Osteotomías distales de los metatarsianos menores realizadas por cirugía abierta vs cirugía percutánea en el tratamiento de las metatarsalgias.

Objetivo. Comparar los resultados clínicos y radiológicos de las osteotomías distales de los metatarsianos menores realizadas por cirugía abierta y por cirugía percutánea en el tratamiento de las metatarsalgias Material y método. Revisión retrospectiva de 44 metatarsalgias: 22 en cada grupo. Recogida de datos epidemiológicos, clínicos y medición de parámetros radiográficos. Resultados. Se consiguieron modificaciones en los parámetros radiográficos con ambas técnicas, con mayor corrección con la cirugía abierta. Las fórmulas metatarsales postoperatorias continuaron siendo no armónicas en ambos grupos. Todos los pacientes mejoraron clínicamente. La cirugía abierta tuvo más complicaciones. Conclusiones. Los resultados clínicos y radiológicos de las osteotomías percutáneas son similares a los obtenidos por cirugía abierta, pero con menos complicaciones. La obtención de una fórmula metatarsal armónica no debería ser el objetivo principal de la cirugía de las metatarsalgias, ya que, según nuestro estudio, no es una condición indispensable para lograr un buen resultado clínicoObjectives. To compare the radiographic and functional outcomes in lesser metatarsal distal osteotomies performed by percutaneous and open surgery for the treatment of metatarsalgia. Methods. A retrospective medical record review of 44 cases of discharge diagnosis of metatarsalgia: 22 patients in each group. Epidemiological data, clinical data and radiological measurements were collected. Results . Improvement of radiological parameters were obtained with both techniques, with better correction with open than with percutaneous surgery. Postoperatively metatarsal parabola continues being nonharmonious in both groups. All patients improved in clinical assessment. Open surgery had more complications than percutaneous surgery. Conclusions . Clinical and radiological outcomes of lesser metatarsal distal osteotomies performed percutaneously are similar to those obtained by open surgery, but with fewer complications. To obtain a harmonic metatarsal parabola should not be the main purpose of surgery of metatarsalgia because it is not an essential condition to achieve a good clinical outcome

PREPARATION AND EVALUATION OF FENTANYL TRANSDREMAL PATCHES USING LIDOCAINE AS A MODEL DRUG AND AZELAIC ACID AS A PENETRATION ENHANCER

Transdermal drug delivery offers numerous advantages over the conventional routs of administration; however, poor permeation of most drug across the skin barrier constitutes a major limitation of this rout. Objective: The possibility of utilizing azelaic acid as penetration enhancer was investigated. And then development of a new transdermal controlled-release device using of non-medicated and lidocaine transdermal patches and then testing the feasibility of loading fentanyl patch. Methods: DSC, FTIR, X-ray diffraction analysis and skin permeability measurements were done for both skin sample untreated and treated with azelaic acid to prove the possibility of utilizing it as permeation enhancer. Multilayered lidocaine transdermal patches were prepared by solvent/evaporation casting technique using Eudragit® E100 as transdermal adhesive polymer, and ethyl vinyl acetate as impermeable backing layer. The flexibility of films required for a good compliance and optimum transdermal adhesion of the Eudragit E films was achieved by employing triethyl citrate or dibutylphthalate at concentration of 25% (w/w) of polymer. A physicochemical interaction between azelaic acid and Eudragit E100 (cationic polymer) has been evaluated using FTIR and DSC. Lidocaine as well as fentanyl bilayerd transdermal patches containing triethylcitrate at concentration of 25% (w/w) of Eudragit E100 with and without azelaic acid were selected for further permeation studies Results: The obtained results indicated that fluorescien permeation through epidermal human skin treated with overnight exposure to saturated aqueous solution of azelaic acid was increased by 8.6 folds while, its permeation through rat skin was increased by 10.89 folds. Additional analysis by FTIR, X-ray diffraction, SEM, and DSC showed that azelaic acid disrupted stratum corneum lipid, which supported its action as promising penetration enhancer.Plasticizers as triethyl citrate or dibutylphthalate at concentration of 25% (w/w) of polymer reduced Tg of Eudragit E100 polymer to about 15.50C and 26.20C respectively. A physicochemical interaction between azelaic acid and Eudragit E100 was proven by FTIR study which indicated the present of ionic bonding between them, while DSC showed that azelaic acid may act as non-traditional plasticizer through its reduction in Tg by 7.30 C.The results of permeation studies indicated that the presence of azelaic acid was significantly increased (P < 0.05) the drug flux as the concentration of azelaic acid increased. As well as; fentanyl transdermal permeability studies revealed similar behavior to lidocaine as drug flux increased by 4.82 folds at AZ concentration of 2mg/cm2. Conclusion: the overall obtained data revealed the feasibility of preparing a controlled release fentanyl transdermal patches containing azelaic acid as penetration enhancer

