247 research outputs found

    The relationships among knowledge management processes, innovation, and organisational performance in the Iraqi MTS

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    Present study examines of the relationships among knowledge management processes, innovation, and organisational performance in the Iraqi mobile telecommunications sector.The perspective of this research suggests that knowledge processes are essential capabilities for effective innovation and organisational performance. Through analysis of surveys collected from 220 mid-level managers, present study empirically tested a proposed theoretical framework by estimating structural equation model. The results show that knowledge management processes had a statistically significant and direct positive effect on innovation.Additionally, the direct relationship of knowledge management processes with organisational performance was positively affected, but it was not statistically significant.More importantly, the findings indicate that knowledge management processes had a positive and statistically significant effect on organisational performance through the partial mediation effect of innovation. Present study concludes with a conclusions and contribution of the research

    Who are the crew members on implementation of knowledge management strategies to enhance innovation and improve organizational performance

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    The purpose of present study is to determine the role of mid-level managers in implementation of knowledge management strategies toward enhancing innovation and improving organizational performance.To address this issue, an intensive literature review was used.There is only one way to survive, stability, and growth for the contemporary organizations.Successful implementation of knowledge management strategies will enable innovation sustainability and organizational performance improvement. Therefore, the organizations must choose the best way to implement knowledge management strategies. However, there has been a lack of an integrated implementation framework for knowledge management strategies. The present study finds that midlevel managers could play a critical role in insuring the successful implementation of knowledge management strategies.As a result, present study proposed theoretical framework that explained how the mid-level managers influence in the implementation of knowledge management strategies. Additionally, how the successful implementation of knowledge management strategies lead to enhance innovation and improve organizational performance

    Who are the Crew Members on Implementation of Knowledge Management Strategies to Enhance Innovation and Improve Organizational Performance

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    The purpose of present study is to determine the role of mid-level managers in implementation of knowledge management strategies toward enhancing innovation and improving organizational performance. To address this issue, an intensive literature review was used. There is only one way to survive, stability, and growth for the contemporary organizations. Successful implementation of knowledge management strategies will enable innovation sustainability and organizational performance improvement. Therefore, the organizations must choose the best way to implement knowledge management strategies. However, there has been a lack of an integrated implementation framework for knowledge management strategies. The present study finds that mid-level managers could play a critical role in insuring the successful implementation of knowledge management strategies. As a result, present study proposed theoretical framework that explained how the mid-level managers influence in the implementation of knowledge management strategies. Additionally, how the successful implementation of knowledge management strategies lead to enhance innovation and improve organizational performance. Keywords Mid-level managers' role, knowledge management strategies, innovation, and organizational performance

    Development of antiproliferative nanohybrid compound with controlled release property using ellagic acid as the active agent

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    An ellagic acid (EA)–zinc layered hydroxide (ZLH) nanohybrid (EAN) was synthesized under a nonaqueous environment using EA and zinc oxide (ZnO) as the precursors. Powder X-ray diffraction showed that the basal spacing of the nanohybrid was 10.4 Å, resulting in the spatial orientation of EA molecules between the interlayers of 22.5° from z-axis with two negative charges at 8,8′ position of the molecules pointed toward the ZLH interlayers. FTIR study showed that the intercalated EA spectral feature is generally similar to that of EA, but with bands slightly shifted. This indicates that some chemical bonding of EA presence between the nanohybrid interlayers was slightly changed, due to the formation of host–guest interaction. The nanohybrid is of mesopores type with 58.8% drug loading and enhanced thermal stability. The release of the drug active, EA from the nanohybrid was found to be sustained and therefore has good potential to be used as a drug controlled-release formulation. In vitro bioassay study showed that the EAN has a mild effect on the hepatocytes cells, similar to its counterpart, free EA

    Preparation of hippurate-zinc layered hydroxide nanohybrid and its synergistic effect with tamoxifen on HepG2 cell lines

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    Samer Hasan Hussein Al Ali1, Mothanna Al-Qubaisi2, Mohd Zobir Hussein1,3, Zulkarnain Zainal1, Muhammad Nazrul Hakim41Department of Chemistry, Faculty of Science; 2Department of Cell and Molecular Biology, Faculty of Biotechnology and Biomolecular Science; 3Advanced Materials and Nanotechnology Laboratory, Institute of Advanced Technology; 4Department of Biomedical Science, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Serdang, Selangor, MalaysiaBackground: A new simple preparation method for a hippurate-intercalated zinc-layered hydroxide (ZLH) nanohybrid has been established, which does not need an anion-exchange procedure to intercalate the hippurate anion into ZLH interlayers.Methods: The hippuric acid nanohybrid (HAN) was prepared by direct reaction of an aqueous suspension of zinc oxide with a solution of hippuric acid via a one-step method.Results: The basal spacing of the nanohybrid was 21.3 Å, indicating that the hippurate anion was successfully intercalated into the interlayer space of ZLH, and arranged in a monolayer fashion with the carboxylate group pointing toward the ZLH inorganic interlayers. A Fourier transform infrared study confirmed the formation of the nanohybrid, while thermogravimetry and differential thermogravimetry analyses showed that the thermal stability of the nanohybrid was markedly enhanced. The loading of hippurate in the nanohybrid was estimated to be about 38.7% (w/w), and the release of hippurate from the nanohybrid was of a controlled manner, and therefore the resulting material was suitable for use as a controlled-release formulation. HAN has synergistic properties with tamoxifen toward a HepG2 cell line, with an IC50 value of 0.35 compared with hippurate. In the antiproliferative assay, the ratio of viable cells account for cells treated by the combination tamoxifen with HAN to untreated cells was sharply reduced from 66% to 13% after 24 and 72 hours, respectively.Conclusion: The release of hippuric acid anions from HAN occurred in a controlled manner, and the resulting material is suitable for a controlled-release formulation.Keywords: hippuric acid, nanohybrids, zinc oxide, zinc-layered hydroxide, synergistic effec

    Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite.

