The dioritic-gabbroic intrusive complex of Susqueda (Montseny–Guilleries massif, Catalonia): lithological units and petrographic features

The intrusive complex of Susqueda constitutes the biggest association of plutonic mafic rocks of the Catalonian Coastal Ranges. It is located in the contact between the large calc-alkaline granitoid intrusions and the Paleozoic country rocks affected by Hercynian regional metamorphism. Intrusive relationships denote contemporaneity of basic magmas and, at least, an acid magma intrusion. A significant part of the outcrop consists of a heterogeneous mixing zone between the two magmas (mingling). The intrusion is made up of two oval-shaped outcrops about 3 km long, elongated in the N–S direction and separated by a NW–SE fault. In these units, the compositions of the plutonic rocks range from quartz diorites and tonalites (in the mixing zones) up to olivine hornblendites. Even though its distribution is quite heterogeneous, a preliminary cartography was made including the different petrographic types in three main groups: 1) hornblende gabbros and olivine hornblendites; 2) biotite-hornblende diorites; and 3) heterogeneous mixing zone between hornblende-biotite quartz diorite, granodiorite, and tonalite. The predominant mineral composition consists of plagioclase and amphibole, typical of dioritic rocks. Nevertheless, in a great part of the outcrop the plagioclase widely exceeds the 50% in An, typical of gabbroic rocksEl complejo intrusivo de Susqueda constituye la mayor asociación plutónica de rocas máficas del batolito de las Cordilleras Costeras Catalanas. Se halla situado en el contacto entre grandes intrusiones de granitoides calcoalcalinos y rocas encajantes paleozoicas afectadas por el metamorfismo regional herciniano. Las relaciones intrusivas indican una clara contemporaneidad entre los magmas básicos y, al menos, una intrusión ácida. Una parte significativa del afloramiento consiste en una zona de mezcla heterogénea entre los dos magmas (mingling). La intrusión está formada por dos afloramientos ovalados de unos 3 km de longitud, alargados en dirección N–S y separados por una falla NW–SE. En su interior se distinguen diversos tipos de rocas plutónicas con composiciones que varían desde cuarzodioritas y tonalitas (en las zonas de mezcla) hasta hornblenditas olivínicas. Aunque su distribución es bastante heterogénea se ha realizado una cartografía preliminar, incluyendo los distintos tipos petrográficos en tres grupos principales: 1) gabros hornbléndicos y hornblenditas olivínicas, 2) dioritas hornbléndico-biotíticas y 3) mezcla heterogénea entre cuarzodioritas biotítico-hornbléndicas, granodioritas y tonalitas. La mineralogía dominante consiste en plagioclasa y anfíbol que es típica de rocas dioríticas. No obstante, en gran parte del afloramiento la plagioclasa supera ampliamente el 50% de An, propia de rocas gabroica

Practical guidelines to manage discordant situations of SMN2 copy number in patients with spinal muscular atrophy

Objective Assessment of SMN2 copy number in patients with spinal muscular atrophy (SMA) is essential to establish careful genotype-phenotype correlations and predict disease evolution. This issue is becoming crucial in the present scenario of therapeutic advances with the perspective of SMA neonatal screening and early diagnosis to initiate treatment, as this value is critical to stratify patients for clinical trials and to define those eligible to receive medication. Several technical pitfalls and interindividual variations may account for reported discrepancies in the estimation of SMN2 copy number and establishment of phenotype-genotype correlations. Methods We propose a management guide based on a sequence of specified actions once SMN2 copy number is determined for a given patient. Regardless of the method used to estimate the number of SMN2 copies, our approach focuses on the manifestations of the patient to recommend how to proceed in each case. Results We defined situations according to SMN2 copy number in a presymptomatic scenario of screening, in which we predict the possible evolution, and when a symptomatic patient is genetically confirmed. Unexpected discordant cases include patients having a single SMN2 copy but noncongenital disease forms, 2 SMN2 copies compatible with type II or III SMA, and 3 or 4 copies of the gene showing more severe disease than expected. Conclusions Our proposed guideline would help to systematically identify discordant SMA cases that warrant further genetic investigation. The SMN2 gene, as the main modifier of SMA phenotype, deserves a more in-depth study to provide more accurate genotype-phenotype correlations

Verificación del comportamiento térmico de un prototipo de vivienda familiar de madera mediante “ECOTECT” y “QUICK II”

Teniendo como antecedente estudios desarrollados mediante monitoreo experimental y simulación dinámica con los programas informáticos TRNSYS y SIMUSOL, para evaluar el comportamiento térmico de un prototipo unifamiliar de madera construido por el In.Vi.Co (Instituto de Viviendas de Corrientes), este trabajo presenta el desarrollo, aplicación y evaluación preliminar de las potencialidades de los programas “ECOTECT” y “QUICK II”. El buen ajuste encontrado entre tendencias y resultados simulados con dichas herramientas informáticas, demuestra que las mismas, permitirán optimizar el nivel de confort térmico de viviendas populares en la etapa de diseño conceptual.Having developed studies by means of experimental monitoring and dynamic simulation with the computer programs TRNSYS and SIMUSOL, in order to evaluate the thermal behaviour of a wooden family prototype built by In.Vi.Co (Instituto de Viviendas de Corrientes), this work presents the development, application and preliminary evaluation of the potentialities of the program "ECOTECT” and “QUICK II”. The good adjustment found between tendencies and simulated results with this computing tools, demonstrates that they will allow to optimize the thermal comfort level of popular houses, in the conceptual design phase.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Verificación del comportamiento térmico de un prototipo de vivienda familiar de madera mediante “ECOTECT” y “QUICK II”

