1,849 research outputs found

    Obtaining Boiler Fuel Gas to Reduce Air Pollution: The Policy of the Federal Power Commission

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    Receptors interacting with the constant domain of immunoglobulins (Igs) have a number of important functions in vertebrates. They facilitate phagocytosis by opsonization, are key components in antibody-dependent cellular cytotoxicity as well as activating cells to release granules. In mammals, four major types of classical Fc receptors (FcRs) for IgG have been identified, one high-affinity receptor for IgE, one for both IgM and IgA, one for IgM and one for IgA. All of these receptors are related in structure and all of them, except the IgA receptor, are found in primates on chromosome 1, indicating that they originate from a common ancestor by successive gene duplications. The number of Ig isotypes has increased gradually during vertebrate evolution and this increase has likely been accompanied by a similar increase in isotype-specific receptors. To test this hypothesis we have performed a detailed bioinformatics analysis of a panel of vertebrate genomes. The first components to appear are the poly-Ig receptors (PIGRs), receptors similar to the classic FcRs in mammals, so called FcRL receptors, and the FcR gamma chain. These molecules are not found in cartilagous fish and may first appear within bony fishes, indicating a major step in Fc receptor evolution at the appearance of bony fish. In contrast, the receptor for IgA is only found in placental mammals, indicating a relatively late appearance. The IgM and IgA/M receptors are first observed in the monotremes, exemplified by the platypus, indicating an appearance during early mammalian evolution. Clearly identifiable classical receptors for IgG and IgE are found only in marsupials and placental mammals, but closely related receptors are found in the platypus, indicating a second major step in Fc receptor evolution during early mammalian evolution, involving the appearance of classical IgG and IgE receptors from FcRL molecules and IgM and IgA/M receptors from PIGR

    Electroweak baryogenesis in the Z3-invariant NMSSM

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    We calculate the baryon asymmetry of the Universe in the Z3-invariant Next-to-Minimal Supersymmetric Standard Model where the interactions of the singlino provide the necessary source of charge and parity violation. Using the closed time path formalism, we derive and solve transport equations for the cases where the singlet acquires a vacuum expectation value (VEV) before and during the electroweak phase transition. We perform a detailed scan to show how the baryon asymmetry varies throughout the relevant parameter space. Our results show that the case where the singlet acquires a VEV during the electroweak phase transition typically generates a larger baryon asymmetry, although we expect that the case where the singlet acquires a VEV first is far more common for any model in which parameters unify at a high scale. Finally, we examine the dependence of the baryon asymmetry on the three-body interactions involving gauge singlets.Comment: 24 pages, version submitted to the journa

    CANCER IS PREVENTABLE- LET US TRY OUR LEVEL BEST

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    Cancer is a chronic disease and the prevalence is increasing at a faster rate in recent years. Most of the cancers are incurable, treatment is very expensive and is not affordable even for above middle-class people. A strong correlation is observed between lifestyle factors and cancer incidence or prevention. Let us know about cancer prevention lifestyle focussing mainly on the role of physical activity and diet. Most of the people leading sedentary life style. There is an overall decline in the level of physical activity. There is strong evidence between adequate physical activity and prevention of colon cancer and breast cancer. Regular and proper physical activity increases the motility of digestive system and decreases the residence time of food carcinogens. Further it will decrease obesity as well as abdominal fat deposition. Moreover regular physical activity is associated with a decrease in the circulating levels of sex hormones, insulin and insulin like growth factor; all are associated with cancer incidence. Let us be active to make world cancer free. Meet you again in the next issue with the role of diet in cancer prevention

    Characteristics of children with medical complexity experiencing medication ordering errors at hospital admission

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    Medication errors make up a staggering portion of medical error in the United States. These medication errors are most likely to occur at transitions in care. Children with medical complexity (CMC) often rely on multiple medications to maintain their health, making accurate medication ordering of utmost importance to avoid exacerbating chronic conditions or unnecessary harm. Because of their increased medication usage, CMC have an increased risk of medication ordering error (MOE). To better inform the medication reconciliation process for CMC, we examine the prevalence, category, and risk factors of MOE at hospital admissions for this patient population. A retrospective cohort analysis of 1,237 hospitalized CMC from two tertiary pediatric teaching hospitals with clinical care services for CMC was performed on data from November 1, 2015 to October 31, 2016. Pharmacists and advance nurse practitioners identified MOEs at admissions through medical record review, patient history at interview, and inpatient team discussions. Identified MOEs were classified as one of seventeen different categories, some of which include duplications, omissions, or incorrect frequency, dose, or route. Statistical analysis was performed using Fisher’s exact test, chi-squares, and generalized linear mix models to examine the relationships between MOEs at admission and patient characteristics, such as ethnicity, number of chronic conditions, or number of medications taken at admission. A total of 115 admission MOEs were identified in 73 hospitalized CMC. The two most common MOE types were wrong dose (41.7%) and omitted medication (33.9%). The median number of medications ordered at admission was 10 (IQR 6-14). Medications most commonly associated with an MOE were cholecalciferol (n=9) and baclofen (n=9). As for patient characteristics, the median age at admission was 5 years ([Interquartile Range [IQR] 1-12). Of the total sample, 96.8% had a complex chronic condition and 72.8% were technology dependent. Children who are Black, require medical technology, or take more than 15 medications during hospitalization were found to have higher MOE rates. Multivariable analysis revealed the highest odds of MOE in children taking baclofen (Odds Ratio [OR] 2.6 [95% Confidence Interval {CI} 1.4-4.7]). MOEs at admission are prevalent among hospitalized CMC. Further study on medication safety in CMC is needed to inform medication reconciliation processes and better prevent patient harm.2019-07-03T00:00:00