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    The intercalation of perindopril erbumine into Zn/Al-NO3-layered double hydroxide resulted in the formation of a host-guest type of material. By virtue of the ionexchange properties of layered double hydroxide, perindopril erbumine was released in a sustained manner. Therefore, this intercalated material can be used as a controlled-release formulation. Results: Perindopril was intercalated into the interlayers and formed a well ordered, layered organic-inorganic nanocomposite. The basal spacing of the products was expanded to 21.7 Å and 19.9 Å by the ion-exchange and coprecipitation methods, respectively, in a bilayer and a monolayer arrangement, respectively. The release of perindopril from the nanocomposite synthesized by the coprecipitation method was slower than that of its counterpart synthesized by the ion-exchange method. The rate of release was governed by pseudo-second order kinetics. An in vitro antihypertensive assay showed that the intercalation process results in effectiveness similar to that of the antihypertensive properties of perindopril. Conclusion: Intercalated perindopril showed better thermal stability than its free counterpart. The resulting material showed sustained-release properties and can therefore be used as a controlled-release formulation

    Core requirements of knowledge management implementation, innovation and organizational performance

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    The present study aims to examine the relationship among core requirements of knowledge management implementation, innovation, and organizational performance in the Iraqi mobile telecommunications sector.A questionnaire was conducted on mobile companies based on a proportionate stratified random sampling technique.The results indicated that core requirements of knowledge management implementation had a statistically significant and direct positive effect on innovation.The critical success factors of knowledge management and knowledge management strategies had a statistically significant and direct positive effect on organizational performance.Then the direct relationship of knowledge management processes with organizational performance was positively affected, but it was not statistically significant.The results also indicated that the innovation had a positive and statistically significant effect on organizational performance. More importantly, the results indicate that core requirements of knowledge management implementation had a positive and statistically significant effect on organizational performance through the partial mediating effect of innovation

    Ideologi Humanisme Islam Salman Faris Dalam Novel Guru Dane Dan Guru Onyeh: Kajian Interteks Dan Implikasinya Sebagai Bahan Ajar Apresiasi Sastra Di SMA

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    Tujuan penelitian ini terdiri atas (1) mendeskripsikan latar sosio-historis Salman Faris sebagai faktor genetik, (2) mendeskripsikan bangunan struktur novel GD dan GO karya Salman Faris, (3) mendeskripsikan wujud ideologi humanisme Islam Salman Faris dan bentuk-bentuk dehumanisasi dalam dua fiksinya, (4) mendeskripsikan hubungan intertektualitas ideologi novel GD dan GO karya Salman Faris, dan (5) mendeskripsikan implikasi hasil penelitian sebagai bahan ajar apresiasi sastra di SMA. Penelitian ini berbentuk kualitatif deskriptif dengan strategi terpancang. Sumber data penelitian ini berupa (1) dokumen, yakni teks novel GO dan GO karya Salman Faris serta buku-buku literature yang relevan, (2) informan, yakni Salman Faris dan tanggapan pembaca terhadap novel tersebut. Teknik pengumpulan data menggunakan teknik pustaka, simak, dan catat. Adapun teknik analisis menggunakan metode reduksi, sajian data dan verifikas serta simpulan, yang divalidkan dengan model pembacaan semiotik, berupa heuristik dan hermeneutic, sedangkan validitas menggunakan triangulasi data. Hasil penelitian ini adalah (1) Secara sosio-hitoris, karya-karya Salman Faris bernuansakan kearifan lokal bahkan multikultural dengan menjadikan Sasak sebagai ikon penciptaan, (2) Telaah terhadap struktur novel GD dan GO menekankan pada tema dan fakta cerita, (3) Wujud ideologi dari dua fiksi tersebut adalah pembebasan manusia, titik tolaknya pada ideologi humanisme Islam, (4) Interteks dari novel GD dan GO adalah ideologi humanisme Islam yang wujudnya (a) misi pembebasan, (b) tidak mengenal kelas, (c) pemahaman terhadap agama, (d) tradisi berpikir dan perjuangan kemanusian, (e) keteguhan prinsip dan identitas, (f) menentang monopoli ekonomi dan kapitalisme, serta (g) perlawanan terhadap otoritas sistem tradisi. Adapun Pada hasil simpulan adalah (5) implementasi ideologi humanisme Islam Salman Faris dapat dijadikan bahan ajar sebagai bahan ajar apresiasi sastra di di SMA, tidak lepas dari tiga aspek penting pembelajaran, yakni sikap, keterampilan, dan pengetahuan dengan titik acuan pada kompetensi inti nomer (3) dan indikatornya ketercapaian pada kompetensi dasar nomor (3.3) berdasarkan kurikulum 2013
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