Cilnidipine Nanocrystals, Formulation and evaluation for Optimization of solubility and Dissolution Rate

Cilnidipine CLD fourth generation Ca+2 channel blockers, since cilnidipine has a very low solubility (BCS Class-II drug Low solubility High permeability) and extremely low medication compliance, it has been used to treat hypertension and hypertensive-associated vascular disorders.so cilnidipine can be formulated as nanocrystals NCs  using solvent anti-solvent technology which can improve the solubility and bioavailability .Two different stabilizers(poloxamer 188 and Tween20) were utilized to prepare  nine formula  with different ratio 1:0.25,1:0.5 and 1:1. Study and evaluation the formulation factors which may effect on particle size and Polydispersity index PDI. The prepared CLD NCs were evaluated for particle size and dissolution study ,F4 was the smallest size 152 nm ,PDI  (0.161 )and the saturated solubility was increased about ten folds, this formula was subjected for freeze drying by adding  3 % mannitol as cryoprotectant .A complete dissolusion was established in about 20 minutes  which confer the DSC and PXRD results in conversion from crystalline into amorphous state .It can conclude that solvent  anti-solvent technique was a useful in preparation of nanocrystals suspension

Investigation of the presence of pharmaceuticals and personal care products (PPCPs) in groundwater of Jazan area, Saudi Arabia

Purpose: To investigate the possible occurrence of some selected  pharmaceutical compounds in the groundwater of Jazan area, Saudi Arabia.Methods: Water samples from 46 wells were collected from different sites covering Jazan area of Saudi Arabia between February and March 2017. These samples were first analyzed to investigate the presence of eleven drugs mostly used in the study area. Thereafter, samples were subjected to liquid chromatography-mass spectrometry (LC-MS/MS) by direct injection and external standard calibration.Results: Despite the low detection limit (0.001 - 0.02 μg/L) applied to the investigated compounds with a variety chemical groups (acetylsalicylic acid, paracetamol, ibuprofen, metronidazole, caffeine, olmesartan, omeprazole, nifedipine, diclofenac sodium, glibenclamide and loratidine), none of these compounds was detected in any of the analyzed samples.Conclusion: The main source of environmental contamination with  pharmaceuticals and personal care products (PPCPs) is wastewater. The results obtained reveal the absence of groundwater contamination by these compounds in Jazan area. However, further extended investigations and monitoring are recommended.Keywords: Pharmaceuticals, Groundwater, Wastewater, Pollution, Personal care products, Liquid chromatography-mass spectrometer (LC-MS/MS

Suppressing scratch-induced brittle fracture in silicon by geometric design modification of the abrasive grits

The overarching goal of this research was to investigate the application of spherically shaped abrasive particles in achieving ductile-mode cutting. Scratching experiments were carried out to assess the differences between arbitrarily and spherically shaped diamond and tungsten carbide (WC) grits in inducing brittle fracture or ductile plasticity in single-crystal silicon. It was observed that the arbitrarily shaped particles produce brittle fracture in contrast to the spherically shaped grits. The sharp edges and corners of grits result in high tensile stress-concentrated regions causing cracking and spalling. Contrary to this, spherically shaped WC particles induce uniform cutting pressure, which suppresses the extent of the brittle fracture and the mode of material removal was completely dominated by ductile-cutting until a threshold load for ductile-to-brittle transition (the first cracks appearance). These observations are expected to provide a suitable pathway in making the Diamond Wire Sawing machining operations more robust by providing a control on brittle damage

Algorithm for Demand Response to Maximize the Penetration of Renewable Energy

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Understanding the machined material’s behaviour in electro-discharge machining (EDM) using a multi-phase smoothed particle hydrodynamics (SPH) modelling

