277 research outputs found
ПОЛИТИЧЕСКИЕ И ЭКОНОМИЧЕСКИЕ ПРОБЛЕМЫ ПРОИСХОДЯТ ОТ ПРОБЛЕМ НРАВСТВЕННОГО ХАРАКТЕРА
Get PDFPolitical and economical problems have their origin in ethical problems.Политические и экономические проблемы происходят от проблем нравственного характера
Probing salicylamide bioisosteric replacement in the design of Plasmodium Falciparum dihydroorotate dehydrogenase (pfDHODH) inhibitors
Get PDFCharacterization of insulin microcrystals using powder diffraction and multivariate data analysis
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A differentiating and apoptotic therapy for acute myeloid leukaemia using potent human dihydroorotate dehydrogenase inhibitors.
Get PDFMolecular dynamics simulations of alcohol dehydrogenase with a four- or five-coordinate catalytic zinc ion
Full text linkEmerging therapies for acute myeloid leukaemia using hDHODH inhibitors able to restore in vitro and in vivo myeloid differentiation
Get PDFThe catalytic power of magnesium chelatase: a benchmark for the AAA(+) ATPases
Get PDFIn the first committed reaction of chlorophyll biosynthesis, magnesium chelatase couples ATP hydrolysis to the thermodynamically unfavorable Mg(2+) insertion into protoporphyrin IX (ΔGº' of ca. 25-33 kJ/mol). We explored the thermodynamic constraints on magnesium chelatase and demonstrate the effect of nucleotide hydrolysis on both the reaction kinetics and thermodynamics. The enzyme produces a significant rate enhancement (kcat /kuncat of 400 x 10(6) M) and a catalytic rate enhancement, kcat /Km (DIX) K0.5 (mg) Kuncat of 30 x 10(15) M(-1) , increasing to 300 x 10(15) M(-1) with the activator protein Gun4. This is the first demonstration of the thermodynamic benefit of ATP hydrolysis in the AAA(+) family. This article is protected by copyright. All rights reserved
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