Level of anxiety, depression, self-esteem and quality of life among the women with vaginitis

Background: Present aim is to evaluate anxiety, depression, quality of life and self-esteem in patients with vaginitis (not only specific to candidasis) and also to determine factors affecting vaginitis such as demographic, cultural and psychological causes.Methods: Each patient completed a self-administered questionnaire (Rosenberg’ Self-Esteem Scale, Short-Form 36, Quality of Life Scale, Beck Anxiety Inventory, and Beck Depression Inventory, Body Image Scale) and underwent a careful examination of the vulva and vagina. The cross-sectional study was carried out with two groups. The first group consisted of 107 women between the ages 18 and 45 years and had no physical disease but reccurrent vulvovaginitis (≥4 in a year).  The comparison control group consisted of 94 healthy (no vaginitis symptoms in 12 months) age matched volunteer participants.Results: Women with vaginitis had significantly higher anxiety and depression scores. There was no statistically significant difference in body image scale. Regarding type of marriage, arranged type was statistically significantly higher in vaginitis group while flirting type was statistically higher in control group. University school degree and income was statistically significantly lower in vaginitis group. Living residence as rent and vaginal douch was statistically significantly higher in vaginitis group.Conclusions: A better detailed history should be taken into consideration for personal stress sources and treatment support should be provided for patients with vaginitis. Not only gynecologists but also a multidisciplinary team should take part in the treatment and follow up of the patients to cope with recurrency even in non-specific vaginitis

The effect of in-bed turning and mobilization training given to patients who undergo lumbar disk surgery on postoperative first mobility level: A single-blind, randomized controlled trial

Objective: This study was conducted to investigate the effects of mobilization and in-bed turning training given through the role-playing technique to patients to undergo lumbar disk surgery on the patient's pain, strain and dependence level during the first postoperative mobilization (turning, sitting, standing and walking). Methods: Patients who would undergo a lumbar disk hernia surgery were recruited from a neurosurgery clinic in Turkey. Patients who met inclusion criteria and agreed to participate (n = 40) in the study were randomly assigned to an intervention group (in-bed turning and mobilization training simulated with the role-playing technique, n = 19) and a control group (usual clinical care, n = 21). The outcome of the study was patient mobility and observer mobility scale scores. Results: Postoperative scores obtained from the patient mobility and observer mobility scale were lower in the intervention group than the scores of the control group, and the difference between the groups was found statistically significant (p < 0.05). The anxiety levels of the intervention group before (38.00 ± 6.59, p < 0.001) and after mobilization (31.63 ± 4.57, p = 0.032) were significantly lower. Conclusion: The findings indicate training improves patient care outcomes for first postoperative mobility. It is recommended that structured training for in-bed turning and mobilization should be integrated into routine clinical care in the preoperative period for patients to undergo lumbar disk hernia surgery. Practice implications: Preoperative training increases the patient's willingness to be mobilized and decreases the anxiety level and perceived pain and strain

Relationship between first trimester vaginal bleeding and the risk of placental abruption

The aim of this study was to analyze influence of first trimester vaginal bleeding on the risk of placental abruption, as well as to assess the relation of first trimester bleeding and perinatal outcome in this patients with placental abruption. The second objective was to assess the connection of first trimester bleeding with low pregnancy-associated plasma protein-A and maternal serum alpha-fetoprotein with placental abruption. This is the first study that evaluated all relations these analytes in placental abruption with first trimester bleeding. Spontaneous, singleton pregnancies with live fetus &#8805;26 weeks of gestation with placental abruption were divided into two groups based on their prensence of first-trimester bleeding (Group 1) or without (Group 2). Maternal age, parity, smoking habits, body mass index, history of abortion and abruption, levels of pregnancy-associated plasma protein-A and Alpha-fetoprotein were also analyzed and compared. Main outcome measures were, mean gestational age, gender of baby, APGAR scores, birth length and weight and cesarean section rates. A total of 122 patients were included in the study.There were 44 patients accompanied with first trimester bleeding (group 1) and 78 patients without first trimester bleeding (group 2). The neonatal birthweight was significantly lower in first trimester bleeding group. The rate of smoking mother was significantly higher in first trimester bleeding group. Regarding serum maternal biomarkers, pregnancy-associated plasma protein-A&#8804;0.5 and Alpha-fetoprotein &#8805;2 MOM was significantly higher in first trimester bleeding group.First trimester bleeding should alert clinicians for the signs of later possible complications in addition to low regnancy-associated plasma protein-A(&#8804;0.5 MOM) and higher Alpha-fetoprotein (&#8805;2 MOM) levels. Presence of vaginal bleeding in first trimester are related with poor maternal and fetal outcome at birth in patient with placental abruption. [Med-Science 2018; 7(3.000): 660-3

