Objective: to evaluate the value of resistin as a predictor of
ovulation induction by clomiphene citrate in cases of PCOS. Design:
prospective, controlled clinical study Setting: kasr Al-Aini Hospital
Materials and Methods: obese subfertile women with PCOS (BMI>30
kg/m2) received clomiphene citrate 50mg / 8hours from the third day of
the cycle and for five days. Based on success of ovulation induction,
women were divided into two groups: Group I who responded to CC and
Group II: those who failed to respond to CC. Blood samples were
collected on day 3 of the cycle and resistin, insulin and sugar were
assayed . Results: There was no significant difference between both
groups regarding background characteristics, however, there was a
significant difference regarding both BMI and resistin between both
groups. Multiple linear regression showed a statistically significant
value of resistin independent of that of BMI. The ROC curve showed a
cut-off value of 4.78 for resistin with area under curve more than
78.9% and sensitivity 66.67% and specificity 82.4% to predict response
to clomiphene citrate in obese PCOS women Conclusion: in obese women,
resistin may be of value in prediction of ovarian response to
clomiphene citrate. This needs to be confirmed in further trials
