking into account its deployment in a critical infrastructure like a Smart Grid

The coexistence of peace and conflict in South America: toward a new conceptualization of types of peace

South America's predominant democratic regimes and its increasing interdependence on regional trade have not precluded the emergence of militarized crises between Colombia and Venezuela or the revival of boundary claims between Chile and Peru. This way, how can we characterize a zone that, in spite of its flourishing democracy and dense economic ties, remain involved in territorial disputes for whose resolution the use of force has not yet been discarded? This article contends that existing classifications of zones of peace are not adequate to explain this unusual coexistence. Thus, its main purpose is to develop a new analytical category of regional peace for assessing this phenomenon: the hybrid peace. It aims to research the evolution of security systems in South America during the previous century and build a new, threefold classification of peace zones: negative peace zones, hybrid peace zones, and positive peace zones

The Transcription Factor ArcA Modulates Salmonella’s Metabolism in Response to Neutrophil Hypochlorous Acid-Mediated Stress

Indexación: ScopusSalmonella Typhimurium, a bacterial pathogen with high metabolic plasticity, can adapt to different environmental conditions; these traits enhance its virulence by enabling bacterial survival. Neutrophils play important roles in the innate immune response, including the production of microbicidal reactive oxygen species (ROS). In addition, the myeloperoxidase in neutrophils catalyzes the formation of hypochlorous acid (HOCl), a highly toxic molecule that reacts with essential biomolecules, causing oxidative damage including lipid peroxidation and protein carbonylation. The bacterial response regulator ArcA regulates adaptive responses to oxygen levels and influences the survival of Salmonella inside phagocytic cells. Here, we demonstrate by whole transcriptomic analyses that ArcA regulates genes related to various metabolic pathways, enabling bacterial survival during HOCl-stress in vitro. Also, inside neutrophils, ArcA controls the transcription of several metabolic pathways by downregulating the expression of genes related to fatty acid degradation, lysine degradation, and arginine, proline, pyruvate, and propanoate metabolism. ArcA also upregulates genes encoding components of the oxidative pathway. These results underscore the importance of ArcA in ATP generation inside the neutrophil phagosome and its participation in bacterial metabolic adaptations during HOCl stress. © Copyright © 2019 Pardo-Esté, Castro-Severyn, Krüger, Cabezas, Briones, Aguirre, Morales, Baquedano, Sulbaran, Hidalgo, Meneses, Poblete-Castro, Castro-Nallar, Valvano and Saavedra.https://www.frontiersin.org/articles/10.3389/fmicb.2019.02754/ful

Carbon-sensitive pedotransfer functions for plant available water

Currently accepted pedotransfer functions show negligible effect of management-induced changes to soil organic carbon (SOC) on plant available water holding capacity (θAWHC), while some studies show the ability to substantially increase θAWHC through management. The Soil Health Institute\u27s North America Project to Evaluate Soil Health Measurements measured water content at field capacity using intact soil cores across 124 long-term research sites that contained increases in SOC as a result of management treatments such as reduced tillage and cover cropping. Pedotransfer functions were created for volumetric water content at field capacity (θFC) and permanent wilting point (θPWP). New pedotransfer functions had predictions of θAWHC that were similarly accurate compared with Saxton and Rawls when tested on samples from the National Soil Characterization database. Further, the new pedotransfer functions showed substantial effects of soil calcareousness and SOC on θAWHC. For an increase in SOC of 10 g kg–1 (1%) in noncalcareous soils, an average increase in θAWHC of 3.0 mm 100 mm–1 soil (0.03 m3 m–3) on average across all soil texture classes was found. This SOC related increase in θAWHC is about double previous estimates. Calcareous soils had an increase in θAWHC of 1.2 mm 100 mm–1 soil associated with a 10 g kg–1 increase in SOC, across all soil texture classes. New equations can aid in quantifying benefits of soil management practices that increase SOC and can be used to model the effect of changes in management on drought resilience

Linking soil microbial community structure to potential carbon mineralization: A continental scale assessment of reduced tillage

Potential carbon mineralization (Cmin) is a commonly used indicator of soil health, with greater Cmin values interpreted as healthier soil. While Cmin values are typically greater in agricultural soils managed with minimal physical disturbance, the mechanisms driving the increases remain poorly understood. This study assessed bacterial and archaeal community structure and potential microbial drivers of Cmin in soils maintained under various degrees of physical disturbance. Potential carbon mineralization, 16S rRNA sequences, and soil characterization data were collected as part of the North American Project to Evaluate Soil Health Measurements (NAPESHM). Results showed that type of cropping system, intensity of physical disturbance, and soil pH influenced microbial sensitivity to physical disturbance. Furthermore, 28% of amplicon sequence variants (ASVs), which were important in modeling Cmin, were enriched under soils managed with minimal physical disturbance. Sequences identified as enriched under minimal disturbance and important for modeling Cmin, were linked to organisms which could produce extracellular polymeric substances and contained metabolic strategies suited for tolerating environmental stressors. Understanding how physical disturbance shapes microbial communities across climates and inherent soil properties and drives changes in Cmin provides the context necessary to evaluate management impacts on standardized measures of soil microbial activity

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity > 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI

DTN Trustworthiness for Permafrost Telemetry IoT Network

The SHETLAND-NET research project aims to build an Internet of Things (IoT) telemetry service in Antarctica to automatize the data collection of permafrost research studies on interconnecting remote wireless sensor networks (WSNs) through near vertical incidence skywave (NVIS) long fat networks (LFN). The proposed architecture presents some properties from challenging networks that require the use of delay tolerant networking (DTN) opportunistic techniques that send the collected data during the night as a bulk data transfer whenever a link comes available. This process might result in network congestion and packet loss. This is a complex architecture that demands a thorough assessment of the solution’s viability and an analysis of the transport protocols in order to find the option which best suits the use case to achieve superior trustworthiness in network congestion situations. A heterogeneous layer-based model is used to measure and improve the trustworthiness of the service. The scenario and different transport protocols are modeled to be compared, and the system’s trustworthiness is assessed through simulations