    GOOD OLD OIL

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    Nowadays everybody is getting puzzled and confused about choosing right oil for daily use. Most of the ads in the market revolving around sunflower oil only with different brand names claiming it is heart friendly. In recent years, younger generation may not be familiar much with our age old traditional oils like sesame oil. Sesame oil is also called as gingelly oil or til oil is rich in vitamin E and B. It is a good source of minerals like calcium, manganese and phosphorous and promotes healing. It contains high amounts of polyunsaturated fatty acids and decreases high blood pressure. Because of its antioxidant property, it decreases cholesterol and good for heart. It acts like a sedative, relieves mental fatigue and promotes sleep when it is used for head massage. It is having laxative nature, relieving constipation. When applied topically on to the skin it is acting as an excellent moisturizer and an emollient. Because of its natural antibacterial, antiviral and anti-inflammatory properties it keeps away the skin and tooth infections. Hence, it can be used by one and all without any hesitation for regular cooking. However, it is not preferred for deep frying. Let us once again say OLD IS GOL

    CANCER CAN BE PREVENTED

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    Life style factors are contributing significantly in cancer prevention. With the intake of proper and balanced diet ,cancer prevention is possible. Many foods are associated either with incidence or prevention of cancer. Plant based foods like fresh fruits, vegetables and whole grains rich in fiber, b-carotene, vitamins and antioxidants can prevent cancer. Fiber rich foods increase bowel movement, decreasing the absorption of cholesterol. Pumpkin, carrots contain b-carotenes. Leafy vegetables, broccoli, cabbage, cauliflower, peas and beans are rich in fiber and stimulate cancer preventing enzyme induction. Vitamin C rich citrus fruits can stimulate immune system. Garlic and onions can stimulate enzymes that can suppress tumor growth. Turmeric used in cooking can prevent colorectal cancer. Topical application of turmeric can prevent breast cancer in women. On the other hand, certain foods can cause cancer. Refined foods, high fat foods, deep fried foods, processed foods and low fiber foods increase cancer risk. Red meat, processed meat and barbeques contain a carcinogen called acrylamide. Foods prepared with hydrogenated fats contain transfats which increase risk for breast, ovarian, cervical and lung cancer. Consumption of alcohol increasing the risk for cancers of digestive system. LET US EAT RIGHT FOODS AND AVOID WRONG FOODS

    Developing a Privacy Code of Practice for Connected and Automated Vehicles

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    Connected and autonomous vehicles (‘‘CAVs”) can collect, store, process and transmit vast amounts of data. Understanding the use (and potential misuse) of this data, particularly when that data is about an identifiable individual within the meaning of data protection law, is regarded critical to the success of this new mode of transportation. However, what constitutes personal information in relation to coneccted and automated vehicle data on a case-by-case basic. This presents a policy challenge for the government and creates uncertainty for businesses wishing to make use of this data

    FEW FACTS ABOUT PHYTOESTROGENS

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    Phytoestrogens mainly belongs to phenolic group of compounds known as flavonoids. Foods which are having highest phytoestrogen content include nuts, oil seeds, soy products, cereals, legumes etc. The highest concentrations of isoflavonoes are found in soybean products. In recent years soya food preparations are widely used for many of their beneficial effects like, as a good substitute for protein and as it is claimed to have cholesterol lowering effects. But there are controversial reports regarding their health benefits. Excessive consumption these phytoestrogens may cause decrease in male infertility and reproductive capability by causing alterations in the hypothalamo-pitutory-gonadal axis. Phytoestrogens have been indicated for centuries in the treatments of menstrual and menopausal problems in women. So phytoestrogens may be beneficial in healthy females. Females with breast cancer should be aware of potential risks of using phytoestrogen rich soya products. So be moderate with the consumption of soya products

    MEMORY IMPROVING FOODS

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    Learning is a lifelong process of transforming information and experience into knowledge, skills, behaviorand attitudes. Memory is the ability of the brain to store, retain and subsequently to recall information received fromthe world. Cognition can be defined as organization of information. It includes acquiring information (perception),selecting (attention), representing (understanding) and retaining (memory) information and using it to guidebehavior (reasoning and coordination of motor outputs).There are so many conditions associated with memory and cognitive impairment which include Aging,Alzheimer’s disease, Stroke, Stress, Head injuries, Seizures, Benzodiazepines, Brain tumors, Depression, Temporallobe defects and Schizophrenia etc.Choline rich foods can enhance memory and learning and may be useful in improving cognitive abilities. Theseinclude sea foods, liver, egg yolk, soysbeans, broccoli, ash gourd. Coloured fruits and vegetables are good source ofantioxidants which improve concentration. It is advised to decrease the consumption of foods rich in transfats likehydrogenated oils, fried foods, beef, pork, mutton and ice creams and pastries. Such foods increase the deposition offats in the neurons and impair cognition. Tea, cocoa and turmeric are reported to have good nootropic activity i.e.improving memory and learning. Apart from the foods, one should keep the brain active to maintain its cognitivefunction well
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