Arkeolojik DNA izolasyonu ve sekans analizi, modern örneklerle karşılaştırılması

Neolitik döneme ait kazı alanlarından elde edilen karbonlasın iş buğday örneklerinden DNA elde edilmiş ve çalışılmıştır. Çalışılan DNA, insanlığın yabanıl bir otu ıslah edip, ekmek yapmayı başardığı günümüzden 8500 yıl öncesine aittir ve dünyadaki en eski buğday DNA'^ıdır. Dolayısıyla, en eski ekmeklik buğday DNA sekansı, bu proje sayesinde bulunmuş, bu da Çatalhöyük halkının ekmeklik buğdayı üretip, tükettiklerinin moleküler düzeydeki ilk kanıtı olmuştur

Comparison of Inflammatory Reactions Following Two Different Cesarean Section Techniques: The Modified Misgav-Ladach Versus the Pfannenstiel-Kerr; A Prospective Randomized Trial

Objectives: There is not yet a consensus on the optimal surgical technique for cesarean section. This is the first study comparing two different (Cesarean Section) with respect to the following inflammatory reaction in means of changes in inflammatory marker levels. To evaluate the differences in inflammatory reactions following two different (Cesarean Section) techniques, the modified Misgav-Ladach versus the Pfannenstiel-Kerr technique. Study Desıgn: The study population included 88 pregnant women who met the inclusion criteria. These women were randomized into two groups according to Consolidated Standards of Reporting Trials guidelines: Group 1 (Misgav-Ladach group) and Group 2 (Pfannenstiel Kerr group). To compare the inflammatory reactions following surgery, Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) levels were measured in venous blood samples drawn from the patients just before (0 hour) and 24 hours (24th hour) after the surgery. In 5 women from Group 1 and 2 women from Group 2, the 24th hour blood samples could not be obtained or were lost. Thus, a total of 81 women, 39 women from Group 1 and 42 women from Group 2, comprised the population of study. The differences in inflammatory reactions between the 0 and 24th hours were analyzed by calculating the percent change in IL-6 and TNF-α levels, and these percentages were then compared between the groups. Results: There was a statistically significant difference between Group 1 and Group 2 regarding the serum IL-6 level change between 0 and 24th hour (530±653% and 196±168%, respectively, p=0.022. The difference in TNF-α was also higher in Group 2, but the difference was not statistically significant (229±306% vs. 571±824%, p=0.12). The mean operation time was significantly shorter in Group 1 (9.44 min. vs. 16.86 min, p=0.0001). Conclusions: The results of this study indicate that the modified Misgav-Ladach technique has a weaker inflammatory reaction, which indicates fewer short- and long-term surgical complications

What is the protective effect of preischemic kisspeptin-10 administration against ischemia/reperfusion injury of striatum on mice?