Teniendo como antecedente estudios desarrollados mediante monitoreo experimental y simulación dinámica con los programas informáticos TRNSYS y SIMUSOL, para evaluar el comportamiento térmico de un prototipo unifamiliar de madera construido por el In.Vi.Co (Instituto de Viviendas de Corrientes), este trabajo presenta el desarrollo, aplicación y evaluación preliminar de las potencialidades de los programas “ECOTECT” y “QUICK II”. El buen ajuste encontrado entre tendencias y resultados simulados con dichas herramientas informáticas, demuestra que las mismas, permitirán optimizar el nivel de confort térmico de viviendas populares en la etapa de diseño conceptual.Having developed studies by means of experimental monitoring and dynamic simulation with the computer programs TRNSYS and SIMUSOL, in order to evaluate the thermal behaviour of a wooden family prototype built by In.Vi.Co (Instituto de Viviendas de Corrientes), this work presents the development, application and preliminary evaluation of the potentialities of the program "ECOTECT” and “QUICK II”. The good adjustment found between tendencies and simulated results with this computing tools, demonstrates that they will allow to optimize the thermal comfort level of popular houses, in the conceptual design phase.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Verificación del comportamiento térmico de un prototipo de vivienda familiar de madera mediante “ECOTECT” y “QUICK II”

Teniendo como antecedente estudios desarrollados mediante monitoreo experimental y simulación dinámica con los programas informáticos TRNSYS y SIMUSOL, para evaluar el comportamiento térmico de un prototipo unifamiliar de madera construido por el In.Vi.Co (Instituto de Viviendas de Corrientes), este trabajo presenta el desarrollo, aplicación y evaluación preliminar de las potencialidades de los programas “ECOTECT” y “QUICK II”. El buen ajuste encontrado entre tendencias y resultados simulados con dichas herramientas informáticas, demuestra que las mismas, permitirán optimizar el nivel de confort térmico de viviendas populares en la etapa de diseño conceptual.Having developed studies by means of experimental monitoring and dynamic simulation with the computer programs TRNSYS and SIMUSOL, in order to evaluate the thermal behaviour of a wooden family prototype built by In.Vi.Co (Instituto de Viviendas de Corrientes), this work presents the development, application and preliminary evaluation of the potentialities of the program "ECOTECT” and “QUICK II”. The good adjustment found between tendencies and simulated results with this computing tools, demonstrates that they will allow to optimize the thermal comfort level of popular houses, in the conceptual design phase.Asociación Argentina de Energías Renovables y Medio Ambiente (ASADES

Adaptation and Validation of the Scale of Types of Users in Gamification with the Spanish Adolescent Population

The video game has been one of the phenomena with the greatest impact on the entire social fabric, and especially among young people. Therefore, it is essential to understand the interaction between the players and the video game itself. However, few instruments have been designed to assess the types of players in the adolescent population. Therefore, the purpose of this study was to validate the Gamification User Types Hexad Scale for the Spanish adolescent population. The sample of participants consisted of 1345 adolescents between the ages of 13 and 18. To evaluate the psychometric properties of the scale, a confirmatory factor analysis and a multi-group analysis of invariance by sex were performed. The results provide evidence of a valid and reliable six-factor instrument to measure the types of players in the Spanish adolescent population, regardless of their sex

Between Level Up and Game Over: A Systematic Literature Review of Gamification in Education

Educational gamification consists of the use of game elements and game design techniques in the educational context. The objective of this study is to examine the existing evidence on the impact of educational gamification on student motivation and academic performance in the last five years in order to analyze its distribution over time, educational level, variables, and most used game elements, and know the advantages of its implementation in the classroom. For this, a systematic review is proposed through the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) methodology in three multidisciplinary databases, through an exhaustive search with inclusion and exclusion criteria on quantitative experimental studies that explore gamification in educational centers, which provide information about the most current lines of research. Fourteen studies were included in this review. These used experimental or quasi-experimental designs. Most of them report gamification as a valid learning strategy. The results support the conclusion that educational gamification has a potential impact on the academic performance, commitment, and motivation of students. Therefore, this study implies the need to expand research on the needs and challenges of students when learning with gamified techniques

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Tomar la palabra (II). Intertextualidad e intermedialidad como herramientas pedagógicas para la enseñanza de la literatura y otros discursos

Este proyecto explora las relaciones entre obras literarias y literatura y otras artes (música, pintura, fotografía, cine, etc.) como medio para desarrollar la competencia lectora y expresiva y estimular el disfrute literario en ámbito universitario

Tiempo de fenómenos : nuevo consumo de televisión y estratégias transmedia en la serie El ministerio del tiempo

En el presente trabajo, se exponen las nuevas formas de consumo de televisión debido a la aparición de un nuevo espectador colaborativo y creador (prosumidor) y las distintas narrativas y estrategias transmedia, así como la implicación de las redes sociales en éstas, dando lugar a la denominada televisión social y, por consiguiente, a nuevas formas de medir audiencia junto a la ya tradicional, como son la social y en diferido. Se toma como ejemplo de todo lo anterior la serie de reciente fenómeno social El Ministerio del Tiempo, exponiendo su estrategia transmedia en ambas temporadas, así como las distintas audiencias generadas y todo lo que esto ha conllevado. Igualmente, se realiza un análisis de su cuenta de Twitter (@MdT_TVE) para ilustrar el tipo de relación que mantiene con sus seguidores y el cumplimiento de todo lo citado anteriormente.Universidad de Sevilla. Grado en Comunicación Audiovisua