Accuracy of three-dimensional multislice view Doppler in diagnosis of morbid adherent placenta

Photograph used for a story in the Daily Oklahoman newspaper. Caption: "Guthrie flood waters carry a 100-foot long frame office buidling downstream before it broke in half, leaving a portion of roof showing above the water. Water is 7 feet in street. O-12-27-59: Road waters raged through many sections of the state as heavy autumn downpours created water crises. This picture shows some of the flood waters at Guthrie.

Influence of Mo+2 ion concentration on crystallization, microstructure, crystal imperfection and morphology of WO3 sprayed thin films

Compositional dependence of microstructure and morphological properties of Mo _x W _1−x O _3 (0.2 ≥ x ≥ 0.0 at. %) thin films was studied. MoWO _3 films were deposited by chemical spray pyrolysis technique on pre-heated glass substrates at 400 °C and the sedimentation rate was kept constant at 70 ml min ^−1 with the deposition time fixed at 10 min to keep the film thickness constant at about 650 ± 5 nm. The prepared thin films were studied using x-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and energy dispersive x-ray analysis (EDAX) techniques. The nature of the as-deposited films displayed by XRD showed beyond a reasonable doubt that they are amorphous. After thermal annealing at 500 °C for 2 h, all samples will be transferred to a polycrystalline having a triclinic structure. The microstructural parameters of the pure and doped samples were measured, using different methods and a comparison between them to determine the accuracy percentage of the measurement of these methods. The results also showed that the average crystallite size of the films decreased from 24 to 12 nm, on the contrary the internal microstrain increased from 23 × 10 ^−3 to 30 × 10 ^−3 with the addition of Mo element in WO _3 . Field emission scanning electron microscopy (FE-SEM) analysis also revealed that Mo dopant caused significant changes in the surface morphology of the films as well as an increase in particle size with increasing molybdenum concentration. The EDX results exhibited that the percentages of the isotropic elements Mo _x W _1−x O _3 agree well with those determined by atomic weight. In general, the results obtained in this study confirm that Mo _x W _1−x O _3 with these properties, is suitable for photovoltaic and optoelectronic applications

Urinary biomarkers for early detection of platinum based drugs induced nephrotoxicity

Abstract Background Nephrotoxicity is a major hazard complicating the use of platinum based drugs (PBD), which can hinder using higher doses protocols to maximize the therapeutic gain. Shortage of serum creatinine level as an accurate biomarker for acute kidney injuries (AKI) necessitates searching for novel biomarkers with better sensitivity and specificity in patients on PBD. Methods In a prospective cohort design, 132 patients receiving PBD were selected for the study. AKI was diagnosed by continuous follow up of serum creatinine level according to Kidney Disease: Improving Global Outcomes (KDIGO) guidelines 2012. Serum creatinine and urinary biomarkers (KIM-1, NGAL and cystatin C) was measured in the day of treatment and for 3 days after PBD cycle. Results AKI occurred in 35 patients (26.52% of patients). KIM-1, Cystatin C, and NGAL showed significant increase in samples collected in the day of AKI in comparison to their corresponding basal levels (P <  0.0001). In addition, significant increase in urinary levels of the biomarkers in samples collected 1 day before AKI in comparison to their basal levels (P <  0.0001, P <  0.0001, and P = 0.013 for KIM-1, NGAL and Cystatin C respectively). Furthermore KIM-1 data showed a significant increase 2 days before serum creatinine rise in comparison to the corresponding KIM-1 levels in patients who developed AKI (P = 0.001). Conclusions Urinary KIM-1, Cystatin C and NGAL can predict PBD induced AKI in earlier stages than serum createnine. KIM-1 is the most sensitive biomarker for early detection of AKI in patients receiving PBD

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

Background: Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods: The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results: NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year. Conclusion: As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population