Background/aim: Kisspeptin is a neuropeptide with a primary role on the onset of puberty and has beneficial effects on ischemia/reperfusion (I/R) injury. In this study, we aimed to investigate the effect of kisspeptin administration on striatal I/R injury in mice.Material and methods: Forty adult C57/BL6 mice were randomly divided into four groups: Sham, Kisspeptin, I/R, and I/R + Kisspeptingroups. The groups were administered with either physiological saline (Sham and I/R groups) or kisspeptin (Kisspeptin and I/R +Kisspeptin groups) intraperitoneally 40 min before the operation. A microdialysis probe was placed in the right striatum accordingto stereotaxic coordinates. During the experimental period, artificial cerebrospinal fluid was passed through the micropump. Then,transient cerebral ischemia was established by compressing both common carotid arteries with an aneurysm clip for 15 min and animalswere reperfused for 2 h. Throughout the process of microdialysis (before, during and after I/R period), samples were collected tomeasure dopamine (DA), noradrenaline (NA), and 3,4-dihydroxyphenylglycine (DHPG) at intervals of 20 min continuously. At theend of the reperfusion period, the animals were decapitated, striatum was dissected, half of the animals were used for oxidative stressanalyses (reduced glutathione, glutathione S-transferase (GST), superoxide dismutase (SOD), malondialdehyde (MDA), and the otherhalf were used for histopathology analyses.Results: Number of glial cells was significantly increased in kisspeptin-administered groups. DA levels in ischemic animals weredecreased by kisspeptin administration (p &lt; 0.0001). NA levels were reduced in animals administered with kisspeptin without I/R injury(p &lt; 0.05). DHPG levels reduced during the reperfusion period in ischemic animals (p &lt; 0.05). Kisspeptin did not exhibit a significantantioxidant activity in the ischemic animals, while GST and SOD levels were reduced in the I/R + kisspeptin group compared to thekisspeptin group (p &lt; 0.05).Conclusion: Our results suggest that kisspeptin may be regulating the neurotransmitter release and metabolism, as well as inflammatoryresponse in brain upon I/R injury.&nbsp;</p

Removable denture-related oral mucosal lesions: descriptive clinical study

Objective: The aim of this study was to investigate whether there was a relationship between removable denture-related oral mucosal lesions and denture type, and demographic characteristics. Materials and Method: The age, sex, denture type, systemic condition and medication use, presence of denture-related oral mucosal lesions (DROML), their locations and patients’ awareness of above mentioned lesions were recorded for 199 patients. Pearson chi-square test was used to analyse the relationship between the DROML and denture type, and demographic characteristics of the patients. Results: Among the patients included to the study, 122 (61.3%) were female and 77 (38.7%) were male. Ninety-six patients (48.2%) exhibited DROML, whereas 103 patients (51.8%) had no DROML. No relationship was detected between DROML and age, and sex (p>0.05). The most commonly detected DROML was denture stomatitis (34.7%). Denture stomatitis was significantly more frequently seen in partial denture wearers (p<0.05), while epulis fissuratum and flabby ridge were statistically more frequent in complete denture wearers (p<0.001). Traumatic ulcer was more frequently found in mandibular complete denture wearers (p<0.05), while epulis fissuratum and flabby ridge were significantly more common in maxillary complete denture wearers (p<0.001). Among the patients with DROML, 57.3% stated that they were unaware of these lesions. Conclusion: In this study sample, the rate of DROML was high in patients wearing removable dentures (48.2%), and more than half of the patients with DROML were not aware of these lesions. Upon these findings, it is considered that removable denture wearers should follow the denture usage instructions and should be informed about the importance of periodic controls

A Novel Atraumatic Tourniquet Technique for Excessive Bleeding during Cesarean Sections

Objective. Controlling excessive bleeding in cesarean sections which may cause a life-threatening event even under well-prepared conditions. We used a novel atraumatic tourniquet technique to temporary arrest blood flow through the uterine and ovarian vessels and compare with other techniques. Toothless vascular clamps were used as clamp. Methods. Tourniquet technique performed postpartum hemorrhage (PPH) cases (19 out of 37) were compared with 18 other cases with PPH. Results. The difference between preoperative and postoperative hemoglobin values was significantly lower in the study group as well as the number of blood products needed during and after surgery. Conclusions. This technique not only prevented massive bleeding from the uterus but also allowed physicians time to consider the necessity of further interventions