Electro-discharge machining (EDM) has been extensively employed for machining hard alloys, and its simulations have been widely conducted using finite element analysis (FEA). However, the majority of mesh-based models depended on forecasting the crater profile only based on the temperature gradient, without offering detailed data regarding the machined material properties. It is crucial to understand the behaviour of the machined material in order to accurately assess the flushing efficiency, analyse the wear on the electrode, and examine the interaction between the debris generated during machining and the remaining workpiece. This is done to ensure that no recast material is left behind after the EDM process. For the first time, a meshless smoothed particle hydrodynamics multi-phase model was implemented to gain practical insights and comprehensively understand a very intricate phenomenon that occurs within a very short time. Additionally, this approach is utilised to investigate the characteristics of the materials being machined. We utilised our SPH model to simulate both the capacitance- and transistor-based EDM of Ti–6Al–4V and AISI304 steel. Our simulation considered the temperature-dependent thermal properties and latent heats of the materials. The accuracy of our model was confirmed by comparing its results with experimental, analytical, and finite element analysis (FEA) results. The machined material was observed during its removal from the surface, and the dimensions of the resulting crater, as well as its aspect ratio and the rate at which the material was removed, were predicted with an error ranging from 2 to 22%. This error is far lower than that of the typical finite element (FE) prediction. This model lays the groundwork for a more complex model that will more accurately represent EDM and other similar manufacturing processes

Perfect secret sharing scheme based on vertex domination set

Due to the fast development in data communication systems and computer networks in recent years, the necessity to protect the secret data has become extremely imperative. Several methods have been proposed to protect the secret data; one of them is the secret sharing scheme. It is a method of distributing a secret K among a finite set of participants, in such a way that only predefined subset of participant is enabled to reconstruct a secret from their shares. A secret sharing scheme realizing uniform access structure described by a graph has received a considerable attention. In this scheme, each vertex represents a participant and each edge represents a minimum authorized subset. In this paper, an independent dominating set of vertices in a graph G is introduced and applied as a novel idea to construct a secret sharing scheme such that the vertices of the graph represent the participants and the dominating set of vertices in G represents the minimal authorized set. While most of the previous schemes were based on the principle of adjacent vertices, the proposed scheme is based upon the principle of non-adjacent vertices. We prove that the scheme is perfect, and the lower bound of the information rate of this new construction is improved when compared to some well-known previous constructions. We include an experiment involving security threats to demonstrate the effectiveness of the proposed scheme

Assessment of Prevalence and Factors Associated with Obesity among Secondary School Students at Makkah in Saudi Arabia

Background: The prevalence of overweight/obesity in children in Saudi Arabia is among the highest in the world. The prevalence of dental caries is also high in Saudi children. Studies on the relationship between caries and obesity in Saudi adolescents are lacking. the World Health Organization (WHO) defines obesity as “abnormal or excessive fat accumulation that may impair health,” while overweight is defined as “a body mass index (BMI) of 25 kg/m2 or more.”1 Overweight and obesity can negatively affect the physiological and psychological well-being of the affected individual, and both have become a global the prevalence of overweight/obesity in high school adolescents. The Overweight and impaired metabolic health might strongly, and independently of other comorbidities, partner with expanded danger diseases. The study aimed: To assessment of prevalence and factors associated with obesity among   secondary school students at Makkah in Saudi Arabia 2021. Method: An online cross-sectional survey was utilized Secondary school students at in Makkah Al-Mukarramah in Saudi Arabia 2021 during the April to June, 2021, a total of 200 student aged 12–18 years, available students of secondary school children were included in the study. A structured online self-reported questionnaire sheet was used to assessment of prevalence and factors associated with obesity among   secondary school students at Makkah in Saudi Arabia 2021 Result: show the total number of participants was 200 regarding the age most participants were classified into 3 age groups, most of them were (45.0%) in the more than 16 years regarding gender of participated female were (63.0%). Regarding Income level in study the most of participant\u27s Below 5000 SR were (31.0%).  Regarding Educational level in study the most of participant\u27s Intermediate school were (22.0%) regarding Sources of information           about obesity most of participant\u27s educational films were (32.0%) Conclusion: with a high obesity prevalence in boys and in children attending schools. The prevalence was not associated with BMI or WC we report a negative independent association between BMI and subsequent academic performance among female high-school students in Saudi Arabia. The current findings highlight the need for community and school programmes targeting overweight/obesity among high school students