Effect of corneal thickness on intraocular pressure measurements with the Pascal dynamic contour, Canon TX-10 non-contact and Goldmann applanation tonometers in healthy subjects

PubMedID: 18637107Purpose: To investigate the effects of central corneal thickness (CCT) on intraocular pressure (IOP) measurements of the Pascal dynamic contour tonometry (DCT), Canon TX-10 non-contact tonometry (NCT) and Goldmann applanation tonometry measurements (GAT) in healthy subjects. Methods: IOP values of 135 eyes with normal corneas of 135 healthy volunteers were determined by DCT, NCT and by GAT. The CCT was measured using an ultrasonic pachymeter after all IOP determinations had been made. Results: When DCT measurements were compared (IOP = 17.52 ± 2.0 mmHg) with NCT measurements (IOP = 16.54 ± 2.77 mmHg) and GAT measurements (IOP = 15.07 ± 2.35 mmHg), DCT measurements were significantly higher than NCT and GAT (p < 0.001). There was a significant correlation between CCT with both NCT (r = 0.260, p = 0.003) and GAT measurements (r = 0.257, p = 0.005). There was a weak correlation that was not statistically significant between CCT and DCT (r = 0.160, p = 0.079). Conclusion: The IOP measurements with DCT seem to be less dependent on CCT. NCT appears to be more affected by variation in CCT than GAT. © 2008 Optometrists Association Australia

Intraocular pressure changes following phacoemulsification [Fakoemülsifikasyon Sonrasında Göz İçi Basınç Degişimleri]

Objective: To analyze the effect of phacoemulsification on intraocular pressure (IOP) and to evaluate the management for high postoperative IOP. Material and Methods: Data of 812 eyes of 584 consecutive patients (330 males and 254 females) who underwent uneventful phacoemulsification in Department of Ophthalmology, Başkent University Adana Research Center were investigated retrospectively. The ages ranged between 26 and 89 years (65.5±9.8 years). Intraocular pressure values of preoperative and postoperative first day, first week and first month visits were recorded. Intraocular pressures over 22 mm Hg were considered as high IOP. Either anterior chamber decompression or antiglaucomatous medication was used to decrease the postoperative rise in IOP. Changes in IOP were analyzed using ANOVA. Results: The mean preoperative IOP was 15.6±4.3 mmHg, which increased to 19.7±9.0 mmHg on the 1st day (p<0.001). The IOP decreased significantly to 12.7±4.5 mmHg at 1st week, and 12.8±3.7 mmHg at 1st month (p<0.001, both). In 249 (30.7%) eyes, high IOP was detected on the first day. In 114 (45.8%) of these eyes, IOP was reduced by anterior chamber decompression while in 73 (29.3%) eyes glaucoma medication was prescribed. At first month 13 (1.6%) eyes had high IOP. Conclusion: Although, a rise in IOP remains a problem in the postoperative first day; both anterior chamber decompression and glaucoma medication seem to be effective and safe to overcome thiscondition. In short term, uneventful phacoemulsification and intraocular lens implantation results in a decrease in IOP. © 2012 by Türkiye Klinikleri

The spectrum of Vogt-Koyanagi-Harada disease in Turkey: VKH in Turkey

PubMedID: 16957877Aim: The aim of this report was to provide a detailed description of the clinical features of Vogt-Koyanagi-Harada (VKH) disease in Turkish patients. Methods: We retrospectively analyzed 45 patients diagnosed with VKH disease at seven referral centers in Turkey. A standard data acquisition form was used for the analysis of demographic and clinical features. Results: The study cohort consisted of 45 patients (32 female, 13 male) who had a mean age at presentation of 31 years. Seven patients (15%) were aged 16 years or younger. Nineteen (42%) patients presented in the acute or subacute stage and 26 (58%) in the chronic stage. According to the revised diagnostic criteria, nine (20%) patients had the complete form of the disease, 23 (51%) had the incomplete form, and 13 (29%) had probable VKH disease. All patients had bilateral ocular involvement. Sunset-glow fundus was observed in 89% of the patients, pigment clumping in 73%, nummular depigmented scars in 71%, cataract in 53%, optic atrophy in 31%, glaucoma in 29%, subretinal fibrosis in 22%, choroidal neovascular membranes in 7%, and phthisis in 4%. All patients who presented at the acute uveitic stage received systemic corticosteroid therapy. Immunosuppressive treatment was employed in 30 (66%) patients, which was initiated at the acute uveitic stage in ten (22%) patients. Final visual acuity was better than 0.5 in 59% of the patients' eyes, between 0.1 and 0.5 in 21%, and less than 0.1 in 20%. Conclusions: VKH disease is rare in Turkey. We conclude that the majority of patients with VKH in Turkey do not have the complete form of the disease. Based on our results, most patients with VKH seem to be late referrals. Ocular complications were common among these patients. © Springer Science+Business Media B.V. 2006

Risk factors for Gram-negative bacterial infection of cardiovascular implantable electronic devices: multicenter observational study (CarDINe Study).

Infections of cardiovascular implantable electronic devices (CIED) are mainly due to gram-positive bacteria (GPB). Data about gram negative bacteria CIED (GNB-CIED) infections are limited. Aims of our work are to investigate risk factors, clinical and diagnostic characteristics, and outcome of patients with GNB-CIED. Multicenter, international, retrospective, case-control-control study on patients undergoing CIED implantation from 2015 to 2019 in 17 centers across Europe. For each patient diagnosed with GNB-CIED, one matching control with GPB-CIED infection and two matching controls without infection were selected. 236 patients were enrolled: 59 with GNB-CIED infection, 59 with GPB-CIED infection and 118 without infection. No differences regarding clinical presentation, diagnostic and therapeutic managements were found between the groups. A trend toward higher rate of FDG PET/CT positivity was observed among patients with GN than in those with GPB-CIED infection (85.7% vs. 66.7%, p=0.208). Risk factors for GNB-CIED infection were Charlson Comorbidity Index Score (RRR=1.211, P= 0.011), obesity (RRR: 5.122, P=0.008), ventricular-pacing ventricular-sensing inhibited-response pacemaker (PM-VVI) implantation (RRR: 3,027, P=0.006) and the right subclavian vein site of implantation (RRR: 5.014, P=0.004). At 180-day survival analysis GNB-CIED infection was associated with increased mortality risk (HR=1.842, P=0.067). Obesity, high number of comorbidities, and right subclavian vein implantation site are associated with increased risk of GNB-CIED infection. A prompt therapeutic intervention that may be guided by the use of FDG PET/CT is suggested in patients with GNB-CIED infection considering the poorer outcome observed in this group