Obesidómica: caracterización del secretoma del tejido adiposo de diferentes localizaciones anatómicas

Comunicaciones a congreso

Metabolic actions of the growth hormone-insulin growth factor-1 axis and its interaction with the central nervous system

The growth hormone/insulin growth factor-1 axis is a key endocrine system that exerts profound efects on metabolism by its actions on diferent peripheral tissues but also in the brain. Growth hormone together with insulin growth factor-1 perform metabolic adjustments, including regulation of food intake, energy expenditure, and glycemia. The dysregulation of this hepatic axis leads to diferent metabolic disorders including obesity, type 2 diabetes or liver disease. In this review, we discuss how the growth hormone/insulin growth factor-1 axis regulates metabolism and its interactions with the central nervous system. Finally, we state our vision for possible therapeutic uses of compounds based in the components of this hepatic axis.Instituto de Salud Carlos III (ISCIII)Ministerio de Ciencia e innovaci?nUni?n EuropeaFundaci?n de la Sociedad Gallega de Endocrinolog?a y nutrici?nCentro de Investigaci?n Biom?dica en Red (CIBER) de Fisiopatolog?a de la Obesidad y Nutrici?n (CIBERobn)European Union/HUMA

Circulating irisin levels are not regulated by nutritional status, obesity, or leptin levels in rodents

Irisin is a cleaved and secreted fragment of fibronectin type III domain containing 5 (FNDC5) that is mainly released by skeletal muscle and was proposed to mediate the beneficial effects of exercise on metabolism. In the present study we aim to investigate the regulation of the circulating levels of irisin in obese animal models (diet-induced obese (DIO) rats and leptin-deficient (ob/ob) mice), as well as the influence of nutritional status and leptin. Irisin levels were measured by Enzyme-Linked Immunosorbent Assay (ELISA) and Radioimmunoassay (RIA). Serum irisin levels remained unaltered in DIO rats and ob/ob mice. Moreover, its circulating levels were also unaffected by fasting, leptin deficiency, and exogenous leptin administration in rodents. In spite of these negative results we find a negative correlation between irisin and insulin in DIO animals and a positive correlation between irisin and glucose under short-term changes in nutritional status. Our findings indicate that serum irisin levels are not modulated by different physiological settings associated to alterations in energy homeostasis. These results suggest that in rodents circulating levels of irisin are not involved in the pathophysiology of obesity and could be unrelated to metabolic status; however, further studies should clarify its precise role in states of glucose homeostasis imbalance.Mar Quiñones is a recipient of a Postdoctoral Fellowship from Galician Government (Xunta de Galicia ED481B2014/039-0). Cintia Folgueira is funded by IDIS. Estrella Sánchez-Rebordelo is a fellowship of the Ministerio de Economia y Competitividad (ref: BES-2013-062796). Omar Al-Massadi is funded by the ISCIII/SERGAS thought a research contract “Sara Borrell” (CD14/00091)S

Identification of energy homeostasis signal from adipose tissues secretome

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Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance

Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balanceThis work is supported by grants of Xunta de Galicia (MQ:2018-PG013). Centro de Investigación Biomédica en Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn). CIBERobn is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds. Western Norway Regional Health Authority (Helse Vest RHF).M.Q. is a recipient of a Postdoctoral contract from Galician Government (Xunta de Galicia ED481B2018/004). O.A.M. was funded by a research contract Miguel Servet (CP20/00146) from the ISCIIIS

Caracterización por Proteómica del tejido muscular esquelético como órgano endocrino

Comunicaciones a congreso

Nutrición y secreción gástrica: un nuevo enfoque proteómico

Comunicación a congreso