Resistin as a predictor for ovarian response to clomiphene citrate in obese PCOS women

Objective: to evaluate the value of resistin as a predictor of ovulation induction by clomiphene citrate in cases of PCOS. Design: prospective, controlled clinical study Setting: kasr Al-Aini Hospital Materials and Methods: obese subfertile women with PCOS (BMI>30 kg/m2) received clomiphene citrate 50mg / 8hours from the third day of the cycle and for five days. Based on success of ovulation induction, women were divided into two groups: Group I who responded to CC and Group II: those who failed to respond to CC. Blood samples were collected on day 3 of the cycle and resistin, insulin and sugar were assayed . Results: There was no significant difference between both groups regarding background characteristics, however, there was a significant difference regarding both BMI and resistin between both groups. Multiple linear regression showed a statistically significant value of resistin independent of that of BMI. The ROC curve showed a cut-off value of 4.78 for resistin with area under curve more than 78.9% and sensitivity 66.67% and specificity 82.4% to predict response to clomiphene citrate in obese PCOS women Conclusion: in obese women, resistin may be of value in prediction of ovarian response to clomiphene citrate. This needs to be confirmed in further trials

Comparative effects of minimally invasive approaches vs. conventional for obese patients undergoing aortic valve replacement: a systematic review and network meta-analysis

Abstract Background Minimally invasive approaches like mini-thoracotomy and mini-sternotomy for Aortic Valve Replacement (AVR) showed impressive outcomes. However, their advantages for obese patients are questionable. We aimed in this network meta-analysis to compare three surgical approaches: Full sternotomy (FS), Mini-sternotomy (MS), and Mini-thoracotomy (MT) for obese patients undergoing AVR. Methods We followed the PRISMA extension for this network meta-analysis. PubMed/Medline, Scopus, Web of Science, and Cochrane searched through March 2023 for relevant articles. The analysis was performed using R version 4.2.3. Results Out of 344, 8 articles met the criteria with 1392 patients. The main outcomes assessed were perioperative mortality, re-exploration, atrial fibrillation, renal failure, ICU stay, hospital stay, cross-clamp time, and bypass time. In favor of MS, the length of ICU stay and hospital stay was significantly lower than for FS [MD -0.84, 95%CI (-1.26; -0.43)], and [MD -2.56, 95%CI (-3.90; -1.22)], respectively. Regarding peri-operative mortality, FS showed a significantly higher risk compared to MS [RR 2.28, 95%CI (1.01;5.16)]. Also, patients who underwent minimally invasive approaches; MT and MS, required less need of re-exploration compared to FS [RR 0.10, 95%CI (0.02;0.45)], and [RR 0.33, 95%CI (0.14;0.79)], respectively. However, Intraoperative timings; including aortic cross-clamp, and cardiopulmonary bypass time, were significantly lower with FS than for MS [MD -9.16, 95%CI (-1.88; -16.45)], [MD -9.61, 95%CI (-18.64; -0.59)], respectively. Conclusion Our network meta-analysis shows that minimally invasive approaches offer some advantages for obese patients undergoing AVR over full sternotomy. Suggesting that these approaches might be considered more beneficial alternatives for obese patients undergoing AVR

Effect of length of LOCATOR abutment and cement type on retention to intraradicular dentin in overdentures.

STATEMENT OF PROBLEM Limited information is available on the effect of LOCATOR abutment length and luting cement type on retention to intraradicular dentin in overdentures. PURPOSE The purpose of this in vitro study was to evaluate the effect of the length of a commercially available LOCATOR abutment and cement type on retention in the root canal. MATERIAL AND METHODS Eighty LOCATOR abutments with a standard length of 6 mm were obtained. Half of them were shortened to 3 mm. Eighty recently extracted single-rooted teeth were divided into 2 groups. The post space was prepared to 6 mm in the first group and 3 mm in the second. After preparation, the LOCATOR abutments were luted with one of the following cements: dual-polymerized glass-reinforced resin cement (Parapost Paracore), dual-polymerized resin cement (Variolink II), self-adhesive resin cement (RelyX Unicem), and conventional cement (zinc phosphate). The tensile force required for the removal of the LOCATOR abutments from their corresponding roots was recorded. Data were statistically analyzed with 2-way ANOVA and the Tukey multiple comparison test. RESULTS Both the cement type (P<.001) and the length of the LOCATOR abutment (P<.001) significantly affected the mean tensile forces. Dual-polymerized glass-reinforced resin cement (Parapost Paracore) presented significantly higher mean tensile forces for the LOCATOR abutment retention among all cements (P<.05). CONCLUSIONS Regardless of the length, LOCATOR abutments luted with Parapost Paracore resin cement presented higher mean resistance to tensile forces compared with those luted with the other cements. LOCATOR abutments of 6 mm in length were more resistant to tensile forces than those of 3 mm in length in combination with all cements

Human herpes simplex virus-6 (HHV-6) detection and seroprevalence among Qatari nationals and immigrants residing in Qatar

BackgroundHuman herpes simplex virus-6 (HHV-6) is the causative agent of exanthema subitum. Transmission mainly occurs through salivary secretions, yet blood transfusions and organ transplantations have also been reported as routes of transmission. Studies of seroprevalence of HHV-6 in the Middle East and North Africa (MENA) region and other parts of Asia are scarce. As such, this study aimed to estimate the seroprevalence of HHV-6 among healthy blood donors in Qatar. MethodsIn total, 620 healthy blood donors from different nationalities residing in Qatar, mainly from the MENA region and Southeast Asia, were tested using a commercial anti-HHV-6 immunoglobulin G (IgG) enzyme-linked immunosorbent assay kit. In addition, HHV-6 DNA from randomly selected samples was tested and quantified using quantitative reverse transcriptase polymerase chain reaction. ResultsAnti-HHV-6 IgG was detected in 71.7% (445/620) [95% confidence interval (CI) 68.2–75.3%] of the tested samples, while 24.3% (61/251) (95% CI 20.0–29.6%) had detectable HHV-6 viraemia. Only 22.5% of individuals with positive IgG status had detectable HHV-6 DNA in their blood, indicating a weak association between viraemia and IgG positivity (P=0.08). Furthermore, no significant difference was associated between HHV-6 viraemia and demographic characteristics, except for nationality. ConclusionThe seroprevalence of HHV-6 in Qatar was found to be similar to rates reported in other parts of the world.This work was made possible by collaborative grant number M-QJRC-2020-5 from Qatar University

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially